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Protein

Probable endoglucanase

Gene

cmcAX

Organism
Komagataeibacter hansenii (Gluconacetobacter hansenii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Enzyme capable of hydrolyzing carboxy-methyl-cellulose (CMC).

Catalytic activityi

Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei57Proton donorBy similarity1
Active sitei114NucleophilePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processCarbohydrate metabolism, Cellulose degradation, Polysaccharide degradation

Protein family/group databases

CAZyiGH8 Glycoside Hydrolase Family 8

Names & Taxonomyi

Protein namesi
Recommended name:
Probable endoglucanase (EC:3.2.1.4)
Alternative name(s):
Cellulase
Endo-1,4-beta-glucanase
Gene namesi
Name:cmcAX
OrganismiKomagataeibacter hansenii (Gluconacetobacter hansenii)
Taxonomic identifieri436 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhodospirillalesAcetobacteraceaeKomagataeibacter

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 201 PublicationAdd BLAST20
ChainiPRO_000000793021 – 342Probable endoglucanaseAdd BLAST322

Proteomic databases

PRIDEiP37696

Structurei

Secondary structure

1342
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 38Combined sources13
Beta strandi48 – 51Combined sources4
Beta strandi53 – 55Combined sources3
Helixi56 – 69Combined sources14
Helixi72 – 85Combined sources14
Beta strandi89 – 92Combined sources4
Beta strandi96 – 99Combined sources4
Beta strandi102 – 106Combined sources5
Helixi113 – 130Combined sources18
Helixi133 – 150Combined sources18
Beta strandi151 – 154Combined sources4
Beta strandi157 – 160Combined sources4
Beta strandi164 – 166Combined sources3
Beta strandi170 – 175Combined sources6
Helixi177 – 179Combined sources3
Helixi182 – 192Combined sources11
Helixi196 – 210Combined sources15
Turni214 – 217Combined sources4
Beta strandi221 – 226Combined sources6
Turni227 – 229Combined sources3
Beta strandi232 – 234Combined sources3
Beta strandi240 – 242Combined sources3
Turni244 – 247Combined sources4
Helixi248 – 255Combined sources8
Helixi261 – 274Combined sources14
Turni285 – 287Combined sources3
Beta strandi292 – 294Combined sources3
Helixi297 – 305Combined sources9
Helixi317 – 319Combined sources3
Helixi323 – 339Combined sources17

3D structure databases

ProteinModelPortaliP37696
SMRiP37696
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37696

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105K2Z Bacteria
COG3405 LUCA

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR002037 Glyco_hydro_8
IPR019834 Glyco_hydro_8_CS
PfamiView protein in Pfam
PF01270 Glyco_hydro_8, 1 hit
PRINTSiPR00735 GLHYDRLASE8
SUPFAMiSSF48208 SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00812 GLYCOSYL_HYDROL_F8, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37696-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVMAAMGGA QVLSSTGAFA DPAPDAVAQQ WAIFRAKYLR PSGRVVDTGN
60 70 80 90 100
GGESHSEGQG YGMLFAASAG DLASFQSMWM WARTNLQHTN DKLFSWRFLK
110 120 130 140 150
GHQPPVPDKN NATDGDLLIA LALGRAGKRF QRPDYIQDAM AIYGDVLNLM
160 170 180 190 200
TMKAGPYVVL MPGAVGFTKK DSVILNLSYY VMPSLLQAFD LTADPRWRQV
210 220 230 240 250
MEDGIRLVSA GRFGQWRLPP DWLAVNRATG ALSIASGWPP RFSYDAIRVP
260 270 280 290 300
LYFYWAHMLA PNVLADFTRF WNNFGANALP GWVDLTTGAR SPYNAPPGYL
310 320 330 340
AVAECTGLDS AGELPTLDHA PDYYSAALTL LVYIARAEET IK
Length:342
Mass (Da):37,443
Last modified:October 1, 1994 - v1
Checksum:i85FF9BDF8B979F81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M96060 Unassigned DNA Translation: AAA16969.1
PIRiA36963

Similar proteinsi

Entry informationi

Entry nameiGUNA_KOMHA
AccessioniPrimary (citable) accession number: P37696
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: May 23, 2018
This is version 92 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

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