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UniProtKB - P37664 (YIAC_ECOLI)
Protein
Peptidyl-lysine N-acetyltransferase YiaC
Gene
yiaC
Organism
Escherichia coli (strain K12)
Status
Functioni
N-epsilon-lysine acetyltransferase that catalyzes acetylation of a large number of proteins. Overexpression inhibits motility.
1 PublicationCatalytic activityi
GO - Molecular functioni
- peptide-lysine-N-acetyltransferase activity Source: EcoCyc
GO - Biological processi
- internal peptidyl-lysine acetylation Source: EcoCyc
Keywordsi
Molecular function | Acyltransferase, Transferase |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12270-MONOMER |
BRENDAi | 2.3.1.286, 2026 |
Names & Taxonomyi
Protein namesi | Recommended name: Peptidyl-lysine N-acetyltransferase YiaCCurated (EC:2.3.1.-1 Publication)Alternative name(s): KAT1 Publication |
Gene namesi | Name:yiaC Ordered Locus Names:b3550, JW3519 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Mutant shows the same motility as wild-type strain.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 70 | F → A: Decreases activity. 1 Publication | 1 | |
Mutagenesisi | 115 | Y → A: Loss of activity. Unable to inhibit motility. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000074614 | 1 – 146 | Peptidyl-lysine N-acetyltransferase YiaCAdd BLAST | 146 |
Proteomic databases
PaxDbi | P37664 |
PRIDEi | P37664 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4261556, 5 interactors 850814, 1 interactor |
IntActi | P37664, 3 interactors |
STRINGi | 511145.b3550 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 143 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 143 |
Sequence similaritiesi
Belongs to the acetyltransferase family.Curated
Phylogenomic databases
eggNOGi | COG0456, Bacteria |
HOGENOMi | CLU_013985_21_2_6 |
InParanoidi | P37664 |
OMAi | RAVNFYH |
PhylomeDBi | P37664 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
i Sequence
Sequence statusi: Complete.
P37664-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIREAQRSEL PAILELWLES TTWGHPFIKA NYWRDCIPLV RDAYLANAQN
60 70 80 90 100
WVWEEDGKLL GFVSIMEGRF LAAMFVAPKA VRRGIGKALM QYVQQRHPHL
110 120 130 140
MLEVYQKNQP AINFYQAQGF HIVDCAWQDE TQLPTWIMSW PVVQTL
Sequence cautioni
The sequence M34827 differs from that shown. Reason: Frameshift.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34827 Genomic DNA No translation available. U00039 Genomic DNA Translation: AAB18527.1 U00096 Genomic DNA Translation: AAC76574.1 AP009048 Genomic DNA Translation: BAE77745.1 |
PIRi | S47771 |
RefSeqi | NP_418006.1, NC_000913.3 WP_000617473.1, NZ_SSZK01000068.1 |
Genome annotation databases
EnsemblBacteriai | AAC76574; AAC76574; b3550 BAE77745; BAE77745; BAE77745 |
GeneIDi | 946460 |
KEGGi | ecj:JW3519 eco:b3550 |
PATRICi | fig|1411691.4.peg.3164 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M34827 Genomic DNA No translation available. U00039 Genomic DNA Translation: AAB18527.1 U00096 Genomic DNA Translation: AAC76574.1 AP009048 Genomic DNA Translation: BAE77745.1 |
PIRi | S47771 |
RefSeqi | NP_418006.1, NC_000913.3 WP_000617473.1, NZ_SSZK01000068.1 |
3D structure databases
AlphaFoldDBi | P37664 |
SMRi | P37664 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261556, 5 interactors 850814, 1 interactor |
IntActi | P37664, 3 interactors |
STRINGi | 511145.b3550 |
Proteomic databases
PaxDbi | P37664 |
PRIDEi | P37664 |
Genome annotation databases
EnsemblBacteriai | AAC76574; AAC76574; b3550 BAE77745; BAE77745; BAE77745 |
GeneIDi | 946460 |
KEGGi | ecj:JW3519 eco:b3550 |
PATRICi | fig|1411691.4.peg.3164 |
Organism-specific databases
EchoBASEi | EB2179 |
Phylogenomic databases
eggNOGi | COG0456, Bacteria |
HOGENOMi | CLU_013985_21_2_6 |
InParanoidi | P37664 |
OMAi | RAVNFYH |
PhylomeDBi | P37664 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12270-MONOMER |
BRENDAi | 2.3.1.286, 2026 |
Miscellaneous databases
PROi | PR:P37664 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | YIAC_ECOLI | |
Accessioni | P37664Primary (citable) accession number: P37664 Secondary accession number(s): Q2M7L1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 140 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families