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Protein

Vasopressin V1a receptor

Gene

AVPR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. Has been involved in social behaviors, including affiliation and attachment.1 Publication

Miscellaneous

Differences in regional receptor expression in the brain as well as differences in social behavior may result from a highly variable repetitive sequence in the 5' flanking region of AVPR1A. One such allelic variant has been linked to autism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • peptide hormone binding Source: Ensembl
  • protein kinase C binding Source: ProtInc
  • V1A vasopressin receptor binding Source: Ensembl
  • vasopressin receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-388479 Vasopressin-like receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-5619099 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vasopressin V1a receptor
Short name:
V1aR
Alternative name(s):
AVPR V1a
Antidiuretic hormone receptor 1a
Vascular/hepatic-type arginine vasopressin receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AVPR1A
Synonyms:AVPR1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000166148.3

Human Gene Nomenclature Database

More...
HGNCi
HGNC:895 AVPR1A

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
600821 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P37288

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 52ExtracellularSequence analysisAdd BLAST52
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei53 – 76Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini77 – 88CytoplasmicSequence analysisAdd BLAST12
Transmembranei89 – 110Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini111 – 125ExtracellularSequence analysisAdd BLAST15
Transmembranei126 – 147Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini148 – 168CytoplasmicSequence analysisAdd BLAST21
Transmembranei169 – 190Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini191 – 218ExtracellularSequence analysisAdd BLAST28
Transmembranei219 – 239Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini240 – 293CytoplasmicSequence analysisAdd BLAST54
Transmembranei294 – 313Helical; Name=6Sequence analysisAdd BLAST20
Topological domaini314 – 331ExtracellularSequence analysisAdd BLAST18
Transmembranei332 – 351Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini352 – 418CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
552

Open Targets

More...
OpenTargetsi
ENSG00000166148

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA25187

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL1889

Drug and drug target database

More...
DrugBanki
DB00872 Conivaptan
DB00035 Desmopressin
DB00093 Felypressin
DB05452 PH-284
DB02638 Terlipressin
DB06212 Tolvaptan
DB00067 Vasopressin

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
366

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
AVPR1A

Domain mapping of disease mutations (DMDM)

More...
DMDMi
586197

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000701971 – 418Vasopressin V1a receptorAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi124 ↔ 203PROSITE-ProRule annotation
Glycosylationi196N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi365S-palmitoyl cysteineBy similarity1
Lipidationi366S-palmitoyl cysteineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei404PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P37288

PeptideAtlas

More...
PeptideAtlasi
P37288

PRoteomics IDEntifications database

More...
PRIDEi
P37288

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55276

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P37288

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P37288

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000166148 Expressed in 155 organ(s), highest expression level in adrenal gland

CleanEx database of gene expression profiles

More...
CleanExi
HS_AVPR1A

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P37288 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P37288 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
107033, 2 interactors

Protein interaction database and analysis system

More...
IntActi
P37288, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000299178

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P37288

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P37288

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P37288

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P37288

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158802

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000237331

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG105710

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P37288

KEGG Orthology (KO)

More...
KOi
K04226

Identification of Orthologs from Complete Genome Data

More...
OMAi
HLQVFAM

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0DB6

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P37288

TreeFam database of animal gene trees

More...
TreeFami
TF106499

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15385 7tmA_V1aR, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015076 DUF1856
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR001224 Vprs_V1A_rcpt

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit
PF08983 DUF1856, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00752 VASOPRSNV1AR

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01164 DUF1856, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P37288-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLSAGPDAG PSGNSSPWWP LATGAGNTSR EAEALGEGNG PPRDVRNEEL
60 70 80 90 100
AKLEIAVLAV TFAVAVLGNS SVLLALHRTP RKTSRMHLFI RHLSLADLAV
110 120 130 140 150
AFFQVLPQMC WDITYRFRGP DWLCRVVKHL QVFGMFASAY MLVVMTADRY
160 170 180 190 200
IAVCHPLKTL QQPARRSRLM IAAAWVLSFV LSTPQYFVFS MIEVNNVTKA
210 220 230 240 250
RDCWATFIQP WGSRAYVTWM TGGIFVAPVV ILGTCYGFIC YNIWCNVRGK
260 270 280 290 300
TASRQSKGAE QAGVAFQKGF LLAPCVSSVK SISRAKIRTV KMTFVIVTAY
310 320 330 340 350
IVCWAPFFII QMWSVWDPMS VWTESENPTI TITALLGSLN SCCNPWIYMF
360 370 380 390 400
FSGHLLQDCV QSFPCCQNMK EKFNKEDTDS MSRRQTFYSN NRSPTNSTGM
410
WKDSPKSSKS IKFIPVST
Length:418
Mass (Da):46,800
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i477D4260EC826561
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VW98F8VW98_HUMAN
Vasopressin V1a receptor
AVPR1A
186Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_0220656G → S. Corresponds to variant dbSNP:rs2228154Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L25615 mRNA Translation: AAA62271.1
U19906 Genomic DNA Translation: AAB19232.1
S73899 mRNA Translation: AAC60638.1
AF030625 mRNA Translation: AAC51861.1
AF101725 mRNA Translation: AAD17891.1
AY322550 mRNA Translation: AAP84363.1
BC074803 mRNA Translation: AAH74803.1
BC074804 mRNA Translation: AAH74804.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS8965.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A53046

NCBI Reference Sequences

More...
RefSeqi
NP_000697.1, NM_000706.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.2131

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000299178; ENSP00000299178; ENSG00000166148

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
552

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:552

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L25615 mRNA Translation: AAA62271.1
U19906 Genomic DNA Translation: AAB19232.1
S73899 mRNA Translation: AAC60638.1
AF030625 mRNA Translation: AAC51861.1
AF101725 mRNA Translation: AAD17891.1
AY322550 mRNA Translation: AAP84363.1
BC074803 mRNA Translation: AAH74803.1
BC074804 mRNA Translation: AAH74804.1
CCDSiCCDS8965.1
PIRiA53046
RefSeqiNP_000697.1, NM_000706.4
UniGeneiHs.2131

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YTVX-ray1.80M/N362-418[»]
ProteinModelPortaliP37288
SMRiP37288
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107033, 2 interactors
IntActiP37288, 2 interactors
STRINGi9606.ENSP00000299178

Chemistry databases

BindingDBiP37288
ChEMBLiCHEMBL1889
DrugBankiDB00872 Conivaptan
DB00035 Desmopressin
DB00093 Felypressin
DB05452 PH-284
DB02638 Terlipressin
DB06212 Tolvaptan
DB00067 Vasopressin
GuidetoPHARMACOLOGYi366

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP37288
PhosphoSitePlusiP37288

Polymorphism and mutation databases

BioMutaiAVPR1A
DMDMi586197

Proteomic databases

PaxDbiP37288
PeptideAtlasiP37288
PRIDEiP37288
ProteomicsDBi55276

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000299178; ENSP00000299178; ENSG00000166148
GeneIDi552
KEGGihsa:552

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
552
DisGeNETi552
EuPathDBiHostDB:ENSG00000166148.3

GeneCards: human genes, protein and diseases

More...
GeneCardsi
AVPR1A

H-Invitational Database, human transcriptome db

More...
H-InvDBi
HIX0171663
HGNCiHGNC:895 AVPR1A
MIMi600821 gene
neXtProtiNX_P37288
OpenTargetsiENSG00000166148
PharmGKBiPA25187

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000158802
HOGENOMiHOG000237331
HOVERGENiHBG105710
InParanoidiP37288
KOiK04226
OMAiHLQVFAM
OrthoDBiEOG091G0DB6
PhylomeDBiP37288
TreeFamiTF106499

Enzyme and pathway databases

ReactomeiR-HSA-388479 Vasopressin-like receptors
R-HSA-416476 G alpha (q) signalling events
R-HSA-5619099 Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)

Miscellaneous databases

EvolutionaryTraceiP37288

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Arginine_vasopressin_receptor_1A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
552

Protein Ontology

More...
PROi
PR:P37288

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000166148 Expressed in 155 organ(s), highest expression level in adrenal gland
CleanExiHS_AVPR1A
ExpressionAtlasiP37288 baseline and differential
GenevisibleiP37288 HS

Family and domain databases

CDDicd15385 7tmA_V1aR, 1 hit
InterProiView protein in InterPro
IPR015076 DUF1856
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001817 Vasoprsn_rcpt
IPR001224 Vprs_V1A_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF08983 DUF1856, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00896 VASOPRESSINR
PR00752 VASOPRSNV1AR
SMARTiView protein in SMART
SM01164 DUF1856, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiV1AR_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37288
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: December 5, 2018
This is version 168 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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