ZEB1

Functionⁱ

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.3 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	170 – 193	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	200 – 222	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	240 – 262	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	268 – 292	C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST	25
DNA bindingⁱ	581 – 640	Homeobox; atypicalAdd BLAST	60
Zinc fingerⁱ	904 – 926	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	932 – 954	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	960 – 981	C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST	22

GO - Molecular functionⁱ

chromatin binding Source: Ensembl
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 8138542
E-box binding Source: UniProtKB
RNA polymerase II transcription factor activity, sequence-specific DNA binding Source: NTNU_SB
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 23765923
transcription coactivator activity
Source: ProtInc
Traceable author statementⁱ
- 8138542
transcription corepressor activity
Source: ProtInc
Traceable author statementⁱ
- 8138542
transcription factor binding Source: Ensembl
zinc ion binding
Source: ProtInc
Traceable author statementⁱ
- 8138542

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cartilage development Source: Ensembl
cell proliferation
Source: ProtInc
Traceable author statementⁱ
- 1840704
cellular response to amino acid stimulus Source: Ensembl
central nervous system development Source: Ensembl
cochlea morphogenesis Source: Ensembl
cytokine-mediated signaling pathway Source: Reactome
embryonic camera-type eye morphogenesis Source: Ensembl
embryonic skeletal system morphogenesis Source: Ensembl
immune response
Source: ProtInc
Traceable author statementⁱ
- 1840704
negative regulation of cell proliferation Source: Ensembl
negative regulation of endothelial cell differentiation
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 23765923
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 20418909
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 23765923
pattern specification process Source: Ensembl
positive regulation of neuron differentiation Source: UniProtKB
positive regulation of transcription by RNA polymerase II Source: Ensembl
regulation of mesenchymal cell proliferation Source: Ensembl
regulation of smooth muscle cell differentiation Source: Ensembl
regulation of T cell differentiation in thymus Source: Ensembl
regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 8138542
regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
semicircular canal morphogenesis Source: Ensembl
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor
Biological process	Differentiation, Neurogenesis, Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkⁱ	P37275
SIGNORⁱ	P37275

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Zinc finger E-box-binding homeobox 1 Alternative name(s): NIL-2-A zinc finger protein Negative regulator of IL2 Transcription factor 8 Short name: TCF-8
Gene namesⁱ	Name:ZEB1 Synonyms:AREB6, TCF8
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 10

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148516.21
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11642 ZEB1
MIMⁱ	189909 gene
neXtProtⁱ	NX_P37275

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Corneal dystrophy, posterior polymorphous, 3 (PPCD3)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA subtype of posterior corneal dystrophy, a disease characterized by alterations of Descemet membrane presenting as vesicles, opacities or band-like lesions on slit-lamp examination and specular microscopy. Affected patient typically are asymptomatic.

Corneal dystrophy, Fuchs endothelial, 6 (FECD6)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA corneal disease caused by loss of endothelium of the central cornea. It is characterized by focal wart-like guttata that arise from Descemet membrane and develop in the central cornea, epithelial blisters, reduced vision and pain. Descemet membrane is thickened by abnormal collagenous deposition.

Keywords - Diseaseⁱ

Corneal dystrophy, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6935
MalaCards human disease database More...MalaCardsⁱ	ZEB1
MIMⁱ	609141 phenotype 613270 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000148516
Orphanetⁱ	98974 Fuchs endothelial corneal dystrophy 98973 Posterior polymorphous corneal dystrophy
PharmGKBⁱ	PA162409589

Polymorphism and mutation databases

BioMutaⁱ	ZEB1
DMDMⁱ	6166575

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000047231	1 – 1124	Zinc finger E-box-binding homeobox 1Add BLAST		1124

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	31	PhosphoserineBy similarity	1
Modified residueⁱ	33	PhosphoserineBy similarity	1
Cross-linkⁱ	186	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	195	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	307	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	313	PhosphoserineBy similarity	1
Modified residueⁱ	322	PhosphoserineCombined sources	1
Cross-linkⁱ	331	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	335	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	347	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linkⁱ	347	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Cross-linkⁱ	439	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	493	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	504	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	515	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	548	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linkⁱ	553	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	642	PhosphoserineCombined sources	1
Modified residueⁱ	679	PhosphoserineCombined sources	1
Modified residueⁱ	686	PhosphoserineBy similarity	1
Modified residueⁱ	693	PhosphoserineBy similarity	1
Modified residueⁱ	700	PhosphoserineBy similarity	1
Modified residueⁱ	702	PhosphothreonineCombined sources	1
Modified residueⁱ	704	PhosphoserineBy similarity	1
Cross-linkⁱ	774	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linkⁱ	774	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P37275
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P37275
PaxDbⁱ	P37275
PeptideAtlas More...PeptideAtlasⁱ	P37275
PRIDEⁱ	P37275
ProteomicsDBⁱ	55272

PTM databases

iPTMnetⁱ	P37275
PhosphoSitePlusⁱ	P37275

Expressionⁱ

Tissue specificityⁱ

Colocalizes with SMARCA4/BRG1 in E-cadherin-negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level). Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000148516 Expressed in 238 organ(s), highest expression level in myometrium
CleanExⁱ	HS_ZEB1
ExpressionAtlasⁱ	P37275 baseline and differential
Genevisibleⁱ	P37275 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB058686 HPA027524

HPAⁱ

CAB058686
HPA027524

Interactionⁱ

Subunit structureⁱ

Interacts (via N-terminus) with SMARCA4/BRG1.1 Publication

GO - Molecular functionⁱ

transcription factor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112796, 37 interactors
CORUMⁱ	P37275
ELMⁱ	P37275
IntActⁱ	P37275, 4 interactors
Molecular INTeraction database More...MINTⁱ	P37275
STRINGⁱ	9606.ENSP00000354487

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	590 – 600	Combined sources	11
Helixⁱ	608 – 618	Combined sources	11
Helixⁱ	622 – 634	Combined sources	13

Show more details

3D structure databases

ProteinModelPortalⁱ	P37275
SMRⁱ	P37275
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P37275

EvolutionaryTraceⁱ

P37275

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	989 – 1124	Glu-rich (acidic)Add BLAST		136

Sequence similaritiesⁱ

Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Length
Zinc fingerⁱ	170 – 193	C2H2-type 1PROSITE-ProRule annotationAdd BLAST	24
Zinc fingerⁱ	200 – 222	C2H2-type 2PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	240 – 262	C2H2-type 3PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	268 – 292	C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST	25
Zinc fingerⁱ	904 – 926	C2H2-type 5PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	932 – 954	C2H2-type 6PROSITE-ProRule annotationAdd BLAST	23
Zinc fingerⁱ	960 – 981	C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST	22

Keywords - Domainⁱ

Homeobox, Repeat, Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3623 Eukaryota ENOG410ZFMZ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00630000089829
HOGENOMⁱ	HOG000264256
HOVERGENⁱ	HBG004697
InParanoidⁱ	P37275
KEGG Orthology (KO) More...KOⁱ	K09299
OMAⁱ	ECEKPQG
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0F7Y
PhylomeDBⁱ	P37275
TreeFamⁱ	TF331759

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR008598 Di19_Zn_binding_dom IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00096 zf-C2H2, 4 hits PF05605 zf-Di19, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P37275-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADGPRCKRR KQANPRRNNV TNYNTVVETN SDSDDEDKLH IVEEESVTDA 
        60         70         80         90        100
ADCEGVPEDD LPTDQTVLPG RSSEREGNAK NCWEDDRKEG QEILGPEAQA 
       110        120        130        140        150
DEAGCTVKDD ECESDAENEQ NHDPNVEEFL QQQDTAVIFP EAPEEDQRQG 
       160        170        180        190        200
TPEASGHDEN GTPDAFSQLL TCPYCDRGYK RFTSLKEHIK YRHEKNEDNF 
       210        220        230        240        250
SCSLCSYTFA YRTQLERHMT SHKSGRDQRH VTQSGCNRKF KCTECGKAFK 
       260        270        280        290        300
YKHHLKEHLR IHSGEKPYEC PNCKKRFSHS GSYSSHISSK KCISLIPVNG 
       310        320        330        340        350
RPRTGLKTSQ CSSPSLSASP GSPTRPQIRQ KIENKPLQEQ LSVNQIKTEP 
       360        370        380        390        400
VDYEFKPIVV ASGINCSTPL QNGVFTGGGP LQATSSPQGM VQAVVLPTVG 
       410        420        430        440        450
LVSPISINLS DIQNVLKVAV DGNVIRQVLE NNQANLASKE QETINASPIQ 
       460        470        480        490        500
QGGHSVISAI SLPLVDQDGT TKIIINYSLE QPSQLQVVPQ NLKKENPVAT 
       510        520        530        540        550
NSCKSEKLPE DLTVKSEKDK SFEGGVNDST CLLCDDCPGD INALPELKHY 
       560        570        580        590        600
DLKQPTQPPP LPAAEAEKPE SSVSSATGDG NLSPSQPPLK NLLSLLKAYY 
       610        620        630        640        650
ALNAQPSAEE LSKIADSVNL PLDVVKKWFE KMQAGQISVQ SSEPSSPEPG 
       660        670        680        690        700
KVNIPAKNND QPQSANANEP QDSTVNLQSP LKMTNSPVLP VGSTTNGSRS 
       710        720        730        740        750
STPSPSPLNL SSSRNTQGYL YTAEGAQEEP QVEPLDLSLP KQQGELLERS 
       760        770        780        790        800
TITSVYQNSV YSVQEEPLNL SCAKKEPQKD SCVTDSEPVV NVIPPSANPI 
       810        820        830        840        850
NIAIPTVTAQ LPTIVAIADQ NSVPCLRALA ANKQTILIPQ VAYTYSTTVS 
       860        870        880        890        900
PAVQEPPLKV IQPNGNQDER QDTSSEGVSN VEDQNDSDST PPKKKMRKTE 
       910        920        930        940        950
NGMYACDLCD KIFQKSSSLL RHKYEHTGKR PHECGICKKA FKHKHHLIEH 
       960        970        980        990       1000
MRLHSGEKPY QCDKCGKRFS HSGSYSQHMN HRYSYCKREA EERDSTEQEE 
      1010       1020       1030       1040       1050
AGPEILSNEH VGARASPSQG DSDERESLTR EEDEDSEKEE EEEDKEMEEL 
      1060       1070       1080       1090       1100
QEEKECEKPQ GDEEEEEEEE EVEEEEVEEA ENEGEEAKTE GLMKDDRAES 
      1110       1120 
QASSLGQKVG ESSEQVSEEK TNEA

Length:1,124

Mass (Da):124,074

Last modified:July 15, 1999 - v2

Checksum:ⁱ0A2714CC37C848D1

GO

Isoform 2 (identifier: P37275-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
87-87: R → TG

« Hide

        10         20         30         40         50
MADGPRCKRR KQANPRRNNV TNYNTVVETN SDSDDEDKLH IVEEESVTDA 
        60         70         80         90        100
ADCEGVPEDD LPTDQTVLPG RSSEREGNAK NCWEDDTGKE GQEILGPEAQ 
       110        120        130        140        150
ADEAGCTVKD DECESDAENE QNHDPNVEEF LQQQDTAVIF PEAPEEDQRQ 
       160        170        180        190        200
GTPEASGHDE NGTPDAFSQL LTCPYCDRGY KRFTSLKEHI KYRHEKNEDN 
       210        220        230        240        250
FSCSLCSYTF AYRTQLERHM TSHKSGRDQR HVTQSGCNRK FKCTECGKAF 
       260        270        280        290        300
KYKHHLKEHL RIHSGEKPYE CPNCKKRFSH SGSYSSHISS KKCISLIPVN 
       310        320        330        340        350
GRPRTGLKTS QCSSPSLSAS PGSPTRPQIR QKIENKPLQE QLSVNQIKTE 
       360        370        380        390        400
PVDYEFKPIV VASGINCSTP LQNGVFTGGG PLQATSSPQG MVQAVVLPTV 
       410        420        430        440        450
GLVSPISINL SDIQNVLKVA VDGNVIRQVL ENNQANLASK EQETINASPI 
       460        470        480        490        500
QQGGHSVISA ISLPLVDQDG TTKIIINYSL EQPSQLQVVP QNLKKENPVA 
       510        520        530        540        550
TNSCKSEKLP EDLTVKSEKD KSFEGGVNDS TCLLCDDCPG DINALPELKH 
       560        570        580        590        600
YDLKQPTQPP PLPAAEAEKP ESSVSSATGD GNLSPSQPPL KNLLSLLKAY 
       610        620        630        640        650
YALNAQPSAE ELSKIADSVN LPLDVVKKWF EKMQAGQISV QSSEPSSPEP 
       660        670        680        690        700
GKVNIPAKNN DQPQSANANE PQDSTVNLQS PLKMTNSPVL PVGSTTNGSR 
       710        720        730        740        750
SSTPSPSPLN LSSSRNTQGY LYTAEGAQEE PQVEPLDLSL PKQQGELLER 
       760        770        780        790        800
STITSVYQNS VYSVQEEPLN LSCAKKEPQK DSCVTDSEPV VNVIPPSANP 
       810        820        830        840        850
INIAIPTVTA QLPTIVAIAD QNSVPCLRAL AANKQTILIP QVAYTYSTTV 
       860        870        880        890        900
SPAVQEPPLK VIQPNGNQDE RQDTSSEGVS NVEDQNDSDS TPPKKKMRKT 
       910        920        930        940        950
ENGMYACDLC DKIFQKSSSL LRHKYEHTGK RPHECGICKK AFKHKHHLIE 
       960        970        980        990       1000
HMRLHSGEKP YQCDKCGKRF SHSGSYSQHM NHRYSYCKRE AEERDSTEQE 
      1010       1020       1030       1040       1050
EAGPEILSNE HVGARASPSQ GDSDERESLT REEDEDSEKE EEEEDKEMEE 
      1060       1070       1080       1090       1100
LQEEKECEKP QGDEEEEEEE EEVEEEEVEE AENEGEEAKT EGLMKDDRAE 
      1110       1120 
SQASSLGQKV GESSEQVSEE KTNEA

Note: No experimental confirmation available.

Show »

Length:1,125

Mass (Da):124,076

Checksum:ⁱ3C327EEBBA18D19B

GO

Isoform 3 (identifier: P37275-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
20-87: VTNYNTVVETNSDSDDEDKLHIVEEESVTDAADCEGVPEDDLPTDQTVLPGRSSEREGNAKNCWEDDR → G

« Hide

        10         20         30         40         50
MADGPRCKRR KQANPRRNNG KEGQEILGPE AQADEAGCTV KDDECESDAE 
        60         70         80         90        100
NEQNHDPNVE EFLQQQDTAV IFPEAPEEDQ RQGTPEASGH DENGTPDAFS 
       110        120        130        140        150
QLLTCPYCDR GYKRFTSLKE HIKYRHEKNE DNFSCSLCSY TFAYRTQLER 
       160        170        180        190        200
HMTSHKSGRD QRHVTQSGCN RKFKCTECGK AFKYKHHLKE HLRIHSGEKP 
       210        220        230        240        250
YECPNCKKRF SHSGSYSSHI SSKKCISLIP VNGRPRTGLK TSQCSSPSLS 
       260        270        280        290        300
ASPGSPTRPQ IRQKIENKPL QEQLSVNQIK TEPVDYEFKP IVVASGINCS 
       310        320        330        340        350
TPLQNGVFTG GGPLQATSSP QGMVQAVVLP TVGLVSPISI NLSDIQNVLK 
       360        370        380        390        400
VAVDGNVIRQ VLENNQANLA SKEQETINAS PIQQGGHSVI SAISLPLVDQ 
       410        420        430        440        450
DGTTKIIINY SLEQPSQLQV VPQNLKKENP VATNSCKSEK LPEDLTVKSE 
       460        470        480        490        500
KDKSFEGGVN DSTCLLCDDC PGDINALPEL KHYDLKQPTQ PPPLPAAEAE 
       510        520        530        540        550
KPESSVSSAT GDGNLSPSQP PLKNLLSLLK AYYALNAQPS AEELSKIADS 
       560        570        580        590        600
VNLPLDVVKK WFEKMQAGQI SVQSSEPSSP EPGKVNIPAK NNDQPQSANA 
       610        620        630        640        650
NEPQDSTVNL QSPLKMTNSP VLPVGSTTNG SRSSTPSPSP LNLSSSRNTQ 
       660        670        680        690        700
GYLYTAEGAQ EEPQVEPLDL SLPKQQGELL ERSTITSVYQ NSVYSVQEEP 
       710        720        730        740        750
LNLSCAKKEP QKDSCVTDSE PVVNVIPPSA NPINIAIPTV TAQLPTIVAI 
       760        770        780        790        800
ADQNSVPCLR ALAANKQTIL IPQVAYTYST TVSPAVQEPP LKVIQPNGNQ 
       810        820        830        840        850
DERQDTSSEG VSNVEDQNDS DSTPPKKKMR KTENGMYACD LCDKIFQKSS 
       860        870        880        890        900
SLLRHKYEHT GKRPHECGIC KKAFKHKHHL IEHMRLHSGE KPYQCDKCGK 
       910        920        930        940        950
RFSHSGSYSQ HMNHRYSYCK REAEERDSTE QEEAGPEILS NEHVGARASP 
       960        970        980        990       1000
SQGDSDERES LTREEDEDSE KEEEEEDKEM EELQEEKECE KPQGDEEEEE 
      1010       1020       1030       1040       1050
EEEEVEEEEV EEAENEGEEA KTEGLMKDDR AESQASSLGQ KVGESSEQVS 

EEKTNEA

Show »

Length:1,057

Mass (Da):116,593

Checksum:ⁱ7C683713C6562DC8

GO

Isoform 4 (identifier: P37275-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
87-107: RKEGQEILGPEAQADEAGCTV → I

« Hide

        10         20         30         40         50
MADGPRCKRR KQANPRRNNV TNYNTVVETN SDSDDEDKLH IVEEESVTDA 
        60         70         80         90        100
ADCEGVPEDD LPTDQTVLPG RSSEREGNAK NCWEDDIKDD ECESDAENEQ 
       110        120        130        140        150
NHDPNVEEFL QQQDTAVIFP EAPEEDQRQG TPEASGHDEN GTPDAFSQLL 
       160        170        180        190        200
TCPYCDRGYK RFTSLKEHIK YRHEKNEDNF SCSLCSYTFA YRTQLERHMT 
       210        220        230        240        250
SHKSGRDQRH VTQSGCNRKF KCTECGKAFK YKHHLKEHLR IHSGEKPYEC 
       260        270        280        290        300
PNCKKRFSHS GSYSSHISSK KCISLIPVNG RPRTGLKTSQ CSSPSLSASP 
       310        320        330        340        350
GSPTRPQIRQ KIENKPLQEQ LSVNQIKTEP VDYEFKPIVV ASGINCSTPL 
       360        370        380        390        400
QNGVFTGGGP LQATSSPQGM VQAVVLPTVG LVSPISINLS DIQNVLKVAV 
       410        420        430        440        450
DGNVIRQVLE NNQANLASKE QETINASPIQ QGGHSVISAI SLPLVDQDGT 
       460        470        480        490        500
TKIIINYSLE QPSQLQVVPQ NLKKENPVAT NSCKSEKLPE DLTVKSEKDK 
       510        520        530        540        550
SFEGGVNDST CLLCDDCPGD INALPELKHY DLKQPTQPPP LPAAEAEKPE 
       560        570        580        590        600
SSVSSATGDG NLSPSQPPLK NLLSLLKAYY ALNAQPSAEE LSKIADSVNL 
       610        620        630        640        650
PLDVVKKWFE KMQAGQISVQ SSEPSSPEPG KVNIPAKNND QPQSANANEP 
       660        670        680        690        700
QDSTVNLQSP LKMTNSPVLP VGSTTNGSRS STPSPSPLNL SSSRNTQGYL 
       710        720        730        740        750
YTAEGAQEEP QVEPLDLSLP KQQGELLERS TITSVYQNSV YSVQEEPLNL 
       760        770        780        790        800
SCAKKEPQKD SCVTDSEPVV NVIPPSANPI NIAIPTVTAQ LPTIVAIADQ 
       810        820        830        840        850
NSVPCLRALA ANKQTILIPQ VAYTYSTTVS PAVQEPPLKV IQPNGNQDER 
       860        870        880        890        900
QDTSSEGVSN VEDQNDSDST PPKKKMRKTE NGMYACDLCD KIFQKSSSLL 
       910        920        930        940        950
RHKYEHTGKR PHECGICKKA FKHKHHLIEH MRLHSGEKPY QCDKCGKRFS 
       960        970        980        990       1000
HSGSYSQHMN HRYSYCKREA EERDSTEQEE AGPEILSNEH VGARASPSQG 
      1010       1020       1030       1040       1050
DSDERESLTR EEDEDSEKEE EEEDKEMEEL QEEKECEKPQ GDEEEEEEEE 
      1060       1070       1080       1090       1100
EVEEEEVEEA ENEGEEAKTE GLMKDDRAES QASSLGQKVG ESSEQVSEEK 

TNEA

Show »

Length:1,104

Mass (Da):122,003

Checksum:ⁱ3F8DAA9A05DFA6E4

GO

Isoform 5 (identifier: P37275-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-19: MADGPRCKRRKQANPRRNN → MK
87-87: R → TG

« Hide

        10         20         30         40         50
MKVTNYNTVV ETNSDSDDED KLHIVEEESV TDAADCEGVP EDDLPTDQTV 
        60         70         80         90        100
LPGRSSEREG NAKNCWEDDT GKEGQEILGP EAQADEAGCT VKDDECESDA 
       110        120        130        140        150
ENEQNHDPNV EEFLQQQDTA VIFPEAPEED QRQGTPEASG HDENGTPDAF 
       160        170        180        190        200
SQLLTCPYCD RGYKRFTSLK EHIKYRHEKN EDNFSCSLCS YTFAYRTQLE 
       210        220        230        240        250
RHMTSHKSGR DQRHVTQSGC NRKFKCTECG KAFKYKHHLK EHLRIHSGEK 
       260        270        280        290        300
PYECPNCKKR FSHSGSYSSH ISSKKCISLI PVNGRPRTGL KTSQCSSPSL 
       310        320        330        340        350
SASPGSPTRP QIRQKIENKP LQEQLSVNQI KTEPVDYEFK PIVVASGINC 
       360        370        380        390        400
STPLQNGVFT GGGPLQATSS PQGMVQAVVL PTVGLVSPIS INLSDIQNVL 
       410        420        430        440        450
KVAVDGNVIR QVLENNQANL ASKEQETINA SPIQQGGHSV ISAISLPLVD 
       460        470        480        490        500
QDGTTKIIIN YSLEQPSQLQ VVPQNLKKEN PVATNSCKSE KLPEDLTVKS 
       510        520        530        540        550
EKDKSFEGGV NDSTCLLCDD CPGDINALPE LKHYDLKQPT QPPPLPAAEA 
       560        570        580        590        600
EKPESSVSSA TGDGNLSPSQ PPLKNLLSLL KAYYALNAQP SAEELSKIAD 
       610        620        630        640        650
SVNLPLDVVK KWFEKMQAGQ ISVQSSEPSS PEPGKVNIPA KNNDQPQSAN 
       660        670        680        690        700
ANEPQDSTVN LQSPLKMTNS PVLPVGSTTN GSRSSTPSPS PLNLSSSRNT 
       710        720        730        740        750
QGYLYTAEGA QEEPQVEPLD LSLPKQQGEL LERSTITSVY QNSVYSVQEE 
       760        770        780        790        800
PLNLSCAKKE PQKDSCVTDS EPVVNVIPPS ANPINIAIPT VTAQLPTIVA 
       810        820        830        840        850
IADQNSVPCL RALAANKQTI LIPQVAYTYS TTVSPAVQEP PLKVIQPNGN 
       860        870        880        890        900
QDERQDTSSE GVSNVEDQND SDSTPPKKKM RKTENGMYAC DLCDKIFQKS 
       910        920        930        940        950
SSLLRHKYEH TGKRPHECGI CKKAFKHKHH LIEHMRLHSG EKPYQCDKCG 
       960        970        980        990       1000
KRFSHSGSYS QHMNHRYSYC KREAEERDST EQEEAGPEIL SNEHVGARAS 
      1010       1020       1030       1040       1050
PSQGDSDERE SLTREEDEDS EKEEEEEDKE MEELQEEKEC EKPQGDEEEE 
      1060       1070       1080       1090       1100
EEEEEVEEEE VEEAENEGEE AKTEGLMKDD RAESQASSLG QKVGESSEQV 

SEEKTNEA

Show »

Length:1,108

Mass (Da):122,084

Checksum:ⁱ33855F3B478635C8

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YMN2	H0YMN2_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 1	ZEB1	277	Annotation score:
H0YMD3	H0YMD3_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 1	ZEB1	274	Annotation score:
F6TDF5	F6TDF5_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 1	ZEB1	289	Annotation score:
H0YND9	H0YND9_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 1	ZEB1	288	Annotation score:
F6U0D0	F6U0D0_HUMAN	Zinc finger E-box-binding homeobox ... Zinc finger E-box-binding homeobox 1	ZEB1	53	Annotation score:

Sequence cautionⁱ

The sequence BAG62481 differs from that shown. Reason: Frameshift at position 177.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	12	Q → R in BAC03673 (PubMed:14702039).Curated	1
Sequence conflictⁱ	81	N → S in BAC03673 (PubMed:14702039).Curated	1
Sequence conflictⁱ	84	E → K in BAC03673 (PubMed:14702039).Curated	1
Sequence conflictⁱ	220	T → A in BAG62481 (PubMed:14702039).Curated	1
Sequence conflictⁱ	390	M → T in BAG62481 (PubMed:14702039).Curated	1
Sequence conflictⁱ	420	V → I in AAA20602 (Ref. 2) Curated	1
Sequence conflictⁱ	472	K → R in BAG58962 (PubMed:14702039).Curated	1
Sequence conflictⁱ	609	E → Q in M81699 (PubMed:1840704).Curated	1
Sequence conflictⁱ	654	I → T in AAA20602 (Ref. 2) Curated	1
Sequence conflictⁱ	672	D → H in M81699 (PubMed:1840704).Curated	1
Sequence conflictⁱ	681	L → S in M81699 (PubMed:1840704).Curated	1
Sequence conflictⁱ	775	K → T in BAG62481 (PubMed:14702039).Curated	1
Sequence conflictⁱ	793 – 794	IP → KY in BAG58962 (PubMed:14702039).Curated	2
Sequence conflictⁱ	797	A → N in BAG58962 (PubMed:14702039).Curated	1
Sequence conflictⁱ	818	A → V in BAG62481 (PubMed:14702039).Curated	1
Sequence conflictⁱ	838	I → T in BAC03673 (PubMed:14702039).Curated	1
Sequence conflictⁱ	1066	E → G in BAC03673 (PubMed:14702039).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_063759	78	N → T in FECD6; no effect on protein expression; no effect on nuclear localization. 3 PublicationsCorresponds to variant dbSNP:rs80194531EnsemblClinVar.	1
Natural variantⁱVAR_052731	90	G → R. Corresponds to variant dbSNP:rs12217419Ensembl.	1
Natural variantⁱVAR_072897	525	G → E Found in a patient with FECD6. 1 Publication	1
Natural variantⁱVAR_031824	553	K → R. Corresponds to variant dbSNP:rs35753967Ensembl.	1
Natural variantⁱVAR_072898	640	Q → H in FECD6; down-regulation of several collagen genes expression. 1 PublicationCorresponds to variant dbSNP:rs779148597Ensembl.	1
Natural variantⁱVAR_063760	649	P → A in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs781750314Ensembl.	1
Natural variantⁱVAR_072899	696	N → S in FECD6; no effect on protein expression; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs567252241Ensembl.	1
Natural variantⁱVAR_063761	810	Q → P in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs199944415Ensembl.	1
Natural variantⁱVAR_063762	840	Q → P in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs118020901EnsemblClinVar.	1
Natural variantⁱVAR_072900	905	A → G in FECD6; no effect on protein expression; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs78449005Ensembl.	1
Natural variantⁱVAR_063763	905	A → T in FECD6. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_047279	1 – 19	MADGP…PRRNN → MK in isoform 5. 1 PublicationAdd BLAST	19
Alternative sequenceⁱVSP_047280	20 – 87	VTNYN…WEDDR → G in isoform 3. 1 PublicationAdd BLAST	68
Alternative sequenceⁱVSP_047281	87 – 107	RKEGQ…AGCTV → I in isoform 4. 1 PublicationAdd BLAST	21
Alternative sequenceⁱVSP_045184	87	R → TG in isoform 2 and isoform 5. 2 Publications	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D15050 mRNA Translation: BAA03646.1 U12170 mRNA Translation: AAA20602.1 AK091478 mRNA Translation: BAC03673.1 AK296244 mRNA Translation: BAG58962.1 AK300830 mRNA Translation: BAG62481.1 Frameshift. AL158080 Genomic DNA No translation available. AL161935 Genomic DNA No translation available. AL117340 Genomic DNA No translation available. AL355148 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW85989.1 BC112392 mRNA Translation: AAI12393.1 M81699 mRNA No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS44370.1 [P37275-5] CCDS53505.1 [P37275-2] CCDS53506.1 [P37275-4] CCDS53507.1 [P37275-3] CCDS7169.1 [P37275-1]
PIRⁱ	JX0293
NCBI Reference Sequences More...RefSeqⁱ	NP_001121600.1, NM_001128128.2 [P37275-5] NP_001167564.1, NM_001174093.1 [P37275-4] NP_001167565.1, NM_001174094.1 NP_001167566.1, NM_001174095.1 [P37275-3] NP_001167567.1, NM_001174096.1 [P37275-2] NP_110378.3, NM_030751.5 [P37275-1]
UniGeneⁱ	Hs.124503

Genome annotation databases

Ensemblⁱ	ENST00000320985; ENSP00000319248; ENSG00000148516 [P37275-1] ENST00000361642; ENSP00000354487; ENSG00000148516 [P37275-2] ENST00000446923; ENSP00000391612; ENSG00000148516 [P37275-5] ENST00000542815; ENSP00000444891; ENSG00000148516 [P37275-3] ENST00000560721; ENSP00000452787; ENSG00000148516 [P37275-4]
GeneIDⁱ	6935
KEGGⁱ	hsa:6935
UCSC genome browser More...UCSCⁱ	uc001ivs.5 human [P37275-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P37275	Zinc finger E-box binding homeobox 1		PANTR		1360	UniRef90_P37275
Zinc finger E-box-binding homeobox 1 (Fragment)		HUMAN		274
Uncharacterized protein		PANPA		1127
Uncharacterized protein		MANLE		1127
Uncharacterized protein		RHIRO		1127
+270
P37275-3	zinc finger E-box-binding homeobox 1 isoform X3		Enhydra lutris kenyoni		1104	UniRef90_P37275-3
Uncharacterized protein		FELCA		1104
Uncharacterized protein		RHIRO		1084
Uncharacterized protein		RHIBE		1084
Zinc finger E-box binding homeobox 1		SAIBB		1084
+44

Protein	Similar proteins		Species	Score	Length	Source
P37275	Zinc finger E-box-binding homeobox 1		MESAU		1043	UniRef50_P37275
Zinc finger E-box-binding homeobox 1		MOUSE		1117
Zinc finger E-box-binding homeobox 1		RAT		1109
Zinc finger E-box-binding homeobox 1		CHICK		1114
Zinc finger E-box binding homeobox 1		PANTR		1360
+612

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	D15050 mRNA Translation: BAA03646.1 U12170 mRNA Translation: AAA20602.1 AK091478 mRNA Translation: BAC03673.1 AK296244 mRNA Translation: BAG58962.1 AK300830 mRNA Translation: BAG62481.1 Frameshift. AL158080 Genomic DNA No translation available. AL161935 Genomic DNA No translation available. AL117340 Genomic DNA No translation available. AL355148 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW85989.1 BC112392 mRNA Translation: AAI12393.1 M81699 mRNA No translation available.
CCDSⁱ	CCDS44370.1 [P37275-5] CCDS53505.1 [P37275-2] CCDS53506.1 [P37275-4] CCDS53507.1 [P37275-3] CCDS7169.1 [P37275-1]
PIRⁱ	JX0293
RefSeqⁱ	NP_001121600.1, NM_001128128.2 [P37275-5] NP_001167564.1, NM_001174093.1 [P37275-4] NP_001167565.1, NM_001174094.1 NP_001167566.1, NM_001174095.1 [P37275-3] NP_001167567.1, NM_001174096.1 [P37275-2] NP_110378.3, NM_030751.5 [P37275-1]
UniGeneⁱ	Hs.124503

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2E19	NMR	-	A	586-642	[»]
ProteinModelPortalⁱ	P37275
SMRⁱ	P37275
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112796, 37 interactors
CORUMⁱ	P37275
ELMⁱ	P37275
IntActⁱ	P37275, 4 interactors
MINTⁱ	P37275
STRINGⁱ	9606.ENSP00000354487

PTM databases

iPTMnetⁱ	P37275
PhosphoSitePlusⁱ	P37275

Polymorphism and mutation databases

BioMutaⁱ	ZEB1
DMDMⁱ	6166575

Proteomic databases

EPDⁱ	P37275
MaxQBⁱ	P37275
PaxDbⁱ	P37275
PeptideAtlasⁱ	P37275
PRIDEⁱ	P37275
ProteomicsDBⁱ	55272

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000320985; ENSP00000319248; ENSG00000148516 [P37275-1] ENST00000361642; ENSP00000354487; ENSG00000148516 [P37275-2] ENST00000446923; ENSP00000391612; ENSG00000148516 [P37275-5] ENST00000542815; ENSP00000444891; ENSG00000148516 [P37275-3] ENST00000560721; ENSP00000452787; ENSG00000148516 [P37275-4]
GeneIDⁱ	6935
KEGGⁱ	hsa:6935
UCSCⁱ	uc001ivs.5 human [P37275-1]

Organism-specific databases

CTDⁱ	6935
DisGeNETⁱ	6935
EuPathDBⁱ	HostDB:ENSG00000148516.21
GeneCardsⁱ	ZEB1
HGNCⁱ	HGNC:11642 ZEB1
HPAⁱ	CAB058686 HPA027524
MalaCardsⁱ	ZEB1
MIMⁱ	189909 gene 609141 phenotype 613270 phenotype
neXtProtⁱ	NX_P37275
OpenTargetsⁱ	ENSG00000148516
Orphanetⁱ	98974 Fuchs endothelial corneal dystrophy 98973 Posterior polymorphous corneal dystrophy
PharmGKBⁱ	PA162409589
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3623 Eukaryota ENOG410ZFMZ LUCA
GeneTreeⁱ	ENSGT00630000089829
HOGENOMⁱ	HOG000264256
HOVERGENⁱ	HBG004697
InParanoidⁱ	P37275
KOⁱ	K09299
OMAⁱ	ECEKPQG
OrthoDBⁱ	EOG091G0F7Y
PhylomeDBⁱ	P37275
TreeFamⁱ	TF331759

Enzyme and pathway databases

Reactomeⁱ	R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
SignaLinkⁱ	P37275
SIGNORⁱ	P37275

Miscellaneous databases

ChiTaRSⁱ	ZEB1 human
EvolutionaryTraceⁱ	P37275
GeneWikiⁱ	ZEB1
GenomeRNAiⁱ	6935
Protein Ontology More...PROⁱ	PR:P37275
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148516 Expressed in 238 organ(s), highest expression level in myometrium
CleanExⁱ	HS_ZEB1
ExpressionAtlasⁱ	P37275 baseline and differential
Genevisibleⁱ	P37275 HS

Family and domain databases

CDDⁱ	cd00086 homeodomain, 1 hit
InterProⁱ	View protein in InterPro IPR008598 Di19_Zn_binding_dom IPR009057 Homeobox-like_sf IPR001356 Homeobox_dom IPR036236 Znf_C2H2_sf IPR013087 Znf_C2H2_type
Pfamⁱ	View protein in Pfam PF00046 Homeobox, 1 hit PF00096 zf-C2H2, 4 hits PF05605 zf-Di19, 1 hit
SMARTⁱ	View protein in SMART SM00389 HOX, 1 hit SM00355 ZnF_C2H2, 7 hits
SUPFAMⁱ	SSF46689 SSF46689, 1 hit SSF57667 SSF57667, 4 hits
PROSITEⁱ	View protein in PROSITE PS00028 ZINC_FINGER_C2H2_1, 5 hits PS50157 ZINC_FINGER_C2H2_2, 6 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ZEB1_HUMAN
Accessionⁱ	P37275Primary (citable) accession number: P37275 Secondary accession number(s): B4DJV0 Q8NB68
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
	Last sequence update:	July 15, 1999
	Last modified:	October 10, 2018
	This is version 191 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P37275 (ZEB1_HUMAN)

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Zinc finger E-box-binding homeobox 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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PTM databases

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Proteomic databases

Protocols and materials databases

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Miscellaneous databases

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Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ