UniProtKB - P37677 (LYXK_ECOLI)
Protein
L-xylulose/3-keto-L-gulonate kinase
Gene
lyx
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalyzes the phosphorylation of L-xylulose and 3-keto-L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate.2 Publications
Catalytic activityi
- EC:2.7.1.53
Kineticsi
- KM=0.8 mM for L-xylulose1 Publication
- KM=0.4 mM for ATP1 Publication
- Vmax=33 µmol/min/mg enzyme with L-xylulose as substrate1 Publication
pH dependencei
Optimum pH is 8.4 with L-xylulose as substrate.1 Publication
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- L-xylulokinase activity Source: EcoCyc
GO - Biological processi
- L-lyxose metabolic process Source: EcoCyc
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Carbohydrate metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:LYXK-MONOMER MetaCyc:LYXK-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:lyx Synonyms:lyxK, sgbK, xylK, yiaP Ordered Locus Names:b3580, JW3552 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000059560 | 1 – 498 | L-xylulose/3-keto-L-gulonate kinaseAdd BLAST | 498 |
Proteomic databases
PaxDbi | P37677 |
PRIDEi | P37677 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
BioGRIDi | 4262550, 7 interactors |
IntActi | P37677, 2 interactors |
STRINGi | 511145.b3580 |
Family & Domainsi
Sequence similaritiesi
Belongs to the FGGY kinase family.Curated
Phylogenomic databases
eggNOGi | COG1070, Bacteria |
HOGENOMi | CLU_009281_3_1_6 |
InParanoidi | P37677 |
PhylomeDBi | P37677 |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR000577, Carb_kinase_FGGY IPR018485, Carb_kinase_FGGY_C IPR018483, Carb_kinase_FGGY_CS IPR018484, Carb_kinase_FGGY_N |
Pfami | View protein in Pfam PF02782, FGGY_C, 1 hit PF00370, FGGY_N, 1 hit |
PIRSFi | PIRSF000538, GlpK, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00445, FGGY_KINASES_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P37677-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTQYWLGLDC GGSWLKAGLY DREGREAGVQ RLPLCALSPQ PGWAERDMAE
60 70 80 90 100
LWQCCMAVIR ALLTHSGVSG EQIVGIGISA QGKGLFLLDK NDKPLGNAIL
110 120 130 140 150
SSDRRAMEIV RRWQEDGIPE KLYPLTRQTL WTGHPVSLLR WLKEHEPERY
160 170 180 190 200
AQIGCVMMTH DYLRWCLTGV KGCEESNISE SNLYNMSLGE YDPCLTDWLG
210 220 230 240 250
IAEINHALPP VVGSAEICGE ITAQTAALTG LKAGTPVVGG LFDVVSTALC
260 270 280 290 300
AGIEDEFTLN AVMGTWAVTS GITRGLRDGE AHPYVYGRYV NDGEFIVHEA
310 320 330 340 350
SPTSSGNLEW FTAQWGEISF DEINQAVASL PKAGGDLFFL PFLYGSNAGL
360 370 380 390 400
EMTSGFYGMQ AIHTRAHLLQ AIYEGVVFSH MTHLNRMRER FTDVHTLRVT
410 420 430 440 450
GGPAHSDVWM QMLADVSGLR IELPQVEETG CFGAALAARV GTGVYHNFSE
460 470 480 490
AQRDLRHPVR TLLPDMTAHQ LYQKKYQRYQ HLIAALQGFH ARIKEHTL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00039 Genomic DNA Translation: AAB18557.1 U00096 Genomic DNA Translation: AAC76604.1 AP009048 Genomic DNA Translation: BAE77713.1 |
PIRi | S47801 |
RefSeqi | NP_418037.1, NC_000913.3 WP_000196054.1, NZ_SSZK01000041.1 |
Genome annotation databases
EnsemblBacteriai | AAC76604; AAC76604; b3580 BAE77713; BAE77713; BAE77713 |
GeneIDi | 948101 |
KEGGi | ecj:JW3552 eco:b3580 |
PATRICi | fig|1411691.4.peg.3132 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00039 Genomic DNA Translation: AAB18557.1 U00096 Genomic DNA Translation: AAC76604.1 AP009048 Genomic DNA Translation: BAE77713.1 |
PIRi | S47801 |
RefSeqi | NP_418037.1, NC_000913.3 WP_000196054.1, NZ_SSZK01000041.1 |
3D structure databases
SMRi | P37677 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262550, 7 interactors |
IntActi | P37677, 2 interactors |
STRINGi | 511145.b3580 |
Proteomic databases
PaxDbi | P37677 |
PRIDEi | P37677 |
Protocols and materials databases
DNASUi | 948101 |
Genome annotation databases
EnsemblBacteriai | AAC76604; AAC76604; b3580 BAE77713; BAE77713; BAE77713 |
GeneIDi | 948101 |
KEGGi | ecj:JW3552 eco:b3580 |
PATRICi | fig|1411691.4.peg.3132 |
Organism-specific databases
EchoBASEi | EB2192 |
Phylogenomic databases
eggNOGi | COG1070, Bacteria |
HOGENOMi | CLU_009281_3_1_6 |
InParanoidi | P37677 |
PhylomeDBi | P37677 |
Enzyme and pathway databases
BioCyci | EcoCyc:LYXK-MONOMER MetaCyc:LYXK-MONOMER |
Miscellaneous databases
PROi | PR:P37677 |
Family and domain databases
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR000577, Carb_kinase_FGGY IPR018485, Carb_kinase_FGGY_C IPR018483, Carb_kinase_FGGY_CS IPR018484, Carb_kinase_FGGY_N |
Pfami | View protein in Pfam PF02782, FGGY_C, 1 hit PF00370, FGGY_N, 1 hit |
PIRSFi | PIRSF000538, GlpK, 1 hit |
SUPFAMi | SSF53067, SSF53067, 2 hits |
PROSITEi | View protein in PROSITE PS00445, FGGY_KINASES_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | LYXK_ECOLI | |
Accessioni | P37677Primary (citable) accession number: P37677 Secondary accession number(s): Q2M7P3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families