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Protein

2,3-diketo-L-gulonate-binding periplasmic protein YiaO

Gene

yiaO

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the tripartite ATP-independent periplasmic (TRAP) transport system YiaMNO involved in the uptake of 2,3-diketo-L-gulonate. This protein specifically binds 2,3-diketo-L-gulonate. Is not able to bind either L-ascorbate or dehydroascorbate.1 Publication

Caution

Was originally proposed to be a subunit from an L-xylulose uptake system, but PubMed:16385129 shows that YiaO does not bind L- or D-xylulose.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: EcoCyc

GO - Biological processi

  • carbohydrate transmembrane transport Source: EcoCyc
  • cellular response to DNA damage stimulus Source: EcoliWiki

Keywordsi

Biological processTransport

Enzyme and pathway databases

BioCyciEcoCyc:EG12283-MONOMER
MetaCyc:EG12283-MONOMER

Protein family/group databases

TCDBi2.A.56.1.2 the tripartite atp-independent periplasmic transporter (trap-t) family

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-diketo-L-gulonate-binding periplasmic protein YiaO
Short name:
2,3-DKG-binding protein
Alternative name(s):
Extracytoplasmic solute receptor protein YiaO
Gene namesi
Name:yiaO
Ordered Locus Names:b3579, JW3551
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12283 yiaO

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24CuratedAdd BLAST24
ChainiPRO_000003181325 – 3282,3-diketo-L-gulonate-binding periplasmic protein YiaOAdd BLAST304

Proteomic databases

PaxDbiP37676
PRIDEiP37676

Interactioni

Subunit structurei

The complex comprises the extracytoplasmic solute receptor protein YiaO, and the two transmembrane proteins YiaM and YiaN.

Protein-protein interaction databases

BioGridi4262009, 5 interactors
STRINGi316385.ECDH10B_3760

Structurei

3D structure databases

ProteinModelPortaliP37676
SMRiP37676
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105DR6 Bacteria
COG1638 LUCA
HOGENOMiHOG000251307
InParanoidiP37676
KOiK21395
OMAiRTQGRIN
PhylomeDBiP37676

Family and domain databases

Gene3Di3.40.190.170, 1 hit
InterProiView protein in InterPro
IPR004682 TRAP_DctP
IPR018389 TRAP_DctP/TeaA
IPR038404 TRAP_DctP_sf
PANTHERiPTHR33376 PTHR33376, 1 hit
PfamiView protein in Pfam
PF03480 DctP, 1 hit
PIRSFiPIRSF006470 DctB, 1 hit
TIGRFAMsiTIGR00787 dctP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLRSVTYAL FIAGLAAFST SSLAAQSLRF GYETSQTDSQ HIAAKKFNDL
60 70 80 90 100
LQERTKGELK LKLFPDSTLG NAQAMISGVR GGTIDMEMSG SNNFAGLSPV
110 120 130 140 150
MNLLDVPFLF RDTAHAHKTL DGKVGDDLKA SLEGKGLKVL AYWENGWRDV
160 170 180 190 200
TNSRAPVKTP ADLKGLKIRT NNSPMNIAAF KVFGANPIPM PFAEVYTGLE
210 220 230 240 250
TRTIDAQEHP INVVWSAKFF EVQKFLSLTH HAYSPLLVVI NKAKFDGLSP
260 270 280 290 300
EFQQALVSSA QEAGNYQRKL VAEDQQKIID GMKEAGVEVI TDLDRKAFSD
310 320
ALGNQVRDMF VKDVPQGADL LKAVDEVQ
Length:328
Mass (Da):35,970
Last modified:October 1, 1994 - v1
Checksum:iEB44605FE87BCFF8
GO

Mass spectrometryi

Molecular mass is 33468.8±2 Da from positions 25 - 328. Determined by ESI. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18556.1
U00096 Genomic DNA Translation: AAC76603.1
AP009048 Genomic DNA Translation: BAE77714.1
PIRiS47800
RefSeqiNP_418036.1, NC_000913.3
WP_000776887.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76603; AAC76603; b3579
BAE77714; BAE77714; BAE77714
GeneIDi948091
KEGGiecj:JW3551
eco:b3579
PATRICifig|1411691.4.peg.3133

Similar proteinsi

Entry informationi

Entry nameiYIAO_ECOLI
AccessioniPrimary (citable) accession number: P37676
Secondary accession number(s): Q2M7P2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: March 28, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

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