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Protein

Peroxisome proliferator-activated receptor gamma

Gene

PPARG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity).By similarity4 Publications
(Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein.1 Publication

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

PDPK1 activates its transcriptional activity independently of its kinase activity.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei317Synthetic agonist9 Publications1
Binding sitei351Synthetic agonist9 Publications1
Binding sitei477Synthetic agonist9 Publications1
Binding sitei501Synthetic agonist9 Publications1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi136 – 210Nuclear receptorPROSITE-ProRule annotationAdd BLAST75
<p>This subsection of the ‘Function’ section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri176 – 198NR C4-typePROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Receptor
Biological processBiological rhythms, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-9022707 MECP2 regulates transcription factors

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
P37231

SIGNOR Signaling Network Open Resource

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SIGNORi
P37231

Protein family/group databases

MoonDB Database of extreme multifunctional and moonlighting proteins

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MoonDBi
P37231 Predicted

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...
SwissLipidsi
SLP:000000396

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisome proliferator-activated receptor gamma
Short name:
PPAR-gamma
Alternative name(s):
Nuclear receptor subfamily 1 group C member 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PPARG
Synonyms:NR1C3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000132170.19

Human Gene Nomenclature Database

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HGNCi
HGNC:9236 PPARG

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601487 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P37231

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in PPARG can lead to type 2 insulin-resistant diabetes and hyptertension. PPARG mutations may be associated with colon cancer.1 Publication
Obesity (OBESITY)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry.
Disease descriptionA condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
See also OMIM:601665
Lipodystrophy, familial partial, 3 (FPLD3)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of lipodystrophy characterized by marked loss of subcutaneous fat from the extremities. Facial adipose tissue may be increased, decreased or normal. Affected individuals show an increased preponderance of insulin resistance, diabetes mellitus and dyslipidemia.
See also OMIM:604367
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_022700388F → L in FPLD3. 1 PublicationCorresponds to variant dbSNP:rs72551363Ensembl.1
Natural variantiVAR_022701425R → C in FPLD3. 1 PublicationCorresponds to variant dbSNP:rs72551364Ensembl.1
Glioma 1 (GLM1)1 Publication
Disease susceptibility may be associated with variations affecting the gene represented in this entry. Polymorphic PPARG alleles have been found to be significantly over-represented among a cohort of American patients with sporadic glioblastoma multiforme suggesting a possible contribution to disease susceptibility.
Disease descriptionGliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes.
See also OMIM:137800

Keywords - Diseasei

Diabetes mellitus, Disease mutation, Obesity

Organism-specific databases

DisGeNET

More...
DisGeNETi
5468

MalaCards human disease database

More...
MalaCardsi
PPARG
MIMi137800 phenotype
601665 phenotype
604367 phenotype
606641 phenotype
609338 phenotype

Open Targets

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OpenTargetsi
ENSG00000132170

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
528 Berardinelli-Seip congenital lipodystrophy
146 Differentiated thyroid carcinoma
251579 Giant cell glioblastoma
251576 Gliosarcoma
79083 PPARG-related familial partial lipodystrophy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA281

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL235

Drug and drug target database

More...
DrugBanki
DB08760 (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid
DB07842 (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
DB08121 (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
DB07675 (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
DB04270 (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid
DB07863 2-chloro-5-nitro-N-phenylbenzamide
DB04689 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
DB07053 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
DB07723 3-(5-methoxy-1H-indol-3-yl)propanoic acid
DB08302 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
DB08560 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
DB07724 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
DB08915 Aleglitazar
DB01014 Balsalazide
DB01393 Bezafibrate
DB05854 CLX-0921
DB07509 difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron
DB05187 GFT505
DB01067 Glipizide
DB01050 Ibuprofen
DB00159 Icosapent
DB00328 Indomethacin
DB00244 Mesalazine
DB01252 Mitiglinide
DB00731 Nateglinide
DB01132 Pioglitazone
DB04971 Reglixane
DB00912 Repaglinide
DB00412 Rosiglitazone
DB00795 Sulfasalazine
DB05490 T131
DB00966 Telmisartan
DB00197 Troglitazone

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
595

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
PPARG

Domain mapping of disease mutations (DMDM)

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DMDMi
13432234

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000534921 – 505Peroxisome proliferator-activated receptor gammaAdd BLAST505

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi84O-linked (GlcNAc) threonineBy similarity1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei112PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-GlcNAcylation at Thr-84 reduces transcriptional activity in adipocytes.By similarity
Phosphorylated in basal conditions and dephosphorylated when treated with the ligand. May be dephosphorylated by PPP5C. The phosphorylated form may be inactive and dephosphorylation at Ser-112 induces adipogenic activity (By similarity).By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P37231

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
P37231

MaxQB - The MaxQuant DataBase

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MaxQBi
P37231

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P37231

PeptideAtlas

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PeptideAtlasi
P37231

PRoteomics IDEntifications database

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PRIDEi
P37231

ProteomicsDB human proteome resource

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ProteomicsDBi
55267
55268 [P37231-2]
55269 [P37231-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P37231

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P37231

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

(Microbial infection) Expression increases when incubated with M.tuberculosis or its lipoprotein LpqH; induction is TLR2-dependent (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000132170 Expressed in 136 organ(s), highest expression level in subcutaneous adipose tissue

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P37231 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P37231 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB004282
HPA051239
HPA063663

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with FOXO1 (acetylated form) (By similarity). Heterodimer with other nuclear receptors, such as RXRA. The heterodimer with the retinoic acid receptor RXRA is called adipocyte-specific transcription factor ARF6. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Interacts with coactivator PPARBP, leading to a mild increase in transcription of target genes. Interacts with NOCA7 in a ligand-inducible manner. Interacts with NCOA1 and NCOA2 LXXLL motifs. Interacts with ASXL1, ASXL2, DNTTIP2, FAM120B, MAP2K1/MEK1, NR0B2, PDPK1, PRDM16, PRMT2 and TGFB1I1. Interacts (when activated by agonist) with PPP5C. Interacts with HELZ2 and THRAP3; the interaction stimulates the transcriptional activity of PPARG. Interacts with PER2, the interaction is ligand dependent and blocks PPARG recruitment to target promoters. Interacts with NOCT. Interacts with ACTN4. Interacts (when in the liganded conformation) with GPS2 (By similarity).By similarity21 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
111464, 139 interactors

ComplexPortal: manually curated resource of macromolecular complexes

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ComplexPortali
CPX-702 PPARgamma-NCOA2 activated nuclear receptor complex
CPX-711 PPARgamma-NCOA1 activated nuclear receptor complex

Database of interacting proteins

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DIPi
DIP-35528N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
P37231

Protein interaction database and analysis system

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IntActi
P37231, 40 interactors

Molecular INTeraction database

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MINTi
P37231

STRING: functional protein association networks

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STRINGi
9606.ENSP00000287820

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P37231

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1505
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FM6X-ray2.10D/X234-505[»]
1FM9X-ray2.10D234-505[»]
1I7IX-ray2.35A/B225-505[»]
1K74X-ray2.30D234-505[»]
1KNUX-ray2.50A/B232-505[»]
1NYXX-ray2.65A/B230-505[»]
1PRGX-ray2.20A/B235-504[»]
1RDTX-ray2.40D235-505[»]
1WM0X-ray2.90X232-505[»]
1ZEOX-ray2.50A/B231-505[»]
1ZGYX-ray1.80A234-505[»]
2ATHX-ray2.28A/B235-505[»]
2F4BX-ray2.07A/B235-505[»]
2FVJX-ray1.99A235-505[»]
2G0GX-ray2.54A/B235-505[»]
2G0HX-ray2.30A/B235-505[»]
2GTKX-ray2.10A235-505[»]
2HFPX-ray2.00A234-505[»]
2HWQX-ray1.97A/B235-505[»]
2HWRX-ray2.34A/B235-505[»]
2I4JX-ray2.10A/B223-504[»]
2I4PX-ray2.10A/B223-504[»]
2I4ZX-ray2.25A/B223-504[»]
2OM9X-ray2.80A/B/C/D232-505[»]
2P4YX-ray2.25A/B231-505[»]
2POBX-ray2.30A/B234-505[»]
2PRGX-ray2.30A/B235-505[»]
2Q59X-ray2.20A/B233-505[»]
2Q5PX-ray2.30A/B233-505[»]
2Q5SX-ray2.05A/B233-505[»]
2Q61X-ray2.20A/B233-505[»]
2Q6RX-ray2.41A/B233-505[»]
2Q6SX-ray2.40A/B233-505[»]
2Q8SX-ray2.30A/B235-505[»]
2QMVNMR-A235-504[»]
2VSRX-ray2.05A/B232-505[»]
2VSTX-ray2.35A/B232-505[»]
2VV0X-ray2.55A/B232-505[»]
2VV1X-ray2.20A/B232-505[»]
2VV2X-ray2.75A/B232-505[»]
2VV3X-ray2.85A/B232-505[»]
2VV4X-ray2.35A/B232-505[»]
2XKWX-ray2.02A/B232-505[»]
2YFEX-ray2.00A/B223-505[»]
2ZK0X-ray2.36A/B223-504[»]
2ZK1X-ray2.61A/B223-504[»]
2ZK2X-ray2.26A/B223-504[»]
2ZK3X-ray2.58A/B223-504[»]
2ZK4X-ray2.57A/B223-504[»]
2ZK5X-ray2.45A/B223-504[»]
2ZK6X-ray2.41A/B223-504[»]
2ZNOX-ray2.40A/B223-504[»]
2ZVTX-ray1.90A/B223-504[»]
3ADSX-ray2.25A/B223-505[»]
3ADTX-ray2.70A/B223-505[»]
3ADUX-ray2.77A/B223-505[»]
3ADVX-ray2.27A/B223-505[»]
3ADWX-ray2.07A/B223-505[»]
3ADXX-ray1.95A/B223-505[»]
3AN3X-ray2.30A/B223-504[»]
3AN4X-ray2.30A/B223-504[»]
3B0QX-ray2.10A/B231-504[»]
3B0RX-ray2.15A/B231-504[»]
3B1MX-ray1.60A234-505[»]
3B3KX-ray2.60A/B223-504[»]
3BC5X-ray2.27A231-505[»]
3CDPX-ray2.80A/B223-504[»]
3CDSX-ray2.65A/B223-504[»]
3CS8X-ray2.30A234-504[»]
3CWDX-ray2.40A/B236-505[»]
3D6DX-ray2.40A/B223-504[»]
3DZUX-ray3.20D102-505[»]
3DZYX-ray3.10D102-505[»]
3E00X-ray3.10D102-505[»]
3ET0X-ray2.40A/B235-505[»]
3ET3X-ray1.95A235-505[»]
3FEJX-ray2.01A235-505[»]
3FURX-ray2.30A234-505[»]
3G9EX-ray2.30A235-505[»]
3GBKX-ray2.30A/B235-505[»]
3H0AX-ray2.10D234-505[»]
3HO0X-ray2.60A/B223-504[»]
3HODX-ray2.10A/B223-504[»]
3IA6X-ray2.31A/B235-505[»]
3K8SX-ray2.55A/B234-505[»]
3KMGX-ray2.10A/D234-505[»]
3LMPX-ray1.90A234-505[»]
3NOAX-ray1.98A/B235-505[»]
3OSIX-ray2.70A/B224-504[»]
3OSWX-ray2.55A/B224-504[»]
3PBAX-ray2.30A/B224-505[»]
3PO9X-ray2.35A/B224-505[»]
3PRGX-ray2.90A232-505[»]
3QT0X-ray2.50A235-505[»]
3R5NX-ray2.00A232-505[»]
3R8AX-ray2.41A/B235-505[»]
3R8IX-ray2.30A/B223-505[»]
3S9SX-ray2.55A234-505[»]
3SZ1X-ray2.30A/B232-505[»]
3T03X-ray2.10A/B234-505[»]
3TY0X-ray2.00A/B231-505[»]
3U9QX-ray1.52A236-504[»]
3V9TX-ray1.65A234-505[»]
3V9VX-ray1.60A234-505[»]
3V9YX-ray2.10A234-505[»]
3VJHX-ray2.22A/B223-504[»]
3VJIX-ray2.61A/B223-504[»]
3VN2X-ray2.18A225-505[»]
3VSOX-ray2.00A/B223-504[»]
3VSPX-ray2.40A/B223-504[»]
3WJ4X-ray1.95A/B235-505[»]
3WJ5X-ray1.89A/B235-505[»]
3WMHX-ray2.10A/B223-504[»]
3X1HX-ray2.30A/B232-505[»]
3X1IX-ray2.40A/B232-505[»]
4A4VX-ray2.00A/B223-505[»]
4A4WX-ray2.00A/B223-505[»]
4CI5X-ray1.77A/B234-505[»]
4E4KX-ray2.50A/B223-505[»]
4E4QX-ray2.50A/B223-505[»]
4EM9X-ray2.10A/B235-505[»]
4EMAX-ray2.54A/B235-505[»]
4F9MX-ray1.90A234-505[»]
4FGYX-ray2.84A235-504[»]
4HEEX-ray2.50X235-505[»]
4JAZX-ray2.85A/B223-505[»]
4JL4X-ray2.50A/B223-505[»]
4L96X-ray2.38A235-505[»]
4L98X-ray2.28A/B235-505[»]
4O8FX-ray2.60A/B223-505[»]
4OJ4X-ray2.30A232-505[»]
4PRGX-ray2.90A/B/C/D235-504[»]
4PVUX-ray2.60A/B223-505[»]
4PWLX-ray2.60A/B223-505[»]
4R06X-ray2.22A/B233-505[»]
4R2UX-ray2.30A/D231-505[»]
4R6SX-ray2.30A/B231-505[»]
4XLDX-ray2.45A231-505[»]
4XTAX-ray2.50A/B232-505[»]
4XUHX-ray2.22A/B232-505[»]
4XUMX-ray2.40A/B232-505[»]
4Y29X-ray1.98A236-504[»]
4YT1X-ray2.20A/B223-504[»]
5AZVX-ray2.70A/B232-505[»]
5DSHX-ray2.95A223-505[»]
5DV3X-ray2.75A223-505[»]
5DV6X-ray2.80A223-505[»]
5DV8X-ray2.75A223-505[»]
5DVCX-ray2.30A223-505[»]
5DWLX-ray2.20A223-505[»]
5F9BX-ray2.25A/B223-505[»]
5GTNX-ray1.85A223-505[»]
5GTOX-ray2.10A223-505[»]
5GTPX-ray2.35A223-505[»]
5HZCX-ray2.00A/B223-505[»]
5JI0X-ray1.98D234-505[»]
5LSGX-ray2.00A/B223-505[»]
5TTOX-ray2.25A/B233-505[»]
5TWOX-ray1.93A234-505[»]
5U5LX-ray2.55A/B233-505[»]
5UGMX-ray2.10A/B235-505[»]
5WQXX-ray2.29A/B232-505[»]
5WR0X-ray2.85A/B232-505[»]
5WR1X-ray2.34A/B232-505[»]
5Y2OX-ray1.80A/B235-505[»]
5Y2TX-ray1.70A/B235-505[»]
5YCNX-ray2.15A223-505[»]
5YCPX-ray2.00A223-505[»]
5Z5SX-ray1.80A234-505[»]
5Z6SX-ray1.80A234-505[»]
6AD9X-ray2.20A223-505[»]
6AN1X-ray2.69A/B224-505[»]
6AUGX-ray2.73A/B231-505[»]
6AVIX-ray2.29A/B231-505[»]
6C5QX-ray2.40A235-505[»]
6C5TX-ray2.75A235-505[»]
6ENQX-ray2.20A/B224-505[»]
6F2LX-ray2.10A/B223-505[»]

Database of protein disorder

More...
DisProti
DP00718

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P37231

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P37231

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P37231

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini238 – 503NR LBDPROSITE-ProRule annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni205 – 280Interaction with FAM120BBy similarityAdd BLAST76

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri139 – 159NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri176 – 198NR C4-typePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3575 Eukaryota
ENOG410XRZC LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000158273

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000119407

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG082808

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P37231

KEGG Orthology (KO)

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KOi
K08530

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRCQFRS

Database of Orthologous Groups

More...
OrthoDBi
492485at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P37231

TreeFam database of animal gene trees

More...
TreeFami
TF316304

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.50.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003074 1Cnucl_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003077 PPAR-gamma
IPR022590 PPARgamma_N
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00104 Hormone_recep, 1 hit
PF12577 PPARgamma_N, 1 hit
PF00105 zf-C4, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01288 PROXISOMEPAR
PR01291 PROXISOMPAGR
PR00398 STRDHORMONER
PR00047 STROIDFINGER

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48508 SSF48508, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: P37231-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGETLGDSPI DPESDSFTDT LSANISQEMT MVDTEMPFWP TNFGISSVDL
60 70 80 90 100
SVMEDHSHSF DIKPFTTVDF SSISTPHYED IPFTRTDPVV ADYKYDLKLQ
110 120 130 140 150
EYQSAIKVEP ASPPYYSEKT QLYNKPHEEP SNSLMAIECR VCGDKASGFH
160 170 180 190 200
YGVHACEGCK GFFRRTIRLK LIYDRCDLNC RIHKKSRNKC QYCRFQKCLA
210 220 230 240 250
VGMSHNAIRF GRMPQAEKEK LLAEISSDID QLNPESADLR ALAKHLYDSY
260 270 280 290 300
IKSFPLTKAK ARAILTGKTT DKSPFVIYDM NSLMMGEDKI KFKHITPLQE
310 320 330 340 350
QSKEVAIRIF QGCQFRSVEA VQEITEYAKS IPGFVNLDLN DQVTLLKYGV
360 370 380 390 400
HEIIYTMLAS LMNKDGVLIS EGQGFMTREF LKSLRKPFGD FMEPKFEFAV
410 420 430 440 450
KFNALELDDS DLAIFIAVII LSGDRPGLLN VKPIEDIQDN LLQALELQLK
460 470 480 490 500
LNHPESSQLF AKLLQKMTDL RQIVTEHVQL LQVIKKTETD MSLHPLLQEI

YKDLY
Length:505
Mass (Da):57,620
Last modified:April 27, 2001 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3933EFF36A0E4CAF
GO
Isoform 1 (identifier: P37231-2) [UniParc]FASTAAdd to basket
Also known as: PPARgamma1(wt)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:477
Mass (Da):54,681
Checksum:i1061C2074B739E0A
GO
Isoform 3 (identifier: P37231-3) [UniParc]FASTAAdd to basket
Also known as: PPARgamma1(tr)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.
     207-213: AIRFGRM → EELQKDS
     214-504: Missing.

Note: Exhibits dominant negative activity over isoform 1.
Show »
Length:186
Mass (Da):21,580
Checksum:i10E780305F860A5D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PFV2E9PFV2_HUMAN
Peroxisome proliferator-activated r...
PPARG
483Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFX5E9PFX5_HUMAN
Peroxisome proliferator-activated r...
PPARG
250Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EUD1E7EUD1_HUMAN
Peroxisome proliferator-activated r...
PPARG
132Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EU07E7EU07_HUMAN
Peroxisome proliferator-activated r...
PPARG
99Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFJ1E9PFJ1_HUMAN
Peroxisome proliferator-activated r...
PPARG
43Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PFV3E9PFV3_HUMAN
Peroxisome proliferator-activated r...
PPARG
40Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAN38992 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA23354 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF83270 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA62153 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti36 – 37MP → IA in BAA18949 (PubMed:9144532).Curated2
Sequence conflicti213 – 214MP → IA in BAA18949 (PubMed:9144532).Curated2
Sequence conflicti240R → RQ in BAA18949 (PubMed:9144532).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Genetic variations in PPARG define the body mass index quantitative trait locus 1 (BMIQ1) [MIMi:606641]. The body max index (BMI) reflects the amount of fat, lean mass, and body build.2 Publications
Genetic variations in PPARG influence the carotid intimal medial thickness (CIMT) [MIMi:609338]. CIMT is a measure of atherosclerosis that is independently associated with traditional atherosclerotic cardiovascular disease risk factors and coronary atherosclerotic burden. 35 to 45% of the variability in multivariable-adjusted CIMT is explained by genetic factors.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01072312P → A Polymorphism; significant independent determinant of CIMT; may protect from early atherosclerosis in subject at risk for diabetes; associated with BMI. 5 PublicationsCorresponds to variant dbSNP:rs1801282EnsemblClinVar.1
Natural variantiVAR_01611640P → A. Corresponds to variant dbSNP:rs1805192Ensembl.1
Natural variantiVAR_010724113P → Q in obesity. 1 PublicationCorresponds to variant dbSNP:rs1800571Ensembl.1
Natural variantiVAR_010725314Q → P in colon cancer; sporadic; somatic mutation; loss of ligand-binding. 1 PublicationCorresponds to variant dbSNP:rs121909242Ensembl.1
Natural variantiVAR_010726316R → H in colon cancer; sporadic; somatic mutation; partial loss of ligand-binding. 1 PublicationCorresponds to variant dbSNP:rs28936407Ensembl.1
Natural variantiVAR_010727318V → M in diabetes. 1 PublicationCorresponds to variant dbSNP:rs72551362Ensembl.1
Natural variantiVAR_022700388F → L in FPLD3. 1 PublicationCorresponds to variant dbSNP:rs72551363Ensembl.1
Natural variantiVAR_022701425R → C in FPLD3. 1 PublicationCorresponds to variant dbSNP:rs72551364Ensembl.1
Natural variantiVAR_010728495P → L in diabetes. 1 PublicationCorresponds to variant dbSNP:rs121909244EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0036451 – 28Missing in isoform 1 and isoform 3. 7 PublicationsAdd BLAST28
Alternative sequenceiVSP_043906207 – 213AIRFGRM → EELQKDS in isoform 3. 1 Publication7
Alternative sequenceiVSP_043907214 – 504Missing in isoform 3. 1 PublicationAdd BLAST291

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U79012 mRNA Translation: AAC51248.1
U63415 mRNA Translation: AAB04028.1
D83233 mRNA Translation: BAA18949.1
L40904 mRNA Translation: AAA80314.2
AB005526 Genomic DNA Translation: BAA23354.1 Sequence problems.
X90563 mRNA Translation: CAA62152.1
X90563 mRNA Translation: CAA62153.1 Different initiation.
DQ356894 mRNA Translation: ABC97372.1
BT007281 mRNA Translation: AAP35945.1
AK290581 mRNA Translation: BAF83270.1 Different initiation.
AB451337 mRNA Translation: BAG70151.1
AB451486 mRNA Translation: BAG70300.1
AY157024 Genomic DNA Translation: AAN38992.2 Different initiation.
AC090947 Genomic DNA No translation available.
AC091492 Genomic DNA No translation available.
AC093174 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64124.1
BC006811 mRNA Translation: AAH06811.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2609.1 [P37231-1]
CCDS2610.2 [P37231-2]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4859
PC4290
PC4429

NCBI Reference Sequences

More...
RefSeqi
NP_005028.4, NM_005037.5 [P37231-2]
NP_056953.2, NM_015869.4 [P37231-1]
NP_619725.2, NM_138711.3 [P37231-2]
NP_619726.2, NM_138712.3 [P37231-2]
XP_011532143.1, XM_011533841.2

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.162646
Hs.655798

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000287820; ENSP00000287820; ENSG00000132170 [P37231-1]
ENST00000309576; ENSP00000312472; ENSG00000132170 [P37231-2]
ENST00000396999; ENSP00000380195; ENSG00000132170 [P37231-3]
ENST00000397010; ENSP00000380205; ENSG00000132170 [P37231-2]
ENST00000397012; ENSP00000380207; ENSG00000132170 [P37231-2]
ENST00000397015; ENSP00000380210; ENSG00000132170 [P37231-2]
ENST00000643197; ENSP00000495840; ENSG00000132170 [P37231-2]
ENST00000643888; ENSP00000494934; ENSG00000132170 [P37231-2]
ENST00000644622; ENSP00000494873; ENSG00000132170 [P37231-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5468

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5468

UCSC genome browser

More...
UCSCi
uc003bwr.4 human [P37231-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
Wikipedia

Peroxisome proliferator-activated receptor entry

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U79012 mRNA Translation: AAC51248.1
U63415 mRNA Translation: AAB04028.1
D83233 mRNA Translation: BAA18949.1
L40904 mRNA Translation: AAA80314.2
AB005526 Genomic DNA Translation: BAA23354.1 Sequence problems.
X90563 mRNA Translation: CAA62152.1
X90563 mRNA Translation: CAA62153.1 Different initiation.
DQ356894 mRNA Translation: ABC97372.1
BT007281 mRNA Translation: AAP35945.1
AK290581 mRNA Translation: BAF83270.1 Different initiation.
AB451337 mRNA Translation: BAG70151.1
AB451486 mRNA Translation: BAG70300.1
AY157024 Genomic DNA Translation: AAN38992.2 Different initiation.
AC090947 Genomic DNA No translation available.
AC091492 Genomic DNA No translation available.
AC093174 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64124.1
BC006811 mRNA Translation: AAH06811.1
CCDSiCCDS2609.1 [P37231-1]
CCDS2610.2 [P37231-2]
PIRiJC4859
PC4290
PC4429
RefSeqiNP_005028.4, NM_005037.5 [P37231-2]
NP_056953.2, NM_015869.4 [P37231-1]
NP_619725.2, NM_138711.3 [P37231-2]
NP_619726.2, NM_138712.3 [P37231-2]
XP_011532143.1, XM_011533841.2
UniGeneiHs.162646
Hs.655798

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FM6X-ray2.10D/X234-505[»]
1FM9X-ray2.10D234-505[»]
1I7IX-ray2.35A/B225-505[»]
1K74X-ray2.30D234-505[»]
1KNUX-ray2.50A/B232-505[»]
1NYXX-ray2.65A/B230-505[»]
1PRGX-ray2.20A/B235-504[»]
1RDTX-ray2.40D235-505[»]
1WM0X-ray2.90X232-505[»]
1ZEOX-ray2.50A/B231-505[»]
1ZGYX-ray1.80A234-505[»]
2ATHX-ray2.28A/B235-505[»]
2F4BX-ray2.07A/B235-505[»]
2FVJX-ray1.99A235-505[»]
2G0GX-ray2.54A/B235-505[»]
2G0HX-ray2.30A/B235-505[»]
2GTKX-ray2.10A235-505[»]
2HFPX-ray2.00A234-505[»]
2HWQX-ray1.97A/B235-505[»]
2HWRX-ray2.34A/B235-505[»]
2I4JX-ray2.10A/B223-504[»]
2I4PX-ray2.10A/B223-504[»]
2I4ZX-ray2.25A/B223-504[»]
2OM9X-ray2.80A/B/C/D232-505[»]
2P4YX-ray2.25A/B231-505[»]
2POBX-ray2.30A/B234-505[»]
2PRGX-ray2.30A/B235-505[»]
2Q59X-ray2.20A/B233-505[»]
2Q5PX-ray2.30A/B233-505[»]
2Q5SX-ray2.05A/B233-505[»]
2Q61X-ray2.20A/B233-505[»]
2Q6RX-ray2.41A/B233-505[»]
2Q6SX-ray2.40A/B233-505[»]
2Q8SX-ray2.30A/B235-505[»]
2QMVNMR-A235-504[»]
2VSRX-ray2.05A/B232-505[»]
2VSTX-ray2.35A/B232-505[»]
2VV0X-ray2.55A/B232-505[»]
2VV1X-ray2.20A/B232-505[»]
2VV2X-ray2.75A/B232-505[»]
2VV3X-ray2.85A/B232-505[»]
2VV4X-ray2.35A/B232-505[»]
2XKWX-ray2.02A/B232-505[»]
2YFEX-ray2.00A/B223-505[»]
2ZK0X-ray2.36A/B223-504[»]
2ZK1X-ray2.61A/B223-504[»]
2ZK2X-ray2.26A/B223-504[»]
2ZK3X-ray2.58A/B223-504[»]
2ZK4X-ray2.57A/B223-504[»]
2ZK5X-ray2.45A/B223-504[»]
2ZK6X-ray2.41A/B223-504[»]
2ZNOX-ray2.40A/B223-504[»]
2ZVTX-ray1.90A/B223-504[»]
3ADSX-ray2.25A/B223-505[»]
3ADTX-ray2.70A/B223-505[»]
3ADUX-ray2.77A/B223-505[»]
3ADVX-ray2.27A/B223-505[»]
3ADWX-ray2.07A/B223-505[»]
3ADXX-ray1.95A/B223-505[»]
3AN3X-ray2.30A/B223-504[»]
3AN4X-ray2.30A/B223-504[»]
3B0QX-ray2.10A/B231-504[»]
3B0RX-ray2.15A/B231-504[»]
3B1MX-ray1.60A234-505[»]
3B3KX-ray2.60A/B223-504[»]
3BC5X-ray2.27A231-505[»]
3CDPX-ray2.80A/B223-504[»]
3CDSX-ray2.65A/B223-504[»]
3CS8X-ray2.30A234-504[»]
3CWDX-ray2.40A/B236-505[»]
3D6DX-ray2.40A/B223-504[»]
3DZUX-ray3.20D102-505[»]
3DZYX-ray3.10D102-505[»]
3E00X-ray3.10D102-505[»]
3ET0X-ray2.40A/B235-505[»]
3ET3X-ray1.95A235-505[»]
3FEJX-ray2.01A235-505[»]
3FURX-ray2.30A234-505[»]
3G9EX-ray2.30A235-505[»]
3GBKX-ray2.30A/B235-505[»]
3H0AX-ray2.10D234-505[»]
3HO0X-ray2.60A/B223-504[»]
3HODX-ray2.10A/B223-504[»]
3IA6X-ray2.31A/B235-505[»]
3K8SX-ray2.55A/B234-505[»]
3KMGX-ray2.10A/D234-505[»]
3LMPX-ray1.90A234-505[»]
3NOAX-ray1.98A/B235-505[»]
3OSIX-ray2.70A/B224-504[»]
3OSWX-ray2.55A/B224-504[»]
3PBAX-ray2.30A/B224-505[»]
3PO9X-ray2.35A/B224-505[»]
3PRGX-ray2.90A232-505[»]
3QT0X-ray2.50A235-505[»]
3R5NX-ray2.00A232-505[»]
3R8AX-ray2.41A/B235-505[»]
3R8IX-ray2.30A/B223-505[»]
3S9SX-ray2.55A234-505[»]
3SZ1X-ray2.30A/B232-505[»]
3T03X-ray2.10A/B234-505[»]
3TY0X-ray2.00A/B231-505[»]
3U9QX-ray1.52A236-504[»]
3V9TX-ray1.65A234-505[»]
3V9VX-ray1.60A234-505[»]
3V9YX-ray2.10A234-505[»]
3VJHX-ray2.22A/B223-504[»]
3VJIX-ray2.61A/B223-504[»]
3VN2X-ray2.18A225-505[»]
3VSOX-ray2.00A/B223-504[»]
3VSPX-ray2.40A/B223-504[»]
3WJ4X-ray1.95A/B235-505[»]
3WJ5X-ray1.89A/B235-505[»]
3WMHX-ray2.10A/B223-504[»]
3X1HX-ray2.30A/B232-505[»]
3X1IX-ray2.40A/B232-505[»]
4A4VX-ray2.00A/B223-505[»]
4A4WX-ray2.00A/B223-505[»]
4CI5X-ray1.77A/B234-505[»]
4E4KX-ray2.50A/B223-505[»]
4E4QX-ray2.50A/B223-505[»]
4EM9X-ray2.10A/B235-505[»]
4EMAX-ray2.54A/B235-505[»]
4F9MX-ray1.90A234-505[»]
4FGYX-ray2.84A235-504[»]
4HEEX-ray2.50X235-505[»]
4JAZX-ray2.85A/B223-505[»]
4JL4X-ray2.50A/B223-505[»]
4L96X-ray2.38A235-505[»]
4L98X-ray2.28A/B235-505[»]
4O8FX-ray2.60A/B223-505[»]
4OJ4X-ray2.30A232-505[»]
4PRGX-ray2.90A/B/C/D235-504[»]
4PVUX-ray2.60A/B223-505[»]
4PWLX-ray2.60A/B223-505[»]
4R06X-ray2.22A/B233-505[»]
4R2UX-ray2.30A/D231-505[»]
4R6SX-ray2.30A/B231-505[»]
4XLDX-ray2.45A231-505[»]
4XTAX-ray2.50A/B232-505[»]
4XUHX-ray2.22A/B232-505[»]
4XUMX-ray2.40A/B232-505[»]
4Y29X-ray1.98A236-504[»]
4YT1X-ray2.20A/B223-504[»]
5AZVX-ray2.70A/B232-505[»]
5DSHX-ray2.95A223-505[»]
5DV3X-ray2.75A223-505[»]
5DV6X-ray2.80A223-505[»]
5DV8X-ray2.75A223-505[»]
5DVCX-ray2.30A223-505[»]
5DWLX-ray2.20A223-505[»]
5F9BX-ray2.25A/B223-505[»]
5GTNX-ray1.85A223-505[»]
5GTOX-ray2.10A223-505[»]
5GTPX-ray2.35A223-505[»]
5HZCX-ray2.00A/B223-505[»]
5JI0X-ray1.98D234-505[»]
5LSGX-ray2.00A/B223-505[»]
5TTOX-ray2.25A/B233-505[»]
5TWOX-ray1.93A234-505[»]
5U5LX-ray2.55A/B233-505[»]
5UGMX-ray2.10A/B235-505[»]
5WQXX-ray2.29A/B232-505[»]
5WR0X-ray2.85A/B232-505[»]
5WR1X-ray2.34A/B232-505[»]
5Y2OX-ray1.80A/B235-505[»]
5Y2TX-ray1.70A/B235-505[»]
5YCNX-ray2.15A223-505[»]
5YCPX-ray2.00A223-505[»]
5Z5SX-ray1.80A234-505[»]
5Z6SX-ray1.80A234-505[»]
6AD9X-ray2.20A223-505[»]
6AN1X-ray2.69A/B224-505[»]
6AUGX-ray2.73A/B231-505[»]
6AVIX-ray2.29A/B231-505[»]
6C5QX-ray2.40A235-505[»]
6C5TX-ray2.75A235-505[»]
6ENQX-ray2.20A/B224-505[»]
6F2LX-ray2.10A/B223-505[»]
DisProtiDP00718
ProteinModelPortaliP37231
SMRiP37231
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111464, 139 interactors
ComplexPortaliCPX-702 PPARgamma-NCOA2 activated nuclear receptor complex
CPX-711 PPARgamma-NCOA1 activated nuclear receptor complex
DIPiDIP-35528N
ELMiP37231
IntActiP37231, 40 interactors
MINTiP37231
STRINGi9606.ENSP00000287820

Chemistry databases

BindingDBiP37231
ChEMBLiCHEMBL235
DrugBankiDB08760 (2S)-2-(4-chlorophenoxy)-3-phenylpropanoic acid
DB07842 (2S)-2-(4-ethylphenoxy)-3-phenylpropanoic acid
DB08121 (2S)-2-(biphenyl-4-yloxy)-3-phenylpropanoic acid
DB07675 (2S)-2-ETHOXY-3-{4-[2-(10H-PHENOXAZIN-10-YL)ETHOXY]PHENYL}PROPANOIC ACID
DB04270 (S)-3-(4-(2-Carbazol-9-Yl-Ethoxy)-Phenyl)-2-Ethoxy-Propionic Acid
DB07863 2-chloro-5-nitro-N-phenylbenzamide
DB04689 2-{5-[3-(6-BENZOYL-1-PROPYLNAPHTHALEN-2-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
DB07053 2-{5-[3-(7-PROPYL-3-TRIFLUOROMETHYLBENZO[D]ISOXAZOL-6-YLOXY)PROPOXY]INDOL-1-YL}ETHANOIC ACID
DB07723 3-(5-methoxy-1H-indol-3-yl)propanoic acid
DB08302 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid
DB08560 3-FLUORO-N-[1-(4-FLUOROPHENYL)-3-(2-THIENYL)-1H-PYRAZOL-5-YL]BENZENESULFONAMIDE
DB07724 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid
DB08915 Aleglitazar
DB01014 Balsalazide
DB01393 Bezafibrate
DB05854 CLX-0921
DB07509 difluoro(5-{2-[(5-octyl-1H-pyrrol-2-yl-kappaN)methylidene]-2H-pyrrol-5-yl-kappaN}pentanoato)boron
DB05187 GFT505
DB01067 Glipizide
DB01050 Ibuprofen
DB00159 Icosapent
DB00328 Indomethacin
DB00244 Mesalazine
DB01252 Mitiglinide
DB00731 Nateglinide
DB01132 Pioglitazone
DB04971 Reglixane
DB00912 Repaglinide
DB00412 Rosiglitazone
DB00795 Sulfasalazine
DB05490 T131
DB00966 Telmisartan
DB00197 Troglitazone
GuidetoPHARMACOLOGYi595
SwissLipidsiSLP:000000396

Protein family/group databases

MoonDBiP37231 Predicted

PTM databases

iPTMnetiP37231
PhosphoSitePlusiP37231

Polymorphism and mutation databases

BioMutaiPPARG
DMDMi13432234

Proteomic databases

EPDiP37231
jPOSTiP37231
MaxQBiP37231
PaxDbiP37231
PeptideAtlasiP37231
PRIDEiP37231
ProteomicsDBi55267
55268 [P37231-2]
55269 [P37231-3]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
5468
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287820; ENSP00000287820; ENSG00000132170 [P37231-1]
ENST00000309576; ENSP00000312472; ENSG00000132170 [P37231-2]
ENST00000396999; ENSP00000380195; ENSG00000132170 [P37231-3]
ENST00000397010; ENSP00000380205; ENSG00000132170 [P37231-2]
ENST00000397012; ENSP00000380207; ENSG00000132170 [P37231-2]
ENST00000397015; ENSP00000380210; ENSG00000132170 [P37231-2]
ENST00000643197; ENSP00000495840; ENSG00000132170 [P37231-2]
ENST00000643888; ENSP00000494934; ENSG00000132170 [P37231-2]
ENST00000644622; ENSP00000494873; ENSG00000132170 [P37231-2]
GeneIDi5468
KEGGihsa:5468
UCSCiuc003bwr.4 human [P37231-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5468
DisGeNETi5468
EuPathDBiHostDB:ENSG00000132170.19

GeneCards: human genes, protein and diseases

More...
GeneCardsi
PPARG
HGNCiHGNC:9236 PPARG
HPAiCAB004282
HPA051239
HPA063663
MalaCardsiPPARG
MIMi137800 phenotype
601487 gene
601665 phenotype
604367 phenotype
606641 phenotype
609338 phenotype
neXtProtiNX_P37231
OpenTargetsiENSG00000132170
Orphaneti528 Berardinelli-Seip congenital lipodystrophy
146 Differentiated thyroid carcinoma
251579 Giant cell glioblastoma
251576 Gliosarcoma
79083 PPARG-related familial partial lipodystrophy
PharmGKBiPA281

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00940000158273
HOGENOMiHOG000119407
HOVERGENiHBG082808
InParanoidiP37231
KOiK08530
OMAiQRCQFRS
OrthoDBi492485at2759
PhylomeDBiP37231
TreeFamiTF316304

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-381340 Transcriptional regulation of white adipocyte differentiation
R-HSA-383280 Nuclear Receptor transcription pathway
R-HSA-4090294 SUMOylation of intracellular receptors
R-HSA-8943724 Regulation of PTEN gene transcription
R-HSA-9022707 MECP2 regulates transcription factors
SignaLinkiP37231
SIGNORiP37231

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
PPARG human
EvolutionaryTraceiP37231

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
Peroxisome_proliferator-activated_receptor_gamma

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5468

Protein Ontology

More...
PROi
PR:P37231

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000132170 Expressed in 136 organ(s), highest expression level in subcutaneous adipose tissue
ExpressionAtlasiP37231 baseline and differential
GenevisibleiP37231 HS

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003074 1Cnucl_rcpt
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR003077 PPAR-gamma
IPR022590 PPARgamma_N
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF12577 PPARgamma_N, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01288 PROXISOMEPAR
PR01291 PROXISOMPAGR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPPARG_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37231
Secondary accession number(s): A8K3G6
, B5BUA1, O00684, O00710, O14515, Q0QJH8, Q15178, Q15179, Q15180, Q15832, Q86U60, Q96J12
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: April 27, 2001
Last modified: January 16, 2019
This is version 250 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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