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Entry version 182 (17 Jun 2020)
Sequence version 2 (07 Dec 2004)
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Protein

Dynein heavy chain, cytoplasmic

Gene

Dhc64C

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1895 – 1902ATPSequence analysis8
Nucleotide bindingi2210 – 2217ATPSequence analysis8
Nucleotide bindingi2580 – 2587ATPSequence analysis8
Nucleotide bindingi2922 – 2929ATPSequence analysis8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMotor protein
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-DME-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DME-6798695 Neutrophil degranulation
R-DME-6807878 COPI-mediated anterograde transport
R-DME-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-DME-9646399 Aggrephagy

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dynein heavy chain, cytoplasmic
Alternative name(s):
Dynein heavy chain, cytosolic
Short name:
DYHC
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dhc64C
Synonyms:cDhc
ORF Names:CG7507
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3L

Organism-specific databases

Drosophila genome database

More...
FlyBasei
FBgn0261797 Dhc64C

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Microtubule

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001146361 – 4639Dynein heavy chain, cytoplasmicAdd BLAST4639

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P37276

PRoteomics IDEntifications database

More...
PRIDEi
P37276

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
FBgn0261797 Expressed in oocyte and 28 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P37276 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P37276 DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Consists of at least two heavy chains and a number of intermediate and light chains.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
64049, 37 interactors

Database of interacting proteins

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DIPi
DIP-59317N

Protein interaction database and analysis system

More...
IntActi
P37276, 5 interactors

STRING: functional protein association networks

More...
STRINGi
7227.FBpp0304991

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P37276

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 1856StemBy similarityAdd BLAST1856
Regioni1857 – 2084AAA 1By similarityAdd BLAST228
Regioni2166 – 2437AAA 2By similarityAdd BLAST272
Regioni2541 – 2790AAA 3By similarityAdd BLAST250
Regioni2884 – 3153AAA 4By similarityAdd BLAST270
Regioni3189 – 3478StalkBy similarityAdd BLAST290
Regioni3539 – 3768AAA 5By similarityAdd BLAST230
Regioni3989 – 4205AAA 6By similarityAdd BLAST217

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili530 – 565Sequence analysisAdd BLAST36
Coiled coili774 – 794Sequence analysisAdd BLAST21
Coiled coili1264 – 1368Sequence analysisAdd BLAST105
Coiled coili3189 – 3261Sequence analysisAdd BLAST73
Coiled coili3382 – 3478Sequence analysisAdd BLAST97
Coiled coili3723 – 3782Sequence analysisAdd BLAST60

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the dynein heavy chain family.Curated

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3595 Eukaryota
COG5245 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156103

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P37276

KEGG Orthology (KO)

More...
KOi
K10413

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P37276

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR043157 Dynein_AAA1S
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR043160 Dynein_C_barrel
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform A (identifier: P37276-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGDSLENPDT SVDPIVNLSI ANYDAFANYL RKAVTILLPE DDVVPASLND
60 70 80 90 100
ALDDPVNQDT IRKFLSDPQV QALYVQRNCI KEDDSEQPAE GEDEKEQVTY
110 120 130 140 150
QISNDVHFTN SRMASLACIK RGLVVEADKS IHSQLRLINF SDGSPYETLH
160 170 180 190 200
AFISKSLAPY FKSYVKESGR ADRDGDKMAP SVEKKLAELE MGLLHLQQNI
210 220 230 240 250
DIPEITLTAH QTVNNVIRKC AEENRKAKVA DFGDKVEDSS FLNLLQNGVN
260 270 280 290 300
RWIAEIKKVT KLNRDPGSGT ALQEISFWLN LERALYRIQE KRESPEVALT
310 320 330 340 350
LDILKHGKRF HATVSFDTDT GLKQALATVA DYNPLMKDFP INDLLSATEL
360 370 380 390 400
EKIRPAVQQI FAHLRKVRNT KYPIQRCLKL IEAISRDLSQ QLLKVLGTRR
410 420 430 440 450
LMHIPFDEFE RVMNQCFEIF SCWDDEYDKL QGLLRDIVKK KRDEHLKMVW
460 470 480 490 500
RVSPAHKKLQ TRMEHMRKFR RQHEQLRTVI LRVLRPTKPA VGDDGNVVET
510 520 530 540 550
KQPYSLDAAD ANAIEEVNLA YENVKEVDCL DITKEGSEAW EAAVKRYEEK
560 570 580 590 600
IDRVETRITA HLRDQLGTAK NANEMFRIFS RFNALFVRPH IRGAIREYQT
610 620 630 640 650
QLIQRVKDDI EALHEKFKVQ YPQSKSCRLS SVRDLPPVAG SIIWARQIDN
660 670 680 690 700
QLTMYLKRVE DVLGKGWETH IEGQKLKADG DSFRAKLSIS DVFHEWARKV
710 720 730 740 750
QERNFGSTGR IFTIESTRSR IGRGNVLRLR VNFLPEIITL AKEVRNIKNL
760 770 780 790 800
GFRVPLTIVN KAHQANQIYP YAISLIESVR TYERTLEKIE DRASIVPLVA
810 820 830 840 850
GLRKDVLNLV SEGIGLIWES YKLDPYVIRL SECVTQFQEK VDDLLVVEEQ
860 870 880 890 900
LDVDVRSLET CPYSAATFVE ILSKIQHAVD DLSLRQYSNL SVWVTRLDEE
910 920 930 940 950
VEKKLALRLQ AGIQAWTEAL TGNKKEVDTS MDTDAPAQPT HKLGGDPQIQ
960 970 980 990 1000
NAVHEIRITN QQMYLYPSIE EARFQIMQQF FAWQAIVTSQ VRLQSTRYQV
1010 1020 1030 1040 1050
GLEKHVSQTY RNLLTKLPEG KILENAYGAI EQKVSEVRNY VDEWLRYQSL
1060 1070 1080 1090 1100
WDLQADMLYG RLGEDVNLWI KCLNDIKQSR TTFDTSDTRR AYGPIIIDYA
1110 1120 1130 1140 1150
KVQAKVTLKY DSWHKEALGK FGTLLGTEMT SFHSKVSKSR TDLEMQSIEA
1160 1170 1180 1190 1200
ASTSDAVSFI TYVQSLKKDM IAWDKQVEVF REAQRILERQ RFQFPNTWLH
1210 1220 1230 1240 1250
VDNIEGEWSA FNEIIKRKDT AIQTQVASLQ AKIVAEDKAV ETRTVDFLND
1260 1270 1280 1290 1300
WEKTKPTGGK IRPDDALQQL QIFESKYSRL KEERDNVVKA KEALELQESA
1310 1320 1330 1340 1350
VPNNSAERMN VALEELQDLR GVWSELSKVW TQIDETREKP WLSVQPRKLR
1360 1370 1380 1390 1400
QQLEAMMAQL KELPARLRMY ESYEYVKKLI QSYIKVNMLI VELKSDALKE
1410 1420 1430 1440 1450
RHWKQLTKQL RVNWVLSDLS LGQVWDVNLQ KNEGIVKDII LVAQGEMALE
1460 1470 1480 1490 1500
EFLKQVRESW QNYELDLINY QNKCRIIRGW DDLFNKVKEH INSVAAMKLS
1510 1520 1530 1540 1550
PYYKVFEEEA LTWEEKLNRI NALFDVWIDV QRRWVYLEGI FSGSADIKTL
1560 1570 1580 1590 1600
LPVETSRFQS ISSEFLGLMK KVTKSPKVMD VLNIPAVQRS LERLADLLGK
1610 1620 1630 1640 1650
IQKALGEYLE RERTSFPRFY FVGDEDLLEI IGNSKNIARL QKHFKKMFAG
1660 1670 1680 1690 1700
VAAILLNEEN NVILGISSRE GEEVHFMNPV STVEHPKINE WLSLVEKQMR
1710 1720 1730 1740 1750
FTLASLLAQA VQDIKQFRDG KIDPQAYMEW CDKYQAQIVV LAAQILWSED
1760 1770 1780 1790 1800
VESALQQASE NNQSKPMQRV LGNVESTLNV LADSVLQEQP PLRRRKLEHL
1810 1820 1830 1840 1850
INEFVHKRTV TRRLLNNGVT SPKSFQWLCE MRFYFDPRQT EVLQQLTIHM
1860 1870 1880 1890 1900
ANARFFYGFE YLGVQDRLVQ TPLTDRCYLT MTQALESRLG GSPFGPAGTG
1910 1920 1930 1940 1950
KTESVKALGN QLGRFVLVFN CDETFDFQAM GRIFVGLCQV GAWGCFDEFN
1960 1970 1980 1990 2000
RLEERMLSAC SQQIQTIQEA LKYEMDSNKE SITVELVGKQ VRVSPDMAIF
2010 2020 2030 2040 2050
ITMNPGYAGR SNLPDNLKKL FRSLAMTTPD RQLIAEVMLF SQGFRSAEKL
2060 2070 2080 2090 2100
ACKIVPFFKL CDEQLSNQSH YDFGLRALKS VLISAGNVKR DRIMKIKEQM
2110 2120 2130 2140 2150
KQRGDENIDE ASVAENLPEQ EILIQSVCET MVPKLVAEDI PLLFSLLSDV
2160 2170 2180 2190 2200
FPNVGYTRAE MKGLKEEIRK VCQEDYLVCG EGDEQGAAWM EKVLQLYQIS
2210 2220 2230 2240 2250
NLNHGLMMVG PSGSGKSTAW KTLLKALERF EGVEGVAHVI DPKAISKEAL
2260 2270 2280 2290 2300
YGVLDPNTRE WTDGLFTHIL RKIIDNVRGE INKRQWIIFD GDVDPEWVEN
2310 2320 2330 2340 2350
LNSVLDDNKL LTLPNGERLS LPPNVRVMFE VQDLKFATLA TVSRCGMVWF
2360 2370 2380 2390 2400
SEDVLSTEMI FENYLSRLRS IPLEDGDEDF VGVIKPAKDK EEEVSPSLQV
2410 2420 2430 2440 2450
QRDIALLLLP FFSADGIVVR TLEYAMDQEH IMDFTRLRAL SSLFSMLNQA
2460 2470 2480 2490 2500
ARNVLTFNAQ HPDFPCSADQ LEHYIPKALV YSVLWSFAGD AKLKVRIDLG
2510 2520 2530 2540 2550
DFVRSVTTVP LPGAAGAPII DYEVNMSGDW VPWSNKVPVI EVETHKVASP
2560 2570 2580 2590 2600
DIVVPTLDTV RHESLLYTWL AEHKPLVLCG PPGSGKTMTL FSALRALPDM
2610 2620 2630 2640 2650
EVVGLNFSSA TTPELLLKTF DHYCEYRKTP NGVVLSPVQI GKWLVLFCDE
2660 2670 2680 2690 2700
INLPDMDSYG TQRVISFLRQ LVEHKGFYRA SDQAWVSLER IQFVGACNPP
2710 2720 2730 2740 2750
TDPGRKPLSH RFLRHVPIIY VDYPGETSLK QIYGTFSRAM LRLMPALRGY
2760 2770 2780 2790 2800
AEPLTNAMVE FYLASQDRFT QDMQPHYVYS PREMTRWVRG ICEAIRPLDS
2810 2820 2830 2840 2850
LPVEGLVRLW AHEALRLFQD RLVDDSERRW TNENIDLVGQ KHFPGINQEE
2860 2870 2880 2890 2900
ALQRPILYSN WLSKDYMPVN REELREYVHA RLKVFYEEEL DVPLVLFDEV
2910 2920 2930 2940 2950
LDHVLRIDRI FRQPQGHLLL IGVSGAGKTT LSRFVAWMNG LSIFQIKVHN
2960 2970 2980 2990 3000
KYTSEDFDED LRCVLRRSGC KDEKIAFILD ESNVLDSGFL ERMNTLLANG
3010 3020 3030 3040 3050
EVPGLFEGDE YTTLMTQCKE GAQREGLMLD SSDELYKWFT QQVMRNLHVV
3060 3070 3080 3090 3100
FTMNPSTDGL KDRAATSPAL FNRCVLNWFG DWSDSALFQV GKEFTTRVDL
3110 3120 3130 3140 3150
EKPNWHAPDF FPSVCPLVPA NPTHRDAVIN SCVYVHQTLH QANARLAKRG
3160 3170 3180 3190 3200
GRTMAVTPRH YLDFIHHFVK LYNEKRSDLE EQQLHLNVGL NKIAETVEQV
3210 3220 3230 3240 3250
EEMQKSLAVK KQELQAKNEA ANAKLKQMFQ DQQEAEKKKI QSQEIQIRLA
3260 3270 3280 3290 3300
DQTVKIEEKR KYVMADLAQV EPAVIDAQAA VKSIRKQQLV EVRTMANPPS
3310 3320 3330 3340 3350
VVKLALESIC LLLGENATDW KSIRAVIMRE NFINSIVSNF GTENITDDVR
3360 3370 3380 3390 3400
EKMKSKYLSN PDYNFEKVNR ASMACGPMVK WAIAQIEYAD MLKRVEPLRE
3410 3420 3430 3440 3450
ELRSLEEQAD VNLASAKETK DLVEQLERSI AAYKEEYAQL ISQAQAIKTD
3460 3470 3480 3490 3500
LENVQAKVDR SIALLKSLNI ERERWESTSE TFKSQMSTII GDVLLSAAFI
3510 3520 3530 3540 3550
AYGGYFDQHY RLNLFTTWSQ HLQAASIQYR ADIARTEYLS NPDERLRWQA
3560 3570 3580 3590 3600
NALPTDDLCT ENAIMLKRFN RYPLIIDPSG QATTFLLNEY AGKKITKTSF
3610 3620 3630 3640 3650
LDDSFRKNLE SALRFGNPLL VQDVENYDPI LNPVLNRELR RTGGRVLITL
3660 3670 3680 3690 3700
GDQDIDLSPS FVIFLSTRDP TVEFPPDICS RVTFVNFTVT RSSLQSQCLN
3710 3720 3730 3740 3750
QVLKAERPDI DEKRSDLLKL QGEFRLRLRQ LEKSLLQALN DAKGKILDDD
3760 3770 3780 3790 3800
SVITTLETLK KEAYDINQKV DETDKVIAEI ETVSQQYLPL SVACSNIYFT
3810 3820 3830 3840 3850
MDSLNQVHFL YQYSLKMFLD IFSTVLYNNP KLEGRTDHSE RLGIVTRDLF
3860 3870 3880 3890 3900
QVCYERVARG MIHIDRLTFA LLMCKIHLKG TSESNLDAEF NFFLRSREGL
3910 3920 3930 3940 3950
LANPTPVEGL SAEQIESVNR LALRLPIFRK LLEKVRSIPE LGAWLQQSSP
3960 3970 3980 3990 4000
EQVVPQLWDE SKALSPIASS VHQLLLIQAF RPDRVIAAAH NVVNTVLGED
4010 4020 4030 4040 4050
FMPNAEQELD FTSVVDKQLN CNTPALLCSV PGFDASGRVD DLAAEQNKQI
4060 4070 4080 4090 4100
SSIAIGSAEG FNQAERAINM ACKTGRWVLL KNVHLAPQWL VQLEKKMHSL
4110 4120 4130 4140 4150
QPHSGFRLFL TMEINPKVPV NLLRAGRIFV FEPPPGIRAN LLRTFSTVPA
4160 4170 4180 4190 4200
ARMMKTPSER ARLYFLLAWF HAIVQERLRY VPLGWAKKYE FNESDLRVAC
4210 4220 4230 4240 4250
DTLDTWIDTT AMGRTNLPPE KVPWDALVTL LSQSIYGGKI DNDFDQRLLT
4260 4270 4280 4290 4300
SFLKKLFTAR SFEADFALVA NVDGASGGLR HITMPDGTRR DHFLKWIENL
4310 4320 4330 4340 4350
TDRQTPSWLG LPNNAEKVLL TTRGTDLVSK LLKMQQLEDD DELAYSVEDQ
4360 4370 4380 4390 4400
SEQSAVGRGE DGRPSWMKTL HNSATAWLEL LPKNLQVLKR TVENIKDPLY
4410 4420 4430 4440 4450
RYFEREVTSG SRLLQTVILD LQDVVLICQG EKKQTNHHRS MLSELVRGII
4460 4470 4480 4490 4500
PKGWKRYTVP AGCTVIQWIT DFSNRVQQLQ KVSQLVSQAG AKELQGFPVW
4510 4520 4530 4540 4550
LGGLLNPEAY ITATRQCVAQ ANSWSLEELA LDVTITDAGL KNDQKDCCFG
4560 4570 4580 4590 4600
VTGLKLQGAQ CKNNELLLAS TIMMDLPVTI LKWIKISSEP RISKLTLPVY
4610 4620 4630
LNSTRTELLF TVDLAVAAGQ ESHSFYERGV AVLTSTALN
Length:4,639
Mass (Da):530,184
Last modified:December 7, 2004 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A3D4F1F8BE52096
GO
Isoform C (identifier: P37276-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3282-3344: KSIRKQQLVE...SIVSNFGTEN → SSIKKKHLAE...SSIVNLETDK

Show »
Length:4,638
Mass (Da):529,905
Checksum:iBD43645B38CD2368
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
M9PBQ3M9PBQ3_DROME
Dynein heavy chain 64C, isoform I
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,661Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PE73M9PE73_DROME
Dynein heavy chain 64C, isoform E
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,647Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PBQ0M9PBQ0_DROME
Dynein heavy chain 64C, isoform D
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,651Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PEC8M9PEC8_DROME
Dynein heavy chain 64C, isoform G
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,648Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PHG8M9PHG8_DROME
Dynein heavy chain 64C, isoform H
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,660Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
M9PEN4M9PEN4_DROME
Dynein heavy chain 64C, isoform F
Dhc64C CD, Cdhc, cDhc, cDhc64C, DHC
4,652Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAK92925 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti151A → V in AAA60323 (PubMed:8089180).Curated1
Sequence conflicti2010R → H in AAA60323 (PubMed:8089180).Curated1
Sequence conflicti2348V → A in AAA60323 (PubMed:8089180).Curated1
Sequence conflicti2370S → T in AAA60323 (PubMed:8089180).Curated1
Sequence conflicti2549S → T in AAA60323 (PubMed:8089180).Curated1
Sequence conflicti3864I → N in AAA60323 (PubMed:8089180).Curated1
Sequence conflicti4073K → N in AAK92925 (PubMed:12537569).Curated1
Sequence conflicti4369T → A in AAA60323 (PubMed:8089180).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0120853282 – 3344KSIRK…FGTEN → SSIKKKHLAEVRSMANPPAV VKLALESVCELLNESATDWK AIRGILVKDSFISSIVNLET DK in isoform C. CuratedAdd BLAST63

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L23195 mRNA Translation: AAA60323.1
AE014296 Genomic DNA Translation: AAF47942.3
AE014296 Genomic DNA Translation: AAN11615.2
L25122 mRNA Translation: AAA28492.1
AY051501 mRNA Translation: AAK92925.1 Different initiation.

Protein sequence database of the Protein Information Resource

More...
PIRi
A54794

NCBI Reference Sequences

More...
RefSeqi
NP_523929.2, NM_079205.4 [P37276-1]
NP_729034.2, NM_168103.3 [P37276-2]

Genome annotation databases

Ensembl metazoan genome annotation project

More...
EnsemblMetazoai
FBtr0073359; FBpp0073215; FBgn0261797 [P37276-1]
FBtr0273370; FBpp0271878; FBgn0261797 [P37276-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
38580

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dme:Dmel_CG7507

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L23195 mRNA Translation: AAA60323.1
AE014296 Genomic DNA Translation: AAF47942.3
AE014296 Genomic DNA Translation: AAN11615.2
L25122 mRNA Translation: AAA28492.1
AY051501 mRNA Translation: AAK92925.1 Different initiation.
PIRiA54794
RefSeqiNP_523929.2, NM_079205.4 [P37276-1]
NP_729034.2, NM_168103.3 [P37276-2]

3D structure databases

SMRiP37276
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi64049, 37 interactors
DIPiDIP-59317N
IntActiP37276, 5 interactors
STRINGi7227.FBpp0304991

Proteomic databases

PaxDbiP37276
PRIDEiP37276

Genome annotation databases

EnsemblMetazoaiFBtr0073359; FBpp0073215; FBgn0261797 [P37276-1]
FBtr0273370; FBpp0271878; FBgn0261797 [P37276-2]
GeneIDi38580
KEGGidme:Dmel_CG7507

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
38580
FlyBaseiFBgn0261797 Dhc64C

Phylogenomic databases

eggNOGiKOG3595 Eukaryota
COG5245 LUCA
GeneTreeiENSGT00940000156103
InParanoidiP37276
KOiK10413
PhylomeDBiP37276

Enzyme and pathway databases

ReactomeiR-DME-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR)
R-DME-6798695 Neutrophil degranulation
R-DME-6807878 COPI-mediated anterograde transport
R-DME-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-DME-9646399 Aggrephagy

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
38580 0 hits in 1 CRISPR screen

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
38580

Protein Ontology

More...
PROi
PR:P37276

Gene expression databases

BgeeiFBgn0261797 Expressed in oocyte and 28 other tissues
ExpressionAtlasiP37276 baseline and differential
GenevisibleiP37276 DM

Family and domain databases

Gene3Di1.10.8.710, 1 hit
1.10.8.720, 1 hit
1.20.140.100, 1 hit
3.10.490.20, 1 hit
3.20.180.20, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR035699 AAA_6
IPR035706 AAA_9
IPR041658 AAA_lid_11
IPR042219 AAA_lid_11_sf
IPR042228 Dynein_2_C
IPR042222 Dynein_2_N
IPR043157 Dynein_AAA1S
IPR041466 Dynein_AAA5_ext
IPR041228 Dynein_C
IPR043160 Dynein_C_barrel
IPR024743 Dynein_HC_stalk
IPR024317 Dynein_heavy_chain_D4_dom
IPR004273 Dynein_heavy_D6_P-loop
IPR013594 Dynein_heavy_dom-1
IPR013602 Dynein_heavy_dom-2
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF12774 AAA_6, 1 hit
PF12780 AAA_8, 1 hit
PF12781 AAA_9, 1 hit
PF18198 AAA_lid_11, 1 hit
PF08385 DHC_N1, 1 hit
PF08393 DHC_N2, 1 hit
PF17852 Dynein_AAA_lid, 1 hit
PF18199 Dynein_C, 1 hit
PF03028 Dynein_heavy, 1 hit
PF12777 MT, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 4 hits
SUPFAMiSSF52540 SSF52540, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDYHC_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37276
Secondary accession number(s): Q8IRA5, Q961M8, Q9VZ83
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: December 7, 2004
Last modified: June 17, 2020
This is version 182 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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