Ppara

Functionⁱ

Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2 (By similarity).By similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	433	Essential for heterodimerization with RXRABy similarity		1

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	99 – 173	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	75
Zinc fingerⁱ	102 – 122	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	139 – 161	NR C4-typePROSITE-ProRule annotationAdd BLAST	23

GO - Molecular functionⁱ

DNA-binding transcription factor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
drug binding Source: UniProtKB
fatty acid binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
lipid binding Source: UniProtKB
MDM2/MDM4 family protein binding
Source: RGD
Inferred from physical interactionⁱ
- 19103650
NFAT protein binding
Source: RGD
Inferred from physical interactionⁱ
- 22198280
nuclear receptor activity
Source: RGD
Inferred from mutant phenotypeⁱ
- 12189208
- 12966092
nuclear receptor transcription coactivator activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphatase binding
Source: RGD
Inferred from physical interactionⁱ
- 8910358
protein-containing complex binding
Source: RGD
Inferred from mutant phenotypeⁱ
- 20132223
protein domain specific binding
Source: RGD
Inferred from direct assayⁱ
- 12189208
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl
RNA polymerase II regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
sequence-specific DNA binding
Source: RGD
Inferred from direct assayⁱ
- 16280383
signaling receptor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
steroid hormone receptor activity
Source: RGD
Traceable author statementⁱ
- 12189208
transcription coactivator binding
Source: RGD
Inferred from physical interactionⁱ
- 22464285
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription regulatory region sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin conjugating enzyme binding Source: Ensembl
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavioral response to nicotine
Source: RGD
Inferred from direct assayⁱ
- 20801430
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
circadian regulation of gene expression Source: UniProtKB
enamel mineralization Source: Ensembl
epidermis development Source: Ensembl
fatty acid metabolic process
Source: RGD
Inferred from mutant phenotypeⁱ
heart development
Source: RGD
Inferred from expression patternⁱ
- 15754086
hormone-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
lipoprotein metabolic process
Source: RGD
Inferred from mutant phenotypeⁱ
- 15537571
multicellular organism development
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of appetite Source: UniProtKB
negative regulation of blood pressure
Source: RGD
Inferred from mutant phenotypeⁱ
- 15967866
negative regulation of cell growth involved in cardiac muscle cell development
Source: RGD
Inferred from mutant phenotypeⁱ
- 22198280
negative regulation of cholesterol storage
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of leukocyte cell-cell adhesion Source: Ensembl
negative regulation of macrophage derived foam cell differentiation Source: Ensembl
negative regulation of neuron death
Source: RGD
Inferred from direct assayⁱ
- 21375604
negative regulation of pri-miRNA transcription by RNA polymerase II Source: Ensembl
negative regulation of protein binding
Source: RGD
Inferred from mutant phenotypeⁱ
- 22198280
negative regulation of receptor biosynthetic process Source: Ensembl
negative regulation of sequestering of triglyceride Source: Ensembl
negative regulation of transcription, DNA-templated
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of fatty acid oxidation Source: Ensembl
positive regulation of gluconeogenesis Source: Ensembl
positive regulation of transcription, DNA-templated Source: UniProtKB
positive regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of cellular ketone metabolic process by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
regulation of circadian rhythm Source: UniProtKB
regulation of fatty acid metabolic process
Source: RGD
Traceable author statementⁱ
- 12189208
regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
regulation of lipid metabolic process
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
regulation of transcription, DNA-templated
Source: RGD
Inferred from direct assayⁱ
- 12189208
response to hypoxia
Source: HGNC
Inferred from direct assayⁱ
- 15292030
response to insulin
Source: RGD
Inferred from mutant phenotypeⁱ
- 16183630
response to lipid
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
wound healing Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor
Biological process	Biological rhythms, Transcription, Transcription regulation
Ligand	Lipid-binding, Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway R-RNO-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-RNO-4090294 SUMOylation of intracellular receptors

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-RNO-4090294 SUMOylation of intracellular receptors

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peroxisome proliferator-activated receptor alpha Short name: PPAR-alpha Alternative name(s): Nuclear receptor subfamily 1 group C member 1
Gene namesⁱ	Name:Ppara Synonyms:Nr1c1, Ppar
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 7

Organism-specific databases

Rat genome database More...RGDⁱ	3369 Ppara

RGDⁱ

3369 Ppara

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2129

ChEMBLⁱ

CHEMBL2129

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053484	1 – 468	Peroxisome proliferator-activated receptor alphaAdd BLAST		468

Post-translational modificationⁱ

Phosphorylated.1 Publication

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

PaxDbⁱ	P37230
PRIDEⁱ	P37230

PTM databases

iPTMnetⁱ	P37230
PhosphoSitePlusⁱ	P37230

Expressionⁱ

Tissue specificityⁱ

Expressed predominantly in liver and kidney.

Gene expression databases

Bgeeⁱ	ENSRNOG00000021463 Expressed in 9 organ(s), highest expression level in liver
Genevisibleⁱ	P37230 RN

Interactionⁱ

Subunit structureⁱ

Heterodimer; with RXRA. This heterodimerization is required for DNA binding and transactivation activity. Interacts with NCOA3 coactivator (By similarity). Interacts with CITED2; the interaction stimulates its transcriptional activity (PubMed:15051727). Also interacts with PPARBP in vitro. Interacts with AKAP13, LPIN1, PRDM16 and coactivator NCOA6. Interacts with ASXL1 and ASXL2. Interacts with PER2. Interacts with SIRT1; the interaction seems to be modulated by NAD⁺ levels (By similarity).By similarity1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Calm3	P62161	2	EBI-15674997,EBI-397530

With

Entry

#Exp.

IntAct

Notes

Calm3

P62161

2

EBI-15674997,EBI-397530

GO - Molecular functionⁱ

MDM2/MDM4 family protein binding
Source: RGD
Inferred from physical interactionⁱ
- 19103650
NFAT protein binding
Source: RGD
Inferred from physical interactionⁱ
- 22198280
phosphatase binding
Source: RGD
Inferred from physical interactionⁱ
- 8910358
protein domain specific binding
Source: RGD
Inferred from direct assayⁱ
- 12189208
RNA polymerase II repressing transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription coactivator binding
Source: RGD
Inferred from physical interactionⁱ
- 22464285
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ubiquitin conjugating enzyme binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	247775, 5 interactors
CORUMⁱ	P37230
Database of interacting proteins More...DIPⁱ	DIP-29529N
IntActⁱ	P37230, 1 interactor
STRINGⁱ	10116.ENSRNOP00000038651

Chemistry databases

BindingDBⁱ

P37230

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P37230
SMRⁱ	P37230
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	239 – 466	NR LBDPROSITE-ProRule annotationAdd BLAST		228

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	304 – 433	Required for heterodimerization with RXRABy similarityAdd BLAST		130

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR1 subfamily.Curated

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	102 – 122	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	139 – 161	NR C4-typePROSITE-ProRule annotationAdd BLAST		23

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00870000136388
HOGENOMⁱ	HOG000261626
HOVERGENⁱ	HBG106004
InParanoidⁱ	P37230
KEGG Orthology (KO) More...KOⁱ	K07294
OMAⁱ	FSFTEYQ
PhylomeDBⁱ	P37230
TreeFamⁱ	TF316304

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003074 1Cnucl_rcpt IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003076 PPAR-alpha IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01288 PROXISOMEPAR PR01289 PROXISOMPAAR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P37230-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVDTESPICP LSPLEADDLE SPLSEEFLQE MGNIQEISQS LGEESSGSFS 
        60         70         80         90        100
FADYQYLGSC PGSEGSVITD TLSPASSPSS VSCPAVPTST DESPGNALNI 
       110        120        130        140        150
ECRICGDKAS GYHYGVHACE GCKGFFRRTI RLKLAYDKCD RSCKIQKKNR 
       160        170        180        190        200
NKCQYCRFHK CLSVGMSHNA IRFGRMPRSE KAKLKAEILT CEHDLKDSET 
       210        220        230        240        250
ADLKSLAKRI HEAYLKNFNM NKVKARVILA GKTSNNPPFV IHDMETLCMA 
       260        270        280        290        300
EKTLVAKMVA NGVENKEAEV RFFHCCQCMS VETVTELTEF AKAIPGFANL 
       310        320        330        340        350
DLNDQVTLLK YGVYEAIFTM LSSLMNKDGM LIAYGNGFIT REFLKNLRKP 
       360        370        380        390        400
FCDIMEPKFD FAMKFNALEL DDSDISLFVA AIICCGDRPG LLNIGYIEKL 
       410        420        430        440        450
QEGIVHVLKL HLQSNHPDDT FLFPKLLQKM VDLRQLVTEH AQLVQVIKKT 
       460 
ESDAALHPLL QEIYRDMY

Length:468

Mass (Da):52,377

Last modified:October 1, 1994 - v1

Checksum:ⁱ2A89E7D715C8DBA9

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M88592 mRNA Translation: AAA41918.1
PIRⁱ	A45288
NCBI Reference Sequences More...RefSeqⁱ	NP_037328.1, NM_013196.1 XP_006242218.1, XM_006242156.2 XP_017450169.1, XM_017594680.1 XP_017450170.1, XM_017594681.1
UniGeneⁱ	Rn.9753

Genome annotation databases

Ensemblⁱ	ENSRNOT00000030082; ENSRNOP00000038651; ENSRNOG00000021463 ENSRNOT00000078928; ENSRNOP00000074329; ENSRNOG00000021463
GeneIDⁱ	25747
KEGGⁱ	rno:25747

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P37230	Peroxisome proliferator-activated receptor alpha (Fragment)		RABIT		83	UniRef100_P37230
UPI0003D0B801		RAT		605

Protein	Similar proteins		Species	Score	Length	Source
P37230	Peroxisome proliferator-activated receptor alpha (Fragment)		RABIT		83	UniRef90_P37230
peroxisome proliferator-activated receptor alpha isoform X1		MESAU		495
Peroxisome proliferator-activated receptor alpha (Fragment)		CRICR		170
Uncharacterized protein		NEOLE		494
UPI0003D0B801		RAT		605
+8

Protein	Similar proteins		Species	Score	Length	Source
P37230	Peroxisome proliferator-activated receptor alpha	)	HUMAN		468	UniRef50_Q07869
Peroxisome proliferator-activated receptor alpha		CANLF		468
Peroxisome proliferator-activated receptor alpha		CAVPO		467
Peroxisome proliferator-activated receptor alpha		PHACI		468
Peroxisome proliferator-activated receptor alpha		MOUSE		468
+447

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	M88592 mRNA Translation: AAA41918.1
PIRⁱ	A45288
RefSeqⁱ	NP_037328.1, NM_013196.1 XP_006242218.1, XM_006242156.2 XP_017450169.1, XM_017594680.1 XP_017450170.1, XM_017594681.1
UniGeneⁱ	Rn.9753

3D structure databases

ProteinModelPortalⁱ	P37230
SMRⁱ	P37230
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	247775, 5 interactors
CORUMⁱ	P37230
DIPⁱ	DIP-29529N
IntActⁱ	P37230, 1 interactor
STRINGⁱ	10116.ENSRNOP00000038651

Chemistry databases

BindingDBⁱ	P37230
ChEMBLⁱ	CHEMBL2129

PTM databases

iPTMnetⁱ	P37230
PhosphoSitePlusⁱ	P37230

Proteomic databases

PaxDbⁱ	P37230
PRIDEⁱ	P37230

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000030082; ENSRNOP00000038651; ENSRNOG00000021463 ENSRNOT00000078928; ENSRNOP00000074329; ENSRNOG00000021463
GeneIDⁱ	25747
KEGGⁱ	rno:25747

Organism-specific databases

CTDⁱ	5465
RGDⁱ	3369 Ppara

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00870000136388
HOGENOMⁱ	HOG000261626
HOVERGENⁱ	HBG106004
InParanoidⁱ	P37230
KOⁱ	K07294
OMAⁱ	FSFTEYQ
PhylomeDBⁱ	P37230
TreeFamⁱ	TF316304

Enzyme and pathway databases

Reactomeⁱ	R-RNO-383280 Nuclear Receptor transcription pathway R-RNO-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) R-RNO-4090294 SUMOylation of intracellular receptors

Reactomeⁱ

R-RNO-383280 Nuclear Receptor transcription pathway
R-RNO-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
R-RNO-4090294 SUMOylation of intracellular receptors

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P37230

PROⁱ

PR:P37230

Gene expression databases

Bgeeⁱ	ENSRNOG00000021463 Expressed in 9 organ(s), highest expression level in liver
Genevisibleⁱ	P37230 RN

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR003074 1Cnucl_rcpt IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR003076 PPAR-alpha IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR01288 PROXISOMEPAR PR01289 PROXISOMPAAR PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PPARA_RAT
Accessionⁱ	P37230Primary (citable) accession number: P37230
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1994
	Last sequence update:	October 1, 1994
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

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Proteomes

Annotation systems

Supporting data

UniProtKB - P37230 (PPARA_RAT)

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Peroxisome proliferator-activated receptor alpha

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ