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Protein

Chitooligosaccharide deacetylase ChbG

Gene

chbG

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ChbG is essential for growth on the acetylated chitooligosaccharides chitobiose and chitotriose but is dispensable for growth on cellobiose and chitosan dimer, the deacetylated form of chitobiose. Deacetylation of chitobiose-6-P and chitotriose-6-P is necessary for both the activation of the chb promoter by the regulatory protein ChbR and the hydrolysis of phosphorylated beta-glucosides by the phospho-beta-glucosidase ChbF. Catalyzes the removal of only one acetyl group from chitobiose-6-P to yield monoacetylchitobiose-6-P, the inducer of ChbR and the substrate of ChbF. It can also use chitobiose and chitotriose as substrates.1 Publication

Caution

Was originally (PubMed:8121401 and PubMed:2179047) characterized as part of a cryptic cel operon for a cellobiose degradation system. The Cel+ phenotype is due to mutations making expression chitobiose-independent and altering the substrate specificity.Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: chitin degradation

This protein is involved in the pathway chitin degradation, which is part of Glycan degradation.1 Publication
View all proteins of this organism that are known to be involved in the pathway chitin degradation and in Glycan degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi61Magnesium; via tele nitrogenBy similarity1
Metal bindingi125Magnesium; via pros nitrogenBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • chitin catabolic process Source: UniProtKB-UniPathway
  • diacetylchitobiose catabolic process Source: EcoCyc
  • polysaccharide catabolic process Source: UniProtKB-UniRule

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Chitin degradation, Polysaccharide degradation
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:EG12198-MONOMER
MetaCyc:EG12198-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00349

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chitooligosaccharide deacetylase ChbG1 Publication (EC:3.5.1.1051 Publication)
Short name:
COD1 Publication
Alternative name(s):
Chitin disaccharide deacetylase1 Publication
Chitobiose deacetylase1 Publication
Chitobiose-6P deacetylase1 Publication
Chitotriose deacetylase1 Publication
Chitotriose-6P deacetylase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:chbG1 Publication
Synonyms:ydjC
Ordered Locus Names:b1733, JW1722
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

Escherichia coli strain K12 genome database

More...
EcoGenei
EG12198 chbG

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Cells lacking this gene are unable to grow on chitobiose and chitotriose.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi11D → A: Unable to induce CnbR and to grow on chitobiose. 1 Publication1
Mutagenesisi61H → A: Unable to induce CnbR and to grow on chitobiose. 1 Publication1
Mutagenesisi125H → A: Unable to induce CnbR and to grow on chitobiose. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000515891 – 249Chitooligosaccharide deacetylase ChbGAdd BLAST249

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P37794

PRoteomics IDEntifications database

More...
PRIDEi
P37794

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By N,N'-diacetylchitobiose.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
4260305, 16 interactors

Protein interaction database and analysis system

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IntActi
P37794, 4 interactors

STRING: functional protein association networks

More...
STRINGi
316385.ECDH10B_1871

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P37794

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P37794

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the YdjC deacetylase family. ChbG subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410901P Bacteria
COG3394 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000225034

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P37794

KEGG Orthology (KO)

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KOi
K03478

Database for complete collections of gene phylogenies

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PhylomeDBi
P37794

Family and domain databases

Conserved Domains Database

More...
CDDi
cd10803 YdjC_EF3048_like, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_01246 COD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR022948 COD_ChbG_bac
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR006879 YdjC-like

The PANTHER Classification System

More...
PANTHERi
PTHR31609 PTHR31609, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF04794 YdjC, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF88713 SSF88713, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P37794-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERLLIVNAD DFGLSKGQNY GIIEACRNGI VTSTTALVNG QAIDHAVQLS
60 70 80 90 100
RDEPSLAIGM HFVLTMGKPL TAMPGLTRDG VLGKWIWQLA EEDALPLEEI
110 120 130 140 150
TQELVSQYLR FIELFGRKPT HLDSHHHVHM FPQIFPIVAR FAAEQGIALR
160 170 180 190 200
ADRQMAFDLP VNLRTTQGFS SAFYGEEISE SLFLQVLDDA GHRGDRSLEV
210 220 230 240
MCHPAFIDNT IRQSAYCFPR LTELDVLTSA SLKGAIAQRG YRLGSYRDV
Length:249
Mass (Da):27,774
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1D4747904C974F11
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6I → L in CAA47260 (PubMed:8121401).Curated1
Sequence conflicti6I → L in X52890 (PubMed:2179047).Curated1
Sequence conflicti16 – 40KGQNY…ALVNG → QRTELRHYRGLSQWDCHCRR RHCEW in CAA47260 (PubMed:8121401).CuratedAdd BLAST25
Sequence conflicti16 – 40KGQNY…ALVNG → QRTELRHYRGLSQWDCHCRR RHCEW in X52890 (PubMed:2179047).CuratedAdd BLAST25
Sequence conflicti48Q → H in CAA47260 (PubMed:8121401).Curated1
Sequence conflicti48Q → H in X52890 (PubMed:2179047).Curated1
Sequence conflicti51R → C in CAA47260 (PubMed:8121401).Curated1
Sequence conflicti51R → C in X52890 (PubMed:2179047).Curated1
Sequence conflicti55S → I in CAA47260 (PubMed:8121401).Curated1
Sequence conflicti55S → I in X52890 (PubMed:2179047).Curated1
Sequence conflicti65T → I in CAA47260 (PubMed:8121401).Curated1
Sequence conflicti65T → I in X52890 (PubMed:2179047).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X66725 Genomic DNA Translation: CAA47260.1
X66725 Genomic DNA Translation: CAA47261.1
U00096 Genomic DNA Translation: AAC74803.1
AP009048 Genomic DNA Translation: BAA15514.1
X52890 Genomic DNA No translation available.
M55161 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

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PIRi
E64932

NCBI Reference Sequences

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RefSeqi
NP_416247.1, NC_000913.3
WP_000440471.1, NZ_LN832404.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC74803; AAC74803; b1733
BAA15514; BAA15514; BAA15514

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
946231

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW1722
eco:b1733

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.523

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66725 Genomic DNA Translation: CAA47260.1
X66725 Genomic DNA Translation: CAA47261.1
U00096 Genomic DNA Translation: AAC74803.1
AP009048 Genomic DNA Translation: BAA15514.1
X52890 Genomic DNA No translation available.
M55161 Genomic DNA No translation available.
PIRiE64932
RefSeqiNP_416247.1, NC_000913.3
WP_000440471.1, NZ_LN832404.1

3D structure databases

ProteinModelPortaliP37794
SMRiP37794
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4260305, 16 interactors
IntActiP37794, 4 interactors
STRINGi316385.ECDH10B_1871

Proteomic databases

PaxDbiP37794
PRIDEiP37794

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC74803; AAC74803; b1733
BAA15514; BAA15514; BAA15514
GeneIDi946231
KEGGiecj:JW1722
eco:b1733
PATRICifig|1411691.4.peg.523

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2115
EcoGeneiEG12198 chbG

Phylogenomic databases

eggNOGiENOG410901P Bacteria
COG3394 LUCA
HOGENOMiHOG000225034
InParanoidiP37794
KOiK03478
PhylomeDBiP37794

Enzyme and pathway databases

UniPathwayi
UPA00349

BioCyciEcoCyc:EG12198-MONOMER
MetaCyc:EG12198-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P37794

Family and domain databases

CDDicd10803 YdjC_EF3048_like, 1 hit
HAMAPiMF_01246 COD, 1 hit
InterProiView protein in InterPro
IPR022948 COD_ChbG_bac
IPR011330 Glyco_hydro/deAcase_b/a-brl
IPR006879 YdjC-like
PANTHERiPTHR31609 PTHR31609, 2 hits
PfamiView protein in Pfam
PF04794 YdjC, 1 hit
SUPFAMiSSF88713 SSF88713, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCHBG_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37794
Secondary accession number(s): P77435
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: July 15, 1998
Last modified: December 5, 2018
This is version 122 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
  4. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
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