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Protein

L-xylulose/3-keto-L-gulonate kinase

Gene

lyx

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of L-xylulose and 3-keto-L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate.2 Publications

Catalytic activityi

ATP + L-xylulose = ADP + L-xylulose 5-phosphate.
ATP + 3-dehydro-L-gulonate = ADP + 3-dehydro-L-gulonate 6-phosphate.

Kineticsi

  1. KM=0.8 mM for L-xylulose1 Publication
  2. KM=0.4 mM for ATP1 Publication
  1. Vmax=33 µmol/min/mg enzyme with L-xylulose as substrate1 Publication

pH dependencei

Optimum pH is 8.4 with L-xylulose as substrate.1 Publication

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • L-xylulokinase activity Source: EcoCyc

GO - Biological processi

  • L-lyxose metabolic process Source: EcoCyc

Keywordsi

Molecular functionKinase, Transferase
Biological processCarbohydrate metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciEcoCyc:LYXK-MONOMER
MetaCyc:LYXK-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
L-xylulose/3-keto-L-gulonate kinase (EC:2.7.1.-, EC:2.7.1.53)
Short name:
L-xylulokinase
Alternative name(s):
3-dehydro-L-gulonate kinase
Gene namesi
Name:lyx
Synonyms:lyxK, sgbK, xylK, yiaP
Ordered Locus Names:b3580, JW3552
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12284 lyx

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000595601 – 498L-xylulose/3-keto-L-gulonate kinaseAdd BLAST498

Proteomic databases

PaxDbiP37677
PRIDEiP37677

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi4262550, 7 interactors
IntActiP37677, 2 interactors
STRINGi316385.ECDH10B_3761

Structurei

3D structure databases

ProteinModelPortaliP37677
SMRiP37677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.Curated

Phylogenomic databases

eggNOGiENOG4105CMG Bacteria
COG1070 LUCA
HOGENOMiHOG000222135
InParanoidiP37677
KOiK00880
OMAiAANLEWF
PhylomeDBiP37677

Family and domain databases

InterProiView protein in InterPro
IPR000577 Carb_kinase_FGGY
IPR018485 Carb_kinase_FGGY_C
IPR018483 Carb_kinase_FGGY_CS
IPR018484 Carb_kinase_FGGY_N
PfamiView protein in Pfam
PF02782 FGGY_C, 1 hit
PF00370 FGGY_N, 1 hit
PIRSFiPIRSF000538 GlpK, 1 hit
PROSITEiView protein in PROSITE
PS00445 FGGY_KINASES_2, 1 hit

Sequencei

Sequence statusi: Complete.

P37677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQYWLGLDC GGSWLKAGLY DREGREAGVQ RLPLCALSPQ PGWAERDMAE
60 70 80 90 100
LWQCCMAVIR ALLTHSGVSG EQIVGIGISA QGKGLFLLDK NDKPLGNAIL
110 120 130 140 150
SSDRRAMEIV RRWQEDGIPE KLYPLTRQTL WTGHPVSLLR WLKEHEPERY
160 170 180 190 200
AQIGCVMMTH DYLRWCLTGV KGCEESNISE SNLYNMSLGE YDPCLTDWLG
210 220 230 240 250
IAEINHALPP VVGSAEICGE ITAQTAALTG LKAGTPVVGG LFDVVSTALC
260 270 280 290 300
AGIEDEFTLN AVMGTWAVTS GITRGLRDGE AHPYVYGRYV NDGEFIVHEA
310 320 330 340 350
SPTSSGNLEW FTAQWGEISF DEINQAVASL PKAGGDLFFL PFLYGSNAGL
360 370 380 390 400
EMTSGFYGMQ AIHTRAHLLQ AIYEGVVFSH MTHLNRMRER FTDVHTLRVT
410 420 430 440 450
GGPAHSDVWM QMLADVSGLR IELPQVEETG CFGAALAARV GTGVYHNFSE
460 470 480 490
AQRDLRHPVR TLLPDMTAHQ LYQKKYQRYQ HLIAALQGFH ARIKEHTL
Length:498
Mass (Da):55,155
Last modified:October 1, 1994 - v1
Checksum:i207EC94507141E34
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18557.1
U00096 Genomic DNA Translation: AAC76604.1
AP009048 Genomic DNA Translation: BAE77713.1
PIRiS47801
RefSeqiNP_418037.1, NC_000913.3
WP_000196054.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76604; AAC76604; b3580
BAE77713; BAE77713; BAE77713
GeneIDi948101
KEGGiecj:JW3552
eco:b3580
PATRICifig|1411691.4.peg.3132

Similar proteinsi

Entry informationi

Entry nameiLYXK_ECOLI
AccessioniPrimary (citable) accession number: P37677
Secondary accession number(s): Q2M7P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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