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UniProtKB - P37306 (ARCC_ECOLI)
Protein
Carbamate kinase
Gene
arcC
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:2.7.2.2
: carbamoyl phosphate degradation Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate. This subpathway is part of the pathway carbamoyl phosphate degradation, which is itself part of Metabolic intermediate metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes CO(2) and NH(3) from carbamoyl phosphate, the pathway carbamoyl phosphate degradation and in Metabolic intermediate metabolism.
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- carbamate kinase activity Source: EcoCyc
GO - Biological processi
- arginine deiminase pathway Source: GO_Central
- carbamoyl phosphate catabolic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Kinase, Transferase |
Biological process | Arginine metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12384-MONOMER |
SABIO-RKi | P37306 |
UniPathwayi | UPA00996;UER00366 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:arcC Synonyms:ybcF Ordered Locus Names:b0521, JW0510 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm Curated
Cytosol
- cytosol Source: GO_Central
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000185119 | 1 – 297 | Carbamate kinaseAdd BLAST | 297 |
Proteomic databases
PaxDbi | P37306 |
PRIDEi | P37306 |
Interactioni
Subunit structurei
Homodimer.
By similarityProtein-protein interaction databases
BioGRIDi | 4262013, 3 interactors |
IntActi | P37306, 3 interactors |
STRINGi | 511145.b0521 |
Family & Domainsi
Sequence similaritiesi
Belongs to the carbamate kinase family.Curated
Phylogenomic databases
eggNOGi | COG0549, Bacteria |
HOGENOMi | CLU_076278_0_1_6 |
InParanoidi | P37306 |
PhylomeDBi | P37306 |
Family and domain databases
CDDi | cd04235, AAK_CK, 1 hit |
Gene3Di | 3.40.1160.10, 1 hit |
InterProi | View protein in InterPro IPR036393, AceGlu_kinase-like_sf IPR001048, Asp/Glu/Uridylate_kinase IPR003964, Carb_kinase |
PANTHERi | PTHR30409, PTHR30409, 1 hit |
Pfami | View protein in Pfam PF00696, AA_kinase, 1 hit |
PIRSFi | PIRSF000723, Carbamate_kin, 1 hit |
SUPFAMi | SSF53633, SSF53633, 1 hit |
TIGRFAMsi | TIGR00746, arcC, 1 hit |
i Sequence
Sequence statusi: Complete.
P37306-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTLVVALGG NALLQRGEAL TAENQYRNIA SAVPALARLA RSYRLAIVHG
60 70 80 90 100
NGPQVGLLAL QNLAWKEVEP YPLDVLVAES QGMIGYMLAQ SLSAQPQMPP
110 120 130 140 150
VTTVLTRIEV SPDDPAFLQP EKFIGPVYQP EEQEALEAAY GWQMKRDGKY
160 170 180 190 200
LRRVVASPQP RKILDSEAIE LLLKEGHVVI CSGGGGVPVT DDGAGSEAVI
210 220 230 240 250
DKDLAAALLA EQINADGLVI LTDADAVYEN WGTPQQRAIR HATPDELAPF
260 270 280 290
AKADGSMGPN VTAVSGYVRS RGKPAWIGAL SRIEETLAGE AGTCISL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 279 – 297 | ALSRI…TCISL → RYRELKRRWRAKRGPVFRCS RRH in X12982 (PubMed:2464576).CuratedAdd BLAST | 19 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82664 Genomic DNA Translation: AAB40273.1 U00096 Genomic DNA Translation: AAC73623.1 AP009048 Genomic DNA Translation: BAE76298.1 M19657 Genomic DNA No translation available. X12982 Genomic DNA No translation available. |
PIRi | H64783 |
RefSeqi | NP_415054.1, NC_000913.3 WP_000855379.1, NZ_LN832404.1 |
Genome annotation databases
EnsemblBacteriai | AAC73623; AAC73623; b0521 BAE76298; BAE76298; BAE76298 |
GeneIDi | 944972 |
KEGGi | ecj:JW0510 eco:b0521 |
PATRICi | fig|1411691.4.peg.1757 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82664 Genomic DNA Translation: AAB40273.1 U00096 Genomic DNA Translation: AAC73623.1 AP009048 Genomic DNA Translation: BAE76298.1 M19657 Genomic DNA No translation available. X12982 Genomic DNA No translation available. |
PIRi | H64783 |
RefSeqi | NP_415054.1, NC_000913.3 WP_000855379.1, NZ_LN832404.1 |
3D structure databases
SMRi | P37306 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262013, 3 interactors |
IntActi | P37306, 3 interactors |
STRINGi | 511145.b0521 |
Proteomic databases
PaxDbi | P37306 |
PRIDEi | P37306 |
Genome annotation databases
EnsemblBacteriai | AAC73623; AAC73623; b0521 BAE76298; BAE76298; BAE76298 |
GeneIDi | 944972 |
KEGGi | ecj:JW0510 eco:b0521 |
PATRICi | fig|1411691.4.peg.1757 |
Organism-specific databases
EchoBASEi | EB2285 |
Phylogenomic databases
eggNOGi | COG0549, Bacteria |
HOGENOMi | CLU_076278_0_1_6 |
InParanoidi | P37306 |
PhylomeDBi | P37306 |
Enzyme and pathway databases
UniPathwayi | UPA00996;UER00366 |
BioCyci | EcoCyc:EG12384-MONOMER |
SABIO-RKi | P37306 |
Miscellaneous databases
PROi | PR:P37306 |
Family and domain databases
CDDi | cd04235, AAK_CK, 1 hit |
Gene3Di | 3.40.1160.10, 1 hit |
InterProi | View protein in InterPro IPR036393, AceGlu_kinase-like_sf IPR001048, Asp/Glu/Uridylate_kinase IPR003964, Carb_kinase |
PANTHERi | PTHR30409, PTHR30409, 1 hit |
Pfami | View protein in Pfam PF00696, AA_kinase, 1 hit |
PIRSFi | PIRSF000723, Carbamate_kin, 1 hit |
SUPFAMi | SSF53633, SSF53633, 1 hit |
TIGRFAMsi | TIGR00746, arcC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARCC_ECOLI | |
Accessioni | P37306Primary (citable) accession number: P37306 Secondary accession number(s): P77419, Q2MBQ8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 143 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families