Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Probable alcohol dehydrogenase

Gene

yiaY

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.
A secondary alcohol + NAD+ = a ketone + NADH.

Cofactori

Fe cationBy similarity

GO - Molecular functioni

  • alcohol dehydrogenase (NAD) activity Source: CACAO
  • L-threonine 3-dehydrogenase activity Source: EcoCyc
  • metal ion binding Source: InterPro

Keywordsi

Molecular functionOxidoreductase
LigandIron, NAD

Enzyme and pathway databases

BioCyciEcoCyc:EG12293-MONOMER
MetaCyc:EG12293-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:yiaY
Ordered Locus Names:b3589, JW5648
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12293 yiaY

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878161 – 383Probable alcohol dehydrogenaseAdd BLAST383

Proteomic databases

PaxDbiP37686
PRIDEiP37686

Interactioni

Protein-protein interaction databases

BioGridi4262556, 14 interactors
DIPiDIP-12414N
STRINGi316385.ECDH10B_3770

Structurei

3D structure databases

ProteinModelPortaliP37686
SMRiP37686
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4105C0A Bacteria
COG1454 LUCA
HOGENOMiHOG000243333
InParanoidiP37686
KOiK13954
OMAiRAACQCP
PhylomeDBiP37686

Family and domain databases

InterProiView protein in InterPro
IPR001670 ADH_Fe/GldA
IPR018211 ADH_Fe_CS
PfamiView protein in Pfam
PF00465 Fe-ADH, 1 hit
PROSITEiView protein in PROSITE
PS00913 ADH_IRON_1, 1 hit
PS00060 ADH_IRON_2, 1 hit

Sequencei

Sequence statusi: Complete.

P37686-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASTFFIPS VNVIGADSLT DAMNMMADYG FTRTLIVTDN MLTKLGMAGD
60 70 80 90 100
VQKALEERNI FSVIYDGTQP NPTTENVAAG LKLLKENNCD SVISLGGGSP
110 120 130 140 150
HDCAKGIALV AANGGDIRDY EGVDRSAKPQ LPMIAINTTA GTASEMTRFC
160 170 180 190 200
IITDEARHIK MAIVDKHVTP LLSVNDSSLM IGMPKSLTAA TGMDALTHAI
210 220 230 240 250
EAYVSIAATP ITDACALKAV TMIAENLPLA VEDGSNAKAR EAMAYAQFLA
260 270 280 290 300
GMAFNNASLG YVHAMAHQLG GFYNLPHGVC NAVLLPHVQV FNSKVAAARL
310 320 330 340 350
RDCAAAMGVN VTGKNDAEGA EACINAIREL AKKVDIPAGL RDLNVKEEDF
360 370 380
AVLATNALKD ACGFTNPIQA THEEIVAIYR AAM
Length:383
Mass (Da):40,351
Last modified:October 11, 2004 - v4
Checksum:i805DC4E488E108F6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti380 – 383RAAM → AAR in AAB18566 (PubMed:8041620).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18566.1
U00096 Genomic DNA Translation: AAT48195.1
AP009048 Genomic DNA Translation: BAE77704.1
L40742 Genomic DNA Translation: AAC36938.1
PIRiS47810
RefSeqiWP_000741518.1, NZ_LN832404.1
YP_026233.1, NC_000913.3

Genome annotation databases

EnsemblBacteriaiAAT48195; AAT48195; b3589
BAE77704; BAE77704; BAE77704
GeneIDi948102
KEGGiecj:JW5648
eco:b3589
PATRICifig|1411691.4.peg.3122

Entry informationi

Entry nameiADH2_ECOLI
AccessioniPrimary (citable) accession number: P37686
Secondary accession number(s): Q2M7Q2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 11, 2004
Last modified: June 20, 2018
This is version 118 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health