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Protein

Arsenical resistance operon repressor

Gene

arsR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi33 – 52H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processArsenical resistance, Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciEcoCyc:EG12235-MONOMER
MetaCyc:EG12235-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Arsenical resistance operon repressor
Gene namesi
Name:arsR
Synonyms:arsE
Ordered Locus Names:b3501, JW3468
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG12235 arsR

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001606131 – 117Arsenical resistance operon repressorAdd BLAST117

Proteomic databases

PaxDbiP37309
PRIDEiP37309

Interactioni

Subunit structurei

Binds DNA as a homodimer.By similarity

Protein-protein interaction databases

BioGridi4261323, 8 interactors
DIPiDIP-9163N
IntActiP37309, 3 interactors
STRINGi316385.ECDH10B_3677

Structurei

3D structure databases

ProteinModelPortaliP37309
SMRiP37309
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 92HTH arsR-typePROSITE-ProRule annotationAdd BLAST92

Phylogenomic databases

eggNOGiENOG4105KBH Bacteria
COG0640 LUCA
HOGENOMiHOG000144506
InParanoidiP37309
KOiK03892
OMAiRHMAILR
PhylomeDBiP37309

Family and domain databases

CDDicd00090 HTH_ARSR, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR011991 ArsR-like_HTH
IPR018334 ArsR_HTH
IPR001845 HTH_ArsR_DNA-bd_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF01022 HTH_5, 1 hit
PRINTSiPR00778 HTHARSR
SMARTiView protein in SMART
SM00418 HTH_ARSR, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00846 HTH_ARSR_1, 1 hit
PS50987 HTH_ARSR_2, 1 hit

Sequencei

Sequence statusi: Complete.

P37309-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSFLLPIQLF KILADETRLG IVLLLSELGE LCVCDLCTAL DQSQPKISRH
60 70 80 90 100
LALLRESGLL LDRKQGKWVH YRLSPHIPAW AAKIIDEAWR CEQEKVQAIV
110
RNLARQNCSG DSKNICS
Length:117
Mass (Da):13,253
Last modified:October 1, 1994 - v1
Checksum:i35BC3F6F94BBD3DB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80057 Genomic DNA Translation: CAA56361.1
U00039 Genomic DNA Translation: AAB18477.1
U00096 Genomic DNA Translation: AAC76526.1
AP009048 Genomic DNA Translation: BAE77793.1
PIRiA56269
RefSeqiNP_417958.1, NC_000913.3
WP_000008957.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76526; AAC76526; b3501
BAE77793; BAE77793; BAE77793
GeneIDi948013
KEGGiecj:JW3468
eco:b3501
PATRICifig|1411691.4.peg.3219

Similar proteinsi

Entry informationi

Entry nameiARSR_ECOLI
AccessioniPrimary (citable) accession number: P37309
Secondary accession number(s): Q2M7G3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: September 12, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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