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UniProtKB - P37303 (GLY1_YEAST)
Protein
Low specificity L-threonine aldolase
Gene
GLY1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde.
Miscellaneous
Present with 106000 molecules/cell in log phase SD medium.1 Publication
Catalytic activityi
Cofactori
: glycine biosynthesis Pathwayi
This protein is involved in step 1 of the subpathway that synthesizes glycine from L-allo-threonine. This subpathway is part of the pathway glycine biosynthesis, which is itself part of Amino-acid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycine from L-allo-threonine, the pathway glycine biosynthesis and in Amino-acid biosynthesis.
Pathwayi: L-threonine degradation via aldolase pathway
This protein is involved in step 1 of the subpathway that synthesizes acetaldehyde and glycine from L-threonine. This subpathway is part of the pathway L-threonine degradation via aldolase pathway, which is itself part of Amino-acid degradation.View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetaldehyde and glycine from L-threonine, the pathway L-threonine degradation via aldolase pathway and in Amino-acid degradation.
GO - Molecular functioni
- L-allo-threonine aldolase activity Source: SGD
- threonine aldolase activity Source: SGD
GO - Biological processi
- glycine biosynthetic process Source: SGD
- threonine catabolic process Source: SGD
Keywordsi
Molecular function | Lyase |
Ligand | Pyridoxal phosphate |
Enzyme and pathway databases
BRENDAi | 4.1.2.48, 984 |
SABIO-RKi | P37303 |
UniPathwayi | UPA00044;UER00429 UPA00288;UER00427 |
Names & Taxonomyi
Protein namesi | Recommended name: Low specificity L-threonine aldolase (EC:4.1.2.48)Short name: Low specificity L-TA Short name: TA |
Gene namesi | Name:GLY1 Ordered Locus Names:YEL046C ORF Names:SYGP-ORF34 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000000772, GLY1 |
VEuPathDBi | FungiDB:YEL046C |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121572 | 1 – 387 | Low specificity L-threonine aldolaseAdd BLAST | 387 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 213 | N6-(pyridoxal phosphate)lysineBy similarity | 1 | |
Cross-linki | 228 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)Combined sources | ||
Modified residuei | 367 | PhosphoserineCombined sources | 1 | |
Modified residuei | 369 | PhosphoserineCombined sources | 1 | |
Modified residuei | 370 | PhosphothreonineCombined sources | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
MaxQBi | P37303 |
PaxDbi | P37303 |
PRIDEi | P37303 |
PTM databases
iPTMneti | P37303 |
Interactioni
Subunit structurei
Homotetramer.
Protein-protein interaction databases
BioGRIDi | 36684, 44 interactors |
DIPi | DIP-4287N |
IntActi | P37303, 6 interactors |
STRINGi | 4932.YEL046C |
Miscellaneous databases
RNActi | P37303, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the threonine aldolase family.Curated
Phylogenomic databases
eggNOGi | KOG1368, Eukaryota |
GeneTreei | ENSGT00390000014681 |
HOGENOMi | CLU_029381_1_0_1 |
InParanoidi | P37303 |
OMAi | NKGGGAC |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR001597, ArAA_b-elim_lyase/Thr_aldolase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small IPR023603, Threonine_aldolase |
PANTHERi | PTHR48097:SF9, PTHR48097:SF9, 1 hit |
Pfami | View protein in Pfam PF01212, Beta_elim_lyase, 1 hit |
PIRSFi | PIRSF017617, Thr_aldolase, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
i Sequence
Sequence statusi: Complete.
P37303-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEFELPPKY ITAANDLRSD TFTTPTAEMM EAALEASIGD AVYGEDVDTV
60 70 80 90 100
RLEQTVARMA GKEAGLFCVS GTLSNQIAIR THLMQPPYSI LCDYRAHVYT
110 120 130 140 150
HEAAGLAILS QAMVVPVVPS NGDYLTLEDI KSHYVPDDGD IHGAPTRLIS
160 170 180 190 200
LENTLHGIVY PLEELVRIKA WCMENGLKLH CDGARIWNAA AQSGVPLKQY
210 220 230 240 250
GEIFDSISIC LSKSMGAPIG SVLVGNLKFV KKATHFRKQQ GGGIRQSGMM
260 270 280 290 300
ARMALVNINN DWKSQLLYSH SLAHELAEYC EAKGIPLESP ADTNFVFINL
310 320 330 340 350
KAARMDPDVL VKKGLKYNVK LMGGRVSFHY QVTRDTLEKV KLAISEAFDY
360 370 380
AKEHPFDCNG PTQIYRSEST EVDVDGNAIR EIKTYKY
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 253 | M → I in AAA72430 (PubMed:8132653).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L28739 Genomic DNA Translation: AAA72430.1 U18779 Genomic DNA Translation: AAB64996.1 BK006939 Genomic DNA Translation: DAA07608.1 |
PIRi | S30831 |
RefSeqi | NP_010868.1, NM_001178861.1 |
Genome annotation databases
EnsemblFungii | YEL046C_mRNA; YEL046C; YEL046C |
GeneIDi | 856665 |
KEGGi | sce:YEL046C |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L28739 Genomic DNA Translation: AAA72430.1 U18779 Genomic DNA Translation: AAB64996.1 BK006939 Genomic DNA Translation: DAA07608.1 |
PIRi | S30831 |
RefSeqi | NP_010868.1, NM_001178861.1 |
3D structure databases
AlphaFoldDBi | P37303 |
SMRi | P37303 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 36684, 44 interactors |
DIPi | DIP-4287N |
IntActi | P37303, 6 interactors |
STRINGi | 4932.YEL046C |
PTM databases
iPTMneti | P37303 |
Proteomic databases
MaxQBi | P37303 |
PaxDbi | P37303 |
PRIDEi | P37303 |
Genome annotation databases
EnsemblFungii | YEL046C_mRNA; YEL046C; YEL046C |
GeneIDi | 856665 |
KEGGi | sce:YEL046C |
Organism-specific databases
SGDi | S000000772, GLY1 |
VEuPathDBi | FungiDB:YEL046C |
Phylogenomic databases
eggNOGi | KOG1368, Eukaryota |
GeneTreei | ENSGT00390000014681 |
HOGENOMi | CLU_029381_1_0_1 |
InParanoidi | P37303 |
OMAi | NKGGGAC |
Enzyme and pathway databases
UniPathwayi | UPA00044;UER00429 UPA00288;UER00427 |
BRENDAi | 4.1.2.48, 984 |
SABIO-RKi | P37303 |
Miscellaneous databases
PROi | PR:P37303 |
RNActi | P37303, protein |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR001597, ArAA_b-elim_lyase/Thr_aldolase IPR015424, PyrdxlP-dep_Trfase IPR015421, PyrdxlP-dep_Trfase_major IPR015422, PyrdxlP-dep_Trfase_small IPR023603, Threonine_aldolase |
PANTHERi | PTHR48097:SF9, PTHR48097:SF9, 1 hit |
Pfami | View protein in Pfam PF01212, Beta_elim_lyase, 1 hit |
PIRSFi | PIRSF017617, Thr_aldolase, 1 hit |
SUPFAMi | SSF53383, SSF53383, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GLY1_YEAST | |
Accessioni | P37303Primary (citable) accession number: P37303 Secondary accession number(s): D3DLK4, P32615 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 5, 2010 | |
Last modified: | May 25, 2022 | |
This is version 182 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - Yeast chromosome V
Yeast (Saccharomyces cerevisiae) chromosome V: entries and gene names - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families