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Entry version 179 (02 Jun 2021)
Sequence version 1 (01 Oct 1994)
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Protein

Cyclin CCL1

Gene

CCL1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulatory component of the TFIIK complex (KIN28-CCL1 dimer) which is the protein kinase component of transcription factor IIH (TFIIH) and phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. TFIIH (or factor B) is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has DNA-dependent ATPase activity and is essential for polymerase II transcription in vitro.

Miscellaneous

Present with 8700 molecules/cell in log phase SD medium.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: SGD

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCyclin
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-SCE-113418, Formation of the Early Elongation Complex
R-SCE-674695, RNA Polymerase II Pre-transcription Events
R-SCE-6781823, Formation of TC-NER Pre-Incision Complex
R-SCE-6782135, Dual incision in TC-NER
R-SCE-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-SCE-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-SCE-69202, Cyclin E associated events during G1/S transition
R-SCE-72086, mRNA Capping
R-SCE-73772, RNA Polymerase I Promoter Escape
R-SCE-73776, RNA Polymerase II Promoter Escape
R-SCE-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SCE-75953, RNA Polymerase II Transcription Initiation
R-SCE-75955, RNA Polymerase II Transcription Elongation
R-SCE-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SCE-77075, RNA Pol II CTD phosphorylation and interaction with CE

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclin CCL1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCL1
Ordered Locus Names:YPR025C
ORF Names:YP9367.05C
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri559292 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002311 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome XVI

Organism-specific databases

Saccharomyces Genome Database

More...
SGDi
S000006229, CCL1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:YPR025C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000805041 – 393Cyclin CCL1Add BLAST393

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P37366

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P37366

PRoteomics IDEntifications database

More...
PRIDEi
P37366

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P37366

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

CCL1 and KIN28 form the TFIIK complex, a component of TFIIH holo complex.

Component of a complex consisting of KIN28, CCL1 and TFB3.

2 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
36202, 154 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-1659, General transcription factor complex TFIIH
CPX-1660, General transcription factor complex TFIIK

Database of interacting proteins

More...
DIPi
DIP-2258N

Protein interaction database and analysis system

More...
IntActi
P37366, 58 interactors

Molecular INTeraction database

More...
MINTi
P37366

STRING: functional protein association networks

More...
STRINGi
4932.YPR025C

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
P37366, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P37366

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 45DisorderedSequence analysisAdd BLAST45
Regioni289 – 325DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 18Polar residuesSequence analysisAdd BLAST18
Compositional biasi20 – 45Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi296 – 325Basic and acidic residuesSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclin family. Cyclin C subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2496, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000168613

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_022620_4_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P37366

Identification of Orthologs from Complete Genome Data

More...
OMAi
SWTFANE

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00043, CYCLIN, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR043198, Cyclin/Ssn8
IPR031658, Cyclin_C_2
IPR006671, Cyclin_N
IPR027081, CyclinH/Ccl1

The PANTHER Classification System

More...
PANTHERi
PTHR10026, PTHR10026, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF16899, Cyclin_C_2, 1 hit
PF00134, Cyclin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00385, CYCLIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47954, SSF47954, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00569, ccl1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P37366-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTDIQLNGKS TLDTPSATMS AKEKEAKLKS ADENNKPPNY KRISDDDLYR
60 70 80 90 100
HSSQYRMWSY TKDQLQEKRV DTNARAIAYI EENLLKFREA HNLTEEEIKV
110 120 130 140 150
LEAKAIPLTM EEELDLVNFY AKKVQVIAQH LNLPTEVVAT AISFFRRFFL
160 170 180 190 200
ENSVMQIDPK SIVHTTIFLA CKSENYFISV DSFAQKAKST RDSVLKFEFK
210 220 230 240 250
LLESLKFSLL NHHPYKPLHG FFLDIQNVLY GKVDLNYMGQ IYDRCKKRIT
260 270 280 290 300
AALLTDVVYF YTPPQITLAT LLIEDEALVT RYLETKFPSR EGSQESVPGN
310 320 330 340 350
EKEEPQNDAS TTEKNKEKST ESEEYSIDSA KLLTIIRECK SIIEDCKPPS
360 370 380 390
TEEAKKIAAK NYYCQNPSTL IQKLKRKLNG EDTSSTVEKK QKT
Length:393
Mass (Da):45,210
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE06E78FC38A8433
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X71902 Genomic DNA Translation: CAA50721.1
Z49274 Genomic DNA Translation: CAA89279.1
Z71255 Genomic DNA Translation: CAA95021.1
BK006949 Genomic DNA Translation: DAA11451.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S39383

NCBI Reference Sequences

More...
RefSeqi
NP_015350.1, NM_001184122.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
YPR025C_mRNA; YPR025C; YPR025C

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
856136

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sce:YPR025C

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71902 Genomic DNA Translation: CAA50721.1
Z49274 Genomic DNA Translation: CAA89279.1
Z71255 Genomic DNA Translation: CAA95021.1
BK006949 Genomic DNA Translation: DAA11451.1
PIRiS39383
RefSeqiNP_015350.1, NM_001184122.1

3D structure databases

SMRiP37366
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi36202, 154 interactors
ComplexPortaliCPX-1659, General transcription factor complex TFIIH
CPX-1660, General transcription factor complex TFIIK
DIPiDIP-2258N
IntActiP37366, 58 interactors
MINTiP37366
STRINGi4932.YPR025C

PTM databases

iPTMnetiP37366

Proteomic databases

MaxQBiP37366
PaxDbiP37366
PRIDEiP37366

Genome annotation databases

EnsemblFungiiYPR025C_mRNA; YPR025C; YPR025C
GeneIDi856136
KEGGisce:YPR025C

Organism-specific databases

SGDiS000006229, CCL1
VEuPathDBiFungiDB:YPR025C

Phylogenomic databases

eggNOGiKOG2496, Eukaryota
GeneTreeiENSGT00940000168613
HOGENOMiCLU_022620_4_2_1
InParanoidiP37366
OMAiSWTFANE

Enzyme and pathway databases

ReactomeiR-SCE-113418, Formation of the Early Elongation Complex
R-SCE-674695, RNA Polymerase II Pre-transcription Events
R-SCE-6781823, Formation of TC-NER Pre-Incision Complex
R-SCE-6782135, Dual incision in TC-NER
R-SCE-6782210, Gap-filling DNA repair synthesis and ligation in TC-NER
R-SCE-6796648, TP53 Regulates Transcription of DNA Repair Genes
R-SCE-69202, Cyclin E associated events during G1/S transition
R-SCE-72086, mRNA Capping
R-SCE-73772, RNA Polymerase I Promoter Escape
R-SCE-73776, RNA Polymerase II Promoter Escape
R-SCE-73779, RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-SCE-75953, RNA Polymerase II Transcription Initiation
R-SCE-75955, RNA Polymerase II Transcription Elongation
R-SCE-76042, RNA Polymerase II Transcription Initiation And Promoter Clearance
R-SCE-77075, RNA Pol II CTD phosphorylation and interaction with CE

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P37366
RNActiP37366, protein

Family and domain databases

CDDicd00043, CYCLIN, 1 hit
InterProiView protein in InterPro
IPR013763, Cyclin-like
IPR036915, Cyclin-like_sf
IPR043198, Cyclin/Ssn8
IPR031658, Cyclin_C_2
IPR006671, Cyclin_N
IPR027081, CyclinH/Ccl1
PANTHERiPTHR10026, PTHR10026, 1 hit
PfamiView protein in Pfam
PF16899, Cyclin_C_2, 1 hit
PF00134, Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385, CYCLIN, 1 hit
SUPFAMiSSF47954, SSF47954, 2 hits
TIGRFAMsiTIGR00569, ccl1, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCL1_YEAST
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37366
Secondary accession number(s): D6W435
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: June 2, 2021
This is version 179 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  2. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families
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