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Entry version 148 (12 Aug 2020)
Sequence version 1 (01 Oct 1994)
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Protein

Multidrug resistance protein MdtF

Gene

mdtF

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Part of the tripartite efflux system MdtEF-TolC, which confers resistance to compounds such as rhodamine 6G, erythromycin, doxorubicin, ethidium bromide, TPP, SDS, deoxycholate, crystal violet and benzalkonium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAntibiotic resistance, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
EcoCyc:YHIV-MONOMER
ECOL316407:JW3482-MONOMER
MetaCyc:YHIV-MONOMER

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.6.2.13, the resistance-nodulation-cell division (rnd) superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Multidrug resistance protein MdtF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:mdtF
Synonyms:yhiV
Ordered Locus Names:b3514, JW3482
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 9CytoplasmicBy similarity9
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei10 – 28Helical; Name=1By similarityAdd BLAST19
Topological domaini29 – 339PeriplasmicBy similarityAdd BLAST311
Transmembranei340 – 359Helical; Name=2By similarityAdd BLAST20
Topological domaini360 – 365CytoplasmicBy similarity6
Transmembranei366 – 385Helical; Name=3By similarityAdd BLAST20
Topological domaini386 – 391PeriplasmicBy similarity6
Transmembranei392 – 413Helical; Name=4By similarityAdd BLAST22
Topological domaini414 – 441CytoplasmicBy similarityAdd BLAST28
Transmembranei442 – 460Helical; Name=5By similarityAdd BLAST19
Topological domaini461 – 473PeriplasmicBy similarityAdd BLAST13
Transmembranei474 – 496Helical; Name=6By similarityAdd BLAST23
Topological domaini497 – 536CytoplasmicBy similarityAdd BLAST40
Transmembranei537 – 555Helical; Name=7By similarityAdd BLAST19
Topological domaini556 – 870PeriplasmicBy similarityAdd BLAST315
Transmembranei871 – 890Helical; Name=8By similarityAdd BLAST20
Topological domaini891 – 896CytoplasmicBy similarity6
Transmembranei897 – 916Helical; Name=9By similarityAdd BLAST20
Topological domaini917 – 922PeriplasmicBy similarity6
Transmembranei923 – 944Helical; Name=10By similarityAdd BLAST22
Topological domaini945 – 972CytoplasmicBy similarityAdd BLAST28
Transmembranei973 – 991Helical; Name=11By similarityAdd BLAST19
Topological domaini992 – 1004PeriplasmicBy similarityAdd BLAST13
Transmembranei1005 – 1027Helical; Name=12By similarityAdd BLAST23
Topological domaini1028 – 1037CytoplasmicBy similarity10

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001618411 – 1037Multidrug resistance protein MdtFAdd BLAST1037

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P37637

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P37637

PRoteomics IDEntifications database

More...
PRIDEi
P37637

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by EvgA, probably via YdeO.4 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer. Part of the tripartite efflux system MdtEF-TolC, which is composed of an inner membrane transporter, MdtF, a membrane fusion protein, MdtE, and an outer membrane component, TolC. The complex forms a large protein conduit and can translocate molecules across both the inner and outer membranes.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
4262521, 292 interactors

Protein interaction database and analysis system

More...
IntActi
P37637, 1 interactor

STRING: functional protein association networks

More...
STRINGi
511145.b3514

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P37637

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
COG0841, Bacteria

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002755_0_2_6

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P37637

KEGG Orthology (KO)

More...
KOi
K18899

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P37637

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.2090.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027463, AcrB_DN_DC_subdom
IPR001036, Acrflvin-R
IPR004764, HAE1

The PANTHER Classification System

More...
PANTHERi
PTHR32063, PTHR32063, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00873, ACR_tran, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00702, ACRIFLAVINRP

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF82714, SSF82714, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00915, 2A0602, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P37637-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANYFIDRPV FAWVLAIIMM LAGGLAIMNL PVAQYPQIAP PTITVSATYP
60 70 80 90 100
GADAQTVEDS VTQVIEQNMN GLDGLMYMSS TSDAAGNASI TLTFETGTSP
110 120 130 140 150
DIAQVQVQNK LQLAMPSLPE AVQQQGISVD KSSSNILMVA AFISDNGSLN
160 170 180 190 200
QYDIADYVAS NIKDPLSRTA GVGSVQLFGS EYAMRIWLDP QKLNKYNLVP
210 220 230 240 250
SDVISQIKVQ NNQISGGQLG GMPQAADQQL NASIIVQTRL QTPEEFGKIL
260 270 280 290 300
LKVQQDGSQV LLRDVARVEL GAEDYSTVAR YNGKPAAGIA IKLAAGANAL
310 320 330 340 350
DTSRAVKEEL NRLSAYFPAS LKTVYPYDTT PFIEISIQEV FKTLVEAIIL
360 370 380 390 400
VFLVMYLFLQ NFRATIIPTI AVPVVILGTF AILSAVGFTI NTLTMFGMVL
410 420 430 440 450
AIGLLVDDAI VVVENVERVI AEDKLPPKEA THKSMGQIQR ALVGIAVVLS
460 470 480 490 500
AVFMPMAFMS GATGEIYRQF SITLISSMLL SVFVAMSLTP ALCATILKAA
510 520 530 540 550
PEGGHKPNAL FARFNTLFEK STQHYTDSTR SLLRCTGRYM VVYLLICAGM
560 570 580 590 600
AVLFLRTPTS FLPEEDQGVF MTTAQLPSGA TMVNTTKVLQ QVTDYYLTKE
610 620 630 640 650
KDNVQSVFTV GGFGFSGQGQ NNGLAFISLK PWSERVGEEN SVTAIIQRAM
660 670 680 690 700
IALSSINKAV VFPFNLPAVA ELGTASGFDM ELLDNGNLGH EKLTQARNEL
710 720 730 740 750
LSLAAQSPNQ VTGVRPNGLE DTPMFKVNVN AAKAEAMGVA LSDINQTIST
760 770 780 790 800
AFGSSYVNDF LNQGRVKKVY VQAGTPFRML PDNINQWYVR NASGTMAPLS
810 820 830 840 850
AYSSTEWTYG SPRLERYNGI PSMEILGEAA AGKSTGDAMK FMADLVAKLP
860 870 880 890 900
AGVGYSWTGL SYQEALSSNQ APALYAISLV VVFLALAALY ESWSIPFSVM
910 920 930 940 950
LVVPLGVVGA LLATDLRGLS NDVYFQVGLL TTIGLSAKNA ILIVEFAVEM
960 970 980 990 1000
MQKEGKTPIE AIIEAARMRL RPILMTSLAF ILGVLPLVIS HGAGSGAQNA
1010 1020 1030
VGTGVMGGMF AATVLAIYFV PVFFVVVEHL FARFKKA
Length:1,037
Mass (Da):111,517
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3B67502160F51724
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18490.1
U00096 Genomic DNA Translation: AAC76539.1
AP009048 Genomic DNA Translation: BAE77780.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S47734

NCBI Reference Sequences

More...
RefSeqi
NP_417971.1, NC_000913.3
WP_000024872.1, NZ_SSZK01000042.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAC76539; AAC76539; b3514
BAE77780; BAE77780; BAE77780

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
948030

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ecj:JW3482
eco:b3514

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|1411691.4.peg.3204

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18490.1
U00096 Genomic DNA Translation: AAC76539.1
AP009048 Genomic DNA Translation: BAE77780.1
PIRiS47734
RefSeqiNP_417971.1, NC_000913.3
WP_000024872.1, NZ_SSZK01000042.1

3D structure databases

SMRiP37637
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4262521, 292 interactors
IntActiP37637, 1 interactor
STRINGi511145.b3514

Protein family/group databases

TCDBi2.A.6.2.13, the resistance-nodulation-cell division (rnd) superfamily

Proteomic databases

jPOSTiP37637
PaxDbiP37637
PRIDEiP37637

Genome annotation databases

EnsemblBacteriaiAAC76539; AAC76539; b3514
BAE77780; BAE77780; BAE77780
GeneIDi948030
KEGGiecj:JW3482
eco:b3514
PATRICifig|1411691.4.peg.3204

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...
EchoBASEi
EB2152

Phylogenomic databases

eggNOGiCOG0841, Bacteria
HOGENOMiCLU_002755_0_2_6
InParanoidiP37637
KOiK18899
PhylomeDBiP37637

Enzyme and pathway databases

BioCyciEcoCyc:YHIV-MONOMER
ECOL316407:JW3482-MONOMER
MetaCyc:YHIV-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P37637

Family and domain databases

Gene3Di3.30.2090.10, 2 hits
InterProiView protein in InterPro
IPR027463, AcrB_DN_DC_subdom
IPR001036, Acrflvin-R
IPR004764, HAE1
PANTHERiPTHR32063, PTHR32063, 1 hit
PfamiView protein in Pfam
PF00873, ACR_tran, 1 hit
PRINTSiPR00702, ACRIFLAVINRP
SUPFAMiSSF82714, SSF82714, 2 hits
TIGRFAMsiTIGR00915, 2A0602, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMDTF_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37637
Secondary accession number(s): Q2M7H6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: August 12, 2020
This is version 148 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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