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Protein

LexA repressor

Gene

lexA

Organism
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.UniRule annotation

Catalytic activityi

Hydrolysis of Ala-|-Gly bond in repressor LexA.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei125For autocatalytic cleavage activityUniRule annotation1
Active sitei162For autocatalytic cleavage activityUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi28 – 48H-T-H motifUniRule annotationAdd BLAST21

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Hydrolase, Repressor
Biological processDNA damage, DNA repair, DNA replication, SOS response, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3059-MONOMER
BRENDAi3.4.21.88 5087

Protein family/group databases

MEROPSiS24.001

Names & Taxonomyi

Protein namesi
Recommended name:
LexA repressorUniRule annotation (EC:3.4.21.88UniRule annotation)
Gene namesi
Name:lexAUniRule annotation
Ordered Locus Names:PA3007
OrganismiPseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
Taxonomic identifieri208964 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
Proteomesi
  • UP000002438 Componenti: Chromosome

Organism-specific databases

PseudoCAPiPA3007

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001700671 – 204LexA repressorAdd BLAST204

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei90 – 91Cleavage; by autolysisUniRule annotation2

Keywords - PTMi

Autocatalytic cleavage

Proteomic databases

PaxDbiP37452

Expressioni

Gene expression databases

CollecTFiEXPREG_00000a60

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi208964.PA3007

Structurei

3D structure databases

ProteinModelPortaliP37452
SMRiP37452
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S24 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DS7 Bacteria
COG1974 LUCA
HOGENOMiHOG000232167
InParanoidiP37452
KOiK01356
OMAiRQMMQAM
PhylomeDBiP37452

Family and domain databases

CDDicd06529 S24_LexA-like, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00015 LexA, 1 hit
InterProiView protein in InterPro
IPR006200 LexA
IPR039418 LexA-like
IPR036286 LexA/Signal_pep-like_sf
IPR006199 LexA_DNA-bd_dom
IPR006197 Peptidase_S24_LexA
IPR015927 Peptidase_S24_S26A/B/C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01726 LexA_DNA_bind, 1 hit
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00726 LEXASERPTASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR00498 lexA, 1 hit

Sequencei

Sequence statusi: Complete.

P37452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQKLTPRQAE ILSFIKRCLE DHGFPPTRAE IAQELGFKSP NAAEEHLKAL
60 70 80 90 100
ARKGAIEMTP GASRGIRIPG FEPHAANDDE GLPVIGRVAA GAPILAEQNI
110 120 130 140 150
EESCRINPAF FNPRADYLLR VRGMSMKDIG ILDGDLLAVH VTREARNGQV
160 170 180 190 200
VVARIGEEVT VKRFKREGSK VWLLAENPEF APIEVDLKEQ ELIIEGLSVG

VIRR
Length:204
Mass (Da):22,506
Last modified:October 1, 1994 - v1
Checksum:i665DF87928D48E94
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63018 Genomic DNA Translation: CAA44750.1
AE004091 Genomic DNA Translation: AAG06395.1
PIRiS30165
RefSeqiNP_251697.1, NC_002516.2
WP_003091196.1, NC_002516.2

Genome annotation databases

EnsemblBacteriaiAAG06395; AAG06395; PA3007
GeneIDi879875
KEGGipae:PA3007
PATRICifig|208964.12.peg.3155

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X63018 Genomic DNA Translation: CAA44750.1
AE004091 Genomic DNA Translation: AAG06395.1
PIRiS30165
RefSeqiNP_251697.1, NC_002516.2
WP_003091196.1, NC_002516.2

3D structure databases

ProteinModelPortaliP37452
SMRiP37452
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi208964.PA3007

Protein family/group databases

MEROPSiS24.001

Proteomic databases

PaxDbiP37452

Protocols and materials databases

DNASUi879875
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAG06395; AAG06395; PA3007
GeneIDi879875
KEGGipae:PA3007
PATRICifig|208964.12.peg.3155

Organism-specific databases

PseudoCAPiPA3007

Phylogenomic databases

eggNOGiENOG4105DS7 Bacteria
COG1974 LUCA
HOGENOMiHOG000232167
InParanoidiP37452
KOiK01356
OMAiRQMMQAM
PhylomeDBiP37452

Enzyme and pathway databases

BioCyciPAER208964:G1FZ6-3059-MONOMER
BRENDAi3.4.21.88 5087

Gene expression databases

CollecTFiEXPREG_00000a60

Family and domain databases

CDDicd06529 S24_LexA-like, 1 hit
Gene3Di1.10.10.10, 1 hit
HAMAPiMF_00015 LexA, 1 hit
InterProiView protein in InterPro
IPR006200 LexA
IPR039418 LexA-like
IPR036286 LexA/Signal_pep-like_sf
IPR006199 LexA_DNA-bd_dom
IPR006197 Peptidase_S24_LexA
IPR015927 Peptidase_S24_S26A/B/C
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01726 LexA_DNA_bind, 1 hit
PF00717 Peptidase_S24, 1 hit
PRINTSiPR00726 LEXASERPTASE
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51306 SSF51306, 1 hit
TIGRFAMsiTIGR00498 lexA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEXA_PSEAE
AccessioniPrimary (citable) accession number: P37452
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 10, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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