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Protein

Metallothionein-3

Gene

Mt3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Inhibits survival and neurite formation of cortical neurons in vitro (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Divalent metal cation; cluster BBy similarity1
Metal bindingi8Divalent metal cation; cluster BBy similarity1
Metal bindingi14Divalent metal cation; cluster BBy similarity1
Metal bindingi16Divalent metal cation; cluster BBy similarity1
Metal bindingi20Divalent metal cation; cluster BBy similarity1
Metal bindingi22Divalent metal cation; cluster BBy similarity1
Metal bindingi25Divalent metal cation; cluster BBy similarity1
Metal bindingi27Divalent metal cation; cluster BBy similarity1
Metal bindingi30Divalent metal cation; cluster BBy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi35Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi38Divalent metal cation; cluster ABy similarity1
Metal bindingi42Divalent metal cation; cluster ABy similarity1
Metal bindingi45Divalent metal cation; cluster ABy similarity1
Metal bindingi49Divalent metal cation; cluster ABy similarity1
Metal bindingi51Divalent metal cation; cluster ABy similarity1
Metal bindingi62Divalent metal cation; cluster ABy similarity1
Metal bindingi64Divalent metal cation; cluster ABy similarity1
Metal bindingi65Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-5661231 Metallothioneins bind metals

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-3
Short name:
MT-3
Alternative name(s):
Growth inhibitory factor
Short name:
GIF
Metallothionein-III
Short name:
MT-III
Gene namesi
Name:Mt3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621252 Mt3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972531 – 66Metallothionein-3Add BLAST66

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei33PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP37361
PRIDEiP37361

PTM databases

iPTMnetiP37361
PhosphoSitePlusiP37361

Expressioni

Tissue specificityi

Brain.

Gene expression databases

BgeeiENSRNOG00000018958 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP37361 RN

Interactioni

Protein-protein interaction databases

IntActiP37361, 2 interactors
MINTiP37361
STRINGi10116.ENSRNOP00000025669

Structurei

3D structure databases

ProteinModelPortaliP37361
SMRiP37361
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 30BetaAdd BLAST30
Regioni31 – 66AlphaAdd BLAST36

Sequence similaritiesi

Phylogenomic databases

GeneTreeiENSGT00730000111484
HOGENOMiHOG000236262
InParanoidiP37361
KOiK14740
OMAiVCKGEEG

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

P37361-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPETCPCPT GGSCTCSDKC KCKGCKCTNC KKSCCSCCPA GCEKCAKDCV
60
CKGEEGAKAE KCSCCQ
Length:66
Mass (Da):6,809
Last modified:October 1, 1994 - v1
Checksum:iBE7538E85664EBF8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65838 mRNA Translation: AAB28366.1
X89603 mRNA Translation: CAA61762.1
Y08235 Genomic DNA Translation: CAA69404.1
BC058453 mRNA Translation: AAH58453.1
PIRiS58086
RefSeqiNP_446420.1, NM_053968.3
UniGeneiRn.11325

Genome annotation databases

EnsembliENSRNOT00000025669; ENSRNOP00000025669; ENSRNOG00000018958
GeneIDi117038
KEGGirno:117038
UCSCiRGD:621252 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S65838 mRNA Translation: AAB28366.1
X89603 mRNA Translation: CAA61762.1
Y08235 Genomic DNA Translation: CAA69404.1
BC058453 mRNA Translation: AAH58453.1
PIRiS58086
RefSeqiNP_446420.1, NM_053968.3
UniGeneiRn.11325

3D structure databases

ProteinModelPortaliP37361
SMRiP37361
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP37361, 2 interactors
MINTiP37361
STRINGi10116.ENSRNOP00000025669

PTM databases

iPTMnetiP37361
PhosphoSitePlusiP37361

Proteomic databases

PaxDbiP37361
PRIDEiP37361

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000025669; ENSRNOP00000025669; ENSRNOG00000018958
GeneIDi117038
KEGGirno:117038
UCSCiRGD:621252 rat

Organism-specific databases

CTDi4504
RGDi621252 Mt3

Phylogenomic databases

GeneTreeiENSGT00730000111484
HOGENOMiHOG000236262
InParanoidiP37361
KOiK14740
OMAiVCKGEEG

Enzyme and pathway databases

ReactomeiR-RNO-5661231 Metallothioneins bind metals

Miscellaneous databases

PROiPR:P37361

Gene expression databases

BgeeiENSRNOG00000018958 Expressed in 10 organ(s), highest expression level in brain
GenevisibleiP37361 RN

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT3_RAT
AccessioniPrimary (citable) accession number: P37361
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Metallothioneins
    Classification of metallothioneins and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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