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UniProtKB - P37232 (PPARA_XENLA)
Protein
Peroxisome proliferator-activated receptor alpha
Gene
ppara
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by lipids. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids (By similarity).
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 106 – 180 | Nuclear receptorPROSITE-ProRule annotationAdd BLAST | 75 | |
Zinc fingeri | 109 – 129 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 146 – 168 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- lipid binding Source: UniProtKB-KW
- nuclear receptor activity Source: InterPro
- sequence-specific DNA binding Source: InterPro
- zinc ion binding Source: InterPro
Keywordsi
Molecular function | Activator, DNA-binding, Receptor |
Biological process | Transcription, Transcription regulation |
Ligand | Lipid-binding, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Peroxisome proliferator-activated receptor alphaShort name: PPAR-alpha Alternative name(s): Nuclear receptor subfamily 1 group C member 1 |
Gene namesi | Name:ppara Synonyms:nr1c1 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Proteomesi |
|
Subcellular locationi
Nucleus
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053485 | 1 – 474 | Peroxisome proliferator-activated receptor alphaAdd BLAST | 474 |
Expressioni
Tissue specificityi
Ubiquitous.
Developmental stagei
Oocytes, embryos, and adults.
Interactioni
Subunit structurei
Heterodimer with the retinoid X receptor.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 245 – 472 | NR LBDPROSITE-ProRule annotationAdd BLAST | 228 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 109 – 129 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 21 | |
Zinc fingeri | 146 – 168 | NR C4-typePROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Zinc-fingerFamily and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR003074, 1Cnucl_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003076, PPAR-alpha IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01288, PROXISOMEPAR PR01289, PROXISOMPAAR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P37232-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTIMVDTNS ELCILTPLDE DDLESPLSGE FLQDIVDIQD ITQTIGDDGS
60 70 80 90 100
TPFGASEHQF FGNSPGSIGS VSTDLTDTLS PASSPASITF PAASGSAEDA
110 120 130 140 150
ACKSLNLECR VCSDKASGFH YGVHACEGCK GFFRRTIRLK LVYDRCERMC
160 170 180 190 200
KIQKKNRNKC QYCRFEKCLN VGMSHNAIRF GRMPRSEKAK LKAEVLMCDQ
210 220 230 240 250
DVKDSQMADL LSLARLIYDA YLKNFNMNKV KARAILTGKA SNPPFVIHDM
260 270 280 290 300
ETLCMAEKTL VAKLVANGIQ NKEAEVRIFH CCQCTSVETV TELTEFAKSI
310 320 330 340 350
PGFTELDLND QVTLLKYGVY EAMFAMLASV MNKDGMLVAY GNGFITREFL
360 370 380 390 400
KSLRKPIGDM MEPKFEFAMK FNALELDDSD LSLFVAALIC CGDRPGLVNI
410 420 430 440 450
PSIEKMQESI VHVLKLHLQS NHPDDSFLFP KLLQKMADLR QLVTEHAQLV
460 470
QTIKKTETDA ALHPLLQEIY RDMY
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84161 mRNA Translation: AAA49935.1 |
PIRi | A42214 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M84161 mRNA Translation: AAA49935.1 |
PIRi | A42214 |
3D structure databases
AlphaFoldDBi | P37232 |
SMRi | P37232 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 1.10.565.10, 1 hit 3.30.50.10, 1 hit |
InterProi | View protein in InterPro IPR003074, 1Cnucl_rcpt IPR035500, NHR-like_dom_sf IPR000536, Nucl_hrmn_rcpt_lig-bd IPR001723, Nuclear_hrmn_rcpt IPR003076, PPAR-alpha IPR001628, Znf_hrmn_rcpt IPR013088, Znf_NHR/GATA |
Pfami | View protein in Pfam PF00104, Hormone_recep, 1 hit PF00105, zf-C4, 1 hit |
PRINTSi | PR01288, PROXISOMEPAR PR01289, PROXISOMPAAR PR00398, STRDHORMONER PR00047, STROIDFINGER |
SMARTi | View protein in SMART SM00430, HOLI, 1 hit SM00399, ZnF_C4, 1 hit |
SUPFAMi | SSF48508, SSF48508, 1 hit |
PROSITEi | View protein in PROSITE PS51843, NR_LBD, 1 hit PS00031, NUCLEAR_REC_DBD_1, 1 hit PS51030, NUCLEAR_REC_DBD_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PPARA_XENLA | |
Accessioni | P37232Primary (citable) accession number: P37232 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | May 25, 2022 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families