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Protein

Verprolin

Gene

VRP1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins (e.g. profilin) or proteins possessing SH3 domains.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • actin binding Source: SGD
  • actin filament binding Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
YEAST:G3O-32416-MONOMER

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

More...
MoonDBi
P37370 Predicted

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Verprolin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:VRP1
Synonyms:END5, MDP2
Ordered Locus Names:YLR337C
ORF Names:L8300.13
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000004329 VRP1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000659291 – 817VerprolinAdd BLAST817

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi109N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi337N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi383N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei519PhosphoserineCombined sources1
Modified residuei762PhosphoserineCombined sources1
Glycosylationi784N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi796N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P37370

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P37370

PRoteomics IDEntifications database

More...
PRIDEi
P37370

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P37370

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
31601, 637 interactors

Database of interacting proteins

More...
DIPi
DIP-860N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...
ELMi
P37370

Protein interaction database and analysis system

More...
IntActi
P37370, 25 interactors

Molecular INTeraction database

More...
MINTi
P37370

STRING: functional protein association networks

More...
STRINGi
4932.YLR337C

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P37370

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P37370

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 47WH2 1PROSITE-ProRule annotationAdd BLAST18
Domaini87 – 106WH2 2PROSITE-ProRule annotationAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi5 – 14Poly-Pro10
Compositional biasi239 – 245Poly-Pro7
Compositional biasi349 – 357Poly-Pro9
Compositional biasi396 – 406Poly-ProAdd BLAST11
Compositional biasi424 – 431Poly-Pro8
Compositional biasi462 – 468Poly-Ser7
Compositional biasi704 – 708Poly-Pro5

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the verprolin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000171387

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P37370

KEGG Orthology (KO)

More...
KOi
K19475

Identification of Orthologs from Complete Genome Data

More...
OMAi
QHFGTMR

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003124 WH2_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02205 WH2, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00246 WH2, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51082 WH2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P37370-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGAPAPPPP PPPPALGGSA PKPAKSVMQG RDALLGDIRK GMKLKKAETN
60 70 80 90 100
DRSAPIVGGG VVSSASGSSG TVSSKGPSMS APPIPGMGAP QLGDILAGGI
110 120 130 140 150
PKLKHINNNA STKPSPSASA PPIPGAVPSV AAPPIPNAPL SPAPAVPSIP
160 170 180 190 200
SSSAPPIPDI PSSAAPPIPI VPSSPAPPLP LSGASAPKVP QNRPHMPSVR
210 220 230 240 250
PAHRSHQRKS SNISLPSVSA PPLPSASLPT HVSNPPQAPP PPPTPTIGLD
260 270 280 290 300
SKNIKPTDNA VSPPSSEVPA GGLPFLAEIN ARRSERGAVE GVSSTKIQTE
310 320 330 340 350
NHKSPSQPPL PSSAPPIPTS HAPPLPPTAP PPPSLPNVTS APKKATSAPA
360 370 380 390 400
PPPPPLPAAM SSASTNSVKA TPVPPTLAPP LPNTTSVPPN KASSMPAPPP
410 420 430 440 450
PPPPPPGAFS TSSALSASSI PLAPLPPPPP PSVATSVPSA PPPPPTLTTN
460 470 480 490 500
KPSASSKQSK ISSSSSSSAV TPGGPLPFLA EIQKKRDDRF VVGGDTGYTT
510 520 530 540 550
QDKQEDVIGS SKDDNVRPSP ISPSINPPKQ SSQNGMSFLD EIESKLHKQT
560 570 580 590 600
SSNAFNAPPP HTDAMAPPLP PSAPPPPITS LPTPTASGDD HTNDKSETVL
610 620 630 640 650
GMKKAKAPAL PGHVPPPPVP PVLSDDSKNN VPAASLLHDV LPSSNLEKPP
660 670 680 690 700
SPPVAAAPPL PTFSAPSLPQ QSVSTSIPSP PPVAPTLSVR TETESISKNP
710 720 730 740 750
TKSPPPPPSP STMDTGTSNS PSKNLKQRLF STGGSTLQHK HNTHTNQPDV
760 770 780 790 800
DVGRYTIGGS NSIVGAKSGN ERIVIDDSRF KWTNVSQMPK PRPFQNKTKL
810
YPSGKGSSVP LDLTLFT
Length:817
Mass (Da):82,594
Last modified:November 1, 1997 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i24C7522D5B1CA1C8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti308P → R in CAA81388 (PubMed:7968536).Curated1
Sequence conflicti350A → R in CAA81388 (PubMed:7968536).Curated1
Sequence conflicti689V → E in CAA81388 (PubMed:7968536).Curated1
Sequence conflicti710 – 817PSTMD…LTLFT → HLRWIPVPLIAPVKTLNNGY FLQVDRRCNTSIIRIQINQM LM (PubMed:7968536).CuratedAdd BLAST108

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z26645 Genomic DNA Translation: CAA81388.1
U19028 Genomic DNA Translation: AAB67263.1
BK006945 Genomic DNA Translation: DAA09643.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S51342

NCBI Reference Sequences

More...
RefSeqi
NP_013441.1, NM_001182226.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YLR337C_mRNA; YLR337C_mRNA; YLR337C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
851051

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YLR337C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26645 Genomic DNA Translation: CAA81388.1
U19028 Genomic DNA Translation: AAB67263.1
BK006945 Genomic DNA Translation: DAA09643.1
PIRiS51342
RefSeqiNP_013441.1, NM_001182226.1

3D structure databases

ProteinModelPortaliP37370
SMRiP37370
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31601, 637 interactors
DIPiDIP-860N
ELMiP37370
IntActiP37370, 25 interactors
MINTiP37370
STRINGi4932.YLR337C

Protein family/group databases

MoonDBiP37370 Predicted

PTM databases

iPTMnetiP37370

Proteomic databases

MaxQBiP37370
PaxDbiP37370
PRIDEiP37370

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLR337C_mRNA; YLR337C_mRNA; YLR337C
GeneIDi851051
KEGGisce:YLR337C

Organism-specific databases

SGDiS000004329 VRP1

Phylogenomic databases

GeneTreeiENSGT00940000171387
InParanoidiP37370
KOiK19475
OMAiQHFGTMR

Enzyme and pathway databases

BioCyciYEAST:G3O-32416-MONOMER

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P37370

Family and domain databases

InterProiView protein in InterPro
IPR003124 WH2_dom
PfamiView protein in Pfam
PF02205 WH2, 2 hits
SMARTiView protein in SMART
SM00246 WH2, 2 hits
PROSITEiView protein in PROSITE
PS51082 WH2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVRP1_YEAST
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37370
Secondary accession number(s): D6VYX7, Q06133
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 1, 1997
Last modified: January 16, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
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