UniProtKB - P37696 (GUNA_KOMHA)
Protein
Probable endoglucanase
Gene
cmcAX
Organism
Komagataeibacter hansenii (Gluconacetobacter hansenii)
Status
Functioni
Enzyme capable of hydrolyzing carboxy-methyl-cellulose (CMC).
Catalytic activityi
- Endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans. EC:3.2.1.4
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 57 | Proton donorBy similarity | 1 | |
Active sitei | 114 | NucleophilePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cellulase activity Source: UniProtKB-EC
GO - Biological processi
- cellulose catabolic process Source: UniProtKB-KW
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Biological process | Carbohydrate metabolism, Cellulose degradation, Polysaccharide degradation |
Protein family/group databases
CAZyi | GH8, Glycoside Hydrolase Family 8 |
Names & Taxonomyi
Protein namesi | Recommended name: Probable endoglucanase (EC:3.2.1.4)Alternative name(s): Cellulase Endo-1,4-beta-glucanase |
Gene namesi | Name:cmcAX |
Organismi | Komagataeibacter hansenii (Gluconacetobacter hansenii) |
Taxonomic identifieri | 436 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Alphaproteobacteria › Rhodospirillales › Acetobacteraceae › Komagataeibacter |
Subcellular locationi
GO - Cellular componenti
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | 1 PublicationAdd BLAST | 20 | |
ChainiPRO_0000007930 | 21 – 342 | Probable endoglucanaseAdd BLAST | 322 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P37696 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P37696 |
Family & Domainsi
Sequence similaritiesi
Belongs to the glycosyl hydrolase 8 (cellulase D) family.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR012341, 6hp_glycosidase-like_sf IPR002037, Glyco_hydro_8 IPR019834, Glyco_hydro_8_CS |
Pfami | View protein in Pfam PF01270, Glyco_hydro_8, 1 hit |
PRINTSi | PR00735, GLHYDRLASE8 |
SUPFAMi | SSF48208, SSF48208, 1 hit |
PROSITEi | View protein in PROSITE PS00812, GLYCOSYL_HYDROL_F8, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P37696-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSVMAAMGGA QVLSSTGAFA DPAPDAVAQQ WAIFRAKYLR PSGRVVDTGN
60 70 80 90 100
GGESHSEGQG YGMLFAASAG DLASFQSMWM WARTNLQHTN DKLFSWRFLK
110 120 130 140 150
GHQPPVPDKN NATDGDLLIA LALGRAGKRF QRPDYIQDAM AIYGDVLNLM
160 170 180 190 200
TMKAGPYVVL MPGAVGFTKK DSVILNLSYY VMPSLLQAFD LTADPRWRQV
210 220 230 240 250
MEDGIRLVSA GRFGQWRLPP DWLAVNRATG ALSIASGWPP RFSYDAIRVP
260 270 280 290 300
LYFYWAHMLA PNVLADFTRF WNNFGANALP GWVDLTTGAR SPYNAPPGYL
310 320 330 340
AVAECTGLDS AGELPTLDHA PDYYSAALTL LVYIARAEET IK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96060 Unassigned DNA Translation: AAA16969.1 |
PIRi | A36963 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M96060 Unassigned DNA Translation: AAA16969.1 |
PIRi | A36963 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1WZZ | X-ray | 1.65 | A | 21-342 | [»] | |
SMRi | P37696 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
CAZyi | GH8, Glycoside Hydrolase Family 8 |
Miscellaneous databases
EvolutionaryTracei | P37696 |
Family and domain databases
Gene3Di | 1.50.10.10, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR012341, 6hp_glycosidase-like_sf IPR002037, Glyco_hydro_8 IPR019834, Glyco_hydro_8_CS |
Pfami | View protein in Pfam PF01270, Glyco_hydro_8, 1 hit |
PRINTSi | PR00735, GLHYDRLASE8 |
SUPFAMi | SSF48208, SSF48208, 1 hit |
PROSITEi | View protein in PROSITE PS00812, GLYCOSYL_HYDROL_F8, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GUNA_KOMHA | |
Accessioni | P37696Primary (citable) accession number: P37696 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | October 7, 2020 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencingDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries