VRP1

Functionⁱ

Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins (e.g. profilin) or proteins possessing SH3 domains.

GO - Molecular functionⁱ

actin binding
Source: SGD
Inferred from physical interactionⁱ
- 9412475
actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin cortical patch assembly
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
actin cortical patch localization
Source: SGD
Inferred from mutant phenotypeⁱ
- 8590801
actin filament-based movement
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
bipolar cellular bud site selection
Source: SGD
Inferred from mutant phenotypeⁱ
- 9412475
endocytosis
Source: SGD
Inferred from mutant phenotypeⁱ
- 8590801
- 9742397
positive regulation of actin nucleation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of Arp2/3 complex-mediated actin nucleation
Source: SGD
Inferred from direct assayⁱ
- 11604421
- 16824951
regulation of cytokinesis
Source: SGD
Inferred from mutant phenotypeⁱ
- 15941409

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-32416-MONOMER

BioCycⁱ

YEAST:G3O-32416-MONOMER

Protein family/group databases

MoonDBⁱ	P37370 Predicted

MoonDBⁱ

P37370 Predicted

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Verprolin
Gene namesⁱ	Name:VRP1 Synonyms:END5, MDP2 Ordered Locus Names:YLR337C ORF Names:L8300.13
Organismⁱ	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifierⁱ	559292 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae
Proteomesⁱ	UP000002311 Componentⁱ: Chromosome XII

Organism-specific databases

Saccharomyces Genome Database More...SGDⁱ	S000004329 VRP1

SGDⁱ

S000004329 VRP1

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000065929	1 – 817	VerprolinAdd BLAST		817

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	109	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	212	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	337	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	383	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	519	PhosphoserineCombined sources	1
Modified residueⁱ	762	PhosphoserineCombined sources	1
Glycosylationⁱ	784	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	796	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

N-glycosylated.1 Publication

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P37370
PaxDbⁱ	P37370
PRIDEⁱ	P37370

PTM databases

iPTMnetⁱ	P37370

iPTMnetⁱ

P37370

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
HOF1	Q05080	4	EBI-20502,EBI-5412
LAS17	Q12446	6	EBI-20502,EBI-10022
MYO3	P36006	11	EBI-20502,EBI-11670
MYO5	Q04439	19	EBI-20502,EBI-11687
RVS167	P39743	3	EBI-20502,EBI-14500

GO - Molecular functionⁱ

actin binding
Source: SGD
Inferred from physical interactionⁱ
- 9412475
actin filament binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	31601, 637 interactors
Database of interacting proteins More...DIPⁱ	DIP-860N
ELMⁱ	P37370
IntActⁱ	P37370, 25 interactors
Molecular INTeraction database More...MINTⁱ	P37370
STRINGⁱ	4932.YLR337C

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P37370
SMRⁱ	P37370
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	30 – 47	WH2 1PROSITE-ProRule annotationAdd BLAST		18
Domainⁱ	87 – 106	WH2 2PROSITE-ProRule annotationAdd BLAST		20

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	5 – 14	Poly-Pro	10
Compositional biasⁱ	239 – 245	Poly-Pro	7
Compositional biasⁱ	349 – 357	Poly-Pro	9
Compositional biasⁱ	396 – 406	Poly-ProAdd BLAST	11
Compositional biasⁱ	424 – 431	Poly-Pro	8
Compositional biasⁱ	462 – 468	Poly-Ser	7
Compositional biasⁱ	704 – 708	Poly-Pro	5

Sequence similaritiesⁱ

Belongs to the verprolin family.Curated

Keywords - Domainⁱ

Repeat

Phylogenomic databases

InParanoidⁱ	P37370
KEGG Orthology (KO) More...KOⁱ	K19475
OMAⁱ	QHFGTMR
Database of Orthologous Groups More...OrthoDBⁱ	EOG092C3BAW

Family and domain databases

InterProⁱ	View protein in InterPro IPR003124 WH2_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02205 WH2, 2 hits
SMARTⁱ	View protein in SMART SM00246 WH2, 2 hits
PROSITEⁱ	View protein in PROSITE PS51082 WH2, 2 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

P37370-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAGAPAPPPP PPPPALGGSA PKPAKSVMQG RDALLGDIRK GMKLKKAETN 
        60         70         80         90        100
DRSAPIVGGG VVSSASGSSG TVSSKGPSMS APPIPGMGAP QLGDILAGGI 
       110        120        130        140        150
PKLKHINNNA STKPSPSASA PPIPGAVPSV AAPPIPNAPL SPAPAVPSIP 
       160        170        180        190        200
SSSAPPIPDI PSSAAPPIPI VPSSPAPPLP LSGASAPKVP QNRPHMPSVR 
       210        220        230        240        250
PAHRSHQRKS SNISLPSVSA PPLPSASLPT HVSNPPQAPP PPPTPTIGLD 
       260        270        280        290        300
SKNIKPTDNA VSPPSSEVPA GGLPFLAEIN ARRSERGAVE GVSSTKIQTE 
       310        320        330        340        350
NHKSPSQPPL PSSAPPIPTS HAPPLPPTAP PPPSLPNVTS APKKATSAPA 
       360        370        380        390        400
PPPPPLPAAM SSASTNSVKA TPVPPTLAPP LPNTTSVPPN KASSMPAPPP 
       410        420        430        440        450
PPPPPPGAFS TSSALSASSI PLAPLPPPPP PSVATSVPSA PPPPPTLTTN 
       460        470        480        490        500
KPSASSKQSK ISSSSSSSAV TPGGPLPFLA EIQKKRDDRF VVGGDTGYTT 
       510        520        530        540        550
QDKQEDVIGS SKDDNVRPSP ISPSINPPKQ SSQNGMSFLD EIESKLHKQT 
       560        570        580        590        600
SSNAFNAPPP HTDAMAPPLP PSAPPPPITS LPTPTASGDD HTNDKSETVL 
       610        620        630        640        650
GMKKAKAPAL PGHVPPPPVP PVLSDDSKNN VPAASLLHDV LPSSNLEKPP 
       660        670        680        690        700
SPPVAAAPPL PTFSAPSLPQ QSVSTSIPSP PPVAPTLSVR TETESISKNP 
       710        720        730        740        750
TKSPPPPPSP STMDTGTSNS PSKNLKQRLF STGGSTLQHK HNTHTNQPDV 
       760        770        780        790        800
DVGRYTIGGS NSIVGAKSGN ERIVIDDSRF KWTNVSQMPK PRPFQNKTKL 
       810 
YPSGKGSSVP LDLTLFT

Length:817

Mass (Da):82,594

Last modified:November 1, 1997 - v2

Checksum:ⁱ24C7522D5B1CA1C8

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	308	P → R in CAA81388 (PubMed:7968536).Curated	1
Sequence conflictⁱ	350	A → R in CAA81388 (PubMed:7968536).Curated	1
Sequence conflictⁱ	689	V → E in CAA81388 (PubMed:7968536).Curated	1
Sequence conflictⁱ	710 – 817	PSTMD…LTLFT → HLRWIPVPLIAPVKTLNNGY FLQVDRRCNTSIIRIQINQM LM (PubMed:7968536).CuratedAdd BLAST	108

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z26645 Genomic DNA Translation: CAA81388.1 U19028 Genomic DNA Translation: AAB67263.1 BK006945 Genomic DNA Translation: DAA09643.1
PIRⁱ	S51342
NCBI Reference Sequences More...RefSeqⁱ	NP_013441.1, NM_001182226.1

Genome annotation databases

EnsemblFungiⁱ	YLR337C; YLR337C; YLR337C
GeneIDⁱ	851051
KEGGⁱ	sce:YLR337C

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P37370	Vrp1p		YEASC		817	UniRef100_P37370

Protein	Similar proteins		Species	Score	Length	Source
P37370	Vrp1p		YEASC		817	UniRef90_P37370
Uncharacterized protein		YEAS1		817
Vrp1p		SACCK		817
VRP1p proline-rich protein verprolin		Saccharomyces sp. 'boulardii'		817
Vrp1p		YEAS2		817
+3

Protein	Similar proteins		Species	Score	Length	Source
P37370	Vrp1p		YEASC		817	UniRef50_P37370
Vrp1p		YEASV		817
Uncharacterized protein		YEAS1		817
Verprolin		YEASX		817
Vrp1p		SACCK		817
+3

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z26645 Genomic DNA Translation: CAA81388.1 U19028 Genomic DNA Translation: AAB67263.1 BK006945 Genomic DNA Translation: DAA09643.1
PIRⁱ	S51342
RefSeqⁱ	NP_013441.1, NM_001182226.1

3D structure databases

ProteinModelPortalⁱ	P37370
SMRⁱ	P37370
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	31601, 637 interactors
DIPⁱ	DIP-860N
ELMⁱ	P37370
IntActⁱ	P37370, 25 interactors
MINTⁱ	P37370
STRINGⁱ	4932.YLR337C

Protein family/group databases

MoonDBⁱ	P37370 Predicted

MoonDBⁱ

P37370 Predicted

PTM databases

iPTMnetⁱ	P37370

iPTMnetⁱ

P37370

Proteomic databases

MaxQBⁱ	P37370
PaxDbⁱ	P37370
PRIDEⁱ	P37370

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblFungiⁱ	YLR337C; YLR337C; YLR337C
GeneIDⁱ	851051
KEGGⁱ	sce:YLR337C

Organism-specific databases

SGDⁱ	S000004329 VRP1

Phylogenomic databases

InParanoidⁱ	P37370
KOⁱ	K19475
OMAⁱ	QHFGTMR
OrthoDBⁱ	EOG092C3BAW

Enzyme and pathway databases

BioCycⁱ	YEAST:G3O-32416-MONOMER

BioCycⁱ

YEAST:G3O-32416-MONOMER

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P37370

PROⁱ

PR:P37370

Family and domain databases

InterProⁱ	View protein in InterPro IPR003124 WH2_dom
Pfamⁱ	View protein in Pfam PF02205 WH2, 2 hits
SMARTⁱ	View protein in SMART SM00246 WH2, 2 hits
PROSITEⁱ	View protein in PROSITE PS51082 WH2, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VRP1_YEAST
Accessionⁱ	P37370Primary (citable) accession number: P37370 Secondary accession number(s): D6VYX7, Q06133
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
	Last sequence update:	November 1, 1997
	Last modified:	November 7, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Fungal Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Yeast chromosome XII
Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names
Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P37370 (VRP1_YEAST)

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Verprolin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ