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Protein

Cyclin CCL1

Gene

CCL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro.

Miscellaneous

Present with 8700 molecules/cell in log phase SD medium.1 Publication

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

BioCyciYEAST:G3O-34185-MONOMER
ReactomeiR-SCE-113418 Formation of the Early Elongation Complex
R-SCE-5696395 Formation of Incision Complex in GG-NER
R-SCE-674695 RNA Polymerase II Pre-transcription Events
R-SCE-6781823 Formation of TC-NER Pre-Incision Complex
R-SCE-6782135 Dual incision in TC-NER
R-SCE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SCE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-SCE-69202 Cyclin E associated events during G1/S transition
R-SCE-69231 Cyclin D associated events in G1
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-SCE-69656 Cyclin A:Cdk2-associated events at S phase entry
R-SCE-72086 mRNA Capping
R-SCE-73776 RNA Polymerase II Promoter Escape
R-SCE-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SCE-75953 RNA Polymerase II Transcription Initiation
R-SCE-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SCE-77075 RNA Pol II CTD phosphorylation and interaction with CE

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin CCL1
Gene namesi
Name:CCL1
Ordered Locus Names:YPR025C
ORF Names:YP9367.05C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

SGDiS000006229 CCL1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000805041 – 393Cyclin CCL1Add BLAST393

Proteomic databases

MaxQBiP37366
PaxDbiP37366
PRIDEiP37366

PTM databases

iPTMnetiP37366

Interactioni

Subunit structurei

CCL1 and KIN28 form the TFIIK complex, a component of TFIIH holo complex. Component of a complex consisting of KIN28, CCL1 and TFB3.2 Publications

Binary interactionsi

Protein-protein interaction databases

BioGridi36202, 149 interactors
ComplexPortaliCPX-1659 General transcription factor complex TFIIH
CPX-1660 General transcription factor complex TFIIK
DIPiDIP-2258N
IntActiP37366, 58 interactors
MINTiP37366
STRINGi4932.YPR025C

Structurei

3D structure databases

ProteinModelPortaliP37366
SMRiP37366
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00390000008634
HOGENOMiHOG000247914
InParanoidiP37366
KOiK06634
OMAiAQFCELP
OrthoDBiEOG092C3VA4

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR031658 Cyclin_C_2
IPR006671 Cyclin_N
IPR027081 CyclinH/Ccl1
PfamiView protein in Pfam
PF16899 Cyclin_C_2, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
TIGRFAMsiTIGR00569 ccl1, 1 hit

Sequencei

Sequence statusi: Complete.

P37366-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDIQLNGKS TLDTPSATMS AKEKEAKLKS ADENNKPPNY KRISDDDLYR
60 70 80 90 100
HSSQYRMWSY TKDQLQEKRV DTNARAIAYI EENLLKFREA HNLTEEEIKV
110 120 130 140 150
LEAKAIPLTM EEELDLVNFY AKKVQVIAQH LNLPTEVVAT AISFFRRFFL
160 170 180 190 200
ENSVMQIDPK SIVHTTIFLA CKSENYFISV DSFAQKAKST RDSVLKFEFK
210 220 230 240 250
LLESLKFSLL NHHPYKPLHG FFLDIQNVLY GKVDLNYMGQ IYDRCKKRIT
260 270 280 290 300
AALLTDVVYF YTPPQITLAT LLIEDEALVT RYLETKFPSR EGSQESVPGN
310 320 330 340 350
EKEEPQNDAS TTEKNKEKST ESEEYSIDSA KLLTIIRECK SIIEDCKPPS
360 370 380 390
TEEAKKIAAK NYYCQNPSTL IQKLKRKLNG EDTSSTVEKK QKT
Length:393
Mass (Da):45,210
Last modified:October 1, 1994 - v1
Checksum:iFE06E78FC38A8433
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71902 Genomic DNA Translation: CAA50721.1
Z49274 Genomic DNA Translation: CAA89279.1
Z71255 Genomic DNA Translation: CAA95021.1
BK006949 Genomic DNA Translation: DAA11451.1
PIRiS39383
RefSeqiNP_015350.1, NM_001184122.1

Genome annotation databases

EnsemblFungiiYPR025C; YPR025C; YPR025C
GeneIDi856136
KEGGisce:YPR025C

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71902 Genomic DNA Translation: CAA50721.1
Z49274 Genomic DNA Translation: CAA89279.1
Z71255 Genomic DNA Translation: CAA95021.1
BK006949 Genomic DNA Translation: DAA11451.1
PIRiS39383
RefSeqiNP_015350.1, NM_001184122.1

3D structure databases

ProteinModelPortaliP37366
SMRiP37366
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi36202, 149 interactors
ComplexPortaliCPX-1659 General transcription factor complex TFIIH
CPX-1660 General transcription factor complex TFIIK
DIPiDIP-2258N
IntActiP37366, 58 interactors
MINTiP37366
STRINGi4932.YPR025C

PTM databases

iPTMnetiP37366

Proteomic databases

MaxQBiP37366
PaxDbiP37366
PRIDEiP37366

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYPR025C; YPR025C; YPR025C
GeneIDi856136
KEGGisce:YPR025C

Organism-specific databases

SGDiS000006229 CCL1

Phylogenomic databases

GeneTreeiENSGT00390000008634
HOGENOMiHOG000247914
InParanoidiP37366
KOiK06634
OMAiAQFCELP
OrthoDBiEOG092C3VA4

Enzyme and pathway databases

BioCyciYEAST:G3O-34185-MONOMER
ReactomeiR-SCE-113418 Formation of the Early Elongation Complex
R-SCE-5696395 Formation of Incision Complex in GG-NER
R-SCE-674695 RNA Polymerase II Pre-transcription Events
R-SCE-6781823 Formation of TC-NER Pre-Incision Complex
R-SCE-6782135 Dual incision in TC-NER
R-SCE-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-SCE-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-SCE-69202 Cyclin E associated events during G1/S transition
R-SCE-69231 Cyclin D associated events in G1
R-SCE-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-SCE-69656 Cyclin A:Cdk2-associated events at S phase entry
R-SCE-72086 mRNA Capping
R-SCE-73776 RNA Polymerase II Promoter Escape
R-SCE-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SCE-75953 RNA Polymerase II Transcription Initiation
R-SCE-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SCE-77075 RNA Pol II CTD phosphorylation and interaction with CE

Miscellaneous databases

PROiPR:P37366

Family and domain databases

CDDicd00043 CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR031658 Cyclin_C_2
IPR006671 Cyclin_N
IPR027081 CyclinH/Ccl1
PfamiView protein in Pfam
PF16899 Cyclin_C_2, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
TIGRFAMsiTIGR00569 ccl1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL1_YEAST
AccessioniPrimary (citable) accession number: P37366
Secondary accession number(s): D6W435
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
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