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UniProtKB - P37619 (QPTR_ECOLI)
Protein
Queuosine precursor transporter
Gene
yhhQ
Organism
Escherichia coli (strain K12)
Status
Functioni
Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. Transports 7-cyano-7-deazaguanine (preQ0) and 7-aminomethyl-7-deazaguanine (preQ1), with a preference for preQ0.
1 PublicationGO - Molecular functioni
- transmembrane transporter activity Source: UniProtKB-UniRule
GO - Biological processi
- pyrimidine-containing compound transmembrane transport Source: EcoCyc
- queuosine salvage Source: EcoCyc
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12217-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Queuosine precursor transporterCuratedShort name: Q precursor transporterUniRule annotationCurated |
Gene namesi | Name:yhhQ Ordered Locus Names:b3471, JW3436 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
- Cell inner membrane UniRule annotation1 Publication; Multi-pass membrane protein UniRule annotation
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB-UniRule
- plasma membrane Source: EcoCyc
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 12 | CytoplasmicCuratedAdd BLAST | 12 | |
Transmembranei | 13 – 33 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 34 | PeriplasmicCurated | 1 | |
Transmembranei | 35 – 55 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 56 – 70 | CytoplasmicCuratedAdd BLAST | 15 | |
Transmembranei | 71 – 91 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 92 – 97 | PeriplasmicCurated | 6 | |
Transmembranei | 98 – 118 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 119 – 143 | CytoplasmicCuratedAdd BLAST | 25 | |
Transmembranei | 144 – 164 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 165 – 184 | PeriplasmicCuratedAdd BLAST | 20 | |
Transmembranei | 185 – 205 | HelicalUniRule annotationAdd BLAST | 21 | |
Topological domaini | 206 – 221 | Cytoplasmic1 PublicationAdd BLAST | 16 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
YhhQ-queD double mutant cannot produce Q modified tRNA in minimal media with preQ0 or preQ1. YhhQ expressed from a plasmid restores the presence of Q modified tRNA.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000169556 | 1 – 221 | Queuosine precursor transporterAdd BLAST | 221 |
Proteomic databases
PaxDbi | P37619 |
PRIDEi | P37619 |
Structurei
Family & Domainsi
Sequence similaritiesi
Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. [View classification]UniRule annotationCurated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG1738, Bacteria |
HOGENOMi | CLU_090905_0_0_6 |
InParanoidi | P37619 |
PhylomeDBi | P37619 |
Family and domain databases
HAMAPi | MF_02088, Q_prec_transport, 1 hit |
InterProi | View protein in InterPro IPR003744, YhhQ |
PANTHERi | PTHR34300, PTHR34300, 1 hit |
Pfami | View protein in Pfam PF02592, Vut_1, 1 hit |
TIGRFAMsi | TIGR00697, TIGR00697, 1 hit |
i Sequence
Sequence statusi: Complete.
P37619-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNVFSQTQRY KALFWLSLFH LLVITSSNYL VQLPVSILGF HTTWGAFSFP
60 70 80 90 100
FIFLATDLTV RIFGAPLARR IIFAVMIPAL LISYVISSLF YMGSWQGFGA
110 120 130 140 150
LAHFNLFVAR IATASFMAYA LGQILDVHVF NRLRQSRRWW LAPTASTLFG
160 170 180 190 200
NVSDTLAFFF IAFWRSPDAF MAEHWMEIAL VDYCFKVLIS IVFFLPMYGV
210 220
LLNMLLKRLA DKSEINALQA S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00039 Genomic DNA Translation: AAB18446.1 U00096 Genomic DNA Translation: AAC76496.1 AP009048 Genomic DNA Translation: BAE77822.1 |
PIRi | S47690 |
RefSeqi | NP_417928.1, NC_000913.3 WP_001100469.1, NZ_SSZK01000008.1 |
Genome annotation databases
EnsemblBacteriai | AAC76496; AAC76496; b3471 BAE77822; BAE77822; BAE77822 |
GeneIDi | 947984 |
KEGGi | ecj:JW3436 eco:b3471 |
PATRICi | fig|1411691.4.peg.3254 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00039 Genomic DNA Translation: AAB18446.1 U00096 Genomic DNA Translation: AAC76496.1 AP009048 Genomic DNA Translation: BAE77822.1 |
PIRi | S47690 |
RefSeqi | NP_417928.1, NC_000913.3 WP_001100469.1, NZ_SSZK01000008.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 511145.b3471 |
Proteomic databases
PaxDbi | P37619 |
PRIDEi | P37619 |
Genome annotation databases
EnsemblBacteriai | AAC76496; AAC76496; b3471 BAE77822; BAE77822; BAE77822 |
GeneIDi | 947984 |
KEGGi | ecj:JW3436 eco:b3471 |
PATRICi | fig|1411691.4.peg.3254 |
Organism-specific databases
EchoBASEi | EB2131 |
Phylogenomic databases
eggNOGi | COG1738, Bacteria |
HOGENOMi | CLU_090905_0_0_6 |
InParanoidi | P37619 |
PhylomeDBi | P37619 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12217-MONOMER |
Miscellaneous databases
PROi | PR:P37619 |
Family and domain databases
HAMAPi | MF_02088, Q_prec_transport, 1 hit |
InterProi | View protein in InterPro IPR003744, YhhQ |
PANTHERi | PTHR34300, PTHR34300, 1 hit |
Pfami | View protein in Pfam PF02592, Vut_1, 1 hit |
TIGRFAMsi | TIGR00697, TIGR00697, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | QPTR_ECOLI | |
Accessioni | P37619Primary (citable) accession number: P37619 Secondary accession number(s): Q2M7D4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families