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UniProtKB - P37698 (GUNF_RUMCH)
Protein
Endoglucanase F
Gene
celCCF
Organism
Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) (Clostridium cellulolyticum)
Status
Functioni
Probable endoglucanase involved in the degradation of cellulose or related beta-glucans.
Catalytic activityi
- Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. EC:3.2.1.4
GO - Molecular functioni
- cellulase activity Source: UniProtKB-EC
GO - Biological processi
- cellulose catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation |
Enzyme and pathway databases
BioCyci | CCEL394503:G1GUL-745-MONOMER |
BRENDAi | 3.2.1.4, 1468 |
Protein family/group databases
CAZyi | GH48, Glycoside Hydrolase Family 48 |
Names & Taxonomyi
Protein namesi | Recommended name: Endoglucanase F (EC:3.2.1.4)Alternative name(s): Cellulase F EGCCF Endo-1,4-beta-glucanase F |
Gene namesi | Name:celCCF Ordered Locus Names:Ccel_0729 |
Organismi | Ruminiclostridium cellulolyticum (strain ATCC 35319 / DSM 5812 / JCM 6584 / H10) (Clostridium cellulolyticum) |
Taxonomic identifieri | 394503 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Clostridia › Eubacteriales › Oscillospiraceae › Ruminiclostridium › |
Proteomesi |
|
Pathology & Biotechi
Chemistry databases
DrugBanki | DB03857, 1,4-dithio-beta-D-glucopyranose DB03584, 4-Thio-beta-D-glucopyranose DB02379, Beta-D-Glucose DB02252, Iodobenzene DB01642, methyl beta-D-glucopyranoside |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | Sequence analysisAdd BLAST | 29 | |
ChainiPRO_0000008026 | 30 – 722 | Endoglucanase FAdd BLAST | 693 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P37698 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P37698 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 661 – 722 | DockerinPROSITE-ProRule annotationAdd BLAST | 62 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 142 – 165 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 150 – 165 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 48 (cellulase L) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | COG5297, Bacteria |
HOGENOMi | CLU_009014_1_0_9 |
OMAi | QWFGFQA |
OrthoDBi | 191946at2 |
Family and domain databases
Gene3Di | 1.10.1330.10, 1 hit 1.50.10.10, 1 hit 2.170.160.10, 1 hit 4.10.870.10, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR012341, 6hp_glycosidase-like_sf IPR002105, Dockerin_1_rpt IPR016134, Dockerin_dom IPR036439, Dockerin_dom_sf IPR023309, Endo-1-4-beta-glucanase_dom2 IPR027390, Endoglucanase_F_dom3 IPR000556, Glyco_hydro_48F |
Pfami | View protein in Pfam PF00404, Dockerin_1, 1 hit PF02011, Glyco_hydro_48, 1 hit |
PRINTSi | PR00844, GLHYDRLASE48 |
SUPFAMi | SSF48208, SSF48208, 1 hit SSF63446, SSF63446, 1 hit |
PROSITEi | View protein in PROSITE PS00448, CLOS_CELLULOSOME_RPT, 2 hits PS51766, DOCKERIN, 1 hit PS00018, EF_HAND_1, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P37698-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSKNFKRVGA VAVAAAMSLS IMATTSINAA SSPANKVYQD RFESMYSKIK
60 70 80 90 100
DPANGYFSEQ GIPYHSIETL MVEAPDYGHV TTSEAMSYYM WLEAMHGRFS
110 120 130 140 150
GDFTGFDKSW SVTEQYLIPT EKDQPNTSMS RYDANKPATY APEFQDPSKY
160 170 180 190 200
PSPLDTSQPV GRDPINSQLT SAYGTSMLYG MHWILDVDNW YGFGARADGT
210 220 230 240 250
SKPSYINTFQ RGEQESTWET IPQPCWDEHK FGGQYGFLDL FTKDTGTPAK
260 270 280 290 300
QFKYTNAPDA DARAVQATYW ADQWAKEQGK SVSTSVGKAT KMGDYLRYSF
310 320 330 340 350
FDKYFRKIGQ PSQAGTGYDA AHYLLSWYYA WGGGIDSTWS WIIGSSHNHF
360 370 380 390 400
GYQNPFAAWV LSTDANFKPK SSNGASDWAK SLDRQLEFYQ WLQSAEGAIA
410 420 430 440 450
GGATNSWNGR YEAVPSGTST FYGMGYVENP VYADPGSNTW FGMQVWSMQR
460 470 480 490 500
VAELYYKTGD ARAKKLLDKW AKWINGEIKF NADGTFQIPS TIDWEGQPDT
510 520 530 540 550
WNPTQGYTGN ANLHVKVVNY GTDLGCASSL ANTLTYYAAK SGDETSRQNA
560 570 580 590 600
QKLLDAMWNN YSDSKGISTV EQRGDYHRFL DQEVFVPAGW TGKMPNGDVI
610 620 630 640 650
KSGVKFIDIR SKYKQDPEWQ TMVAALQAGQ VPTQRLHRFW AQSEFAVANG
660 670 680 690 700
VYAILFPDQG PEKLLGDVNG DETVDAIDLA ILKKYLLNSS TTINTANADM
710 720
NSDNAIDAID YALLKKALLS IQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U30321 Genomic DNA Translation: AAB41452.1 CP001348 Genomic DNA Translation: ACL75108.1 M87018 Genomic DNA Translation: AAA73866.1 |
PIRi | PC1139 |
RefSeqi | WP_015924275.1, NC_011898.1 |
Genome annotation databases
EnsemblBacteriai | ACL75108; ACL75108; Ccel_0729 |
KEGGi | cce:Ccel_0729 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U30321 Genomic DNA Translation: AAB41452.1 CP001348 Genomic DNA Translation: ACL75108.1 M87018 Genomic DNA Translation: AAA73866.1 |
PIRi | PC1139 |
RefSeqi | WP_015924275.1, NC_011898.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1F9D | X-ray | 2.30 | A | 30-658 | [»] | |
1F9O | X-ray | 2.50 | A | 30-658 | [»] | |
1FAE | X-ray | 2.00 | A | 30-658 | [»] | |
1FBO | X-ray | 2.30 | A | 30-658 | [»] | |
1FBW | X-ray | 2.00 | A | 30-658 | [»] | |
1FCE | X-ray | 2.00 | A | 30-658 | [»] | |
1G9G | X-ray | 1.90 | A | 30-658 | [»] | |
1G9J | X-ray | 1.90 | A | 30-658 | [»] | |
2QNO | X-ray | 2.00 | A | 30-658 | [»] | |
SMRi | P37698 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
STRINGi | 394503.Ccel_0729 |
Chemistry databases
DrugBanki | DB03857, 1,4-dithio-beta-D-glucopyranose DB03584, 4-Thio-beta-D-glucopyranose DB02379, Beta-D-Glucose DB02252, Iodobenzene DB01642, methyl beta-D-glucopyranoside |
Protein family/group databases
CAZyi | GH48, Glycoside Hydrolase Family 48 |
Genome annotation databases
EnsemblBacteriai | ACL75108; ACL75108; Ccel_0729 |
KEGGi | cce:Ccel_0729 |
Phylogenomic databases
eggNOGi | COG5297, Bacteria |
HOGENOMi | CLU_009014_1_0_9 |
OMAi | QWFGFQA |
OrthoDBi | 191946at2 |
Enzyme and pathway databases
BioCyci | CCEL394503:G1GUL-745-MONOMER |
BRENDAi | 3.2.1.4, 1468 |
Miscellaneous databases
EvolutionaryTracei | P37698 |
Family and domain databases
Gene3Di | 1.10.1330.10, 1 hit 1.50.10.10, 1 hit 2.170.160.10, 1 hit 4.10.870.10, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR012341, 6hp_glycosidase-like_sf IPR002105, Dockerin_1_rpt IPR016134, Dockerin_dom IPR036439, Dockerin_dom_sf IPR023309, Endo-1-4-beta-glucanase_dom2 IPR027390, Endoglucanase_F_dom3 IPR000556, Glyco_hydro_48F |
Pfami | View protein in Pfam PF00404, Dockerin_1, 1 hit PF02011, Glyco_hydro_48, 1 hit |
PRINTSi | PR00844, GLHYDRLASE48 |
SUPFAMi | SSF48208, SSF48208, 1 hit SSF63446, SSF63446, 1 hit |
PROSITEi | View protein in PROSITE PS00448, CLOS_CELLULOSOME_RPT, 2 hits PS51766, DOCKERIN, 1 hit PS00018, EF_HAND_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GUNF_RUMCH | |
Accessioni | P37698Primary (citable) accession number: P37698 Secondary accession number(s): B8I7V1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1996 | |
Last modified: | June 2, 2021 | |
This is version 131 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families