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UniProtKB - P37506 (STA_BACSU)
Protein
Streptothricin acetyltransferase A
Gene
satA
Organism
Bacillus subtilis (strain 168)
Status
Functioni
Involved in resistance to streptothricin, a broad-spectrum antibiotic produced by streptomycetes. Detoxifies streptothricin via acetylation of the beta amino group of the first beta-lysyl moiety of streptothricin.
1 PublicationCatalytic activityi
Kineticsi
- KM=1 µM for streptothricin1 Publication
- KM=107 µM for acetyl-CoA1 Publication
GO - Molecular functioni
- acyltransferase activity, transferring groups other than amino-acyl groups Source: GO_Central
- N-acetyltransferase activity Source: InterPro
GO - Biological processi
- response to antibiotic Source: UniProtKB-KW
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Antibiotic resistance |
Enzyme and pathway databases
BioCyci | BSUB:BSU40740-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:satA1 Publication Synonyms:yyaR Ordered Locus Names:BSU40740 |
Organismi | Bacillus subtilis (strain 168) |
Taxonomic identifieri | 224308 [NCBI] |
Taxonomic lineagei | Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › |
Proteomesi |
|
Pathology & Biotechi
Disruption phenotypei
Deletion mutant is susceptible to streptothricin.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000050058 | 1 – 173 | Streptothricin acetyltransferase AAdd BLAST | 173 |
Proteomic databases
PaxDbi | P37506 |
Interactioni
Subunit structurei
Homodimer.
1 PublicationProtein-protein interaction databases
STRINGi | 224308.BSU40740 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 21 – 173 | N-acetyltransferasePROSITE-ProRule annotationAdd BLAST | 153 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0456, Bacteria |
InParanoidi | P37506 |
OMAi | WNHYAYI |
PhylomeDBi | P37506 |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom IPR008125, Streptothricin_AcTrfase |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
PRINTSi | PR01754, SACTRNSFRASE |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
i Sequence
Sequence statusi: Complete.
P37506-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIMKMTHLNM KDFNKPNEPF VVFGRMIPAF ENGVWTYTEE RFSKPYFKQY
60 70 80 90 100
EDDDMDVSYV EEEGKAAFLY YLENNCIGRI KIRSNWNGYA LIEDIAVAKD
110 120 130 140 150
YRKKGVGTAL LHKAIEWAKE NHFCGLMLET QDINISACHF YAKHHFIIGA
160 170
VDTMLYSNFP TANEIAIFWY YKF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26185 Genomic DNA Translation: BAA05205.1 AL009126 Genomic DNA Translation: CAB16111.1 |
PIRi | S65999 |
RefSeqi | NP_391954.1, NC_000964.3 WP_003242546.1, NZ_JNCM01000034.1 |
Genome annotation databases
EnsemblBacteriai | CAB16111; CAB16111; BSU_40740 |
GeneIDi | 937878 |
KEGGi | bsu:BSU40740 |
PATRICi | fig|224308.179.peg.4416 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D26185 Genomic DNA Translation: BAA05205.1 AL009126 Genomic DNA Translation: CAB16111.1 |
PIRi | S65999 |
RefSeqi | NP_391954.1, NC_000964.3 WP_003242546.1, NZ_JNCM01000034.1 |
3D structure databases
AlphaFoldDBi | P37506 |
SMRi | P37506 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 224308.BSU40740 |
Proteomic databases
PaxDbi | P37506 |
Genome annotation databases
EnsemblBacteriai | CAB16111; CAB16111; BSU_40740 |
GeneIDi | 937878 |
KEGGi | bsu:BSU40740 |
PATRICi | fig|224308.179.peg.4416 |
Phylogenomic databases
eggNOGi | COG0456, Bacteria |
InParanoidi | P37506 |
OMAi | WNHYAYI |
PhylomeDBi | P37506 |
Enzyme and pathway databases
BioCyci | BSUB:BSU40740-MONOMER |
Family and domain databases
InterProi | View protein in InterPro IPR016181, Acyl_CoA_acyltransferase IPR000182, GNAT_dom IPR008125, Streptothricin_AcTrfase |
Pfami | View protein in Pfam PF00583, Acetyltransf_1, 1 hit |
PRINTSi | PR01754, SACTRNSFRASE |
SUPFAMi | SSF55729, SSF55729, 1 hit |
PROSITEi | View protein in PROSITE PS51186, GNAT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STA_BACSU | |
Accessioni | P37506Primary (citable) accession number: P37506 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 121 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families