UniProtKB - P37289 (PF2R_BOVIN)
Protein
Prostaglandin F2-alpha receptor
Gene
PTGFR
Organism
Bos taurus (Bovine)
Status
Functioni
Receptor for prostaglandin F2-alpha (PGF2-alpha). The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. Initiates luteolysis in the corpus luteum (By similarity).By similarity
GO - Molecular functioni
- prostaglandin F receptor activity Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Prostaglandin F2-alpha receptorShort name: PGF receptor Short name: PGF2-alpha receptor Alternative name(s): Prostanoid FP receptor |
Gene namesi | Name:PTGFR |
Organismi | Bos taurus (Bovine) |
Taxonomic identifieri | 9913 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Bovinae › Bos |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cell Source: GOC
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 31 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 32 – 54 | Helical; Name=1Sequence analysisAdd BLAST | 23 | |
Topological domaini | 55 – 69 | CytoplasmicSequence analysisAdd BLAST | 15 | |
Transmembranei | 70 – 90 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 91 – 109 | ExtracellularSequence analysisAdd BLAST | 19 | |
Transmembranei | 110 – 131 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 132 – 152 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 153 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 23 | |
Topological domaini | 176 – 198 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 199 – 224 | Helical; Name=5Sequence analysisAdd BLAST | 26 | |
Topological domaini | 225 – 250 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 251 – 267 | Helical; Name=6Sequence analysisAdd BLAST | 17 | |
Topological domaini | 268 – 285 | ExtracellularSequence analysisAdd BLAST | 18 | |
Transmembranei | 286 – 307 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Topological domaini | 308 – 362 | CytoplasmicSequence analysisAdd BLAST | 55 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000070069 | 1 – 362 | Prostaglandin F2-alpha receptorAdd BLAST | 362 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 4 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 19 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 108 ↔ 186 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P37289 |
Interactioni
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000041321 |
Chemistry databases
BindingDBi | P37289 |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
HOGENOMi | HOG000015238 |
InParanoidi | P37289 |
KOi | K04262 |
OrthoDBi | 972015at2759 |
TreeFami | TF324982 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000141 PglndnF_rcpt IPR008365 Prostanoid_rcpt IPR001244 Prostglndn_DP_rcpt |
PANTHERi | PTHR11866 PTHR11866, 1 hit PTHR11866:SF4 PTHR11866:SF4, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00428 PROSTAGLNDNR PR01788 PROSTANOIDR PR00855 PRSTNOIDFPR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P37289-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTNSSIQPV SPESELLSNT TCQLEEDLSI SFSIIFMTVG ILSNSLAIAI
60 70 80 90 100
LMKAYQRFRQ KYKSSFLLLA SALVITDFFG HLINGTIAVF VYASDKDWIY
110 120 130 140 150
FDKSNILCSI FGICMVFSGL CPLFLGSLMA IERCIGVTKP IFHSTKITTK
160 170 180 190 200
HVKMMLSGVC FFAVFVALLP ILGHRDYKIQ ASRTWCFYKT DEIKDWEDRF
210 220 230 240 250
YLLLFAFLGL LALGISFVCN AITGISLLKV KFRSQQHRQG RSHHFEMVIQ
260 270 280 290 300
LLGIMCVSCI CWSPFLVTMA SIGMNIQDFK DSCERTLFTL RMATWNQILD
310 320 330 340 350
PWVYILLRKA VLRNLYVCTR RCCGVHVISL HVWELSSIKD SLKVAAISDL
360
PVTEKVTQQT ST
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 340 | D → N in BAA20871 (PubMed:9197544).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D17395 mRNA Translation: BAA04218.1 D89039 Genomic DNA Translation: BAA20871.1 |
PIRi | A53058 |
RefSeqi | NP_851368.1, NM_181025.3 XP_005204428.1, XM_005204371.3 |
Genome annotation databases
GeneIDi | 282020 |
KEGGi | bta:282020 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D17395 mRNA Translation: BAA04218.1 D89039 Genomic DNA Translation: BAA20871.1 |
PIRi | A53058 |
RefSeqi | NP_851368.1, NM_181025.3 XP_005204428.1, XM_005204371.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9913.ENSBTAP00000041321 |
Chemistry databases
BindingDBi | P37289 |
ChEMBLi | CHEMBL4820 |
DrugCentrali | P37289 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PaxDbi | P37289 |
Genome annotation databases
GeneIDi | 282020 |
KEGGi | bta:282020 |
Organism-specific databases
CTDi | 5737 |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
HOGENOMi | HOG000015238 |
InParanoidi | P37289 |
KOi | K04262 |
OrthoDBi | 972015at2759 |
TreeFami | TF324982 |
Miscellaneous databases
PROi | PR:P37289 |
Family and domain databases
InterProi | View protein in InterPro IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM IPR000141 PglndnF_rcpt IPR008365 Prostanoid_rcpt IPR001244 Prostglndn_DP_rcpt |
PANTHERi | PTHR11866 PTHR11866, 1 hit PTHR11866:SF4 PTHR11866:SF4, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00428 PROSTAGLNDNR PR01788 PROSTANOIDR PR00855 PRSTNOIDFPR |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PF2R_BOVIN | |
Accessioni | P37289Primary (citable) accession number: P37289 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | November 13, 2019 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families