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Protein

Peroxisome proliferator-activated receptor gamma

Gene

PPARG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).By similarity4 Publications
(Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.1 Publication

Activity regulationi

PDPK1 activates its transcriptional activity independently of its kinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei317Synthetic agonist9 Publications1
Binding sitei351Synthetic agonist9 Publications1
Binding sitei477Synthetic agonist9 Publications1
Binding sitei501Synthetic agonist9 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi136 – 210Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri176 – 198NR C4-typePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processBiological rhythms, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-8943724 Regulation of PTEN gene transcription
SignaLinkiP37231
SIGNORiP37231

Protein family/group databases

MoonDBiP37231 Predicted

Chemistry databases

SwissLipidsiSLP:000000396

Names & Taxonomyi

Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma
Short name:
PPAR-gamma
Alternative name(s):
Nuclear receptor subfamily 1 group C member 3
Gene namesi
Name:PPARG
Synonyms:NR1C3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000132170.19
HGNCiHGNC:9236 PPARG
MIMi601487 gene
neXtProtiNX_P37231

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.1 Publication
Obesity (OBESITY)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
See also OMIM:601665
Lipodystrophy, familial partial, 3 (FPLD3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lipodystrophy characterized by marked loss of subcutaneous fat from the extremities. Facial adipose tissue may be increased, decreased or normal. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.
See also OMIM:604367
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_022700388F → L in FPLD3. 1 PublicationCorresponds to variant dbSNP:rs72551363Ensembl.1
Natural variantiVAR_022701425R → C in FPLD3. 1 PublicationCorresponds to variant dbSNP:rs72551364Ensembl.1
Glioma 1 (GLM1)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry. Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
Disease descriptionGliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
See also OMIM:137800

Keywords - Diseasei

Diabetes mellitus, Disease mutation, Obesity

Organism-specific databases

DisGeNETi5468
MalaCardsiPPARG
MIMi137800 phenotype
601665 phenotype
604367 phenotype
606641 phenotype
609338 phenotype
OpenTargetsiENSG00000132170
Orphaneti528 Berardinelli-Seip congenital lipodystrophy
146 Differentiated thyroid carcinoma
251579 Giant cell glioblastoma
251576 Gliosarcoma
79083 PPARG-related familial partial lipodystrophy
PharmGKBiPA281

Chemistry databases

ChEMBLiCHEMBL235
DrugBankiDB08760 (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid
DB07842 (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
DB08121 (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
DB07675 (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
DB04270 (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid
DB07863 2-chloro-5-nitro-N-phenylbenzamide
DB04689 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
DB07053 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
DB07723 3-(5-methoxy-1H-indol-3-yl)propanoic acid
DB08302 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
DB08560 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
DB07724 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
DB08915 Aleglitazar
DB01014 Balsalazide
DB01393 Bezafibrate
DB05854 CLX-0921
DB07509 difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron
DB05187 GFT505
DB01067 Glipizide
DB01050 Ibuprofen
DB00159 Icosapent
DB00328 Indomethacin
DB00244 Mesalazine
DB01252 Mitiglinide
DB00731 Nateglinide
DB01132 Pioglitazone
DB04971 Reglixane
DB00912 Repaglinide
DB00412 Rosiglitazone
DB00795 Sulfasalazine
DB05490 T131
DB00966 Telmisartan
DB00197 Troglitazone
GuidetoPHARMACOLOGYi595

Polymorphism and mutation databases

BioMutaiPPARG
DMDMi13432234

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000534921 – 505Peroxisome proliferator-activated receptor gammaAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi84O-linked (GlcNAc) threonineBy similarity1
Modified residuei112PhosphoserineCombined sources1

Post-translational modificationi

O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes.By similarity
Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP37231
MaxQBiP37231
PaxDbiP37231
PeptideAtlasiP37231
PRIDEiP37231
ProteomicsDBi55267
55268 [P37231-2]
55269 [P37231-3]

PTM databases

iPTMnetiP37231
PhosphoSitePlusiP37231

Expressioni

Tissue specificityi

Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.1 Publication

Inductioni

(Microbial infection) Expression increases when incubated with M.tuberculosis or its lipoprotein LpqH; induction is TLR2-dependent (at protein level).1 Publication

Gene expression databases

BgeeiENSG00000132170 Expressed in 136 organ(s), highest expression level in subcutaneous adipose tissue
ExpressionAtlasiP37231 baseline and differential
GenevisibleiP37231 HS

Organism-specific databases

HPAiCAB004282
HPA051239
HPA063663

Interactioni

Subunit structurei

Interacts with FOXO1 (acetylated form) (By similarity). Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG. Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters. Interacts with NOCT. Interacts with ACTN4. Interacts (when in the liganded conformation) with GPS2 (By similarity).By similarity21 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111464, 138 interactors
ComplexPortaliCPX-702 PPARgamma-NCOA2 activated nuclear receptor complex
CPX-711 PPARgamma-NCOA1 activated nuclear receptor complex
DIPiDIP-35528N
ELMiP37231
IntActiP37231, 39 interactors
MINTiP37231
STRINGi9606.ENSP00000287820

Chemistry databases

BindingDBiP37231

Structurei

Secondary structure

1505
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

DisProtiDP00718
ProteinModelPortaliP37231
SMRiP37231
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37231

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 503NR LBDPROSITE-ProRule annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni205 – 280Interaction with FAM120BBy similarityAdd BLAST76

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri176 – 198NR C4-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000119407
HOVERGENiHBG082808
InParanoidiP37231
KOiK08530
OMAiQRCQFRS
OrthoDBiEOG091G05U8
PhylomeDBiP37231
TreeFamiTF316304

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003074 1Cnucl_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003077 PPAR-gamma
IPR022590 PPARgamma_N
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF12577 PPARgamma_N, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01288 PROXISOMEPAR
PR01291 PROXISOMPAGR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: P37231-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGETLGDSPI DPESDSFTDT LSANISQEMT MVDTEMPFWP TNFGISSVDL
60 70 80 90 100
SVMEDHSHSF DIKPFTTVDF SSISTPHYED IPFTRTDPVV ADYKYDLKLQ
110 120 130 140 150
EYQSAIKVEP ASPPYYSEKT QLYNKPHEEP SNSLMAIECR VCGDKASGFH
160 170 180 190 200
YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA
210 220 230 240 250
VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY
260 270 280 290 300
IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE
310 320 330 340 350
QSKEVAIRIF QGCQFRSVEA VQEITEYAKS IPGFVNLDLN DQVTLLKYGV
360 370 380 390 400
HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV
410 420 430 440 450
KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK
460 470 480 490 500
LNHPESSQLF AKLLQKMTDL RQIVTEHVQL LQVIKKTETD MSLHPLLQEI

YKDLY
Length:505
Mass (Da):57,620
Last modified:April 27, 2001 - v3
Checksum:i3933EFF36A0E4CAF
GO
Isoform 1 (identifier: P37231-2) [UniParc]FASTAAdd to basket
Also known as: PPARgamma1(wt)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:477
Mass (Da):54,681
Checksum:i1061C2074B739E0A
GO
Isoform 3 (identifier: P37231-3) [UniParc]FASTAAdd to basket
Also known as: PPARgamma1(tr)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     207-213: AIRFGRM → EELQKDS
     214-504: Missing.

Note: Exhibits dominant negative activity over isoform 1.
Show »
Length:186
Mass (Da):21,580
Checksum:i10E780305F860A5D
GO

Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFV2E9PFV2_HUMAN
Peroxisome proliferator-activated r...
PPARG
483Annotation score:
E9PFX5E9PFX5_HUMAN
Peroxisome proliferator-activated r...
PPARG
250Annotation score:
E7EUD1E7EUD1_HUMAN
Peroxisome proliferator-activated r...
PPARG
132Annotation score:
E7EU07E7EU07_HUMAN
Peroxisome proliferator-activated r...
PPARG
99Annotation score:
E9PFJ1E9PFJ1_HUMAN
Peroxisome proliferator-activated r...
PPARG
43Annotation score:
E9PFV3E9PFV3_HUMAN
Peroxisome proliferator-activated r...
PPARG
40Annotation score:

Sequence cautioni

The sequence AAN38992 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA23354 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF83270 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA62153 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 37MP → IA in BAA18949 (PubMed:9144532).Curated2
Sequence conflicti213 – 214MP → IA in BAA18949 (PubMed:9144532).Curated2
Sequence conflicti240R → RQ in BAA18949 (PubMed:9144532).Curated1

Polymorphismi

Genetic variations in PPARG define the body mass index quantitative trait locus 1 (BMIQ1) [MIMi:606641]. The body max index (BMI) reflects the amount of fat, lean mass, and body build.2 Publications
Genetic variations in PPARG influence the carotid intimal medial thickness (CIMT) [MIMi:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01072312P → A Polymorphism; significant independent determinant of CIMT; may protect from early atherosclerosis in subject at risk for diabetes; associated with BMI. 5 PublicationsCorresponds to variant dbSNP:rs1801282EnsemblClinVar.1
Natural variantiVAR_01611640P → A. Corresponds to variant dbSNP:rs1805192Ensembl.1
Natural variantiVAR_010724113P → Q in obesity. 1 PublicationCorresponds to variant dbSNP:rs1800571Ensembl.1
Natural variantiVAR_010725314Q → P in colon cancer; sporadic; somatic mutation; loss of ligand-binding. 1 PublicationCorresponds to variant dbSNP:rs121909242Ensembl.1
Natural variantiVAR_010726316R → H in colon cancer; sporadic; somatic mutation; partial loss of ligand-binding. 1 PublicationCorresponds to variant dbSNP:rs28936407Ensembl.1
Natural variantiVAR_010727318V → M in diabetes. 1 PublicationCorresponds to variant dbSNP:rs72551362Ensembl.1
Natural variantiVAR_022700388F → L in FPLD3. 1 PublicationCorresponds to variant dbSNP:rs72551363Ensembl.1
Natural variantiVAR_022701425R → C in FPLD3. 1 PublicationCorresponds to variant dbSNP:rs72551364Ensembl.1
Natural variantiVAR_010728495P → L in diabetes. 1 PublicationCorresponds to variant dbSNP:rs121909244EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0036451 – 28Missing in isoform 1 and isoform 3. 7 PublicationsAdd BLAST28
Alternative sequenceiVSP_043906207 – 213AIRFGRM → EELQKDS in isoform 3. 1 Publication7
Alternative sequenceiVSP_043907214 – 504Missing in isoform 3. 1 PublicationAdd BLAST291

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79012 mRNA Translation: AAC51248.1
U63415 mRNA Translation: AAB04028.1
D83233 mRNA Translation: BAA18949.1
L40904 mRNA Translation: AAA80314.2
AB005526 Genomic DNA Translation: BAA23354.1 Sequence problems.
X90563 mRNA Translation: CAA62152.1
X90563 mRNA Translation: CAA62153.1 Different initiation.
DQ356894 mRNA Translation: ABC97372.1
BT007281 mRNA Translation: AAP35945.1
AK290581 mRNA Translation: BAF83270.1 Different initiation.
AB451337 mRNA Translation: BAG70151.1
AB451486 mRNA Translation: BAG70300.1
AY157024 Genomic DNA Translation: AAN38992.2 Different initiation.
AC090947 Genomic DNA No translation available.
AC091492 Genomic DNA No translation available.
AC093174 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64124.1
BC006811 mRNA Translation: AAH06811.1
CCDSiCCDS2609.1 [P37231-1]
CCDS2610.2 [P37231-2]
PIRiJC4859
PC4290
PC4429
RefSeqiNP_005028.4, NM_005037.5 [P37231-2]
NP_056953.2, NM_015869.4 [P37231-1]
NP_619725.2, NM_138711.3 [P37231-2]
NP_619726.2, NM_138712.3 [P37231-2]
XP_011532143.1, XM_011533841.2
UniGeneiHs.162646
Hs.655798

Genome annotation databases

EnsembliENST00000287820; ENSP00000287820; ENSG00000132170 [P37231-1]
ENST00000309576; ENSP00000312472; ENSG00000132170 [P37231-2]
ENST00000396999; ENSP00000380195; ENSG00000132170 [P37231-3]
ENST00000397010; ENSP00000380205; ENSG00000132170 [P37231-2]
ENST00000397012; ENSP00000380207; ENSG00000132170 [P37231-2]
ENST00000397015; ENSP00000380210; ENSG00000132170 [P37231-2]
ENST00000643197; ENSP00000495840; ENSG00000132170 [P37231-2]
ENST00000643888; ENSP00000494934; ENSG00000132170 [P37231-2]
ENST00000644622; ENSP00000494873; ENSG00000132170 [P37231-2]
GeneIDi5468
KEGGihsa:5468
UCSCiuc003bwr.4 human [P37231-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Peroxisome proliferator-activated receptor entry

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79012 mRNA Translation: AAC51248.1
U63415 mRNA Translation: AAB04028.1
D83233 mRNA Translation: BAA18949.1
L40904 mRNA Translation: AAA80314.2
AB005526 Genomic DNA Translation: BAA23354.1 Sequence problems.
X90563 mRNA Translation: CAA62152.1
X90563 mRNA Translation: CAA62153.1 Different initiation.
DQ356894 mRNA Translation: ABC97372.1
BT007281 mRNA Translation: AAP35945.1
AK290581 mRNA Translation: BAF83270.1 Different initiation.
AB451337 mRNA Translation: BAG70151.1
AB451486 mRNA Translation: BAG70300.1
AY157024 Genomic DNA Translation: AAN38992.2 Different initiation.
AC090947 Genomic DNA No translation available.
AC091492 Genomic DNA No translation available.
AC093174 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64124.1
BC006811 mRNA Translation: AAH06811.1
CCDSiCCDS2609.1 [P37231-1]
CCDS2610.2 [P37231-2]
PIRiJC4859
PC4290
PC4429
RefSeqiNP_005028.4, NM_005037.5 [P37231-2]
NP_056953.2, NM_015869.4 [P37231-1]
NP_619725.2, NM_138711.3 [P37231-2]
NP_619726.2, NM_138712.3 [P37231-2]
XP_011532143.1, XM_011533841.2
UniGeneiHs.162646
Hs.655798

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FM6X-ray2.10D/X234-505[»]
1FM9X-ray2.10D234-505[»]
1I7IX-ray2.35A/B225-505[»]
1K74X-ray2.30D234-505[»]
1KNUX-ray2.50A/B232-505[»]
1NYXX-ray2.65A/B230-505[»]
1PRGX-ray2.20A/B235-504[»]
1RDTX-ray2.40D235-505[»]
1WM0X-ray2.90X232-505[»]
1ZEOX-ray2.50A/B231-505[»]
1ZGYX-ray1.80A234-505[»]
2ATHX-ray2.28A/B235-505[»]
2F4BX-ray2.07A/B235-505[»]
2FVJX-ray1.99A235-505[»]
2G0GX-ray2.54A/B235-505[»]
2G0HX-ray2.30A/B235-505[»]
2GTKX-ray2.10A235-505[»]
2HFPX-ray2.00A234-505[»]
2HWQX-ray1.97A/B235-505[»]
2HWRX-ray2.34A/B235-505[»]
2I4JX-ray2.10A/B223-504[»]
2I4PX-ray2.10A/B223-504[»]
2I4ZX-ray2.25A/B223-504[»]
2OM9X-ray2.80A/B/C/D232-505[»]
2P4YX-ray2.25A/B231-505[»]
2POBX-ray2.30A/B234-505[»]
2PRGX-ray2.30A/B235-505[»]
2Q59X-ray2.20A/B233-505[»]
2Q5PX-ray2.30A/B233-505[»]
2Q5SX-ray2.05A/B233-505[»]
2Q61X-ray2.20A/B233-505[»]
2Q6RX-ray2.41A/B233-505[»]
2Q6SX-ray2.40A/B233-505[»]
2Q8SX-ray2.30A/B235-505[»]
2QMVNMR-A235-504[»]
2VSRX-ray2.05A/B232-505[»]
2VSTX-ray2.35A/B232-505[»]
2VV0X-ray2.55A/B232-505[»]
2VV1X-ray2.20A/B232-505[»]
2VV2X-ray2.75A/B232-505[»]
2VV3X-ray2.85A/B232-505[»]
2VV4X-ray2.35A/B232-505[»]
2XKWX-ray2.02A/B232-505[»]
2YFEX-ray2.00A/B223-505[»]
2ZK0X-ray2.36A/B223-504[»]
2ZK1X-ray2.61A/B223-504[»]
2ZK2X-ray2.26A/B223-504[»]
2ZK3X-ray2.58A/B223-504[»]
2ZK4X-ray2.57A/B223-504[»]
2ZK5X-ray2.45A/B223-504[»]
2ZK6X-ray2.41A/B223-504[»]
2ZNOX-ray2.40A/B223-504[»]
2ZVTX-ray1.90A/B223-504[»]
3ADSX-ray2.25A/B223-505[»]
3ADTX-ray2.70A/B223-505[»]
3ADUX-ray2.77A/B223-505[»]
3ADVX-ray2.27A/B223-505[»]
3ADWX-ray2.07A/B223-505[»]
3ADXX-ray1.95A/B223-505[»]
3AN3X-ray2.30A/B223-504[»]
3AN4X-ray2.30A/B223-504[»]
3B0QX-ray2.10A/B231-504[»]
3B0RX-ray2.15A/B231-504[»]
3B1MX-ray1.60A234-505[»]
3B3KX-ray2.60A/B223-504[»]
3BC5X-ray2.27A231-505[»]
3CDPX-ray2.80A/B223-504[»]
3CDSX-ray2.65A/B223-504[»]
3CS8X-ray2.30A234-504[»]
3CWDX-ray2.40A/B236-505[»]
3D6DX-ray2.40A/B223-504[»]
3DZUX-ray3.20D102-505[»]
3DZYX-ray3.10D102-505[»]
3E00X-ray3.10D102-505[»]
3ET0X-ray2.40A/B235-505[»]
3ET3X-ray1.95A235-505[»]
3FEJX-ray2.01A235-505[»]
3FURX-ray2.30A234-505[»]
3G9EX-ray2.30A235-505[»]
3GBKX-ray2.30A/B235-505[»]
3H0AX-ray2.10D234-505[»]
3HO0X-ray2.60A/B223-504[»]
3HODX-ray2.10A/B223-504[»]
3IA6X-ray2.31A/B235-505[»]
3K8SX-ray2.55A/B234-505[»]
3KMGX-ray2.10A/D234-505[»]
3LMPX-ray1.90A234-505[»]
3NOAX-ray1.98A/B235-505[»]
3OSIX-ray2.70A/B224-504[»]
3OSWX-ray2.55A/B224-504[»]
3PBAX-ray2.30A/B224-505[»]
3PO9X-ray2.35A/B224-505[»]
3PRGX-ray2.90A232-505[»]
3QT0X-ray2.50A235-505[»]
3R5NX-ray2.00A232-505[»]
3R8AX-ray2.41A/B235-505[»]
3R8IX-ray2.30A/B223-505[»]
3S9SX-ray2.55A234-505[»]
3SZ1X-ray2.30A/B232-505[»]
3T03X-ray2.10A/B234-505[»]
3TY0X-ray2.00A/B231-505[»]
3U9QX-ray1.52A236-504[»]
3V9TX-ray1.65A234-505[»]
3V9VX-ray1.60A234-505[»]
3V9YX-ray2.10A234-505[»]
3VJHX-ray2.22A/B223-504[»]
3VJIX-ray2.61A/B223-504[»]
3VN2X-ray2.18A225-505[»]
3VSOX-ray2.00A/B223-504[»]
3VSPX-ray2.40A/B223-504[»]
3WJ4X-ray1.95A/B235-505[»]
3WJ5X-ray1.89A/B235-505[»]
3WMHX-ray2.10A/B223-504[»]
3X1HX-ray2.30A/B232-505[»]
3X1IX-ray2.40A/B232-505[»]
4A4VX-ray2.00A/B223-505[»]
4A4WX-ray2.00A/B223-505[»]
4CI5X-ray1.77A/B234-505[»]
4E4KX-ray2.50A/B223-505[»]
4E4QX-ray2.50A/B223-505[»]
4EM9X-ray2.10A/B235-505[»]
4EMAX-ray2.54A/B235-505[»]
4F9MX-ray1.90A234-505[»]
4FGYX-ray2.84A235-504[»]
4HEEX-ray2.50X235-505[»]
4JAZX-ray2.85A/B223-505[»]
4JL4X-ray2.50A/B223-505[»]
4L96X-ray2.38A235-505[»]
4L98X-ray2.28A/B235-505[»]
4O8FX-ray2.60A/B223-505[»]
4OJ4X-ray2.30A232-505[»]
4PRGX-ray2.90A/B/C/D235-504[»]
4PVUX-ray2.60A/B223-505[»]
4PWLX-ray2.60A/B223-505[»]
4R06X-ray2.22A/B233-505[»]
4R2UX-ray2.30A/D231-505[»]
4R6SX-ray2.30A/B231-505[»]
4XLDX-ray2.45A231-505[»]
4XTAX-ray2.50A/B232-505[»]
4XUHX-ray2.22A/B232-505[»]
4XUMX-ray2.40A/B232-505[»]
4Y29X-ray1.98A236-504[»]
4YT1X-ray2.20A/B223-504[»]
5AZVX-ray2.70A/B232-505[»]
5DSHX-ray2.95A223-505[»]
5DV3X-ray2.75A223-505[»]
5DV6X-ray2.80A223-505[»]
5DV8X-ray2.75A223-505[»]
5DVCX-ray2.30A223-505[»]
5DWLX-ray2.20A223-505[»]
5F9BX-ray2.25A/B223-505[»]
5GTNX-ray1.85A223-505[»]
5GTOX-ray2.10A223-505[»]
5GTPX-ray2.35A223-505[»]
5HZCX-ray2.00A/B223-505[»]
5JI0X-ray1.98D234-505[»]
5LSGX-ray2.00A/B223-505[»]
5TTOX-ray2.25A/B233-505[»]
5TWOX-ray1.93A234-505[»]
5U5LX-ray2.55A/B233-505[»]
5UGMX-ray2.10A/B235-505[»]
5WQXX-ray2.29A/B232-505[»]
5WR0X-ray2.85A/B232-505[»]
5WR1X-ray2.34A/B232-505[»]
5Y2OX-ray1.80A/B235-505[»]
5Y2TX-ray1.70A/B235-505[»]
5YCNX-ray2.15A223-505[»]
5YCPX-ray2.00A223-505[»]
6AN1X-ray2.69A/B224-505[»]
6AUGX-ray2.73A/B231-505[»]
6AVIX-ray2.29A/B231-505[»]
6C5QX-ray2.40A235-505[»]
6C5TX-ray2.75A235-505[»]
6ENQX-ray2.20A/B224-505[»]
6F2LX-ray2.10A/B223-505[»]
DisProtiDP00718
ProteinModelPortaliP37231
SMRiP37231
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111464, 138 interactors
ComplexPortaliCPX-702 PPARgamma-NCOA2 activated nuclear receptor complex
CPX-711 PPARgamma-NCOA1 activated nuclear receptor complex
DIPiDIP-35528N
ELMiP37231
IntActiP37231, 39 interactors
MINTiP37231
STRINGi9606.ENSP00000287820

Chemistry databases

BindingDBiP37231
ChEMBLiCHEMBL235
DrugBankiDB08760 (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid
DB07842 (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
DB08121 (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
DB07675 (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
DB04270 (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid
DB07863 2-chloro-5-nitro-N-phenylbenzamide
DB04689 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
DB07053 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
DB07723 3-(5-methoxy-1H-indol-3-yl)propanoic acid
DB08302 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
DB08560 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
DB07724 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
DB08915 Aleglitazar
DB01014 Balsalazide
DB01393 Bezafibrate
DB05854 CLX-0921
DB07509 difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron
DB05187 GFT505
DB01067 Glipizide
DB01050 Ibuprofen
DB00159 Icosapent
DB00328 Indomethacin
DB00244 Mesalazine
DB01252 Mitiglinide
DB00731 Nateglinide
DB01132 Pioglitazone
DB04971 Reglixane
DB00912 Repaglinide
DB00412 Rosiglitazone
DB00795 Sulfasalazine
DB05490 T131
DB00966 Telmisartan
DB00197 Troglitazone
GuidetoPHARMACOLOGYi595
SwissLipidsiSLP:000000396

Protein family/group databases

MoonDBiP37231 Predicted

PTM databases

iPTMnetiP37231
PhosphoSitePlusiP37231

Polymorphism and mutation databases

BioMutaiPPARG
DMDMi13432234

Proteomic databases

EPDiP37231
MaxQBiP37231
PaxDbiP37231
PeptideAtlasiP37231
PRIDEiP37231
ProteomicsDBi55267
55268 [P37231-2]
55269 [P37231-3]

Protocols and materials databases

DNASUi5468
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287820; ENSP00000287820; ENSG00000132170 [P37231-1]
ENST00000309576; ENSP00000312472; ENSG00000132170 [P37231-2]
ENST00000396999; ENSP00000380195; ENSG00000132170 [P37231-3]
ENST00000397010; ENSP00000380205; ENSG00000132170 [P37231-2]
ENST00000397012; ENSP00000380207; ENSG00000132170 [P37231-2]
ENST00000397015; ENSP00000380210; ENSG00000132170 [P37231-2]
ENST00000643197; ENSP00000495840; ENSG00000132170 [P37231-2]
ENST00000643888; ENSP00000494934; ENSG00000132170 [P37231-2]
ENST00000644622; ENSP00000494873; ENSG00000132170 [P37231-2]
GeneIDi5468
KEGGihsa:5468
UCSCiuc003bwr.4 human [P37231-1]

Organism-specific databases

CTDi5468
DisGeNETi5468
EuPathDBiHostDB:ENSG00000132170.19
GeneCardsiPPARG
HGNCiHGNC:9236 PPARG
HPAiCAB004282
HPA051239
HPA063663
MalaCardsiPPARG
MIMi137800 phenotype
601487 gene
601665 phenotype
604367 phenotype
606641 phenotype
609338 phenotype
neXtProtiNX_P37231
OpenTargetsiENSG00000132170
Orphaneti528 Berardinelli-Seip congenital lipodystrophy
146 Differentiated thyroid carcinoma
251579 Giant cell glioblastoma
251576 Gliosarcoma
79083 PPARG-related familial partial lipodystrophy
PharmGKBiPA281
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136388
HOGENOMiHOG000119407
HOVERGENiHBG082808
InParanoidiP37231
KOiK08530
OMAiQRCQFRS
OrthoDBiEOG091G05U8
PhylomeDBiP37231
TreeFamiTF316304

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-8943724 Regulation of PTEN gene transcription
SignaLinkiP37231
SIGNORiP37231

Miscellaneous databases

ChiTaRSiPPARG human
EvolutionaryTraceiP37231
GeneWikiiPeroxisome_proliferator-activated_receptor_gamma
GenomeRNAii5468
PROiPR:P37231
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000132170 Expressed in 136 organ(s), highest expression level in subcutaneous adipose tissue
ExpressionAtlasiP37231 baseline and differential
GenevisibleiP37231 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003074 1Cnucl_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003077 PPAR-gamma
IPR022590 PPARgamma_N
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF12577 PPARgamma_N, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01288 PROXISOMEPAR
PR01291 PROXISOMPAGR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPPARG_HUMAN
AccessioniPrimary (citable) accession number: P37231
Secondary accession number(s): A8K3G6
, B5BUA1, O00684, O00710, O14515, Q0QJH8, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 27, 2001
Last modified: November 7, 2018
This is version 248 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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