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UniProtKB - P37798 (ACCC_PSEAE)
Protein
Biotin carboxylase
Gene
accC
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Functioni
This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA.
By similarityCatalytic activityi
- ATP + hydrogencarbonate + N6-biotinyl-L-lysyl-[protein] = ADP + H+ + N6-carboxybiotinyl-L-lysyl-[protein] + phosphateEC:6.3.4.14
- EC:6.4.1.2
: malonyl-CoA biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes malonyl-CoA from acetyl-CoA. This subpathway is part of the pathway malonyl-CoA biosynthesis, which is itself part of Lipid metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes malonyl-CoA from acetyl-CoA, the pathway malonyl-CoA biosynthesis and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 116 | ATPBy similarity | 1 | |
Binding sitei | 201 | ATPBy similarity | 1 | |
Binding sitei | 236 | ATPBy similarity | 1 | |
Active sitei | 292 | Sequence analysis | 1 |
GO - Molecular functioni
- acetyl-CoA carboxylase activity Source: UniProtKB-EC
- ATP binding Source: UniProtKB-KW
- biotin carboxylase activity Source: UniProtKB-EC
- metal ion binding Source: InterPro
GO - Biological processi
- fatty acid biosynthetic process Source: UniProtKB-KW
- malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism |
Ligand | ATP-binding, Biotin, Nucleotide-binding |
Enzyme and pathway databases
UniPathwayi | UPA00655;UER00711 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:accC Synonyms:fabG Ordered Locus Names:PA4848 |
Organismi | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Taxonomic identifieri | 208964 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
Proteomesi |
|
Organism-specific databases
PseudoCAPi | PA4848 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000146794 | 1 – 449 | Biotin carboxylaseAdd BLAST | 449 |
Proteomic databases
PaxDbi | P37798 |
PRIDEi | P37798 |
Interactioni
Subunit structurei
Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.
By similarityProtein-protein interaction databases
STRINGi | 287.DR97_2199 |
Chemistry databases
BindingDBi | P37798 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P37798 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P37798 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 445 | Biotin carboxylationAdd BLAST | 445 | |
Domaini | 120 – 317 | ATP-graspPROSITE-ProRule annotationAdd BLAST | 198 |
Phylogenomic databases
HOGENOMi | CLU_000395_3_2_6 |
InParanoidi | P37798 |
OMAi | TGFYDRH |
PhylomeDBi | P37798 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR004549, Acetyl_CoA_COase_biotin_COase IPR011761, ATP-grasp IPR013815, ATP_grasp_subdomain_1 IPR005481, BC-like_N IPR011764, Biotin_carboxylation_dom IPR005482, Biotin_COase_C IPR005479, CbamoylP_synth_lsu-like_ATP-bd IPR016185, PreATP-grasp_dom_sf IPR011054, Rudment_hybrid_motif |
Pfami | View protein in Pfam PF02785, Biotin_carb_C, 1 hit PF00289, Biotin_carb_N, 1 hit PF02786, CPSase_L_D2, 1 hit |
SMARTi | View protein in SMART SM00878, Biotin_carb_C, 1 hit |
SUPFAMi | SSF51246, SSF51246, 1 hit SSF52440, SSF52440, 1 hit |
TIGRFAMsi | TIGR00514, accC, 1 hit |
PROSITEi | View protein in PROSITE PS50975, ATP_GRASP, 1 hit PS50979, BC, 1 hit PS00866, CPSASE_1, 1 hit PS00867, CPSASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P37798-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLEKVLIANR GEIALRILRA CKELGIKTVA VHSTADRELM HLSLADESVC
60 70 80 90 100
IGPAPATQSY LQIPAIIAAA EVTGATAIHP GYGFLAENAD FAEQIERSGF
110 120 130 140 150
TFVGPTAEVI RLMGDKVSAK DAMKRAGVPT VPGSDGPLPE DEETALAIAR
160 170 180 190 200
EVGYPVIIKA AGGGGGRGMR VVYDESELIK SAKLTRTEAG AAFGNPMVYL
210 220 230 240 250
EKFLTNPRHV EVQVLSDGQG NAIHLGDRDC SLQRRHQKVI EEAPAPGIDE
260 270 280 290 300
KARQEVFARC VQACIEIGYR GAGTFEFLYE NGRFYFIEMN TRVQVEHPVS
310 320 330 340 350
EMVTGVDIVK EMLRIASGEK LSIRQEDVVI RGHALECRIN AEDPKTFMPS
360 370 380 390 400
PGKVKHFHAP GGNGVRVDSH LYSGYSVPPN YDSLVGKVIT YGADRDEALA
410 420 430 440
RMRNALDELI VDGIKTNTEL HKDLVRDAAF CKGGVNIHYL EKKLGMDKH
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14612 Unassigned DNA Translation: AAA16041.1 AE004091 Genomic DNA Translation: AAG08233.1 |
PIRi | B49342 |
RefSeqi | NP_253535.1, NC_002516.2 WP_003095391.1, NZ_QZGE01000002.1 |
Genome annotation databases
EnsemblBacteriai | AAG08233; AAG08233; PA4848 |
GeneIDi | 879558 |
KEGGi | pae:PA4848 |
PATRICi | fig|208964.12.peg.5080 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L14612 Unassigned DNA Translation: AAA16041.1 AE004091 Genomic DNA Translation: AAG08233.1 |
PIRi | B49342 |
RefSeqi | NP_253535.1, NC_002516.2 WP_003095391.1, NZ_QZGE01000002.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2C00 | X-ray | 2.50 | A/B | 1-449 | [»] | |
2VQD | X-ray | 2.41 | A | 1-449 | [»] | |
SMRi | P37798 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 287.DR97_2199 |
Chemistry databases
BindingDBi | P37798 |
ChEMBLi | CHEMBL4523221 |
Proteomic databases
PaxDbi | P37798 |
PRIDEi | P37798 |
Genome annotation databases
EnsemblBacteriai | AAG08233; AAG08233; PA4848 |
GeneIDi | 879558 |
KEGGi | pae:PA4848 |
PATRICi | fig|208964.12.peg.5080 |
Organism-specific databases
PseudoCAPi | PA4848 |
Phylogenomic databases
HOGENOMi | CLU_000395_3_2_6 |
InParanoidi | P37798 |
OMAi | TGFYDRH |
PhylomeDBi | P37798 |
Enzyme and pathway databases
UniPathwayi | UPA00655;UER00711 |
Miscellaneous databases
EvolutionaryTracei | P37798 |
Family and domain databases
Gene3Di | 3.30.1490.20, 1 hit |
InterProi | View protein in InterPro IPR004549, Acetyl_CoA_COase_biotin_COase IPR011761, ATP-grasp IPR013815, ATP_grasp_subdomain_1 IPR005481, BC-like_N IPR011764, Biotin_carboxylation_dom IPR005482, Biotin_COase_C IPR005479, CbamoylP_synth_lsu-like_ATP-bd IPR016185, PreATP-grasp_dom_sf IPR011054, Rudment_hybrid_motif |
Pfami | View protein in Pfam PF02785, Biotin_carb_C, 1 hit PF00289, Biotin_carb_N, 1 hit PF02786, CPSase_L_D2, 1 hit |
SMARTi | View protein in SMART SM00878, Biotin_carb_C, 1 hit |
SUPFAMi | SSF51246, SSF51246, 1 hit SSF52440, SSF52440, 1 hit |
TIGRFAMsi | TIGR00514, accC, 1 hit |
PROSITEi | View protein in PROSITE PS50975, ATP_GRASP, 1 hit PS50979, BC, 1 hit PS00866, CPSASE_1, 1 hit PS00867, CPSASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACCC_PSEAE | |
Accessioni | P37798Primary (citable) accession number: P37798 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references