UniProtKB - P37236 (FREQ_DROME)
Protein
Frequenin-1
Gene
Frq1
Organism
Drosophila melanogaster (Fruit fly)
Status
Functioni
Ca2+-dependent modulation of synaptic efficacy.1 Publication
Miscellaneous
May bind 3 calcium ions via the second, third and fourth EF-hand.By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 73 – 84 | 1PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 109 – 120 | 2PROSITE-ProRule annotationAdd BLAST | 12 | |
Calcium bindingi | 156 – 167 | 3PROSITE-ProRule annotationAdd BLAST | 12 |
GO - Molecular functioni
- calcium ion binding Source: FlyBase
- calcium sensitive guanylate cyclase activator activity Source: FlyBase
GO - Biological processi
- chemical synaptic transmission Source: FlyBase
- neuromuscular junction development Source: FlyBase
- neurotransmitter secretion Source: FlyBase
- regulation of neurotransmitter secretion Source: FlyBase
Keywordsi
Ligand | Calcium, Metal-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Frequenin-1Alternative name(s): d-FRQ |
Gene namesi | Name:Frq1 Synonyms:Frq ORF Names:CG5744 |
Organismi | Drosophila melanogaster (Fruit fly) |
Taxonomic identifieri | 7227 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora › |
Proteomesi |
|
Organism-specific databases
FlyBasei | FBgn0030897, Frq1 |
Subcellular locationi
Other locations
- Membrane By similarity; Lipid-anchor By similarity
Other locations
- membrane Source: UniProtKB-SubCell
- presynapse Source: GOC
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000073800 | 2 – 187 | Frequenin-1Add BLAST | 186 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycineBy similarity | 1 |
Keywords - PTMi
Lipoprotein, MyristateProteomic databases
PaxDbi | P37236 |
Expressioni
Tissue specificityi
Enriched in synapses, such as the motor nerve endings at neuromuscular junctions.1 Publication
Developmental stagei
Expressed throughout development.1 Publication
Gene expression databases
Bgeei | FBgn0030897, Expressed in brain and 25 other tissues |
ExpressionAtlasi | P37236, baseline and differential |
Genevisiblei | P37236, DM |
Interactioni
Protein-protein interaction databases
BioGRIDi | 59117, 3 interactors |
DIPi | DIP-23066N |
IntActi | P37236, 3 interactors |
STRINGi | 7227.FBpp0074319 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 24 – 59 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 60 – 95 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 96 – 131 | EF-hand 3PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 143 – 178 | EF-hand 4PROSITE-ProRule annotationAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the recoverin family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0044, Eukaryota |
GeneTreei | ENSGT00940000163010 |
HOGENOMi | CLU_072366_1_0_1 |
InParanoidi | P37236 |
OMAi | EFQGIYK |
OrthoDBi | 1369072at2759 |
PhylomeDBi | P37236 |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P37236-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGKKSSKLKQ DTIDRLTTDT YFTEKEIRQW HKGFLKDCPN GLLTEQGFIK
60 70 80 90 100
IYKQFFPQGD PSKFASLVFR VFDENNDGSI EFEEFIRALS VTSKGNLDEK
110 120 130 140 150
LQWAFRLYDV DNDGYITREE MYNIVDAIYQ MVGQQPQSED ENTPQKRVDK
160 170 180
IFDQMDKNHD GKLTLEEFRE GSKADPRIVQ ALSLGGG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM9PHW6 | M9PHW6_DROME | Frequenin 1, isoform D | Frq1 Dmel\CG5744, Frq, frq, frq1, HL-II | 187 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08064 Genomic DNA Translation: AAA28539.1 AE014298 Genomic DNA Translation: AAG22356.1 AE014298 Genomic DNA Translation: ABC67191.1 |
RefSeqi | NP_001033853.1, NM_001038764.2 NP_001259673.1, NM_001272744.1 NP_001259674.1, NM_001272745.1 NP_573271.1, NM_133043.3 |
Genome annotation databases
EnsemblMetazoai | FBtr0074545; FBpp0074319; FBgn0030897 FBtr0100239; FBpp0099625; FBgn0030897 FBtr0335119; FBpp0307120; FBgn0030897 FBtr0335120; FBpp0307121; FBgn0030897 |
GeneIDi | 32797 |
KEGGi | dme:Dmel_CG5744 |
UCSCi | CG5744-RC, d. melanogaster |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L08064 Genomic DNA Translation: AAA28539.1 AE014298 Genomic DNA Translation: AAG22356.1 AE014298 Genomic DNA Translation: ABC67191.1 |
RefSeqi | NP_001033853.1, NM_001038764.2 NP_001259673.1, NM_001272744.1 NP_001259674.1, NM_001272745.1 NP_573271.1, NM_133043.3 |
3D structure databases
SMRi | P37236 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 59117, 3 interactors |
DIPi | DIP-23066N |
IntActi | P37236, 3 interactors |
STRINGi | 7227.FBpp0074319 |
Proteomic databases
PaxDbi | P37236 |
Genome annotation databases
EnsemblMetazoai | FBtr0074545; FBpp0074319; FBgn0030897 FBtr0100239; FBpp0099625; FBgn0030897 FBtr0335119; FBpp0307120; FBgn0030897 FBtr0335120; FBpp0307121; FBgn0030897 |
GeneIDi | 32797 |
KEGGi | dme:Dmel_CG5744 |
UCSCi | CG5744-RC, d. melanogaster |
Organism-specific databases
CTDi | 32797 |
FlyBasei | FBgn0030897, Frq1 |
Phylogenomic databases
eggNOGi | KOG0044, Eukaryota |
GeneTreei | ENSGT00940000163010 |
HOGENOMi | CLU_072366_1_0_1 |
InParanoidi | P37236 |
OMAi | EFQGIYK |
OrthoDBi | 1369072at2759 |
PhylomeDBi | P37236 |
Miscellaneous databases
BioGRID-ORCSi | 32797, 0 hits in 1 CRISPR screen |
GenomeRNAii | 32797 |
PROi | PR:P37236 |
Gene expression databases
Bgeei | FBgn0030897, Expressed in brain and 25 other tissues |
ExpressionAtlasi | P37236, baseline and differential |
Genevisiblei | P37236, DM |
Family and domain databases
CDDi | cd00051, EFh, 2 hits |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom IPR028846, Recoverin |
PANTHERi | PTHR23055, PTHR23055, 1 hit |
Pfami | View protein in Pfam PF00036, EF-hand_1, 1 hit PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 3 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 3 hits PS50222, EF_HAND_2, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FREQ_DROME | |
Accessioni | P37236Primary (citable) accession number: P37236 Secondary accession number(s): A4V4Q8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 157 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Drosophila annotation project |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Drosophila
Drosophila: entries, gene names and cross-references to FlyBase - SIMILARITY comments
Index of protein domains and families