UniProtKB - P37300 (O17C_CONMA)
Protein
Omega-conotoxin MVIIC
Gene
N/A
Organism
Conus magus (Magus cone) (Magician's cone snail)
Status
Functioni
Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin preferentially blocks P/Q-type calcium channels (Cav2.1/CACNA1A) (IC50=0.60 nM) (PubMed:1352986, PubMed:10938268). Shows also an inhibition on Cav2.2/CACNA1A channels (IC50=7.0 nM) (PubMed:10938268).2 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 15 | Important for Cav2.1/CACNA1A calcium channel binding1 Publication | 1 |
GO - Molecular functioni
- ion channel inhibitor activity Source: InterPro
- toxin activity Source: UniProtKB-KW
Keywordsi
Molecular function | Calcium channel impairing toxin, Ion channel impairing toxin, Neurotoxin, Presynaptic neurotoxin, Toxin, Voltage-gated calcium channel impairing toxin |
Names & Taxonomyi
Protein namesi | Recommended name: Omega-conotoxin MVIIC2 PublicationsShort name: Omega-CgTxMVIIC1 Publication Alternative name(s): SNX-230 |
Organismi | Conus magus (Magus cone) (Magician's cone snail) |
Taxonomic identifieri | 6492 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Lophotrochozoa › Mollusca › Gastropoda › Caenogastropoda › Neogastropoda › Conoidea › Conidae › Conus › Pionoconus |
Organism-specific databases
ConoServeri | 822 MVIIC precursor |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Other locations
- other organism presynaptic membrane Source: UniProtKB-KW
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 15 | Y → A: High decrease in activity on Cav2.1/CACNA1A. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
PropeptideiPRO_0000034916 | ‹1 – 2 | ›2 | ||
PeptideiPRO_0000034917 | 3 – 28 | Omega-conotoxin MVIIC1 PublicationAdd BLAST | 26 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 3 ↔ 18 | 2 PublicationsImported | ||
Disulfide bondi | 10 ↔ 22 | 2 PublicationsImported | ||
Disulfide bondi | 17 ↔ 28 | 2 PublicationsImported | ||
Modified residuei | 28 | Cysteine amide1 Publication | 1 |
Post-translational modificationi
Not hydroxylated; hydroxylation, on a synthetic hydroxylated MVIIC, has a significant impact on the oxidative folding but not on the biological activity.1 Publication
Keywords - PTMi
Amidation, Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom duct.1 Publication
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CNN | NMR | - | A | 3-28 | [»] | |
1OMN | NMR | - | A | 3-28 | [»] | |
1V4Q | NMR | - | A | 3-26 | [»] | |
ProteinModelPortali | P37300 | |||||
SMRi | P37300 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P37300 |
Family & Domainsi
Domaini
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.2 Publications
The cysteine framework is VI/VII (C-C-CC-C-C).Curated
Sequence similaritiesi
Belongs to the conotoxin O1 superfamily.Curated
Keywords - Domaini
KnottinFamily and domain databases
InterProi | View protein in InterPro IPR012321 Conotoxin_omega-typ_CS |
PROSITEi | View protein in PROSITE PS60004 OMEGA_CONOTOXIN, 1 hit |
i Sequence
Sequence statusi: Fragment.
: The displayed sequence is further processed into a mature form. Sequence processingi
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S40826 mRNA Translation: AAB22674.1 |
PIRi | JH0699 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | S40826 mRNA Translation: AAB22674.1 |
PIRi | JH0699 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1CNN | NMR | - | A | 3-28 | [»] | |
1OMN | NMR | - | A | 3-28 | [»] | |
1V4Q | NMR | - | A | 3-26 | [»] | |
ProteinModelPortali | P37300 | |||||
SMRi | P37300 | |||||
ModBasei | Search... | |||||
MobiDBi | Search... |
Protocols and materials databases
Structural Biology Knowledgebase | Search... |
Organism-specific databases
ConoServeri | 822 MVIIC precursor |
Miscellaneous databases
EvolutionaryTracei | P37300 |
Family and domain databases
InterProi | View protein in InterPro IPR012321 Conotoxin_omega-typ_CS |
PROSITEi | View protein in PROSITE PS60004 OMEGA_CONOTOXIN, 1 hit |
ProtoNeti | Search... |
Entry informationi
Entry namei | O17C_CONMA | |
Accessioni | P37300Primary (citable) accession number: P37300 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | October 10, 2018 | |
This is version 103 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- SIMILARITY comments
Index of protein domains and families - PDB cross-references
Index of Protein Data Bank (PDB) cross-references