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Protein

Alpha-synuclein

Gene

Snca

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in the regulation of dopamine release and transport.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2CopperBy similarity1
Metal bindingi50CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-synuclein
Gene namesi
Name:Snca
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi3729 Snca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840311 – 140Alpha-synucleinAdd BLAST140

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei125Phosphotyrosine; by FYNBy similarity1
Modified residuei129Phosphoserine; by PLK2By similarity1

Post-translational modificationi

Phosphorylated, predominantly on serine residues. Phosphorylated on Tyr-125 upon osmotic stress (By similarity).By similarity
Ubiquitinated. The predominant conjugate is the diubiquitinated form.1 Publication
Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PeptideAtlasiP37377
PRIDEiP37377

2D gel databases

World-2DPAGEi0004:P37377

PTM databases

iPTMnetiP37377
PhosphoSitePlusiP37377

Expressioni

Tissue specificityi

Found only in brain (hippocampus, brainstem and cortex). Specifically expressed in neuronal cell bodies and synapses.

Gene expression databases

BgeeiENSRNOG00000008656 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP37377 RN

Interactioni

Subunit structurei

Interacts with UCHL1.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247897, 79 interactors
IntActiP37377, 3 interactors

Structurei

3D structure databases

ProteinModelPortaliP37377
SMRiP37377
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 674 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiP37377
KOiK04528
OMAiSEAYEMP
OrthoDBiEOG091G11PA
PhylomeDBiP37377
TreeFamiTF332776

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002460 Synuclein_alpha
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF5 PTHR13820:SF5, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01212 ASYNUCLEIN
PR01211 SYNUCLEIN

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.
Isoform Syn1 (identifier: P37377-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH
60 70 80 90 100
GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGNIAA ATGFVKKDQM
110 120 130 140
GKGEEGYPQE GILEDMPVDP SSEAYEMPSE EGYQDYEPEA
Length:140
Mass (Da):14,515
Last modified:October 1, 1994 - v1
Checksum:i1FFD19CD3B9E636C
GO
Isoform Syn2 (identifier: P37377-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     104-140: EEGYPQEGIL...EGYQDYEPEA → YPMGECTNHP...CVVMDPFLPT

Show »
Length:149
Mass (Da):15,755
Checksum:i972D3414A95EA9DE
GO
Isoform Syn3 (identifier: P37377-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     42-42: S → R
     43-140: Missing.

Show »
Length:42
Mass (Da):4,354
Checksum:iDE5143DA62A2DEC3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00636542S → R in isoform Syn3. Curated1
Alternative sequenceiVSP_00636643 – 140Missing in isoform Syn3. CuratedAdd BLAST98
Alternative sequenceiVSP_006367104 – 140EEGYP…YEPEA → YPMGECTNHPPRLIALRVKS RYREHSWRPRKQLSLACVVM DPFLPT in isoform Syn2. 1 PublicationAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73007 mRNA Translation: AAB20688.1
S73008 mRNA Translation: AAB20689.1
S73009 mRNA Translation: AAB20690.1
AF007758 mRNA Translation: AAC16026.1
AY550005 mRNA Translation: AAS55694.1
AY550006 mRNA Translation: AAS55695.1
BC087682 mRNA Translation: AAH87682.1
PIRiB43959
RefSeqiNP_062042.1, NM_019169.2 [P37377-1]
XP_006236653.1, XM_006236591.3 [P37377-2]
XP_017447989.1, XM_017592500.1 [P37377-2]
UniGeneiRn.1827

Genome annotation databases

EnsembliENSRNOT00000039247; ENSRNOP00000030609; ENSRNOG00000008656 [P37377-1]
GeneIDi29219
KEGGirno:29219
UCSCiRGD:3729 rat [P37377-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S73007 mRNA Translation: AAB20688.1
S73008 mRNA Translation: AAB20689.1
S73009 mRNA Translation: AAB20690.1
AF007758 mRNA Translation: AAC16026.1
AY550005 mRNA Translation: AAS55694.1
AY550006 mRNA Translation: AAS55695.1
BC087682 mRNA Translation: AAH87682.1
PIRiB43959
RefSeqiNP_062042.1, NM_019169.2 [P37377-1]
XP_006236653.1, XM_006236591.3 [P37377-2]
XP_017447989.1, XM_017592500.1 [P37377-2]
UniGeneiRn.1827

3D structure databases

ProteinModelPortaliP37377
SMRiP37377
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247897, 79 interactors
IntActiP37377, 3 interactors

PTM databases

iPTMnetiP37377
PhosphoSitePlusiP37377

2D gel databases

World-2DPAGEi0004:P37377

Proteomic databases

PeptideAtlasiP37377
PRIDEiP37377

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000039247; ENSRNOP00000030609; ENSRNOG00000008656 [P37377-1]
GeneIDi29219
KEGGirno:29219
UCSCiRGD:3729 rat [P37377-1]

Organism-specific databases

CTDi6622
RGDi3729 Snca

Phylogenomic databases

GeneTreeiENSGT00390000016161
HOGENOMiHOG000008691
HOVERGENiHBG000481
InParanoidiP37377
KOiK04528
OMAiSEAYEMP
OrthoDBiEOG091G11PA
PhylomeDBiP37377
TreeFamiTF332776

Miscellaneous databases

PROiPR:P37377

Gene expression databases

BgeeiENSRNOG00000008656 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP37377 RN

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002460 Synuclein_alpha
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF5 PTHR13820:SF5, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01212 ASYNUCLEIN
PR01211 SYNUCLEIN
ProtoNetiSearch...

Entry informationi

Entry nameiSYUA_RAT
AccessioniPrimary (citable) accession number: P37377
Secondary accession number(s): P37378, Q53YM9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 10, 2018
This is version 154 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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