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UniProtKB - P37460 (PROY_SALTY)
Protein
Proline-specific permease ProY
Gene
proY
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Functioni
Permease that is involved in the transport across the cytoplasmic membrane of proline.
GO - Molecular functioni
- amino acid transmembrane transporter activity Source: GO_Central
GO - Biological processi
- amino acid transmembrane transport Source: GO_Central
Keywordsi
Biological process | Amino-acid transport, Transport |
Protein family/group databases
TCDBi | 2.A.3.1.6, the amino acid-polyamine-organocation (apc) family |
Names & Taxonomyi
Protein namesi | Recommended name: Proline-specific permease ProY |
Gene namesi | Name:proY Ordered Locus Names:STM0400 |
Organismi | Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) |
Taxonomic identifieri | 99287 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Salmonella › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 18 – 38 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 39 – 59 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 60 – 95 | CytoplasmicSequence analysisAdd BLAST | 36 | |
Transmembranei | 96 – 116 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 117 – 137 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 138 – 156 | CytoplasmicSequence analysisAdd BLAST | 19 | |
Transmembranei | 157 – 177 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 197 | PeriplasmicSequence analysisAdd BLAST | 20 | |
Transmembranei | 198 – 218 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 219 – 242 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 243 – 263 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 264 – 277 | PeriplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 278 – 298 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 299 – 331 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 332 – 352 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 353 – 355 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 356 – 376 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 377 – 399 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 400 – 420 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 421 – 424 | PeriplasmicSequence analysis | 4 | |
Transmembranei | 425 – 445 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 446 – 456 | CytoplasmicSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054210 | 1 – 456 | Proline-specific permease ProYAdd BLAST | 456 |
Proteomic databases
PaxDbi | P37460 |
Family & Domainsi
Sequence similaritiesi
Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
HOGENOMi | CLU_007946_9_3_6 |
OMAi | PHWVWVL |
PhylomeDBi | P37460 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
i Sequence
Sequence statusi: Complete.
P37460-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MESNNKLKRG LSTRHIRFMA LGSAIGTGLF YGSADAIKMA GPSVLLAYII
60 70 80 90 100
GGVAAYIIMR ALGEMSVHNP AASSFSRYAQ ENLGPLAGYI TGWTYCFEIL
110 120 130 140 150
IVAIADVTAF GIYMGVWFPA VPHWIWVLSV VLIICAINLM SVKVFGELEF
160 170 180 190 200
WFSFFKVATI IIMIVAGIGI IVWGIGNGGQ PTGIHNLWSN GGFFSNGWLG
210 220 230 240 250
MIMSLQMVMF AYGGIEIIGI TAGEAKDPEK SIPRAINSVP MRILVFYVGT
260 270 280 290 300
LFVIMSIYPW NQVGTNGSPF VLTFQHMGIT FAASILNFVV LTASLSAINS
310 320 330 340 350
DVFGVGRMLH GMAEQGSAPK VFAKTSRRGI PWVTVLVMTI ALLFAVYLNY
360 370 380 390 400
IMPENVFLVI ASLATFATVW VWIMILLSQI AFRRRLPPEE VKALKFKVPG
410 420 430 440 450
GVVTTIAGLI FLVFIIALIG YHPDTRISLY VGFAWIVLLL IGWIFKRRRD
RQLAQA
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74420 Genomic DNA Translation: CAA52441.1 AE006468 Genomic DNA Translation: AAL19354.1 |
PIRi | S35983 |
RefSeqi | NP_459395.1, NC_003197.2 WP_001555879.1, NC_003197.2 |
Genome annotation databases
EnsemblBacteriai | AAL19354; AAL19354; STM0400 |
GeneIDi | 1251919 |
KEGGi | stm:STM0400 |
PATRICi | fig|99287.12.peg.427 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X74420 Genomic DNA Translation: CAA52441.1 AE006468 Genomic DNA Translation: AAL19354.1 |
PIRi | S35983 |
RefSeqi | NP_459395.1, NC_003197.2 WP_001555879.1, NC_003197.2 |
3D structure databases
SMRi | P37460 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 99287.STM0400 |
Protein family/group databases
TCDBi | 2.A.3.1.6, the amino acid-polyamine-organocation (apc) family |
Proteomic databases
PaxDbi | P37460 |
Genome annotation databases
EnsemblBacteriai | AAL19354; AAL19354; STM0400 |
GeneIDi | 1251919 |
KEGGi | stm:STM0400 |
PATRICi | fig|99287.12.peg.427 |
Phylogenomic databases
HOGENOMi | CLU_007946_9_3_6 |
OMAi | PHWVWVL |
PhylomeDBi | P37460 |
Family and domain databases
InterProi | View protein in InterPro IPR004841, AA-permease/SLC12A_dom IPR004840, Amoino_acid_permease_CS |
Pfami | View protein in Pfam PF00324, AA_permease, 1 hit |
PROSITEi | View protein in PROSITE PS00218, AMINO_ACID_PERMEASE_1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PROY_SALTY | |
Accessioni | P37460Primary (citable) accession number: P37460 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | November 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 128 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families