UniProtKB - P37370 (VRP1_YEAST)
Protein
Verprolin
Gene
VRP1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins (e.g. profilin) or proteins possessing SH3 domains.
GO - Molecular functioni
- actin binding Source: SGD
GO - Biological processi
- actin cortical patch localization Source: SGD
- bipolar cellular bud site selection Source: SGD
- endocytosis Source: SGD
- positive regulation of Arp2/3 complex-mediated actin nucleation Source: SGD
- regulation of cytokinesis Source: SGD
Protein family/group databases
MoonDBi | P37370, Predicted |
Names & Taxonomyi
Protein namesi | Recommended name: Verprolin |
Gene namesi | Name:VRP1 Synonyms:END5, MDP2 Ordered Locus Names:YLR337C ORF Names:L8300.13 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
EuPathDBi | FungiDB:YLR337C |
SGDi | S000004329, VRP1 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Cytoskeleton
- actin cortical patch Source: SGD
Other locations
- cellular bud neck Source: SGD
- incipient cellular bud site Source: SGD
- mating projection tip Source: SGD
Keywords - Cellular componenti
Cytoplasm, CytoskeletonPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000065929 | 1 – 817 | VerprolinAdd BLAST | 817 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 109 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 212 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 337 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 383 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 519 | PhosphoserineCombined sources | 1 | |
Modified residuei | 762 | PhosphoserineCombined sources | 1 | |
Glycosylationi | 784 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 796 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.1 Publication
Keywords - PTMi
Glycoprotein, PhosphoproteinProteomic databases
MaxQBi | P37370 |
PaxDbi | P37370 |
PRIDEi | P37370 |
PTM databases
iPTMneti | P37370 |
Interactioni
Binary interactionsi
Hide detailsP37370
With | #Exp. | IntAct |
---|---|---|
HOF1 [Q05080] | 4 | EBI-20502,EBI-5412 |
LAS17 [Q12446] | 6 | EBI-20502,EBI-10022 |
MYO3 [P36006] | 11 | EBI-20502,EBI-11670 |
MYO5 [Q04439] | 19 | EBI-20502,EBI-11687 |
RVS167 [P39743] | 3 | EBI-20502,EBI-14500 |
GO - Molecular functioni
- actin binding Source: SGD
Protein-protein interaction databases
BioGRIDi | 31601, 639 interactors |
DIPi | DIP-860N |
ELMi | P37370 |
IntActi | P37370, 25 interactors |
MINTi | P37370 |
STRINGi | 4932.YLR337C |
Miscellaneous databases
RNActi | P37370, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 30 – 47 | WH2 1PROSITE-ProRule annotationAdd BLAST | 18 | |
Domaini | 87 – 106 | WH2 2PROSITE-ProRule annotationAdd BLAST | 20 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 5 – 14 | Poly-Pro | 10 | |
Compositional biasi | 239 – 245 | Poly-Pro | 7 | |
Compositional biasi | 349 – 357 | Poly-Pro | 9 | |
Compositional biasi | 396 – 406 | Poly-ProAdd BLAST | 11 | |
Compositional biasi | 424 – 431 | Poly-Pro | 8 | |
Compositional biasi | 462 – 468 | Poly-Ser | 7 | |
Compositional biasi | 704 – 708 | Poly-Pro | 5 |
Sequence similaritiesi
Belongs to the verprolin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG4462, Eukaryota |
GeneTreei | ENSGT00940000171387 |
HOGENOMi | CLU_386454_0_0_1 |
InParanoidi | P37370 |
OMAi | ETPVMHT |
Family and domain databases
InterProi | View protein in InterPro IPR003124, WH2_dom |
Pfami | View protein in Pfam PF02205, WH2, 2 hits |
SMARTi | View protein in SMART SM00246, WH2, 2 hits |
PROSITEi | View protein in PROSITE PS51082, WH2, 2 hits |
i Sequence
Sequence statusi: Complete.
P37370-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAGAPAPPPP PPPPALGGSA PKPAKSVMQG RDALLGDIRK GMKLKKAETN
60 70 80 90 100
DRSAPIVGGG VVSSASGSSG TVSSKGPSMS APPIPGMGAP QLGDILAGGI
110 120 130 140 150
PKLKHINNNA STKPSPSASA PPIPGAVPSV AAPPIPNAPL SPAPAVPSIP
160 170 180 190 200
SSSAPPIPDI PSSAAPPIPI VPSSPAPPLP LSGASAPKVP QNRPHMPSVR
210 220 230 240 250
PAHRSHQRKS SNISLPSVSA PPLPSASLPT HVSNPPQAPP PPPTPTIGLD
260 270 280 290 300
SKNIKPTDNA VSPPSSEVPA GGLPFLAEIN ARRSERGAVE GVSSTKIQTE
310 320 330 340 350
NHKSPSQPPL PSSAPPIPTS HAPPLPPTAP PPPSLPNVTS APKKATSAPA
360 370 380 390 400
PPPPPLPAAM SSASTNSVKA TPVPPTLAPP LPNTTSVPPN KASSMPAPPP
410 420 430 440 450
PPPPPPGAFS TSSALSASSI PLAPLPPPPP PSVATSVPSA PPPPPTLTTN
460 470 480 490 500
KPSASSKQSK ISSSSSSSAV TPGGPLPFLA EIQKKRDDRF VVGGDTGYTT
510 520 530 540 550
QDKQEDVIGS SKDDNVRPSP ISPSINPPKQ SSQNGMSFLD EIESKLHKQT
560 570 580 590 600
SSNAFNAPPP HTDAMAPPLP PSAPPPPITS LPTPTASGDD HTNDKSETVL
610 620 630 640 650
GMKKAKAPAL PGHVPPPPVP PVLSDDSKNN VPAASLLHDV LPSSNLEKPP
660 670 680 690 700
SPPVAAAPPL PTFSAPSLPQ QSVSTSIPSP PPVAPTLSVR TETESISKNP
710 720 730 740 750
TKSPPPPPSP STMDTGTSNS PSKNLKQRLF STGGSTLQHK HNTHTNQPDV
760 770 780 790 800
DVGRYTIGGS NSIVGAKSGN ERIVIDDSRF KWTNVSQMPK PRPFQNKTKL
810
YPSGKGSSVP LDLTLFT
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 308 | P → R in CAA81388 (PubMed:7968536).Curated | 1 | |
Sequence conflicti | 350 | A → R in CAA81388 (PubMed:7968536).Curated | 1 | |
Sequence conflicti | 689 | V → E in CAA81388 (PubMed:7968536).Curated | 1 | |
Sequence conflicti | 710 – 817 | PSTMD…LTLFT → HLRWIPVPLIAPVKTLNNGY FLQVDRRCNTSIIRIQINQM LM (PubMed:7968536).CuratedAdd BLAST | 108 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z26645 Genomic DNA Translation: CAA81388.1 U19028 Genomic DNA Translation: AAB67263.1 BK006945 Genomic DNA Translation: DAA09643.1 |
PIRi | S51342 |
RefSeqi | NP_013441.1, NM_001182226.1 |
Genome annotation databases
EnsemblFungii | YLR337C_mRNA; YLR337C; YLR337C |
GeneIDi | 851051 |
KEGGi | sce:YLR337C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z26645 Genomic DNA Translation: CAA81388.1 U19028 Genomic DNA Translation: AAB67263.1 BK006945 Genomic DNA Translation: DAA09643.1 |
PIRi | S51342 |
RefSeqi | NP_013441.1, NM_001182226.1 |
3D structure databases
SMRi | P37370 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 31601, 639 interactors |
DIPi | DIP-860N |
ELMi | P37370 |
IntActi | P37370, 25 interactors |
MINTi | P37370 |
STRINGi | 4932.YLR337C |
Protein family/group databases
MoonDBi | P37370, Predicted |
PTM databases
iPTMneti | P37370 |
Proteomic databases
MaxQBi | P37370 |
PaxDbi | P37370 |
PRIDEi | P37370 |
Genome annotation databases
EnsemblFungii | YLR337C_mRNA; YLR337C; YLR337C |
GeneIDi | 851051 |
KEGGi | sce:YLR337C |
Organism-specific databases
EuPathDBi | FungiDB:YLR337C |
SGDi | S000004329, VRP1 |
Phylogenomic databases
eggNOGi | KOG4462, Eukaryota |
GeneTreei | ENSGT00940000171387 |
HOGENOMi | CLU_386454_0_0_1 |
InParanoidi | P37370 |
OMAi | ETPVMHT |
Miscellaneous databases
PROi | PR:P37370 |
RNActi | P37370, protein |
Family and domain databases
InterProi | View protein in InterPro IPR003124, WH2_dom |
Pfami | View protein in Pfam PF02205, WH2, 2 hits |
SMARTi | View protein in SMART SM00246, WH2, 2 hits |
PROSITEi | View protein in PROSITE PS51082, WH2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VRP1_YEAST | |
Accessioni | P37370Primary (citable) accession number: P37370 Secondary accession number(s): D6VYX7, Q06133 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 165 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names - SIMILARITY comments
Index of protein domains and families - Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD