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Protein

Transgelin-2

Gene

TAGLN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
  • platelet degranulation Source: Reactome

Enzyme and pathway databases

ReactomeiR-HSA-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transgelin-2
Alternative name(s):
Epididymis tissue protein Li 7e
SM22-alpha homolog
Gene namesi
Name:TAGLN2
Synonyms:KIAA0120
ORF Names:CDABP0035
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000158710.14
HGNCiHGNC:11554 TAGLN2
MIMi604634 gene
neXtProtiNX_P37802

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi8407
OpenTargetsiENSG00000158710
PharmGKBiPA36325

Polymorphism and mutation databases

DMDMi586000

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00002047862 – 199Transgelin-2Add BLAST198

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1 Publication1
Modified residuei11PhosphoserineCombined sources1
Modified residuei17N6-acetyllysineCombined sources1
Modified residuei20N6-acetyllysineCombined sources1
Modified residuei163PhosphoserineCombined sources1
Cross-linki171Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei180PhosphothreonineCombined sources1
Modified residuei182Omega-N-methylarginineCombined sources1
Modified residuei196Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP37802
MaxQBiP37802
PaxDbiP37802
PeptideAtlasiP37802
PRIDEiP37802
ProteomicsDBi55277
TopDownProteomicsiP37802-1 [P37802-1]

2D gel databases

DOSAC-COBS-2DPAGEiP37802
OGPiP37802
REPRODUCTION-2DPAGEiP37802

PTM databases

iPTMnetiP37802
PhosphoSitePlusiP37802
SwissPalmiP37802

Expressioni

Tissue specificityi

Expressed in epididymis (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000158710
CleanExiHS_TAGLN2
ExpressionAtlasiP37802 baseline and differential
GenevisibleiP37802 HS

Organism-specific databases

HPAiHPA001925

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ACTBP607093EBI-1056740,EBI-353944

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113995, 127 interactors
IntActiP37802, 32 interactors
STRINGi9606.ENSP00000357075

Structurei

Secondary structure

1199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi24 – 37Combined sources14
Beta strandi38 – 40Combined sources3
Helixi49 – 57Combined sources9
Helixi60 – 69Combined sources10
Turni72 – 74Combined sources3
Helixi86 – 103Combined sources18
Turni107 – 109Combined sources3
Helixi113 – 117Combined sources5
Helixi122 – 136Combined sources15
Beta strandi140 – 142Combined sources3
Beta strandi148 – 151Combined sources4

3D structure databases

ProteinModelPortaliP37802
SMRiP37802
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37802

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 136Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST113
Repeati174 – 199Calponin-likeAdd BLAST26

Sequence similaritiesi

Belongs to the calponin family.Curated

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOGENOMiHOG000232113
HOVERGENiHBG005186
InParanoidiP37802
KOiK20526
OMAiRATKSGF
OrthoDBiEOG091G0LY2
PhylomeDBiP37802
TreeFamiTF313921

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
IPR001061 TAGLN2
PANTHERiPTHR18959:SF41 PTHR18959:SF41, 1 hit
PfamiView protein in Pfam
PF00402 Calponin, 1 hit
PF00307 CH, 1 hit
PRINTSiPR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 1 hit
PS51122 CALPONIN_2, 1 hit
PS50021 CH, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P37802-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANRGPAYGL SREVQQKIEK QYDADLEQIL IQWITTQCRK DVGRPQPGRE
60 70 80 90 100
NFQNWLKDGT VLCELINALY PEGQAPVKKI QASTMAFKQM EQISQFLQAA
110 120 130 140 150
ERYGINTTDI FQTVDLWEGK NMACVQRTLM NLGGLAVARD DGLFSGDPNW
160 170 180 190
FPKKSKENPR NFSDNQLQEG KNVIGLQMGT NRGASQAGMT GYGMPRQIL
Length:199
Mass (Da):22,391
Last modified:January 23, 2007 - v3
Checksum:i07DFC1652CE2383D
GO
Isoform 2 (identifier: P37802-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MSAFSLALALVSSPQPPPPIGM

Note: No experimental confirmation available.
Show »
Length:220
Mass (Da):24,454
Checksum:iDD4502C038B8D6F6
GO

Sequence cautioni

The sequence BAA04802 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAI14604 differs from that shown. Reason: Erroneous initiation.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04790369L → Q1 PublicationCorresponds to variant dbSNP:rs17849636Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0553111M → MSAFSLALALVSSPQPPPPI GM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY007127 mRNA Translation: AAG01993.1
D21261 mRNA Translation: BAA04802.2 Different initiation.
GU727636 mRNA Translation: ADU87638.1
AK291562 mRNA Translation: BAF84251.1
CR542126 mRNA Translation: CAG46923.1
CR542136 mRNA Translation: CAG46933.1
AL513485 Genomic DNA Translation: CAI14603.1
AL513485 Genomic DNA Translation: CAI14604.1 Different initiation.
AL513485 Genomic DNA Translation: CAI14602.1
CH471121 Genomic DNA Translation: EAW52760.1
BC002616 mRNA Translation: AAH02616.1
BC009357 mRNA Translation: AAH09357.1
CCDSiCCDS1189.1 [P37802-1]
CCDS60314.1 [P37802-2]
RefSeqiNP_001264152.1, NM_001277223.1 [P37802-1]
NP_001264153.1, NM_001277224.1 [P37802-2]
NP_003555.1, NM_003564.2 [P37802-1]
UniGeneiHs.517168

Genome annotation databases

EnsembliENST00000320307; ENSP00000357075; ENSG00000158710 [P37802-1]
ENST00000368096; ENSP00000357076; ENSG00000158710 [P37802-2]
ENST00000368097; ENSP00000357077; ENSG00000158710 [P37802-1]
GeneIDi8407
KEGGihsa:8407
UCSCiuc001fun.3 human [P37802-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTAGL2_HUMAN
AccessioniPrimary (citable) accession number: P37802
Secondary accession number(s): E9KL39
, Q5JRQ6, Q5JRQ7, Q6FGI1, Q9BUH5, Q9H4P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 187 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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