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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila persimilis (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
ORF Names:GL25993
OrganismiDrosophila persimilis (Fruit fly)
Taxonomic identifieri7234 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000008744 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012635 Dper\Adh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000544882 – 254Alcohol dehydrogenaseAdd BLAST253

Interactioni

Subunit structurei

Homodimer.

Structurei

3D structure databases

ProteinModelPortaliP37473
SMRiP37473
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00001
OMAiWSKHWDS
OrthoDBiEOG091G0OC9
PhylomeDBiP37473

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P37473-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSLTNKNVVF VAGLGGIGLD TSRELVKRNL KNLVILDRID NPAAIAELKA
60 70 80 90 100
INPKVTITFY PYDVTVPVAE TTKLLKTIFA QVKTIDVLIN GAGILDDHQI
110 120 130 140 150
ERTIAVNYTG LVNTTTAILD FWDKRKGGPG GIICNIGSVT GFNAIYQVPV
160 170 180 190 200
YSGSKAAVVN FTSSLAKLAP ITGVTAYTVN PGITRTTLVH KFNSWLDVEP
210 220 230 240 250
RVAEKLLEHP TQTSQQCAEN FVKAIELNKN GAIWKLDLGT LEPITWTQHW

DSGI
Length:254
Mass (Da):27,645
Last modified:January 23, 2007 - v2
Checksum:iC76A72252371F0B6
GO

Sequence cautioni

The sequence AAB80702 differs from that shown. Reason: Frameshift at position 186.Curated
The sequence AAB80704 differs from that shown. Reason: Frameshift at position 186.Curated
The sequence AAB80708 differs from that shown. Reason: Frameshift at position 186.Curated
The sequence AAB80710 differs from that shown. Reason: Frameshift at position 186.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti16G → A in AAB80702 (PubMed:9383055).Curated1
Sequence conflicti16G → A in AAB80704 (PubMed:9383055).Curated1
Sequence conflicti16G → A in AAB80706 (PubMed:9383055).Curated1
Sequence conflicti16G → A in AAB80708 (PubMed:9383055).Curated1
Sequence conflicti16G → A in AAB80710 (PubMed:9383055).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti82V → L in strain: Persimi50. 1 Publication1
Natural varianti185R → K in strain: Persimi44. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60997 Genomic DNA Translation: AAA99035.1
AF006564 Genomic DNA Translation: AAB80702.1 Frameshift.
AF006565 Genomic DNA Translation: AAB80704.1 Frameshift.
AF006566 Genomic DNA Translation: AAB80706.1
AF006567 Genomic DNA Translation: AAB80708.1 Frameshift.
AF006568 Genomic DNA Translation: AAB80710.1 Frameshift.
CH479184 Genomic DNA Translation: EDW36993.1
PIRiS26784
RefSeqiXP_002018797.1, XM_002018761.1

Genome annotation databases

EnsemblMetazoaiFBtr0191608; FBpp0190100; FBgn0012635
GeneIDi6593284
KEGGidpe:Dper_GL25993

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M60997 Genomic DNA Translation: AAA99035.1
AF006564 Genomic DNA Translation: AAB80702.1 Frameshift.
AF006565 Genomic DNA Translation: AAB80704.1 Frameshift.
AF006566 Genomic DNA Translation: AAB80706.1
AF006567 Genomic DNA Translation: AAB80708.1 Frameshift.
AF006568 Genomic DNA Translation: AAB80710.1 Frameshift.
CH479184 Genomic DNA Translation: EDW36993.1
PIRiS26784
RefSeqiXP_002018797.1, XM_002018761.1

3D structure databases

ProteinModelPortaliP37473
SMRiP37473
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0191608; FBpp0190100; FBgn0012635
GeneIDi6593284
KEGGidpe:Dper_GL25993

Organism-specific databases

FlyBaseiFBgn0012635 Dper\Adh

Phylogenomic databases

KOiK00001
OMAiWSKHWDS
OrthoDBiEOG091G0OC9
PhylomeDBiP37473

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROPE
AccessioniPrimary (citable) accession number: P37473
Secondary accession number(s): B4GK27
, O16093, O16095, O16097, O18661, Q7KQD6, Q7KQD7, Q7KQD8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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