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Protein

Transaldolase

Gene

TALDO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.

Catalytic activityi

Sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate.

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Transaldolase (TALDO1), Transaldolase, Transaldolase (tal), Transaldolase (TALDO1)
  3. no protein annotated in this organism
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-glyceraldehyde 3-phosphate and beta-D-fructose 6-phosphate from D-ribose 5-phosphate and D-xylulose 5-phosphate (non-oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei142Schiff-base intermediate with substrate1 Publication1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processPentose shunt
LigandSchiff base

Enzyme and pathway databases

ReactomeiR-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-HSA-6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P
R-HSA-6791462 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P
R-HSA-71336 Pentose phosphate pathway
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
UniPathwayi
UPA00115;UER00414

Names & Taxonomyi

Protein namesi
Recommended name:
Transaldolase (EC:2.2.1.2)
Gene namesi
Name:TALDO1
Synonyms:TAL, TALDO, TALDOR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

EuPathDBiHostDB:ENSG00000177156.10
HGNCiHGNC:11559 TALDO1
MIMi602063 gene
neXtProtiNX_P37837

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Transaldolase deficiency (TALDOD)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn inborn error of the pentose phosphate pathway resulting in early-onset multisystem disease. Clinical features include growth retardation, dysmorphic features, cutis laxa, congenital heart disease, hepatosplenomegaly, telangiectases of the skin, pancytopenia, and bleeding tendency.
See also OMIM:606003
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011511171Missing in TALDOD. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi6888
MalaCardsiTALDO1
MIMi606003 phenotype
OpenTargetsiENSG00000177156
Orphaneti101028 Transaldolase deficiency
PharmGKBiPA36328

Protein family/group databases

Allergomei9551 Hom s Transaldolase

Polymorphism and mutation databases

BioMutaiTALDO1
DMDMi6648092

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001735641 – 337TransaldolaseAdd BLAST337

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei115N6-acetyllysineBy similarity1
Modified residuei219N6-acetyllysineCombined sources1
Modified residuei237PhosphoserineCombined sources1
Modified residuei256PhosphoserineCombined sources1
Modified residuei269N6-acetyllysineCombined sources1
Modified residuei286N6-acetyllysineCombined sources1
Modified residuei321N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP37837
MaxQBiP37837
PaxDbiP37837
PeptideAtlasiP37837
PRIDEiP37837
ProteomicsDBi55278
TopDownProteomicsiP37837

2D gel databases

OGPiP37837
REPRODUCTION-2DPAGEiIPI00744692

PTM databases

iPTMnetiP37837
PhosphoSitePlusiP37837
SwissPalmiP37837

Expressioni

Gene expression databases

BgeeiENSG00000177156 Expressed in 227 organ(s), highest expression level in bone marrow
CleanExiHS_TALDO1
ExpressionAtlasiP37837 baseline and differential
GenevisibleiP37837 HS

Organism-specific databases

HPAiHPA040373
HPA048089

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TERF2IPQ9NYB02EBI-1056712,EBI-750109

Protein-protein interaction databases

BioGridi112751, 79 interactors
IntActiP37837, 11 interactors
MINTiP37837
STRINGi9606.ENSP00000321259

Structurei

Secondary structure

1337
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP37837
SMRiP37837
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37837

Family & Domainsi

Sequence similaritiesi

Belongs to the transaldolase family. Type 1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2772 Eukaryota
COG0176 LUCA
GeneTreeiENSGT00390000017361
HOGENOMiHOG000281234
HOVERGENiHBG054014
InParanoidiP37837
KOiK00616
OMAiMAFDKLH
OrthoDBiEOG091G0FTU
PhylomeDBiP37837
TreeFamiTF300757

Family and domain databases

CDDicd00957 Transaldolase_TalAB, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00492 Transaldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR004730 Transaldolase_1
IPR018225 Transaldolase_AS
PANTHERiPTHR10683 PTHR10683, 1 hit
PTHR10683:SF20 PTHR10683:SF20, 1 hit
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00874 talAB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P37837-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSPVKRQR MESALDQLKQ FTTVVADTGD FHAIDEYKPQ DATTNPSLIL
60 70 80 90 100
AAAQMPAYQE LVEEAIAYGR KLGGSQEDQI KNAIDKLFVL FGAEILKKIP
110 120 130 140 150
GRVSTEVDAR LSFDKDAMVA RARRLIELYK EAGISKDRIL IKLSSTWEGI
160 170 180 190 200
QAGKELEEQH GIHCNMTLLF SFAQAVACAE AGVTLISPFV GRILDWHVAN
210 220 230 240 250
TDKKSYEPLE DPGVKSVTKI YNYYKKFSYK TIVMGASFRN TGEIKALAGC
260 270 280 290 300
DFLTISPKLL GELLQDNAKL VPVLSAKAAQ ASDLEKIHLD EKSFRWLHNE
310 320 330
DQMAVEKLSD GIRKFAADAV KLERMLTERM FNAENGK
Length:337
Mass (Da):37,540
Last modified:May 30, 2000 - v2
Checksum:i8CB4992AEF364E64
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z393F2Z393_HUMAN
Transaldolase
TALDO1
318Annotation score:
E9PKI8E9PKI8_HUMAN
Transaldolase
TALDO1
93Annotation score:
E9PM01E9PM01_HUMAN
Transaldolase
TALDO1
50Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_011511171Missing in TALDOD. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19437 mRNA Translation: AAB53943.1
AF010400, AF010398, AF010399 Genomic DNA Translation: AAC52068.1
AF058913 Genomic DNA Translation: AAF40478.1
AK313427 mRNA Translation: BAG36219.1
BC010103 mRNA Translation: AAH10103.1
BC018847 mRNA Translation: AAH18847.2
L27346 Genomic DNA Translation: AAL31313.1
CCDSiCCDS7712.1
PIRiA49985
RefSeqiNP_006746.1, NM_006755.1
UniGeneiHs.438678

Genome annotation databases

EnsembliENST00000319006; ENSP00000321259; ENSG00000177156
GeneIDi6888
KEGGihsa:6888
UCSCiuc001lqz.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19437 mRNA Translation: AAB53943.1
AF010400, AF010398, AF010399 Genomic DNA Translation: AAC52068.1
AF058913 Genomic DNA Translation: AAF40478.1
AK313427 mRNA Translation: BAG36219.1
BC010103 mRNA Translation: AAH10103.1
BC018847 mRNA Translation: AAH18847.2
L27346 Genomic DNA Translation: AAL31313.1
CCDSiCCDS7712.1
PIRiA49985
RefSeqiNP_006746.1, NM_006755.1
UniGeneiHs.438678

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1F05X-ray2.45A/B1-337[»]
ProteinModelPortaliP37837
SMRiP37837
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112751, 79 interactors
IntActiP37837, 11 interactors
MINTiP37837
STRINGi9606.ENSP00000321259

Protein family/group databases

Allergomei9551 Hom s Transaldolase

PTM databases

iPTMnetiP37837
PhosphoSitePlusiP37837
SwissPalmiP37837

Polymorphism and mutation databases

BioMutaiTALDO1
DMDMi6648092

2D gel databases

OGPiP37837
REPRODUCTION-2DPAGEiIPI00744692

Proteomic databases

EPDiP37837
MaxQBiP37837
PaxDbiP37837
PeptideAtlasiP37837
PRIDEiP37837
ProteomicsDBi55278
TopDownProteomicsiP37837

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000319006; ENSP00000321259; ENSG00000177156
GeneIDi6888
KEGGihsa:6888
UCSCiuc001lqz.4 human

Organism-specific databases

CTDi6888
DisGeNETi6888
EuPathDBiHostDB:ENSG00000177156.10
GeneCardsiTALDO1
HGNCiHGNC:11559 TALDO1
HPAiHPA040373
HPA048089
MalaCardsiTALDO1
MIMi602063 gene
606003 phenotype
neXtProtiNX_P37837
OpenTargetsiENSG00000177156
Orphaneti101028 Transaldolase deficiency
PharmGKBiPA36328
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2772 Eukaryota
COG0176 LUCA
GeneTreeiENSGT00390000017361
HOGENOMiHOG000281234
HOVERGENiHBG054014
InParanoidiP37837
KOiK00616
OMAiMAFDKLH
OrthoDBiEOG091G0FTU
PhylomeDBiP37837
TreeFamiTF300757

Enzyme and pathway databases

UniPathwayi
UPA00115;UER00414

ReactomeiR-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate
R-HSA-6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P
R-HSA-6791462 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P
R-HSA-71336 Pentose phosphate pathway
R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation

Miscellaneous databases

ChiTaRSiTALDO1 human
EvolutionaryTraceiP37837
GenomeRNAii6888
PROiPR:P37837
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000177156 Expressed in 227 organ(s), highest expression level in bone marrow
CleanExiHS_TALDO1
ExpressionAtlasiP37837 baseline and differential
GenevisibleiP37837 HS

Family and domain databases

CDDicd00957 Transaldolase_TalAB, 1 hit
Gene3Di3.20.20.70, 1 hit
HAMAPiMF_00492 Transaldolase_1, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR001585 TAL/FSA
IPR004730 Transaldolase_1
IPR018225 Transaldolase_AS
PANTHERiPTHR10683 PTHR10683, 1 hit
PTHR10683:SF20 PTHR10683:SF20, 1 hit
PfamiView protein in Pfam
PF00923 TAL_FSA, 1 hit
TIGRFAMsiTIGR00874 talAB, 1 hit
PROSITEiView protein in PROSITE
PS01054 TRANSALDOLASE_1, 1 hit
PS00958 TRANSALDOLASE_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTALDO_HUMAN
AccessioniPrimary (citable) accession number: P37837
Secondary accession number(s): B2R8M2
, O00751, Q8WV32, Q8WZ45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: May 30, 2000
Last modified: November 7, 2018
This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
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