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Protein

Verprolin

Gene

VRP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins (e.g. profilin) or proteins possessing SH3 domains.

GO - Molecular functioni

  • actin binding Source: SGD
  • actin filament binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

BioCyciYEAST:G3O-32416-MONOMER

Protein family/group databases

MoonDBiP37370 Predicted

Names & Taxonomyi

Protein namesi
Recommended name:
Verprolin
Gene namesi
Name:VRP1
Synonyms:END5, MDP2
Ordered Locus Names:YLR337C
ORF Names:L8300.13
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

SGDiS000004329 VRP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659291 – 817VerprolinAdd BLAST817

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei519PhosphoserineCombined sources1
Modified residuei762PhosphoserineCombined sources1
Glycosylationi784N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP37370
PaxDbiP37370
PRIDEiP37370

PTM databases

iPTMnetiP37370

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi31601, 637 interactors
DIPiDIP-860N
ELMiP37370
IntActiP37370, 25 interactors
MINTiP37370
STRINGi4932.YLR337C

Structurei

3D structure databases

ProteinModelPortaliP37370
SMRiP37370
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 47WH2 1PROSITE-ProRule annotationAdd BLAST18
Domaini87 – 106WH2 2PROSITE-ProRule annotationAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi5 – 14Poly-Pro10
Compositional biasi239 – 245Poly-Pro7
Compositional biasi349 – 357Poly-Pro9
Compositional biasi396 – 406Poly-ProAdd BLAST11
Compositional biasi424 – 431Poly-Pro8
Compositional biasi462 – 468Poly-Ser7
Compositional biasi704 – 708Poly-Pro5

Sequence similaritiesi

Belongs to the verprolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

InParanoidiP37370
KOiK19475
OMAiQHFGTMR
OrthoDBiEOG092C3BAW

Family and domain databases

InterProiView protein in InterPro
IPR003124 WH2_dom
PfamiView protein in Pfam
PF02205 WH2, 2 hits
SMARTiView protein in SMART
SM00246 WH2, 2 hits
PROSITEiView protein in PROSITE
PS51082 WH2, 2 hits

Sequencei

Sequence statusi: Complete.

P37370-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAPAPPPP PPPPALGGSA PKPAKSVMQG RDALLGDIRK GMKLKKAETN
60 70 80 90 100
DRSAPIVGGG VVSSASGSSG TVSSKGPSMS APPIPGMGAP QLGDILAGGI
110 120 130 140 150
PKLKHINNNA STKPSPSASA PPIPGAVPSV AAPPIPNAPL SPAPAVPSIP
160 170 180 190 200
SSSAPPIPDI PSSAAPPIPI VPSSPAPPLP LSGASAPKVP QNRPHMPSVR
210 220 230 240 250
PAHRSHQRKS SNISLPSVSA PPLPSASLPT HVSNPPQAPP PPPTPTIGLD
260 270 280 290 300
SKNIKPTDNA VSPPSSEVPA GGLPFLAEIN ARRSERGAVE GVSSTKIQTE
310 320 330 340 350
NHKSPSQPPL PSSAPPIPTS HAPPLPPTAP PPPSLPNVTS APKKATSAPA
360 370 380 390 400
PPPPPLPAAM SSASTNSVKA TPVPPTLAPP LPNTTSVPPN KASSMPAPPP
410 420 430 440 450
PPPPPPGAFS TSSALSASSI PLAPLPPPPP PSVATSVPSA PPPPPTLTTN
460 470 480 490 500
KPSASSKQSK ISSSSSSSAV TPGGPLPFLA EIQKKRDDRF VVGGDTGYTT
510 520 530 540 550
QDKQEDVIGS SKDDNVRPSP ISPSINPPKQ SSQNGMSFLD EIESKLHKQT
560 570 580 590 600
SSNAFNAPPP HTDAMAPPLP PSAPPPPITS LPTPTASGDD HTNDKSETVL
610 620 630 640 650
GMKKAKAPAL PGHVPPPPVP PVLSDDSKNN VPAASLLHDV LPSSNLEKPP
660 670 680 690 700
SPPVAAAPPL PTFSAPSLPQ QSVSTSIPSP PPVAPTLSVR TETESISKNP
710 720 730 740 750
TKSPPPPPSP STMDTGTSNS PSKNLKQRLF STGGSTLQHK HNTHTNQPDV
760 770 780 790 800
DVGRYTIGGS NSIVGAKSGN ERIVIDDSRF KWTNVSQMPK PRPFQNKTKL
810
YPSGKGSSVP LDLTLFT
Length:817
Mass (Da):82,594
Last modified:November 1, 1997 - v2
Checksum:i24C7522D5B1CA1C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti308P → R in CAA81388 (PubMed:7968536).Curated1
Sequence conflicti350A → R in CAA81388 (PubMed:7968536).Curated1
Sequence conflicti689V → E in CAA81388 (PubMed:7968536).Curated1
Sequence conflicti710 – 817PSTMD…LTLFT → HLRWIPVPLIAPVKTLNNGY FLQVDRRCNTSIIRIQINQM LM (PubMed:7968536).CuratedAdd BLAST108

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26645 Genomic DNA Translation: CAA81388.1
U19028 Genomic DNA Translation: AAB67263.1
BK006945 Genomic DNA Translation: DAA09643.1
PIRiS51342
RefSeqiNP_013441.1, NM_001182226.1

Genome annotation databases

EnsemblFungiiYLR337C; YLR337C; YLR337C
GeneIDi851051
KEGGisce:YLR337C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26645 Genomic DNA Translation: CAA81388.1
U19028 Genomic DNA Translation: AAB67263.1
BK006945 Genomic DNA Translation: DAA09643.1
PIRiS51342
RefSeqiNP_013441.1, NM_001182226.1

3D structure databases

ProteinModelPortaliP37370
SMRiP37370
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31601, 637 interactors
DIPiDIP-860N
ELMiP37370
IntActiP37370, 25 interactors
MINTiP37370
STRINGi4932.YLR337C

Protein family/group databases

MoonDBiP37370 Predicted

PTM databases

iPTMnetiP37370

Proteomic databases

MaxQBiP37370
PaxDbiP37370
PRIDEiP37370

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR337C; YLR337C; YLR337C
GeneIDi851051
KEGGisce:YLR337C

Organism-specific databases

SGDiS000004329 VRP1

Phylogenomic databases

InParanoidiP37370
KOiK19475
OMAiQHFGTMR
OrthoDBiEOG092C3BAW

Enzyme and pathway databases

BioCyciYEAST:G3O-32416-MONOMER

Miscellaneous databases

PROiPR:P37370

Family and domain databases

InterProiView protein in InterPro
IPR003124 WH2_dom
PfamiView protein in Pfam
PF02205 WH2, 2 hits
SMARTiView protein in SMART
SM00246 WH2, 2 hits
PROSITEiView protein in PROSITE
PS51082 WH2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiVRP1_YEAST
AccessioniPrimary (citable) accession number: P37370
Secondary accession number(s): D6VYX7, Q06133
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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