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Entry version 159 (07 Apr 2021)
Sequence version 3 (23 Jan 2007)
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Protein

ATP synthase subunit alpha

Gene

atpA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei362Required for activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi169 – 176ATPUniRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
Biological processATP synthesis, Hydrogen ion transport, Ion transport, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
BSUB:BSU36830-MONOMER

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
P37808

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP synthase subunit alphaUniRule annotation (EC:7.1.2.2UniRule annotation)
Alternative name(s):
ATP synthase F1 sector subunit alphaUniRule annotation
F-ATPase subunit alphaUniRule annotation
Vegetative protein 100
Short name:
VEG100
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:atpAUniRule annotation
Ordered Locus Names:BSU36830
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiBacillus subtilis (strain 168)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri224308 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001570 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, CF(1), Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001443192 – 502ATP synthase subunit alphaAdd BLAST501

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P37808

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P37808

PRoteomics IDEntifications database

More...
PRIDEi
P37808

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains (Probable). The F1F0 complex interacts with SpoIIIJ and YqjG; YqgA is found in the same complex.

UniRule annotationCurated1 Publication

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
P37808, 3 interactors

Molecular INTeraction database

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MINTi
P37808

STRING: functional protein association networks

More...
STRINGi
224308.BSU36830

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P37808

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ATPase alpha/beta chains family.UniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0056, Bacteria

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P37808

Identification of Orthologs from Complete Genome Data

More...
OMAi
NAQIKSM

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P37808

Family and domain databases

Conserved Domains Database

More...
CDDi
cd18113, ATP-synt_F1_alpha_C, 1 hit
cd01132, F1_ATPase_alpha, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.150.20, 1 hit
2.40.30.20, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01346, ATP_synth_alpha_bact, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR023366, ATP_synth_asu-like_sf
IPR000793, ATP_synth_asu_C
IPR038376, ATP_synth_asu_C_sf
IPR033732, ATP_synth_F1_a
IPR005294, ATP_synth_F1_asu
IPR020003, ATPase_a/bsu_AS
IPR004100, ATPase_F1/V1/A1_a/bsu_N
IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF00306, ATP-synt_ab_C, 1 hit
PF02874, ATP-synt_ab_N, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF039088, F_ATPase_subunit_alpha, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50615, SSF50615, 1 hit
SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00962, atpA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P37808-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIKAEEIST LIKQQIQNYQ SDIEVQDVGT VIQVGDGIAR VHGLDNCMAG
60 70 80 90 100
ELVEFSNGVL GMAQNLEESN VGIVILGPFS EIREGDEVKR TGRIMEVPVG
110 120 130 140 150
EELIGRIVNP LGQPVDGLGP ILTSKTRPIE SPAPGVMDRK SVHEPLQTGI
160 170 180 190 200
KAIDALIPIG RGQRELIIGD RQTGKTSVAI DAILNQKDQD MICVYVAIGQ
210 220 230 240 250
KESTVRGVVE TLRKHGALDY TIVVTASASQ PAPLLYLAPY AGVTMAEEFM
260 270 280 290 300
YNGKHVLVVY DDLSKQAAAY RELSLLLRRP PGREAFPGDV FYLHSRLLER
310 320 330 340 350
AAKLSDAKGA GSITALPFVE TQAGDISAYI PTNVISITDG QIFLQSDLFF
360 370 380 390 400
SGVRPAINAG LSVSRVGGSA QIKAMKKVSG TLRLDLASYR ELEAFAQFGS
410 420 430 440 450
DLDQATQAKL NRGARTVEVL KQDLNKPLPV EKQVAILYAL TKGYLDDIPV
460 470 480 490 500
ADIRRFEEEY YMYLDQNHKD LLDGIAKTGN LPADEDFKAA IEGFKRTFAP

SN
Length:502
Mass (Da):54,598
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5DBBD671B37C974C
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z28592 Genomic DNA Translation: CAA82258.1
AL009126 Genomic DNA Translation: CAB15700.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I40366

NCBI Reference Sequences

More...
RefSeqi
NP_391564.1, NC_000964.3
WP_003243657.1, NZ_JNCM01000034.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CAB15700; CAB15700; BSU_36830

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
936995

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
bsu:BSU36830

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|224308.179.peg.3989

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28592 Genomic DNA Translation: CAA82258.1
AL009126 Genomic DNA Translation: CAB15700.1
PIRiI40366
RefSeqiNP_391564.1, NC_000964.3
WP_003243657.1, NZ_JNCM01000034.1

3D structure databases

SMRiP37808
ModBaseiSearch...

Protein-protein interaction databases

IntActiP37808, 3 interactors
MINTiP37808
STRINGi224308.BSU36830

Proteomic databases

jPOSTiP37808
PaxDbiP37808
PRIDEiP37808

Genome annotation databases

EnsemblBacteriaiCAB15700; CAB15700; BSU_36830
GeneIDi936995
KEGGibsu:BSU36830
PATRICifig|224308.179.peg.3989

Phylogenomic databases

eggNOGiCOG0056, Bacteria
InParanoidiP37808
OMAiNAQIKSM
PhylomeDBiP37808

Enzyme and pathway databases

BioCyciBSUB:BSU36830-MONOMER
SABIO-RKiP37808

Family and domain databases

CDDicd18113, ATP-synt_F1_alpha_C, 1 hit
cd01132, F1_ATPase_alpha, 1 hit
Gene3Di1.20.150.20, 1 hit
2.40.30.20, 1 hit
HAMAPiMF_01346, ATP_synth_alpha_bact, 1 hit
InterProiView protein in InterPro
IPR023366, ATP_synth_asu-like_sf
IPR000793, ATP_synth_asu_C
IPR038376, ATP_synth_asu_C_sf
IPR033732, ATP_synth_F1_a
IPR005294, ATP_synth_F1_asu
IPR020003, ATPase_a/bsu_AS
IPR004100, ATPase_F1/V1/A1_a/bsu_N
IPR036121, ATPase_F1/V1/A1_a/bsu_N_sf
IPR000194, ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF00006, ATP-synt_ab, 1 hit
PF00306, ATP-synt_ab_C, 1 hit
PF02874, ATP-synt_ab_N, 1 hit
PIRSFiPIRSF039088, F_ATPase_subunit_alpha, 1 hit
SUPFAMiSSF50615, SSF50615, 1 hit
SSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00962, atpA, 1 hit
PROSITEiView protein in PROSITE
PS00152, ATPASE_ALPHA_BETA, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATPA_BACSU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37808
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: April 7, 2021
This is version 159 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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