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UniProtKB - P37802 (TAGL2_HUMAN)
Protein
Transgelin-2
Gene
TAGLN2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
GO - Biological processi
- epithelial cell differentiation Source: UniProtKB
Enzyme and pathway databases
PathwayCommonsi | P37802 |
Reactomei | R-HSA-114608, Platelet degranulation |
SignaLinki | P37802 |
SIGNORi | P37802 |
Names & Taxonomyi
Protein namesi | Recommended name: Transgelin-2Alternative name(s): Epididymis tissue protein Li 7e SM22-alpha homolog |
Gene namesi | Name:TAGLN2 Synonyms:KIAA0120 ORF Names:CDABP0035 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11554, TAGLN2 |
MIMi | 604634, gene |
neXtProti | NX_P37802 |
VEuPathDBi | HostDB:ENSG00000158710 |
Subcellular locationi
Cytoskeleton
- cytoskeleton Source: GO_Central
Cytosol
- cytosol Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Other locations
- vesicle Source: UniProtKB
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 8407 |
OpenTargetsi | ENSG00000158710 |
PharmGKBi | PA36325 |
Miscellaneous databases
Pharosi | P37802, Tbio |
Chemistry databases
DrugBanki | DB11638, Artenimol |
Genetic variation databases
BioMutai | TAGLN2 |
DMDMi | 586000 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000204786 | 2 – 199 | Transgelin-2Add BLAST | 198 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 11 | PhosphoserineCombined sources | 1 | |
Modified residuei | 17 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 20 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 163 | PhosphoserineCombined sources | 1 | |
Cross-linki | 171 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 180 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 182 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 196 | Omega-N-methylarginineCombined sources | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P37802 |
jPOSTi | P37802 |
MassIVEi | P37802 |
MaxQBi | P37802 |
PaxDbi | P37802 |
PeptideAtlasi | P37802 |
PRIDEi | P37802 |
ProteomicsDBi | 55277 [P37802-1] |
TopDownProteomicsi | P37802-1 [P37802-1] |
2D gel databases
DOSAC-COBS-2DPAGEi | P37802 |
OGPi | P37802 |
REPRODUCTION-2DPAGEi | P37802 |
PTM databases
GlyGeni | P37802, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P37802 |
MetOSitei | P37802 |
PhosphoSitePlusi | P37802 |
SwissPalmi | P37802 |
Expressioni
Tissue specificityi
Expressed in epididymis (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000158710, Expressed in blood and 226 other tissues |
ExpressionAtlasi | P37802, baseline and differential |
Genevisiblei | P37802, HS |
Organism-specific databases
HPAi | ENSG00000158710, Low tissue specificity |
Interactioni
Binary interactionsi
P37802
GO - Molecular functioni
- cadherin binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 113995, 167 interactors |
IntActi | P37802, 40 interactors |
MINTi | P37802 |
STRINGi | 9606.ENSP00000357076 |
Miscellaneous databases
RNActi | P37802, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P37802 |
SMRi | P37802 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P37802 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 136 | Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST | 113 | |
Repeati | 174 – 199 | Calponin-likeAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the calponin family.Curated
Phylogenomic databases
eggNOGi | KOG2046, Eukaryota |
GeneTreei | ENSGT00940000158886 |
HOGENOMi | CLU_055232_1_0_1 |
InParanoidi | P37802 |
OMAi | IQWITSQ |
OrthoDBi | 861989at2759 |
PhylomeDBi | P37802 |
TreeFami | TF313921 |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR003096, SM22_calponin IPR001061, TAGLN2 |
PANTHERi | PTHR18959:SF41, PTHR18959:SF41, 1 hit |
Pfami | View protein in Pfam PF00402, Calponin, 1 hit PF00307, CH, 1 hit |
PRINTSi | PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 1 hit PS51122, CALPONIN_2, 1 hit PS50021, CH, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: P37802-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MANRGPAYGL SREVQQKIEK QYDADLEQIL IQWITTQCRK DVGRPQPGRE
60 70 80 90 100
NFQNWLKDGT VLCELINALY PEGQAPVKKI QASTMAFKQM EQISQFLQAA
110 120 130 140 150
ERYGINTTDI FQTVDLWEGK NMACVQRTLM NLGGLAVARD DGLFSGDPNW
160 170 180 190
FPKKSKENPR NFSDNQLQEG KNVIGLQMGT NRGASQAGMT GYGMPRQIL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketX6RJP6 | X6RJP6_HUMAN | Transgelin-2 | TAGLN2 | 187 | Annotation score: |
Sequence cautioni
The sequence BAA04802 differs from that shown. Reason: Erroneous initiation.Curated
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047903 | 69 | L → Q1 PublicationCorresponds to variant dbSNP:rs17849636Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055311 | 1 | M → MSAFSLALALVSSPQPPPPI GM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY007127 mRNA Translation: AAG01993.1 D21261 mRNA Translation: BAA04802.2 Different initiation. GU727636 mRNA Translation: ADU87638.1 AK291562 mRNA Translation: BAF84251.1 CR542126 mRNA Translation: CAG46923.1 CR542136 mRNA Translation: CAG46933.1 AL513485 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52760.1 BC002616 mRNA Translation: AAH02616.1 BC009357 mRNA Translation: AAH09357.1 |
CCDSi | CCDS1189.1 [P37802-1] CCDS60314.1 [P37802-2] |
RefSeqi | NP_001264152.1, NM_001277223.1 [P37802-1] NP_001264153.1, NM_001277224.1 [P37802-2] NP_003555.1, NM_003564.2 [P37802-1] |
Genome annotation databases
Ensembli | ENST00000320307.8; ENSP00000357075.1; ENSG00000158710.15 ENST00000368096.5; ENSP00000357076.1; ENSG00000158710.15 [P37802-2] ENST00000368097.9; ENSP00000357077.5; ENSG00000158710.15 |
GeneIDi | 8407 |
KEGGi | hsa:8407 |
MANE-Selecti | ENST00000368097.9; ENSP00000357077.5; NM_003564.3; NP_003555.1 |
UCSCi | uc001fun.3, human [P37802-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY007127 mRNA Translation: AAG01993.1 D21261 mRNA Translation: BAA04802.2 Different initiation. GU727636 mRNA Translation: ADU87638.1 AK291562 mRNA Translation: BAF84251.1 CR542126 mRNA Translation: CAG46923.1 CR542136 mRNA Translation: CAG46933.1 AL513485 Genomic DNA No translation available. CH471121 Genomic DNA Translation: EAW52760.1 BC002616 mRNA Translation: AAH02616.1 BC009357 mRNA Translation: AAH09357.1 |
CCDSi | CCDS1189.1 [P37802-1] CCDS60314.1 [P37802-2] |
RefSeqi | NP_001264152.1, NM_001277223.1 [P37802-1] NP_001264153.1, NM_001277224.1 [P37802-2] NP_003555.1, NM_003564.2 [P37802-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WYM | NMR | - | A | 16-157 | [»] | |
AlphaFoldDBi | P37802 | |||||
SMRi | P37802 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113995, 167 interactors |
IntActi | P37802, 40 interactors |
MINTi | P37802 |
STRINGi | 9606.ENSP00000357076 |
Chemistry databases
DrugBanki | DB11638, Artenimol |
PTM databases
GlyGeni | P37802, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P37802 |
MetOSitei | P37802 |
PhosphoSitePlusi | P37802 |
SwissPalmi | P37802 |
Genetic variation databases
BioMutai | TAGLN2 |
DMDMi | 586000 |
2D gel databases
DOSAC-COBS-2DPAGEi | P37802 |
OGPi | P37802 |
REPRODUCTION-2DPAGEi | P37802 |
Proteomic databases
EPDi | P37802 |
jPOSTi | P37802 |
MassIVEi | P37802 |
MaxQBi | P37802 |
PaxDbi | P37802 |
PeptideAtlasi | P37802 |
PRIDEi | P37802 |
ProteomicsDBi | 55277 [P37802-1] |
TopDownProteomicsi | P37802-1 [P37802-1] |
Protocols and materials databases
Antibodypediai | 1099, 242 antibodies from 31 providers |
DNASUi | 8407 |
Genome annotation databases
Ensembli | ENST00000320307.8; ENSP00000357075.1; ENSG00000158710.15 ENST00000368096.5; ENSP00000357076.1; ENSG00000158710.15 [P37802-2] ENST00000368097.9; ENSP00000357077.5; ENSG00000158710.15 |
GeneIDi | 8407 |
KEGGi | hsa:8407 |
MANE-Selecti | ENST00000368097.9; ENSP00000357077.5; NM_003564.3; NP_003555.1 |
UCSCi | uc001fun.3, human [P37802-1] |
Organism-specific databases
CTDi | 8407 |
DisGeNETi | 8407 |
GeneCardsi | TAGLN2 |
HGNCi | HGNC:11554, TAGLN2 |
HPAi | ENSG00000158710, Low tissue specificity |
MIMi | 604634, gene |
neXtProti | NX_P37802 |
OpenTargetsi | ENSG00000158710 |
PharmGKBi | PA36325 |
VEuPathDBi | HostDB:ENSG00000158710 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2046, Eukaryota |
GeneTreei | ENSGT00940000158886 |
HOGENOMi | CLU_055232_1_0_1 |
InParanoidi | P37802 |
OMAi | IQWITSQ |
OrthoDBi | 861989at2759 |
PhylomeDBi | P37802 |
TreeFami | TF313921 |
Enzyme and pathway databases
PathwayCommonsi | P37802 |
Reactomei | R-HSA-114608, Platelet degranulation |
SignaLinki | P37802 |
SIGNORi | P37802 |
Miscellaneous databases
BioGRID-ORCSi | 8407, 31 hits in 1072 CRISPR screens |
ChiTaRSi | TAGLN2, human |
EvolutionaryTracei | P37802 |
GeneWikii | TAGLN2 |
GenomeRNAii | 8407 |
Pharosi | P37802, Tbio |
PROi | PR:P37802 |
RNActi | P37802, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000158710, Expressed in blood and 226 other tissues |
ExpressionAtlasi | P37802, baseline and differential |
Genevisiblei | P37802, HS |
Family and domain databases
CDDi | cd00014, CH, 1 hit |
Gene3Di | 1.10.418.10, 1 hit |
InterProi | View protein in InterPro IPR000557, Calponin_repeat IPR001715, CH-domain IPR036872, CH_dom_sf IPR003096, SM22_calponin IPR001061, TAGLN2 |
PANTHERi | PTHR18959:SF41, PTHR18959:SF41, 1 hit |
Pfami | View protein in Pfam PF00402, Calponin, 1 hit PF00307, CH, 1 hit |
PRINTSi | PR00888, SM22CALPONIN |
SMARTi | View protein in SMART SM00033, CH, 1 hit |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS01052, CALPONIN_1, 1 hit PS51122, CALPONIN_2, 1 hit PS50021, CH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TAGL2_HUMAN | |
Accessioni | P37802Primary (citable) accession number: P37802 Secondary accession number(s): E9KL39 Q9H4P0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | May 25, 2022 | |
This is version 213 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families