UniProtKB - P37309 (ARSR_ECOLI)
Protein
Arsenical resistance operon repressor
Gene
arsR
Organism
Escherichia coli (strain K12)
Status
Functioni
Transcriptional repressor for the arsEFG operon. ArsE is a trans-acting regulatory protein which controls its own expression. The repressive effect of ArsE is alleviated by oxyions of +III oxidation state of arsenic, antimony, and bismuth, as well as arsenate (As(V)) (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 33 – 52 | H-T-H motifPROSITE-ProRule annotationAdd BLAST | 20 |
GO - Molecular functioni
- DNA binding Source: EcoCyc
- DNA-binding transcription factor activity Source: InterPro
- transcription regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription, DNA-templated Source: EcoCyc
- response to arsenic-containing substance Source: EcoCyc
- transcription, DNA-templated Source: EcoCyc
Keywordsi
Molecular function | DNA-binding, Repressor |
Biological process | Arsenical resistance, Transcription, Transcription regulation |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12235-MONOMER MetaCyc:EG12235-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Arsenical resistance operon repressor |
Gene namesi | Name:arsR Synonyms:arsE Ordered Locus Names:b3501, JW3468 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000160613 | 1 – 117 | Arsenical resistance operon repressorAdd BLAST | 117 |
Proteomic databases
PaxDbi | P37309 |
PRIDEi | P37309 |
Interactioni
Subunit structurei
Binds DNA as a homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 4261323, 8 interactors 852321, 1 interactor |
DIPi | DIP-9163N |
IntActi | P37309, 3 interactors |
STRINGi | 511145.b3501 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 92 | HTH arsR-typePROSITE-ProRule annotationAdd BLAST | 92 |
Phylogenomic databases
eggNOGi | COG0640, Bacteria |
HOGENOMi | CLU_097806_3_1_6 |
InParanoidi | P37309 |
PhylomeDBi | P37309 |
Family and domain databases
CDDi | cd00090, HTH_ARSR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR011991, ArsR-like_HTH IPR018334, ArsR_HTH IPR001845, HTH_ArsR_DNA-bd_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF01022, HTH_5, 1 hit |
PRINTSi | PR00778, HTHARSR |
SMARTi | View protein in SMART SM00418, HTH_ARSR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00846, HTH_ARSR_1, 1 hit PS50987, HTH_ARSR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P37309-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFLLPIQLF KILADETRLG IVLLLSELGE LCVCDLCTAL DQSQPKISRH
60 70 80 90 100
LALLRESGLL LDRKQGKWVH YRLSPHIPAW AAKIIDEAWR CEQEKVQAIV
110
RNLARQNCSG DSKNICS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80057 Genomic DNA Translation: CAA56361.1 U00039 Genomic DNA Translation: AAB18477.1 U00096 Genomic DNA Translation: AAC76526.1 AP009048 Genomic DNA Translation: BAE77793.1 |
PIRi | A56269 |
RefSeqi | NP_417958.1, NC_000913.3 WP_000008957.1, NZ_STEB01000046.1 |
Genome annotation databases
EnsemblBacteriai | AAC76526; AAC76526; b3501 BAE77793; BAE77793; BAE77793 |
GeneIDi | 57729116 948013 |
KEGGi | ecj:JW3468 eco:b3501 |
PATRICi | fig|1411691.4.peg.3219 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X80057 Genomic DNA Translation: CAA56361.1 U00039 Genomic DNA Translation: AAB18477.1 U00096 Genomic DNA Translation: AAC76526.1 AP009048 Genomic DNA Translation: BAE77793.1 |
PIRi | A56269 |
RefSeqi | NP_417958.1, NC_000913.3 WP_000008957.1, NZ_STEB01000046.1 |
3D structure databases
SMRi | P37309 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4261323, 8 interactors 852321, 1 interactor |
DIPi | DIP-9163N |
IntActi | P37309, 3 interactors |
STRINGi | 511145.b3501 |
Proteomic databases
PaxDbi | P37309 |
PRIDEi | P37309 |
Genome annotation databases
EnsemblBacteriai | AAC76526; AAC76526; b3501 BAE77793; BAE77793; BAE77793 |
GeneIDi | 57729116 948013 |
KEGGi | ecj:JW3468 eco:b3501 |
PATRICi | fig|1411691.4.peg.3219 |
Organism-specific databases
EchoBASEi | EB2147 |
Phylogenomic databases
eggNOGi | COG0640, Bacteria |
HOGENOMi | CLU_097806_3_1_6 |
InParanoidi | P37309 |
PhylomeDBi | P37309 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12235-MONOMER MetaCyc:EG12235-MONOMER |
Miscellaneous databases
PROi | PR:P37309 |
Family and domain databases
CDDi | cd00090, HTH_ARSR, 1 hit |
Gene3Di | 1.10.10.10, 1 hit |
InterProi | View protein in InterPro IPR011991, ArsR-like_HTH IPR018334, ArsR_HTH IPR001845, HTH_ArsR_DNA-bd_dom IPR036388, WH-like_DNA-bd_sf IPR036390, WH_DNA-bd_sf |
Pfami | View protein in Pfam PF01022, HTH_5, 1 hit |
PRINTSi | PR00778, HTHARSR |
SMARTi | View protein in SMART SM00418, HTH_ARSR, 1 hit |
SUPFAMi | SSF46785, SSF46785, 1 hit |
PROSITEi | View protein in PROSITE PS00846, HTH_ARSR_1, 1 hit PS50987, HTH_ARSR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARSR_ECOLI | |
Accessioni | P37309Primary (citable) accession number: P37309 Secondary accession number(s): Q2M7G3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | February 10, 2021 | |
This is version 145 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |