UniProtKB - P37275 (ZEB1_HUMAN)
Zinc finger E-box-binding homeobox 1
ZEB1
Functioni
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
3 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 170 – 193 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 200 – 222 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 292 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
DNA bindingi | 581 – 640 | Homeobox; atypicalAdd BLAST | 60 | |
Zinc fingeri | 904 – 926 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 932 – 954 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 960 – 981 | C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST | 22 |
GO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA-binding transcription factor activity Source: ProtInc
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: BHF-UCL
- E-box binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- zinc ion binding Source: ProtInc
GO - Biological processi
- anatomical structure development Source: GO_Central
- cartilage development Source: Ensembl
- cell differentiation Source: UniProtKB-KW
- cellular response to amino acid stimulus Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- cochlea morphogenesis Source: Ensembl
- embryonic camera-type eye morphogenesis Source: Ensembl
- embryonic skeletal system morphogenesis Source: Ensembl
- forebrain development Source: Ensembl
- negative regulation of cell population proliferation Source: Ensembl
- negative regulation of endothelial cell differentiation Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- pattern specification process Source: Ensembl
- positive regulation of neuron differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of mesenchymal cell proliferation Source: Ensembl
- regulation of smooth muscle cell differentiation Source: Ensembl
- regulation of T cell differentiation in thymus Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
- regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- response to activity Source: Ensembl
- response to nutrient levels Source: Ensembl
- semicircular canal morphogenesis Source: Ensembl
Keywordsi
Molecular function | Activator, DNA-binding, Repressor |
Biological process | Differentiation, Neurogenesis, Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
PathwayCommonsi | P37275 |
Reactomei | R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling |
SignaLinki | P37275 |
SIGNORi | P37275 |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger E-box-binding homeobox 1Alternative name(s): NIL-2-A zinc finger protein Negative regulator of IL2 Transcription factor 8 Short name: TCF-8 |
Gene namesi | Name:ZEB1 Synonyms:AREB6, TCF8 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11642, ZEB1 |
MIMi | 189909, gene |
neXtProti | NX_P37275 |
VEuPathDBi | HostDB:ENSG00000148516 |
Subcellular locationi
Nucleus
- Nucleus 2 Publications
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromatin Source: NTNU_SB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Involvement in diseasei
Corneal dystrophy, posterior polymorphous, 3 (PPCD3)2 Publications
Corneal dystrophy, Fuchs endothelial, 6 (FECD6)3 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063759 | 78 | N → T in FECD6; no effect on protein expression; no effect on nuclear localization. 3 PublicationsCorresponds to variant dbSNP:rs80194531EnsemblClinVar. | 1 | |
Natural variantiVAR_072898 | 640 | Q → H in FECD6; down-regulation of several collagen genes expression. 1 PublicationCorresponds to variant dbSNP:rs779148597Ensembl. | 1 | |
Natural variantiVAR_063760 | 649 | P → A in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs781750314Ensembl. | 1 | |
Natural variantiVAR_072899 | 696 | N → S in FECD6; no effect on protein expression; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs567252241Ensembl. | 1 | |
Natural variantiVAR_063761 | 810 | Q → P in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs199944415Ensembl. | 1 | |
Natural variantiVAR_063762 | 840 | Q → P in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs118020901Ensembl. | 1 | |
Natural variantiVAR_072900 | 905 | A → G in FECD6; no effect on protein expression; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs78449005Ensembl. | 1 | |
Natural variantiVAR_063763 | 905 | A → T in FECD6. 1 Publication | 1 |
Keywords - Diseasei
Corneal dystrophy, Disease variantOrganism-specific databases
DisGeNETi | 6935 |
MalaCardsi | ZEB1 |
MIMi | 609141, phenotype 613270, phenotype |
OpenTargetsi | ENSG00000148516 |
Orphaneti | 98974, Fuchs endothelial corneal dystrophy 98973, Posterior polymorphous corneal dystrophy |
PharmGKBi | PA162409589 |
Miscellaneous databases
Pharosi | P37275, Tbio |
Genetic variation databases
BioMutai | ZEB1 |
DMDMi | 6166575 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047231 | 1 – 1124 | Zinc finger E-box-binding homeobox 1Add BLAST | 1124 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 31 | PhosphoserineBy similarity | 1 | |
Modified residuei | 33 | PhosphoserineBy similarity | 1 | |
Cross-linki | 186 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 195 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 307 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 313 | PhosphoserineBy similarity | 1 | |
Modified residuei | 322 | PhosphoserineCombined sources | 1 | |
Cross-linki | 331 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 335 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 347 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate | ||
Cross-linki | 347 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources | ||
Cross-linki | 439 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 493 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 504 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 515 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 548 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 553 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Modified residuei | 642 | PhosphoserineCombined sources | 1 | |
Modified residuei | 679 | PhosphoserineCombined sources | 1 | |
Modified residuei | 686 | PhosphoserineBy similarity | 1 | |
Modified residuei | 693 | PhosphoserineBy similarity | 1 | |
Modified residuei | 700 | PhosphoserineBy similarity | 1 | |
Modified residuei | 702 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 704 | PhosphoserineBy similarity | 1 | |
Cross-linki | 774 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate | ||
Cross-linki | 774 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P37275 |
jPOSTi | P37275 |
MassIVEi | P37275 |
MaxQBi | P37275 |
PaxDbi | P37275 |
PeptideAtlasi | P37275 |
PRIDEi | P37275 |
ProteomicsDBi | 19473 26586 55272 [P37275-1] 61322 65678 |
PTM databases
GlyGeni | P37275, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P37275 |
PhosphoSitePlusi | P37275 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000148516, Expressed in calcaneal tendon and 249 other tissues |
ExpressionAtlasi | P37275, baseline and differential |
Genevisiblei | P37275, HS |
Organism-specific databases
HPAi | ENSG00000148516, Low tissue specificity |
Interactioni
Subunit structurei
Interacts (via N-terminus) with SMARCA4/BRG1.
1 PublicationProtein-protein interaction databases
BioGRIDi | 112796, 48 interactors |
CORUMi | P37275 |
ELMi | P37275 |
IntActi | P37275, 8 interactors |
MINTi | P37275 |
STRINGi | 9606.ENSP00000354487 |
Miscellaneous databases
RNActi | P37275, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P37275 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P37275 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 124 | DisorderedSequence analysisAdd BLAST | 124 | |
Regioni | 142 – 163 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 304 – 327 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 551 – 586 | DisorderedSequence analysisAdd BLAST | 36 | |
Regioni | 636 – 714 | DisorderedSequence analysisAdd BLAST | 79 | |
Regioni | 856 – 898 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 989 – 1124 | DisorderedSequence analysisAdd BLAST | 136 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 31 – 47 | Basic and acidic residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 77 – 95 | Basic and acidic residuesSequence analysisAdd BLAST | 19 | |
Compositional biasi | 570 – 586 | Polar residuesSequence analysisAdd BLAST | 17 | |
Compositional biasi | 656 – 714 | Polar residuesSequence analysisAdd BLAST | 59 | |
Compositional biasi | 860 – 886 | Polar residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 989 – 1004 | Basic and acidic residuesSequence analysisAdd BLAST | 16 | |
Compositional biasi | 1027 – 1050 | Acidic residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 1058 – 1085 | Acidic residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 170 – 193 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 200 – 222 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 240 – 262 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 268 – 292 | C2H2-type 4; atypicalPROSITE-ProRule annotationAdd BLAST | 25 | |
Zinc fingeri | 904 – 926 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 932 – 954 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 960 – 981 | C2H2-type 7; atypicalPROSITE-ProRule annotationAdd BLAST | 22 |
Keywords - Domaini
Homeobox, Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG3623, Eukaryota |
GeneTreei | ENSGT00950000183208 |
HOGENOMi | CLU_005890_0_1_1 |
InParanoidi | P37275 |
OMAi | RAFKHKH |
OrthoDBi | 890458at2759 |
PhylomeDBi | P37275 |
TreeFami | TF331759 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR008598, Di19_Zn-bd IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits PF05605, zf-Di19, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
s (5+)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 5 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MADGPRCKRR KQANPRRNNV TNYNTVVETN SDSDDEDKLH IVEEESVTDA
60 70 80 90 100
ADCEGVPEDD LPTDQTVLPG RSSEREGNAK NCWEDDRKEG QEILGPEAQA
110 120 130 140 150
DEAGCTVKDD ECESDAENEQ NHDPNVEEFL QQQDTAVIFP EAPEEDQRQG
160 170 180 190 200
TPEASGHDEN GTPDAFSQLL TCPYCDRGYK RFTSLKEHIK YRHEKNEDNF
210 220 230 240 250
SCSLCSYTFA YRTQLERHMT SHKSGRDQRH VTQSGCNRKF KCTECGKAFK
260 270 280 290 300
YKHHLKEHLR IHSGEKPYEC PNCKKRFSHS GSYSSHISSK KCISLIPVNG
310 320 330 340 350
RPRTGLKTSQ CSSPSLSASP GSPTRPQIRQ KIENKPLQEQ LSVNQIKTEP
360 370 380 390 400
VDYEFKPIVV ASGINCSTPL QNGVFTGGGP LQATSSPQGM VQAVVLPTVG
410 420 430 440 450
LVSPISINLS DIQNVLKVAV DGNVIRQVLE NNQANLASKE QETINASPIQ
460 470 480 490 500
QGGHSVISAI SLPLVDQDGT TKIIINYSLE QPSQLQVVPQ NLKKENPVAT
510 520 530 540 550
NSCKSEKLPE DLTVKSEKDK SFEGGVNDST CLLCDDCPGD INALPELKHY
560 570 580 590 600
DLKQPTQPPP LPAAEAEKPE SSVSSATGDG NLSPSQPPLK NLLSLLKAYY
610 620 630 640 650
ALNAQPSAEE LSKIADSVNL PLDVVKKWFE KMQAGQISVQ SSEPSSPEPG
660 670 680 690 700
KVNIPAKNND QPQSANANEP QDSTVNLQSP LKMTNSPVLP VGSTTNGSRS
710 720 730 740 750
STPSPSPLNL SSSRNTQGYL YTAEGAQEEP QVEPLDLSLP KQQGELLERS
760 770 780 790 800
TITSVYQNSV YSVQEEPLNL SCAKKEPQKD SCVTDSEPVV NVIPPSANPI
810 820 830 840 850
NIAIPTVTAQ LPTIVAIADQ NSVPCLRALA ANKQTILIPQ VAYTYSTTVS
860 870 880 890 900
PAVQEPPLKV IQPNGNQDER QDTSSEGVSN VEDQNDSDST PPKKKMRKTE
910 920 930 940 950
NGMYACDLCD KIFQKSSSLL RHKYEHTGKR PHECGICKKA FKHKHHLIEH
960 970 980 990 1000
MRLHSGEKPY QCDKCGKRFS HSGSYSQHMN HRYSYCKREA EERDSTEQEE
1010 1020 1030 1040 1050
AGPEILSNEH VGARASPSQG DSDERESLTR EEDEDSEKEE EEEDKEMEEL
1060 1070 1080 1090 1100
QEEKECEKPQ GDEEEEEEEE EVEEEEVEEA ENEGEEAKTE GLMKDDRAES
1110 1120
QASSLGQKVG ESSEQVSEEK TNEA
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6TDF5 | F6TDF5_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB1 | 289 | Annotation score: | ||
H0YND9 | H0YND9_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB1 | 288 | Annotation score: | ||
H0YMD3 | H0YMD3_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB1 | 274 | Annotation score: | ||
F6U0D0 | F6U0D0_HUMAN | Zinc finger E-box-binding homeobox ... | ZEB1 | 53 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 12 | Q → R in BAC03673 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 81 | N → S in BAC03673 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 84 | E → K in BAC03673 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 220 | T → A in BAG62481 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 390 | M → T in BAG62481 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 420 | V → I in AAA20602 (Ref. 2) Curated | 1 | |
Sequence conflicti | 472 | K → R in BAG58962 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 609 | E → Q in M81699 (PubMed:1840704).Curated | 1 | |
Sequence conflicti | 654 | I → T in AAA20602 (Ref. 2) Curated | 1 | |
Sequence conflicti | 672 | D → H in M81699 (PubMed:1840704).Curated | 1 | |
Sequence conflicti | 681 | L → S in M81699 (PubMed:1840704).Curated | 1 | |
Sequence conflicti | 775 | K → T in BAG62481 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 793 – 794 | IP → KY in BAG58962 (PubMed:14702039).Curated | 2 | |
Sequence conflicti | 797 | A → N in BAG58962 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 818 | A → V in BAG62481 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 838 | I → T in BAC03673 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 1066 | E → G in BAC03673 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_063759 | 78 | N → T in FECD6; no effect on protein expression; no effect on nuclear localization. 3 PublicationsCorresponds to variant dbSNP:rs80194531EnsemblClinVar. | 1 | |
Natural variantiVAR_052731 | 90 | G → R. Corresponds to variant dbSNP:rs12217419Ensembl. | 1 | |
Natural variantiVAR_072897 | 525 | G → E Found in a patient with FECD6. 1 Publication | 1 | |
Natural variantiVAR_031824 | 553 | K → R. Corresponds to variant dbSNP:rs35753967Ensembl. | 1 | |
Natural variantiVAR_072898 | 640 | Q → H in FECD6; down-regulation of several collagen genes expression. 1 PublicationCorresponds to variant dbSNP:rs779148597Ensembl. | 1 | |
Natural variantiVAR_063760 | 649 | P → A in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs781750314Ensembl. | 1 | |
Natural variantiVAR_072899 | 696 | N → S in FECD6; no effect on protein expression; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs567252241Ensembl. | 1 | |
Natural variantiVAR_063761 | 810 | Q → P in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs199944415Ensembl. | 1 | |
Natural variantiVAR_063762 | 840 | Q → P in FECD6; no effect on protein expression; no effect on nuclear localization. 2 PublicationsCorresponds to variant dbSNP:rs118020901Ensembl. | 1 | |
Natural variantiVAR_072900 | 905 | A → G in FECD6; no effect on protein expression; no effect on nuclear localization. 1 PublicationCorresponds to variant dbSNP:rs78449005Ensembl. | 1 | |
Natural variantiVAR_063763 | 905 | A → T in FECD6. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_047279 | 1 – 19 | MADGP…PRRNN → MK in isoform 5. 1 PublicationAdd BLAST | 19 | |
Alternative sequenceiVSP_047280 | 20 – 87 | VTNYN…WEDDR → G in isoform 3. 1 PublicationAdd BLAST | 68 | |
Alternative sequenceiVSP_047281 | 87 – 107 | RKEGQ…AGCTV → I in isoform 4. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_045184 | 87 | R → TG in isoform 2 and isoform 5. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D15050 mRNA Translation: BAA03646.1 U12170 mRNA Translation: AAA20602.1 AK091478 mRNA Translation: BAC03673.1 AK296244 mRNA Translation: BAG58962.1 AK300830 mRNA Translation: BAG62481.1 Frameshift. AL158080 Genomic DNA No translation available. AL161935 Genomic DNA No translation available. AL117340 Genomic DNA No translation available. AL355148 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW85989.1 BC112392 mRNA Translation: AAI12393.1 M81699 mRNA No translation available. |
CCDSi | CCDS44370.1 [P37275-5] CCDS53505.1 [P37275-2] CCDS53506.1 [P37275-4] CCDS53507.1 [P37275-3] CCDS7169.1 [P37275-1] |
PIRi | JX0293 |
RefSeqi | NP_001121600.1, NM_001128128.2 [P37275-5] NP_001167564.1, NM_001174093.1 [P37275-4] NP_001167565.1, NM_001174094.1 NP_001167566.1, NM_001174095.1 [P37275-3] NP_001167567.1, NM_001174096.1 [P37275-2] NP_110378.3, NM_030751.5 [P37275-1] |
Genome annotation databases
Ensembli | ENST00000320985; ENSP00000319248; ENSG00000148516 ENST00000424869; ENSP00000415961; ENSG00000148516 [P37275-2] ENST00000446923; ENSP00000391612; ENSG00000148516 [P37275-5] ENST00000542815; ENSP00000444891; ENSG00000148516 [P37275-3] ENST00000560721; ENSP00000452787; ENSG00000148516 [P37275-4] |
GeneIDi | 6935 |
KEGGi | hsa:6935 |
MANE-Selecti | ENST00000424869.6; ENSP00000415961.2; NM_001174096.2; NP_001167567.1 [P37275-2] |
UCSCi | uc001ivs.5, human [P37275-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D15050 mRNA Translation: BAA03646.1 U12170 mRNA Translation: AAA20602.1 AK091478 mRNA Translation: BAC03673.1 AK296244 mRNA Translation: BAG58962.1 AK300830 mRNA Translation: BAG62481.1 Frameshift. AL158080 Genomic DNA No translation available. AL161935 Genomic DNA No translation available. AL117340 Genomic DNA No translation available. AL355148 Genomic DNA No translation available. CH471072 Genomic DNA Translation: EAW85989.1 BC112392 mRNA Translation: AAI12393.1 M81699 mRNA No translation available. |
CCDSi | CCDS44370.1 [P37275-5] CCDS53505.1 [P37275-2] CCDS53506.1 [P37275-4] CCDS53507.1 [P37275-3] CCDS7169.1 [P37275-1] |
PIRi | JX0293 |
RefSeqi | NP_001121600.1, NM_001128128.2 [P37275-5] NP_001167564.1, NM_001174093.1 [P37275-4] NP_001167565.1, NM_001174094.1 NP_001167566.1, NM_001174095.1 [P37275-3] NP_001167567.1, NM_001174096.1 [P37275-2] NP_110378.3, NM_030751.5 [P37275-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2E19 | NMR | - | A | 586-642 | [»] | |
SMRi | P37275 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112796, 48 interactors |
CORUMi | P37275 |
ELMi | P37275 |
IntActi | P37275, 8 interactors |
MINTi | P37275 |
STRINGi | 9606.ENSP00000354487 |
PTM databases
GlyGeni | P37275, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P37275 |
PhosphoSitePlusi | P37275 |
Genetic variation databases
BioMutai | ZEB1 |
DMDMi | 6166575 |
Proteomic databases
EPDi | P37275 |
jPOSTi | P37275 |
MassIVEi | P37275 |
MaxQBi | P37275 |
PaxDbi | P37275 |
PeptideAtlasi | P37275 |
PRIDEi | P37275 |
ProteomicsDBi | 19473 26586 55272 [P37275-1] 61322 65678 |
Protocols and materials databases
Antibodypediai | 12930, 719 antibodies from 45 providers |
CPTCi | P37275, 3 antibodies |
DNASUi | 6935 |
Genome annotation databases
Ensembli | ENST00000320985; ENSP00000319248; ENSG00000148516 ENST00000424869; ENSP00000415961; ENSG00000148516 [P37275-2] ENST00000446923; ENSP00000391612; ENSG00000148516 [P37275-5] ENST00000542815; ENSP00000444891; ENSG00000148516 [P37275-3] ENST00000560721; ENSP00000452787; ENSG00000148516 [P37275-4] |
GeneIDi | 6935 |
KEGGi | hsa:6935 |
MANE-Selecti | ENST00000424869.6; ENSP00000415961.2; NM_001174096.2; NP_001167567.1 [P37275-2] |
UCSCi | uc001ivs.5, human [P37275-1] |
Organism-specific databases
CTDi | 6935 |
DisGeNETi | 6935 |
GeneCardsi | ZEB1 |
HGNCi | HGNC:11642, ZEB1 |
HPAi | ENSG00000148516, Low tissue specificity |
MalaCardsi | ZEB1 |
MIMi | 189909, gene 609141, phenotype 613270, phenotype |
neXtProti | NX_P37275 |
OpenTargetsi | ENSG00000148516 |
Orphaneti | 98974, Fuchs endothelial corneal dystrophy 98973, Posterior polymorphous corneal dystrophy |
PharmGKBi | PA162409589 |
VEuPathDBi | HostDB:ENSG00000148516 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3623, Eukaryota |
GeneTreei | ENSGT00950000183208 |
HOGENOMi | CLU_005890_0_1_1 |
InParanoidi | P37275 |
OMAi | RAFKHKH |
OrthoDBi | 890458at2759 |
PhylomeDBi | P37275 |
TreeFami | TF331759 |
Enzyme and pathway databases
PathwayCommonsi | P37275 |
Reactomei | R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling |
SignaLinki | P37275 |
SIGNORi | P37275 |
Miscellaneous databases
BioGRID-ORCSi | 6935, 28 hits in 1069 CRISPR screens |
ChiTaRSi | ZEB1, human |
EvolutionaryTracei | P37275 |
GeneWikii | ZEB1 |
GenomeRNAii | 6935 |
Pharosi | P37275, Tbio |
PROi | PR:P37275 |
RNActi | P37275, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000148516, Expressed in calcaneal tendon and 249 other tissues |
ExpressionAtlasi | P37275, baseline and differential |
Genevisiblei | P37275, HS |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR008598, Di19_Zn-bd IPR009057, Homeobox-like_sf IPR001356, Homeobox_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 4 hits PF05605, zf-Di19, 1 hit |
SMARTi | View protein in SMART SM00389, HOX, 1 hit SM00355, ZnF_C2H2, 7 hits |
SUPFAMi | SSF46689, SSF46689, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 5 hits PS50157, ZINC_FINGER_C2H2_2, 6 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZEB1_HUMAN | |
Accessioni | P37275Primary (citable) accession number: P37275 Secondary accession number(s): B4DJV0 Q8NB68 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | July 15, 1999 | |
Last modified: | February 23, 2022 | |
This is version 213 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families