Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Fibulin-2

Gene

Fbln2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Names & Taxonomyi

Protein namesi
Recommended name:
Fibulin-2
Short name:
FIBL-2
Gene namesi
Name:Fbln2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95488 Fbln2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 261 PublicationAdd BLAST26
ChainiPRO_000000756927 – 1221Fibulin-2Add BLAST1195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi435 ↔ 462By similarity
Disulfide bondi436 ↔ 469By similarity
Disulfide bondi449 ↔ 470By similarity
Disulfide bondi479 ↔ 508By similarity
Disulfide bondi492 ↔ 509By similarity
Glycosylationi497N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi511 ↔ 535By similarity
Disulfide bondi512 ↔ 542By similarity
Disulfide bondi525 ↔ 543By similarity
Disulfide bondi598 ↔ 610By similarity
Disulfide bondi606 ↔ 619By similarity
Disulfide bondi621 ↔ 634By similarity
Disulfide bondi673 ↔ 683By similarity
Disulfide bondi679 ↔ 692By similarity
Disulfide bondi694 ↔ 707By similarity
Disulfide bondi713 ↔ 726By similarity
Disulfide bondi720 ↔ 735By similarity
Glycosylationi737N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi742 ↔ 754By similarity
Disulfide bondi805 ↔ 818By similarity
Disulfide bondi812 ↔ 827By similarity
Disulfide bondi833 ↔ 845By similarity
Disulfide bondi899 ↔ 912By similarity
Disulfide bondi906 ↔ 921By similarity
Disulfide bondi923 ↔ 936By similarity
Disulfide bondi942 ↔ 954By similarity
Disulfide bondi950 ↔ 963By similarity
Disulfide bondi965 ↔ 978By similarity
Disulfide bondi984 ↔ 993By similarity
Disulfide bondi989 ↔ 1002By similarity
Disulfide bondi1004 ↔ 1017By similarity
Disulfide bondi1023 ↔ 1035By similarity
Disulfide bondi1031 ↔ 1044By similarity
Disulfide bondi1046 ↔ 1060By similarity
Disulfide bondi1066 ↔ 1079By similarity
Glycosylationi1072N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1073 ↔ 1088By similarity
Disulfide bondi1093 ↔ 1105By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP37889
PaxDbiP37889
PeptideAtlasiP37889
PRIDEiP37889

PTM databases

iPTMnetiP37889
PhosphoSitePlusiP37889

Miscellaneous databases

PMAP-CutDBiP37889

Expressioni

Tissue specificityi

Component of both basement membranes and other connective tissues.

Developmental stagei

The differential expression of the fibulin family contributes to the formation of molecularly distinct extracellular matrices already during early developmental stages of a large number of tissues.1 Publication

Inductioni

Glucocorticoids suppressed mRNA expression and protein synthesis.

Gene expression databases

BgeeiENSMUSG00000064080 Expressed in 249 organ(s), highest expression level in fibroblast
CleanExiMM_FBLN2
ExpressionAtlasiP37889 baseline and differential
GenevisibleiP37889 MM

Interactioni

Subunit structurei

Homotrimer; disulfide-linked. Interacts with LAMA2 (PubMed:10022829). Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1 (By similarity).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
Irak1Q62406-110EBI-645953,EBI-488313

Protein-protein interaction databases

BioGridi199606, 2 interactors
IntActiP37889, 5 interactors
STRINGi10090.ENSMUSP00000048334

Structurei

3D structure databases

ProteinModelPortaliP37889
SMRiP37889
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini435 – 477Anaphylatoxin-like 1PROSITE-ProRule annotationAdd BLAST43
Domaini478 – 510Anaphylatoxin-like 2PROSITE-ProRule annotationAdd BLAST33
Domaini511 – 543Anaphylatoxin-like 3PROSITE-ProRule annotationAdd BLAST33
Domaini594 – 635EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini669 – 708EGF-like 2PROSITE-ProRule annotationAdd BLAST40
Domaini709 – 755EGF-like 3; calcium-bindingPROSITE-ProRule annotationAdd BLAST47
Domaini756 – 800EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd BLAST45
Domaini801 – 846EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST46
Domaini847 – 894EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST48
Domaini895 – 937EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini938 – 979EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST42
Domaini980 – 1018EGF-like 9; calcium-bindingPROSITE-ProRule annotationAdd BLAST39
Domaini1019 – 1061EGF-like 10; calcium-bindingPROSITE-ProRule annotationAdd BLAST43
Domaini1062 – 1106EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST45

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni27 – 434NAdd BLAST408
Regioni27 – 176Subdomain NA (Cys-rich)Add BLAST150
Regioni177 – 434Subdomain NB (Cys-free)Add BLAST258
Regioni1111 – 1221Domain IIIAdd BLAST111

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi421 – 423Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the fibulin family.Curated

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IR7F Eukaryota
ENOG410Y194 LUCA
GeneTreeiENSGT00760000118806
HOGENOMiHOG000007079
HOVERGENiHBG051559
InParanoidiP37889
KOiK17307
OMAiCKVCHCP
OrthoDBiEOG091G02LJ
TreeFamiTF317514

Family and domain databases

CDDicd00017 ANATO, 2 hits
InterProiView protein in InterPro
IPR000020 Anaphylatoxin/fibulin
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037286 Fibulin-2
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44887 PTHR44887, 1 hit
PfamiView protein in Pfam
PF01821 ANATO, 1 hit
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 6 hits
SMARTiView protein in SMART
SM00104 ANATO, 3 hits
SM00181 EGF, 11 hits
SM00179 EGF_CA, 10 hits
SUPFAMiSSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS01177 ANAPHYLATOXIN_1, 3 hits
PS01178 ANAPHYLATOXIN_2, 3 hits
PS00010 ASX_HYDROXYL, 5 hits
PS01186 EGF_2, 5 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 10 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P37889-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLLQESAGVW LALALVTALT PSPSMAVPWQ DCTGAECPLL ENCIEEALEP
60 70 80 90 100
GACCATCVQQ GCACEGYQYY DCVQGGFVDG RVPAGQSYFV DFGSTECSCP
110 120 130 140 150
PGGGKISCQF MLCPELPPNC IEAVVVADSC PQCGQVGCVH SGRKYAAGHT
160 170 180 190 200
VHLSSCRACH CPDAGGELIC YQLPGCHGNF SDAEEGDSER QYEDPYSYDQ
210 220 230 240 250
EVAEAEATTA IVNEVQAGAE GPPAALGGGN LPPSSIRVTP WPVALPRPTA
260 270 280 290 300
AAALGPPAPV QAKARRVTLD TEEDEEEEEE ETLVTEPPTA GSPGRLDSLP
310 320 330 340 350
TRSPARPGFP VQEKEAEAKA GPEENLIPDA QVTPRSVMQE GAAPLPRSGL
360 370 380 390 400
AALSPSLATD SSSEDPVKPS DHPTLSTLPP DRAQVSPSPE TPEEIPQHPQ
410 420 430 440 450
LLPRFRAEED IDPNSVHSVP RGDLDGSTKD LIETCCAAGQ QWAIDNDECQ
460 470 480 490 500
EIPENGAQSD ICRIAQRQCC ISYLKEKSCV AGVMGAKEGE TCGAEDNDTC
510 520 530 540 550
GVSLYKQCCD CCGLGLRVRA EGQSCESNPN LGYPCNHVML SCCEGEEPLI
560 570 580 590 600
VPEVRRPPEP EAAPRRVSEM EMASREALSL GTEAELPNSL PGDDQDECLM
610 620 630 640 650
LPGELCQHLC INTVGSYRCA CFPGFELQGD GRTCRPDRGA PQLDTARESA
660 670 680 690 700
PRSESAQVSP NTIPLPVPQP NTCKDNGPCR QVCRVVGDTA MCSCFPGYAI
710 720 730 740 750
MADGVSCEDQ DECLMGTHDC SWKQFCVNTL GSFYCVNHTV LCAEGYILNA
760 770 780 790 800
HRKCVDINEC VTDLHTCTRA EHCVNTPGSF QCYKALTCEP GYVLTDGECT
810 820 830 840 850
DVDECVTGTH NCQAGFSCQN TKGSFYCQAR QRCMDGFLQD PEGNCVDINE
860 870 880 890 900
CTSLLEPCRS GFSCINTVGS YTCQRNPLVC GRGYHANEEG SECVDVNECE
910 920 930 940 950
TGVHRCGEGQ LCYNLPGSYR CDCKPGFQRD AFGRTCIDVN ECWVSPGRLC
960 970 980 990 1000
QHTCENTPGS YRCSCAAGFL LAADGKHCED VNECETRRCS QECANIYGSY
1010 1020 1030 1040 1050
QCYCRQGYQL AEDGHTCTDI DECAQGAGIL CTFRCVNVPG SYQCACPEQG
1060 1070 1080 1090 1100
YTMMANGRSC KDLDECALGT HNCSEAETCH NIQGSFRCLR FDCPPNYVRV
1110 1120 1130 1140 1150
SETKCERTTC QDITECQTSP ARITHYQLNF QTGLLVPAHI FRIGPAPAFA
1160 1170 1180 1190 1200
GDTISLTITK GNEEGYFVTR RLNAYTGVVS LQRSVLEPRD FALDVEMKLW
1210 1220
RQGSVTTFLA KMYIFFTTFA P
Length:1,221
Mass (Da):131,834
Last modified:October 3, 2012 - v2
Checksum:iF74113CD292FF51C
GO
Isoform 2 (identifier: P37889-2) [UniParc]FASTAAdd to basket
Also known as: EGF3-less

The sequence of this isoform differs from the canonical sequence as follows:
     709-755: Missing.

Show »
Length:1,174
Mass (Da):126,497
Checksum:i041D8E5939A51B18
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z5B0D3Z5B0_MOUSE
Fibulin-2
Fbln2
69Annotation score:
D3Z5S2D3Z5S2_MOUSE
Fibulin-2
Fbln2
76Annotation score:
A0A1C7ZMZ9A0A1C7ZMZ9_MOUSE
Fibulin-2
Fbln2
10Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti140 – 159HSGRK…SCRAC → TVAVSICWPYRPPLILPGF in AAD34456 (PubMed:10406956).CuratedAdd BLAST20
Sequence conflicti345L → V in CAA53040 (PubMed:8245130).Curated1
Sequence conflicti345L → V in AAD34456 (PubMed:10406956).Curated1
Sequence conflicti348S → L in AAD34456 (PubMed:10406956).Curated1
Sequence conflicti506K → KQ in AAD34456 (PubMed:10406956).Curated1
Sequence conflicti1102E → Q in CAA53040 (PubMed:8245130).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001391709 – 755Missing in isoform 2. CuratedAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75285 mRNA Translation: CAA53040.1
AF135253
, AF135239, AF135240, AF135241, AF135242, AF135243, AF135244, AF135245, AF135246, AF135247, AF135248, AF135249, AF135250, AF135251, AF135252 Genomic DNA Translation: AAD34456.1
AC121990 Genomic DNA No translation available.
AC131764 Genomic DNA No translation available.
CH466523 Genomic DNA Translation: EDK99296.1
CCDSiCCDS39566.1 [P37889-1]
CCDS39567.1 [P37889-2]
PIRiA49457
RefSeqiNP_032018.2, NM_007992.2 [P37889-1]
XP_006505593.1, XM_006505530.3 [P37889-1]
UniGeneiMm.249146
Mm.410235

Genome annotation databases

EnsembliENSMUST00000041544; ENSMUSP00000048334; ENSMUSG00000064080 [P37889-1]
ENSMUST00000113498; ENSMUSP00000109126; ENSMUSG00000064080 [P37889-2]
GeneIDi14115
KEGGimmu:14115
UCSCiuc009cxw.1 mouse [P37889-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X75285 mRNA Translation: CAA53040.1
AF135253
, AF135239, AF135240, AF135241, AF135242, AF135243, AF135244, AF135245, AF135246, AF135247, AF135248, AF135249, AF135250, AF135251, AF135252 Genomic DNA Translation: AAD34456.1
AC121990 Genomic DNA No translation available.
AC131764 Genomic DNA No translation available.
CH466523 Genomic DNA Translation: EDK99296.1
CCDSiCCDS39566.1 [P37889-1]
CCDS39567.1 [P37889-2]
PIRiA49457
RefSeqiNP_032018.2, NM_007992.2 [P37889-1]
XP_006505593.1, XM_006505530.3 [P37889-1]
UniGeneiMm.249146
Mm.410235

3D structure databases

ProteinModelPortaliP37889
SMRiP37889
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199606, 2 interactors
IntActiP37889, 5 interactors
STRINGi10090.ENSMUSP00000048334

PTM databases

iPTMnetiP37889
PhosphoSitePlusiP37889

Proteomic databases

MaxQBiP37889
PaxDbiP37889
PeptideAtlasiP37889
PRIDEiP37889

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000041544; ENSMUSP00000048334; ENSMUSG00000064080 [P37889-1]
ENSMUST00000113498; ENSMUSP00000109126; ENSMUSG00000064080 [P37889-2]
GeneIDi14115
KEGGimmu:14115
UCSCiuc009cxw.1 mouse [P37889-1]

Organism-specific databases

CTDi2199
MGIiMGI:95488 Fbln2

Phylogenomic databases

eggNOGiENOG410IR7F Eukaryota
ENOG410Y194 LUCA
GeneTreeiENSGT00760000118806
HOGENOMiHOG000007079
HOVERGENiHBG051559
InParanoidiP37889
KOiK17307
OMAiCKVCHCP
OrthoDBiEOG091G02LJ
TreeFamiTF317514

Enzyme and pathway databases

ReactomeiR-MMU-2129379 Molecules associated with elastic fibres

Miscellaneous databases

PMAP-CutDBiP37889
PROiPR:P37889
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000064080 Expressed in 249 organ(s), highest expression level in fibroblast
CleanExiMM_FBLN2
ExpressionAtlasiP37889 baseline and differential
GenevisibleiP37889 MM

Family and domain databases

CDDicd00017 ANATO, 2 hits
InterProiView protein in InterPro
IPR000020 Anaphylatoxin/fibulin
IPR026823 cEGF
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR037286 Fibulin-2
IPR009030 Growth_fac_rcpt_cys_sf
PANTHERiPTHR44887 PTHR44887, 1 hit
PfamiView protein in Pfam
PF01821 ANATO, 1 hit
PF12662 cEGF, 2 hits
PF07645 EGF_CA, 6 hits
SMARTiView protein in SMART
SM00104 ANATO, 3 hits
SM00181 EGF, 11 hits
SM00179 EGF_CA, 10 hits
SUPFAMiSSF57184 SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS01177 ANAPHYLATOXIN_1, 3 hits
PS01178 ANAPHYLATOXIN_2, 3 hits
PS00010 ASX_HYDROXYL, 5 hits
PS01186 EGF_2, 5 hits
PS50026 EGF_3, 5 hits
PS01187 EGF_CA, 10 hits
ProtoNetiSearch...

Entry informationi

Entry nameiFBLN2_MOUSE
AccessioniPrimary (citable) accession number: P37889
Secondary accession number(s): G5E8B3, Q9WUI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again