UniProtKB - P37285 (KLC1_RAT)
Kinesin light chain 1
Klc1
Functioni
Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.
1 PublicationCaution
GO - Molecular functioni
- tubulin binding Source: RGD
GO - Biological processi
- axo-dendritic transport Source: RGD
- intracellular protein transport Source: RGD
- protein localization to synapse Source: UniProtKB
- stress granule disassembly Source: RGD
Keywordsi
Molecular function | Motor protein |
Enzyme and pathway databases
Reactomei | R-RNO-2132295, MHC class II antigen presentation R-RNO-5625970, RHO GTPases activate KTN1 R-RNO-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-RNO-983189, Kinesins |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin light chain 1Short name: KLC 1 |
Gene namesi | Name:Klc1 Synonyms:Klc, Kns2 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621411, Klc1 |
Subcellular locationi
Cytoskeleton
- cytoskeleton 1 Publication
Other locations
- growth cone 1 Publication
- Cytoplasmic vesicle 1 Publication
Cytoskeleton
- ciliary rootlet Source: RGD
- kinesin complex Source: RGD
- microtubule Source: UniProtKB-KW
Cytosol
- cytosol Source: RGD
Other locations
- axon Source: RGD
- cytoplasm Source: RGD
- cytoplasmic vesicle Source: RGD
- growth cone Source: UniProtKB
- membrane Source: BHF-UCL
- membrane-bounded organelle Source: RGD
- neuron projection Source: RGD
- neuronal cell body Source: RGD
- vesicle Source: RGD
Keywords - Cellular componenti
Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000215094 | 1 – 560 | Kinesin light chain 1Add BLAST | 560 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 162 | PhosphoserineCombined sources | 1 | |
Modified residuei | 449 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 460 | PhosphoserineBy similarity | 1 | |
Modified residuei | 521 | PhosphoserineCombined sources | 1 | |
Modified residuei | 524 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
jPOSTi | P37285 |
PaxDbi | P37285 |
PRIDEi | P37285 |
PTM databases
iPTMneti | P37285 |
PhosphoSitePlusi | P37285 |
SwissPalmi | P37285 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSRNOG00000011572, Expressed in frontal cortex and 21 other tissues |
ExpressionAtlasi | P37285, baseline and differential |
Genevisiblei | P37285, RN |
Interactioni
Subunit structurei
Oligomeric complex composed of two heavy chains and two light chains.
Interacts with SPAG9.
Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections.
Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex.
Interacts with BORCS5 (By similarity).
Interacts with MAPK8IP3/JIP3 and NTRK2/TRKB; interaction with NTRK2/TRKB is mediated by MAPK8IP3/JIP3 (PubMed:21775604).
By similarity3 PublicationsBinary interactionsi
P37285
With | #Exp. | IntAct |
---|---|---|
VACWR159 [P68619] from Vaccinia virus (strain Western Reserve). | 4 | EBI-917396,EBI-7133540 |
GO - Molecular functioni
- tubulin binding Source: RGD
Protein-protein interaction databases
BioGRIDi | 251058, 5 interactors |
CORUMi | P37285 |
DIPi | DIP-36927N |
ELMi | P37285 |
IntActi | P37285, 4 interactors |
MINTi | P37285 |
STRINGi | 10116.ENSRNOP00000015935 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 213 – 246 | TPR 1Add BLAST | 34 | |
Repeati | 255 – 288 | TPR 2Add BLAST | 34 | |
Repeati | 297 – 330 | TPR 3Add BLAST | 34 | |
Repeati | 339 – 372 | TPR 4Add BLAST | 34 | |
Repeati | 381 – 414 | TPR 5Add BLAST | 34 | |
Repeati | 464 – 497 | TPR 6Add BLAST | 34 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 156 – 203 | DisorderedSequence analysisAdd BLAST | 48 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 27 – 156 | Add BLAST | 130 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 156 – 178 | Basic and acidic residuesSequence analysisAdd BLAST | 23 | |
Compositional biasi | 187 – 201 | Polar residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Repeat, TPR repeatPhylogenomic databases
eggNOGi | KOG1840, Eukaryota |
GeneTreei | ENSGT00940000155555 |
InParanoidi | P37285 |
OrthoDBi | 511880at2759 |
PhylomeDBi | P37285 |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR002151, Kinesin_light IPR015792, Kinesin_light_repeat IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF13176, TPR_7, 1 hit |
PRINTSi | PR00381, KINESINLIGHT |
SMARTi | View protein in SMART SM00028, TPR, 5 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS01160, KINESIN_LIGHT, 4 hits PS50005, TPR, 6 hits PS50293, TPR_REGION, 2 hits |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MHDNMSTMVY MKEEKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL
60 70 80 90 100
ETLKCLKKDD ESNLVEEKSS MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE
110 120 130 140 150
SEKQKLRAQV RRLCQENQWL RDELANTQQK LQKSEQSVAQ LEEEKKHLEF
160 170 180 190 200
MNQLKKYDDD ISPSEDKDSD SSKEPLDDLF PNDEDDPGQG IQQQHSSAAA
210 220 230 240 250
AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL EDLEKTSGHD
260 270 280 290 300
HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG RDHPAVAATL
310 320 330 340 350
NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ
360 370 380 390 400
NQGKYEEVEY YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA
410 420 430 440 450
ETLYKEILTR AHEREFGSVD DENKPIWMHA EEREECKGKQ KDGSSFGEYG
460 470 480 490 500
GWYKACKVDS PTVTTTLKNL GALYRRQGKF EAAETLEEAA LRSRKQGLDN
510 520 530 540 550
VHKQRVAEVL NDPENVEKRR SRESLNVDVV KYESGPDGGE EVSMSVEWNG
560
MRKMKLGLVK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A140TAB3 | A0A140TAB3_RAT | Kinesin light chain | Klc1 | 552 | Annotation score: | ||
A0A1B0GWT8 | A0A1B0GWT8_RAT | Kinesin light chain 1 | Klc1 | 51 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002872 | 542 – 560 | VSMSV…LGLVK → A in isoform A. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_002871 | 542 – 550 | Missing in isoform B. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M75146 mRNA No translation available. M75147 mRNA No translation available. M75148 mRNA No translation available. |
RefSeqi | NP_001075442.1, NM_001081973.1 [P37285-3] NP_001075443.1, NM_001081974.1 [P37285-1] |
Genome annotation databases
Ensembli | ENSRNOT00000065281; ENSRNOP00000060469; ENSRNOG00000011572 [P37285-2] ENSRNOT00000092774; ENSRNOP00000075931; ENSRNOG00000011572 [P37285-1] ENSRNOT00000093106; ENSRNOP00000076048; ENSRNOG00000011572 [P37285-3] |
GeneIDi | 171041 |
KEGGi | rno:171041 |
UCSCi | RGD:621411, rat [P37285-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M75146 mRNA No translation available. M75147 mRNA No translation available. M75148 mRNA No translation available. |
RefSeqi | NP_001075442.1, NM_001081973.1 [P37285-3] NP_001075443.1, NM_001081974.1 [P37285-1] |
3D structure databases
SMRi | P37285 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 251058, 5 interactors |
CORUMi | P37285 |
DIPi | DIP-36927N |
ELMi | P37285 |
IntActi | P37285, 4 interactors |
MINTi | P37285 |
STRINGi | 10116.ENSRNOP00000015935 |
Chemistry databases
ChEMBLi | CHEMBL2176819 |
PTM databases
iPTMneti | P37285 |
PhosphoSitePlusi | P37285 |
SwissPalmi | P37285 |
Proteomic databases
jPOSTi | P37285 |
PaxDbi | P37285 |
PRIDEi | P37285 |
Genome annotation databases
Ensembli | ENSRNOT00000065281; ENSRNOP00000060469; ENSRNOG00000011572 [P37285-2] ENSRNOT00000092774; ENSRNOP00000075931; ENSRNOG00000011572 [P37285-1] ENSRNOT00000093106; ENSRNOP00000076048; ENSRNOG00000011572 [P37285-3] |
GeneIDi | 171041 |
KEGGi | rno:171041 |
UCSCi | RGD:621411, rat [P37285-1] |
Organism-specific databases
CTDi | 3831 |
RGDi | 621411, Klc1 |
Phylogenomic databases
eggNOGi | KOG1840, Eukaryota |
GeneTreei | ENSGT00940000155555 |
InParanoidi | P37285 |
OrthoDBi | 511880at2759 |
PhylomeDBi | P37285 |
Enzyme and pathway databases
Reactomei | R-RNO-2132295, MHC class II antigen presentation R-RNO-5625970, RHO GTPases activate KTN1 R-RNO-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-RNO-983189, Kinesins |
Miscellaneous databases
PROi | PR:P37285 |
Gene expression databases
Bgeei | ENSRNOG00000011572, Expressed in frontal cortex and 21 other tissues |
ExpressionAtlasi | P37285, baseline and differential |
Genevisiblei | P37285, RN |
Family and domain databases
Gene3Di | 1.25.40.10, 1 hit |
InterProi | View protein in InterPro IPR002151, Kinesin_light IPR015792, Kinesin_light_repeat IPR011990, TPR-like_helical_dom_sf IPR019734, TPR_repeat |
Pfami | View protein in Pfam PF13176, TPR_7, 1 hit |
PRINTSi | PR00381, KINESINLIGHT |
SMARTi | View protein in SMART SM00028, TPR, 5 hits |
SUPFAMi | SSF48452, SSF48452, 2 hits |
PROSITEi | View protein in PROSITE PS01160, KINESIN_LIGHT, 4 hits PS50005, TPR, 6 hits PS50293, TPR_REGION, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KLC1_RAT | |
Accessioni | P37285Primary (citable) accession number: P37285 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | November 25, 2008 | |
Last modified: | September 29, 2021 | |
This is version 170 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families