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Protein

Transgelin

Gene

Tagln

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Actin cross-linking/gelling protein.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMuscle protein

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin
Alternative name(s):
Actin-associated protein p27
Smooth muscle protein 22-alpha
Short name:
SM22-alpha
Gene namesi
Name:Tagln
Synonyms:Sm22, Sm22a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:106012 Tagln

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedSequence analysis
ChainiPRO_00002047822 – 201TransgelinAdd BLAST200

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineSequence analysisBy similarity1
Modified residuei166PhosphoserineBy similarity1
Modified residuei172N6-acetyllysineCombined sources1
Modified residuei181PhosphoserineBy similarity1
Modified residuei183Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiP37804
PaxDbiP37804
PeptideAtlasiP37804
PRIDEiP37804

2D gel databases

REPRODUCTION-2DPAGEiIPI00226515

PTM databases

iPTMnetiP37804
PhosphoSitePlusiP37804
SwissPalmiP37804

Expressioni

Inductioni

By growth factors.

Gene expression databases

BgeeiENSMUSG00000032085 Expressed in 258 organ(s), highest expression level in urinary bladder
CleanExiMM_TAGLN
ExpressionAtlasiP37804 baseline and differential
GenevisibleiP37804 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi203960, 1 interactor
IntActiP37804, 3 interactors
MINTiP37804
STRINGi10090.ENSMUSP00000034590

Structurei

Secondary structure

1201
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP37804
SMRiP37804
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37804

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 137Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST114
Repeati175 – 200Calponin-likeAdd BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOGENOMiHOG000232113
HOVERGENiHBG005186
InParanoidiP37804
KOiK20526
OMAiVEWIVMQ
OrthoDBiEOG091G0LY2
PhylomeDBiP37804
TreeFamiTF313921

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
IPR029976 TAGLN
PANTHERiPTHR18959:SF40 PTHR18959:SF40, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P37804-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANKGPSYGM SREVQSKIEK KYDEELEERL VEWIVVQCGP DVGRPDRGRL
60 70 80 90 100
GFQVWLKNGV ILSKLVNSLY PEGSKPVKVP ENPPSMVFKQ MEQVAQFLKA
110 120 130 140 150
AEDYGVIKTD MFQTVDLYEG KDMAAVQRTL MALGSLAVTK NDGNYRGDPN
160 170 180 190 200
WFMKKAQEHK RDFTDSQLQE GKHVIGLQMG SNRGASQAGM TGYGRPRQII

S
Length:201
Mass (Da):22,576
Last modified:January 23, 2007 - v3
Checksum:i465F732D706F760A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1STN8A0A1L1STN8_MOUSE
Transgelin
Tagln
109Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti44R → A no nucleotide entry (PubMed:2924801).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41170, L41169 Genomic DNA Translation: AAA79165.1
L41154 mRNA Translation: AAA79166.1
Z68618 Genomic DNA Translation: CAA92941.1
U36588 mRNA Translation: AAC52418.1
AK002880 mRNA Translation: BAB22427.1
AK077235 mRNA Translation: BAC36700.1
BC003795 mRNA Translation: AAH03795.1
CCDSiCCDS23137.1
PIRiA57015
A60598
RefSeqiNP_035656.1, NM_011526.5
UniGeneiMm.283283

Genome annotation databases

EnsembliENSMUST00000034590; ENSMUSP00000034590; ENSMUSG00000032085
GeneIDi21345
KEGGimmu:21345
UCSCiuc009pgs.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L41170, L41169 Genomic DNA Translation: AAA79165.1
L41154 mRNA Translation: AAA79166.1
Z68618 Genomic DNA Translation: CAA92941.1
U36588 mRNA Translation: AAC52418.1
AK002880 mRNA Translation: BAB22427.1
AK077235 mRNA Translation: BAC36700.1
BC003795 mRNA Translation: AAH03795.1
CCDSiCCDS23137.1
PIRiA57015
A60598
RefSeqiNP_035656.1, NM_011526.5
UniGeneiMm.283283

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UJONMR-A24-154[»]
ProteinModelPortaliP37804
SMRiP37804
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203960, 1 interactor
IntActiP37804, 3 interactors
MINTiP37804
STRINGi10090.ENSMUSP00000034590

PTM databases

iPTMnetiP37804
PhosphoSitePlusiP37804
SwissPalmiP37804

2D gel databases

REPRODUCTION-2DPAGEiIPI00226515

Proteomic databases

MaxQBiP37804
PaxDbiP37804
PeptideAtlasiP37804
PRIDEiP37804

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034590; ENSMUSP00000034590; ENSMUSG00000032085
GeneIDi21345
KEGGimmu:21345
UCSCiuc009pgs.2 mouse

Organism-specific databases

CTDi6876
MGIiMGI:106012 Tagln

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOGENOMiHOG000232113
HOVERGENiHBG005186
InParanoidiP37804
KOiK20526
OMAiVEWIVMQ
OrthoDBiEOG091G0LY2
PhylomeDBiP37804
TreeFamiTF313921

Miscellaneous databases

ChiTaRSiTagln2 mouse
EvolutionaryTraceiP37804
PROiPR:P37804
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000032085 Expressed in 258 organ(s), highest expression level in urinary bladder
CleanExiMM_TAGLN
ExpressionAtlasiP37804 baseline and differential
GenevisibleiP37804 MM

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
IPR029976 TAGLN
PANTHERiPTHR18959:SF40 PTHR18959:SF40, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTAGL_MOUSE
AccessioniPrimary (citable) accession number: P37804
Secondary accession number(s): Q545W0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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