UniProtKB - P37596 (NORW_ECOLI)
Protein
Nitric oxide reductase FlRd-NAD(+) reductase
Gene
norW
Organism
Escherichia coli (strain K12)
Status
Functioni
One of at least two accessory proteins for anaerobic nitric oxide (NO) reductase. Reduces the rubredoxin moiety of NO reductase.
Catalytic activityi
Cofactori
FADCurated
: nitric oxide reduction Pathwayi
This protein is involved in the pathway nitric oxide reduction, which is part of Nitrogen metabolism.View all proteins of this organism that are known to be involved in the pathway nitric oxide reduction and in Nitrogen metabolism.
GO - Molecular functioni
- flavin adenine dinucleotide binding Source: EcoCyc
- oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor Source: EcoCyc
- rubredoxin-NAD+ reductase activity Source: EcoCyc
GO - Biological processi
- cellular response to nitric oxide Source: EcoCyc
- nitric oxide catabolic process Source: EcoCyc
Keywordsi
Molecular function | Oxidoreductase |
Ligand | FAD, Flavoprotein, NAD |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12450-MONOMER |
UniPathwayi | UPA00638 |
Names & Taxonomyi
Protein namesi | Recommended name: Nitric oxide reductase FlRd-NAD(+) reductase (EC:1.18.1.-)Alternative name(s): Flavorubredoxin reductase Short name: FlRd-reductase Short name: FlavoRb reductase |
Gene namesi | Name:norW Synonyms:flrR, ygbD Ordered Locus Names:b2711, JW2681 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
GO - Cellular componenti
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000167662 | 1 – 377 | Nitric oxide reductase FlRd-NAD(+) reductaseAdd BLAST | 377 |
Proteomic databases
PaxDbi | P37596 |
PRIDEi | P37596 |
Expressioni
Inductioni
Submicromolar concentrations of NO induce anaerobic expression. Repressed by oxygen in the presence of NO.
Interactioni
Protein-protein interaction databases
BioGRIDi | 4259424, 14 interactors |
STRINGi | 511145.b2711 |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAD-dependent oxidoreductase family.Curated
Phylogenomic databases
eggNOGi | COG0446, Bacteria |
HOGENOMi | CLU_003291_4_4_6 |
InParanoidi | P37596 |
PhylomeDBi | P37596 |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
HAMAPi | MF_01313, NorW, 1 hit |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR023961, NO_rdtase_NorW IPR041364, Rbx-bd |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit PF18113, Rbx_binding, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
i Sequence
Sequence statusi: Complete.
P37596-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNGIVIIGS GFAARQLVKN IRKQDATIPL TLIAADSMDE YNKPDLSHVI
60 70 80 90 100
SQGQRADDLT RQTAGEFAEQ FNLHLFPQTW VTDIDAEARV VKSQNNQWQY
110 120 130 140 150
DKLVLATGAS AFVPPVPGRE LMLTLNSQQE YRACETQLRD ARRVLIVGGG
160 170 180 190 200
LIGSELAMDF CRAGKAVTLI DNAASILASL MPPEVSSRLQ HRLTEMGVHL
210 220 230 240 250
LLKSQLQGLE KTDSGIQATL DRQRNIEVDA VIAATGLRPE TALARRAGLT
260 270 280 290 300
INRGVCVDSY LQTSNTDIYA LGDCAEINGQ VLPFLQPIQL SAMVLAKNLL
310 320 330 340 350
GNNTPLKLPA MLVKIKTPEL PLHLAGETQR QDLRWQINTE RQGMVARGVD
360 370
DADQLRAFVV SEDRMKEAFG LLKTLPM
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 264 | S → N (Ref. 1) Curated | 1 | |
Sequence conflicti | 264 | S → N (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D28595 Genomic DNA Translation: BAA05934.1 U29579 Genomic DNA Translation: AAA69221.1 U00096 Genomic DNA Translation: AAC75753.1 AP009048 Genomic DNA Translation: BAE76788.1 D14422 Genomic DNA No translation available. |
PIRi | C65051 |
RefSeqi | NP_417191.1, NC_000913.3 WP_000064752.1, NZ_STEB01000027.1 |
Genome annotation databases
EnsemblBacteriai | AAC75753; AAC75753; b2711 BAE76788; BAE76788; BAE76788 |
GeneIDi | 947088 |
KEGGi | ecj:JW2681 eco:b2711 |
PATRICi | fig|1411691.4.peg.4031 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D28595 Genomic DNA Translation: BAA05934.1 U29579 Genomic DNA Translation: AAA69221.1 U00096 Genomic DNA Translation: AAC75753.1 AP009048 Genomic DNA Translation: BAE76788.1 D14422 Genomic DNA No translation available. |
PIRi | C65051 |
RefSeqi | NP_417191.1, NC_000913.3 WP_000064752.1, NZ_STEB01000027.1 |
3D structure databases
SMRi | P37596 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4259424, 14 interactors |
STRINGi | 511145.b2711 |
Proteomic databases
PaxDbi | P37596 |
PRIDEi | P37596 |
Genome annotation databases
EnsemblBacteriai | AAC75753; AAC75753; b2711 BAE76788; BAE76788; BAE76788 |
GeneIDi | 947088 |
KEGGi | ecj:JW2681 eco:b2711 |
PATRICi | fig|1411691.4.peg.4031 |
Organism-specific databases
EchoBASEi | EB2344 |
Phylogenomic databases
eggNOGi | COG0446, Bacteria |
HOGENOMi | CLU_003291_4_4_6 |
InParanoidi | P37596 |
PhylomeDBi | P37596 |
Enzyme and pathway databases
UniPathwayi | UPA00638 |
BioCyci | EcoCyc:EG12450-MONOMER |
Miscellaneous databases
PROi | PR:P37596 |
Family and domain databases
Gene3Di | 3.50.50.60, 2 hits |
HAMAPi | MF_01313, NorW, 1 hit |
InterProi | View protein in InterPro IPR036188, FAD/NAD-bd_sf IPR023753, FAD/NAD-binding_dom IPR023961, NO_rdtase_NorW IPR041364, Rbx-bd |
Pfami | View protein in Pfam PF07992, Pyr_redox_2, 1 hit PF18113, Rbx_binding, 1 hit |
SUPFAMi | SSF51905, SSF51905, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NORW_ECOLI | |
Accessioni | P37596Primary (citable) accession number: P37596 Secondary accession number(s): Q2MAB8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | July 19, 2003 | |
Last modified: | December 2, 2020 | |
This is version 155 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families