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Protein

Kinesin light chain 1

Gene

Klc1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.1 Publication

Caution

It is uncertain whether Met-1 or Met-5 is the initiator.Curated

GO - Molecular functioni

  • microtubule motor activity Source: InterPro
  • tubulin binding Source: RGD

GO - Biological processi

  • intracellular protein transport Source: RGD
  • protein localization to synapse Source: UniProtKB

Keywordsi

Molecular functionMotor protein

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin light chain 1
Short name:
KLC 1
Gene namesi
Name:Klc1
Synonyms:Klc, Kns2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi621411 Klc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Microtubule

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2176819

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002150941 – 560Kinesin light chain 1Add BLAST560

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei162PhosphoserineCombined sources1
Modified residuei449PhosphotyrosineBy similarity1
Modified residuei460PhosphoserineBy similarity1
Modified residuei521PhosphoserineCombined sources1
Modified residuei524PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP37285
PRIDEiP37285

PTM databases

iPTMnetiP37285
PhosphoSitePlusiP37285
SwissPalmiP37285

Expressioni

Tissue specificityi

Expressed in brain (at protein level).1 Publication

Gene expression databases

BgeeiENSRNOG00000011572
ExpressionAtlasiP37285 baseline and differential
GenevisibleiP37285 RN

Interactioni

Subunit structurei

Oligomeric complex composed of two heavy chains and two light chains. Interacts with SPAG9. Interacts with ATCAY; may link mitochondria to KLC1 and regulate mitochondria localization into neuron projections. Interacts (via TPR repeats) with TOR1A; the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with BORCS5 (By similarity).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
VACWR159P686194EBI-917396,EBI-7133540From Vaccinia virus (strain Western Reserve).

GO - Molecular functioni

  • tubulin binding Source: RGD

Protein-protein interaction databases

BioGridi251058, 3 interactors
CORUMiP37285
DIPiDIP-36927N
ELMiP37285
IntActiP37285, 3 interactors
MINTiP37285
STRINGi10116.ENSRNOP00000015935

Structurei

3D structure databases

ProteinModelPortaliP37285
SMRiP37285
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati213 – 246TPR 1Add BLAST34
Repeati255 – 288TPR 2Add BLAST34
Repeati297 – 330TPR 3Add BLAST34
Repeati339 – 372TPR 4Add BLAST34
Repeati381 – 414TPR 5Add BLAST34
Repeati464 – 497TPR 6Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili27 – 156Add BLAST130

Sequence similaritiesi

Belongs to the kinesin light chain family.Curated

Keywords - Domaini

Coiled coil, Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG1840 Eukaryota
COG0457 LUCA
GeneTreeiENSGT00390000006393
HOGENOMiHOG000261663
HOVERGENiHBG006217
InParanoidiP37285
KOiK10407
OrthoDBiEOG091G05DM
PhylomeDBiP37285

Family and domain databases

Gene3Di1.25.40.10, 1 hit
InterProiView protein in InterPro
IPR002151 Kinesin_light
IPR015792 Kinesin_light_repeat
IPR013026 TPR-contain_dom
IPR011990 TPR-like_helical_dom_sf
IPR019734 TPR_repeat
PRINTSiPR00381 KINESINLIGHT
SMARTiView protein in SMART
SM00028 TPR, 5 hits
SUPFAMiSSF48452 SSF48452, 3 hits
PROSITEiView protein in PROSITE
PS01160 KINESIN_LIGHT, 4 hits
PS50005 TPR, 6 hits
PS50293 TPR_REGION, 2 hits

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.
Isoform C (identifier: P37285-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHDNMSTMVY MKEEKLEKLT QDEIISKTKQ VIQGLEALKN EHNSILQSLL
60 70 80 90 100
ETLKCLKKDD ESNLVEEKSS MIRKSLEMLE LGLSEAQVMM ALSNHLNAVE
110 120 130 140 150
SEKQKLRAQV RRLCQENQWL RDELANTQQK LQKSEQSVAQ LEEEKKHLEF
160 170 180 190 200
MNQLKKYDDD ISPSEDKDSD SSKEPLDDLF PNDEDDPGQG IQQQHSSAAA
210 220 230 240 250
AAQQGGYEIP ARLRTLHNLV IQYASQGRYE VAVPLCKQAL EDLEKTSGHD
260 270 280 290 300
HPDVATMLNI LALVYRDQNK YKDAANLLND ALAIREKTLG RDHPAVAATL
310 320 330 340 350
NNLAVLYGKR GKYKEAEPLC KRALEIREKV LGKDHPDVAK QLNNLALLCQ
360 370 380 390 400
NQGKYEEVEY YYQRALEIYQ TKLGPDDPNV AKTKNNLASC YLKQGKFKQA
410 420 430 440 450
ETLYKEILTR AHEREFGSVD DENKPIWMHA EEREECKGKQ KDGSSFGEYG
460 470 480 490 500
GWYKACKVDS PTVTTTLKNL GALYRRQGKF EAAETLEEAA LRSRKQGLDN
510 520 530 540 550
VHKQRVAEVL NDPENVEKRR SRESLNVDVV KYESGPDGGE EVSMSVEWNG
560
MRKMKLGLVK
Length:560
Mass (Da):63,745
Last modified:November 25, 2008 - v2
Checksum:i24D0C4CF9E304366
GO
Isoform A (identifier: P37285-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     542-560: VSMSVEWNGMRKMKLGLVK → A

Show »
Length:542
Mass (Da):61,640
Checksum:iC3C983FE82395AD9
GO
Isoform B (identifier: P37285-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     542-550: Missing.

Show »
Length:551
Mass (Da):62,755
Checksum:i3DFC93C236D877DA
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002872542 – 560VSMSV…LGLVK → A in isoform A. 1 PublicationAdd BLAST19
Alternative sequenceiVSP_002871542 – 550Missing in isoform B. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75146 mRNA No translation available.
M75147 mRNA No translation available.
M75148 mRNA No translation available.
RefSeqiNP_001075442.1, NM_001081973.1 [P37285-3]
NP_001075443.1, NM_001081974.1 [P37285-1]
UniGeneiRn.106230

Genome annotation databases

EnsembliENSRNOT00000065281; ENSRNOP00000060469; ENSRNOG00000011572 [P37285-2]
ENSRNOT00000092774; ENSRNOP00000075931; ENSRNOG00000011572 [P37285-1]
ENSRNOT00000093106; ENSRNOP00000076048; ENSRNOG00000011572 [P37285-3]
GeneIDi171041
KEGGirno:171041
UCSCiRGD:621411 rat [P37285-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiKLC1_RAT
AccessioniPrimary (citable) accession number: P37285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: November 25, 2008
Last modified: May 23, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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