Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback. Take me to UniProt BETA

UniProtKB - P37349 (DHAM_ECOLI)

Entry version 177 (25 May 2022)
Sequence version 3 (24 Nov 2009)
Previous versions | rss
Add a publicationFeedback
Protein

PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM

Gene

dhaM

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone.

1 Publication

Miscellaneous

Unlike the carbohydrate-specific transporters of the PTS, the complex DhaKLM has no transport activity.1 Publication

Caution

Was reported to be a protein deacetylase that removes acetyl groups on specific lysine residues in target proteins (PubMed:26716769). However, later experiments demonstrate that this protein does not have any protein deacetylase activity; the discrepancy observed seems to be due to contaminants having proteolytic activity (PubMed:29939131).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 2.8 sec(-1). Values measured with the DhaKLM complex.1 Publication
  1. KM=45 µM for dihydroxyacetone1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: glycerol degradation

This protein is involved in the pathway glycerol degradation, which is part of Polyol metabolism.Curated
View all proteins of this organism that are known to be involved in the pathway glycerol degradation and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei9Tele-phosphohistidine intermediatePROSITE-ProRule annotation1 Publication1
Active sitei169Pros-phosphohistidine intermediatePROSITE-ProRule annotation1 Publication1
Active sitei430Tele-phosphohistidine intermediate1 Publication1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG12399-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.1.29, 2026

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P37349

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00616

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaM1 Publication (EC:2.7.1.1211 Publication)
Alternative name(s):
Dihydroxyacetone kinase subunit M1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dhaM1 Publication
Synonyms:ycgC
Ordered Locus Names:b1198, JW5185
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi9H → A: Loss of phosphotransfer activity. 1 Publication1
Mutagenesisi169H → A: Loss of phosphotransfer activity. 1 Publication1
Mutagenesisi430H → A: Loss of phosphotransfer activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001867131 – 472PEP-dependent dihydroxyacetone kinase, phosphoryl donor subunit DhaMAdd BLAST472

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P37349

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P37349

PRoteomics IDEntifications database

More...PRIDEi		P37349

2D gel databases

Two-dimensional polyacrylamide gel electrophoresis database from the Geneva University Hospital

More...SWISS-2DPAGEi		P37349

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:11350937). The dihydroxyacetone kinase complex is composed of a homodimer of DhaM, a homodimer of DhaK and the subunit DhaL.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		4260761, 22 interactors
850116, 1 interactor

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-2634, Dha Kinase

Database of interacting proteins

More...DIPi		DIP-11551N

Protein interaction database and analysis system

More...IntActi		P37349, 7 interactors

STRING: functional protein association networks

More...STRINGi		511145.b1198

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		P37349

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P37349

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 135PTS EIIA type-4PROSITE-ProRule annotation1 PublicationAdd BLAST135
Domaini155 – 242HPrPROSITE-ProRule annotation1 PublicationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni264 – 472PTS EI-like, N-terminal part1 PublicationAdd BLAST209

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Consists of three domains. The N-terminal dimerization domain has the same fold as the IIA domain of the mannose transporter of the bacterial phosphoenolpyruvate:sugar phosphotransferase system (PTS). The middle domain is similar to HPr and the C-terminus is similar to the N-terminal domain of enzyme I (EI) of the PTS. The IIA domain of DhaM (via phospho-His-9), instead of ATP, is the phosphoryl donor to dihydroxyacetone (Dha). The phosphoryl flow likely involves HPr ('His-15') -> DhaM (His-430 -> His-169 -> His-9) -> DhaL-ADP -> Dha. The HPr-like domain of DhaM cannot efficiently substitute for the general carrier protein HPr.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the PEP-utilizing enzyme family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG1080, Bacteria
COG1925, Bacteria
COG3412, Bacteria

Identification of Orthologs from Complete Genome Data

More...OMAi		TDHVLVM

Database for complete collections of gene phylogenies

More...PhylomeDBi		P37349

Family and domain databases

Conserved Domains Database

More...CDDi		cd00367, PTS-HPr_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.274.10, 1 hit
3.30.1340.10, 1 hit
3.40.50.510, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR039643, DhaM
IPR012844, DhaM_N
IPR000032, HPr-like
IPR035895, HPr-like_sf
IPR008279, PEP-util_enz_mobile_dom
IPR036637, Phosphohistidine_dom_sf
IPR004701, PTS_EIIA_man-typ
IPR036662, PTS_EIIA_man-typ_sf
IPR008731, PTS_EIN
IPR001020, PTS_HPr_His_P_site
IPR036618, PtsI_HPr-bd_sf

The PANTHER Classification System

More...PANTHERi		PTHR38594, PTHR38594, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03610, EIIA-man, 1 hit
PF05524, PEP-utilisers_N, 1 hit
PF00391, PEP-utilizers, 1 hit
PF00381, PTS-HPr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00107, PHOSPHOCPHPR

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47831, SSF47831, 1 hit
SSF52009, SSF52009, 1 hit
SSF53062, SSF53062, 1 hit
SSF55594, SSF55594, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR02364, dha_pts, 1 hit
TIGR01003, PTS_HPr_family, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51096, PTS_EIIA_TYPE_4, 1 hit
PS51350, PTS_HPR_DOM, 1 hit
PS00369, PTS_HPR_HIS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P37349-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVNLVIVSHS SRLGEGVGEL ARQMLMSDSC KIAIAAGIDD PQNPIGTDAV 
        60         70         80         90        100
KVMEAIESVA DADHVLVMMD MGSALLSAET ALELLAPEIA AKVRLCAAPL 
       110        120        130        140        150
VEGTLAATVS AASGADIDKV IFDAMHALEA KREQLGLPSS DTEISDTCPA 
       160        170        180        190        200
YDEEARSLAV VIKNRNGLHV RPASRLVYTL STFNADMLLE KNGKCVTPES 
       210        220        230        240        250
INQIALLQVR YNDTLRLIAK GPEAEEALIA FRQLAEDNFG ETEEVAPPTL 
       260        270        280        290        300
RPVPPVSGKA FYYQPVLCTV QAKSTLTVEE EQDRLRQAID FTLLDLMTLT 
       310        320        330        340        350
AKAEASGLDD IAAIFSGHHT LLDDPELLAA ASELLQHEHC TAEYAWQQVL 
       360        370        380        390        400
KELSQQYQQL DDEYLQARYI DVDDLLHRTL VHLTQTKEEL PQFNSPTILL 
       410        420        430        440        450
AENIYPSTVL QLDPAVVKGI CLSAGSPVSH SALIARELGI GWICQQGEKL 
       460        470 
YAIQPEETLT LDVKTQRFNR QG
Length:472
Mass (Da):51,449
Last modified:November 24, 2009 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7CEBEFBA1544C65E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74282.4
AP009048 Genomic DNA Translation: BAA36055.1
X15868 Genomic DNA No translation available.

Protein sequence database of the Protein Information Resource

More...PIRi		C64866

NCBI Reference Sequences

More...RefSeqi		NP_415716.4, NC_000913.3
WP_001301101.1, NZ_SSZK01000010.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC74282; AAC74282; b1198
BAA36055; BAA36055; BAA36055

Database of genes from NCBI RefSeq genomes

More...GeneIDi		945749

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW5185
eco:b1198

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.1087

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00096 Genomic DNA Translation: AAC74282.4
AP009048 Genomic DNA Translation: BAA36055.1
X15868 Genomic DNA No translation available.
PIRiC64866
RefSeqiNP_415716.4, NC_000913.3
WP_001301101.1, NZ_SSZK01000010.1

3D structure databases

AlphaFoldDBiP37349
SMRiP37349
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi4260761, 22 interactors
850116, 1 interactor
ComplexPortaliCPX-2634, Dha Kinase
DIPiDIP-11551N
IntActiP37349, 7 interactors
STRINGi511145.b1198

2D gel databases

SWISS-2DPAGEiP37349

Proteomic databases

jPOSTiP37349
PaxDbiP37349
PRIDEiP37349

Genome annotation databases

EnsemblBacteriaiAAC74282; AAC74282; b1198
BAA36055; BAA36055; BAA36055
GeneIDi945749
KEGGiecj:JW5185
eco:b1198
PATRICifig|1411691.4.peg.1087

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB2299

Phylogenomic databases

eggNOGiCOG1080, Bacteria
COG1925, Bacteria
COG3412, Bacteria
OMAiTDHVLVM
PhylomeDBiP37349

Enzyme and pathway databases

UniPathwayiUPA00616
BioCyciEcoCyc:EG12399-MONOMER
BRENDAi2.7.1.29, 2026
SABIO-RKiP37349

Miscellaneous databases

Protein Ontology

More...PROi		PR:P37349

Family and domain databases

CDDicd00367, PTS-HPr_like, 1 hit
Gene3Di1.10.274.10, 1 hit
3.30.1340.10, 1 hit
3.40.50.510, 1 hit
InterProiView protein in InterPro
IPR039643, DhaM
IPR012844, DhaM_N
IPR000032, HPr-like
IPR035895, HPr-like_sf
IPR008279, PEP-util_enz_mobile_dom
IPR036637, Phosphohistidine_dom_sf
IPR004701, PTS_EIIA_man-typ
IPR036662, PTS_EIIA_man-typ_sf
IPR008731, PTS_EIN
IPR001020, PTS_HPr_His_P_site
IPR036618, PtsI_HPr-bd_sf
PANTHERiPTHR38594, PTHR38594, 1 hit
PfamiView protein in Pfam
PF03610, EIIA-man, 1 hit
PF05524, PEP-utilisers_N, 1 hit
PF00391, PEP-utilizers, 1 hit
PF00381, PTS-HPr, 1 hit
PRINTSiPR00107, PHOSPHOCPHPR
SUPFAMiSSF47831, SSF47831, 1 hit
SSF52009, SSF52009, 1 hit
SSF53062, SSF53062, 1 hit
SSF55594, SSF55594, 1 hit
TIGRFAMsiTIGR02364, dha_pts, 1 hit
TIGR01003, PTS_HPr_family, 1 hit
PROSITEiView protein in PROSITE
PS51096, PTS_EIIA_TYPE_4, 1 hit
PS51350, PTS_HPR_DOM, 1 hit
PS00369, PTS_HPR_HIS, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHAM_ECOLI
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37349
Secondary accession number(s): P76013
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 24, 2009
Last modified: May 25, 2022
This is version 177 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again