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Protein

Negative regulator of genetic competence ClpC/MecB

Gene

clpC

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Competence gene repressor; required for cell growth at high temperature. Negative regulator of comK expression. May interact with MecA to negatively regulate comK.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 215ATPSequence analysis8
Nucleotide bindingi545 – 552ATPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone, Repressor
Biological processCompetence, Transcription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBSUB:BSU00860-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Negative regulator of genetic competence ClpC/MecB
Gene namesi
Name:clpC
Synonyms:mecB
Ordered Locus Names:BSU00860
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001912281 – 810Negative regulator of genetic competence ClpC/MecBAdd BLAST810

Proteomic databases

PaxDbiP37571
PRIDEiP37571

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
mecAP3795811EBI-7349302,EBI-5254676

Protein-protein interaction databases

DIPiDIP-43708N
IntActiP37571, 5 interactors
MINTiP37571
STRINGi224308.Bsubs1_010100000445

Structurei

Secondary structure

1810
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP37571
SMRiP37571
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37571

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati19 – 501Add BLAST32
Repeati93 – 1242Add BLAST32
Domaini417 – 452UVRPROSITE-ProRule annotationAdd BLAST36

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 1242 X 32 AA approximate repeatsAdd BLAST106
Regioni163 – 410IAdd BLAST248
Regioni471 – 662IIAdd BLAST192

Sequence similaritiesi

Belongs to the ClpA/ClpB family. ClpC subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG0542 LUCA
HOGENOMiHOG000218210
InParanoidiP37571
KOiK03696
OMAiHHKVRIK
PhylomeDBiP37571

Family and domain databases

Gene3Di1.10.1780.10, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR019489 Clp_ATPase_C
IPR004176 Clp_N
IPR036628 Clp_N_dom_sf
IPR001270 ClpA/B
IPR018368 ClpA/B_CS1
IPR028299 ClpA/B_CS2
IPR027417 P-loop_NTPase
IPR001943 UVR_dom
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF07724 AAA_2, 1 hit
PF02861 Clp_N, 2 hits
PF10431 ClpB_D2-small, 1 hit
PF02151 UVR, 1 hit
PRINTSiPR00300 CLPPROTEASEA
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SM01086 ClpB_D2-small, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
SSF81923 SSF81923, 1 hit
PROSITEiView protein in PROSITE
PS00870 CLPAB_1, 1 hit
PS00871 CLPAB_2, 1 hit
PS50151 UVR, 1 hit

Sequencei

Sequence statusi: Complete.

P37571-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMFGRFTERA QKVLALAQEE ALRLGHNNIG TEHILLGLVR EGEGIAAKAL
60 70 80 90 100
QALGLGSEKI QKEVESLIGR GQEMSQTIHY TPRAKKVIEL SMDEARKLGH
110 120 130 140 150
SYVGTEHILL GLIREGEGVA ARVLNNLGVS LNKARQQVLQ LLGSNETGSS
160 170 180 190 200
AAGTNSNANT PTLDSLARDL TAIAKEDSLD PVIGRSKEIQ RVIEVLSRRT
210 220 230 240 250
KNNPVLIGEP GVGKTAIAEG LAQQIINNEV PEILRDKRVM TLDMGTVVAG
260 270 280 290 300
TKYRGEFEDR LKKVMDEIRQ AGNIILFIDE LHTLIGAGGA EGAIDASNIL
310 320 330 340 350
KPSLARGELQ CIGATTLDEY RKYIEKDAAL ERRFQPIQVD QPSVDESIQI
360 370 380 390 400
LQGLRDRYEA HHRVSITDDA IEAAVKLSDR YISDRFLPDK AIDLIDEAGS
410 420 430 440 450
KVRLRSFTTP PNLKELEQKL DEVRKEKDAA VQSQEFEKAA SLRDTEQRLR
460 470 480 490 500
EQVEDTKKSW KEKQGQENSE VTVDDIAMVV SSWTGVPVSK IAQTETDKLL
510 520 530 540 550
NMENILHSRV IGQDEAVVAV AKAVRRARAG LKDPKRPIGS FIFLGPTGVG
560 570 580 590 600
KTELARALAE SIFGDEESMI RIDMSEYMEK HSTSRLVGSP PGYVGYDEGG
610 620 630 640 650
QLTEKVRRKP YSVVLLDEIE KAHPDVFNIL LQVLEDGRLT DSKGRTVDFR
660 670 680 690 700
NTILIMTSNV GASELKRNKY VGFNVQDETQ NHKDMKDKVM GELKRAFRPE
710 720 730 740 750
FINRIDEIIV FHSLEKKHLT EIVSLMSDQL TKRLKEQDLS IELTDAAKAK
760 770 780 790 800
VAEEGVDLEY GARPLRRAIQ KHVEDRLSEE LLRGNIHKGQ HIVLDVEDGE
810
FVVKTTAKTN
Length:810
Mass (Da):90,119
Last modified:October 1, 1994 - v1
Checksum:i9592231886C2E870
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U02604 Genomic DNA Translation: AAA19233.1
D26185 Genomic DNA Translation: BAA05320.1
AL009126 Genomic DNA Translation: CAB11862.1
X75930 Genomic DNA Translation: CAA53534.1
PIRiI40508
RefSeqiNP_387967.1, NC_000964.3
WP_003235011.1, NZ_JNCM01000029.1

Genome annotation databases

EnsemblBacteriaiCAB11862; CAB11862; BSU00860
GeneIDi938481
KEGGibsu:BSU00860
PATRICifig|224308.179.peg.87

Similar proteinsi

Entry informationi

Entry nameiCLPC_BACSU
AccessioniPrimary (citable) accession number: P37571
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: February 28, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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