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Protein

Malate dehydrogenase, mitochondrial

Gene
N/A
Organism
Schistosoma mansoni (Blood fluke)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei26NADBy similarity1
Binding sitei73SubstratePROSITE-ProRule annotation1
Binding sitei79SubstratePROSITE-ProRule annotation1
Binding sitei86NADBy similarity1
Binding sitei111SubstratePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1 – 6NADBy similarity6
Nucleotide bindingi109 – 111NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Enzyme and pathway databases

SABIO-RKiP37227

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase, mitochondrial (EC:1.1.1.37)
OrganismiSchistosoma mansoni (Blood fluke)
Taxonomic identifieri6183 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesTrematodaDigeneaStrigeididaSchistosomatoideaSchistosomatidaeSchistosoma

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000113340‹1 – ›142Malate dehydrogenase, mitochondrialAdd BLAST›142

Expressioni

Developmental stagei

Expressed in relatively high level in adults as compared to larval worms.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP37227
SMRiP37227
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily. MDH type 1 family.Curated

Phylogenomic databases

eggNOGiKOG1494 Eukaryota
COG0039 LUCA
OrthoDBiEOG091G0AVO

Family and domain databases

InterProiView protein in InterPro
IPR001236 Lactate/malate_DH_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00056 Ldh_1_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Fragment.

P37227-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
ASGGIGEPLS LLLKQSPLIS QLALYDIAHV KGVAADLSHI ETQAHVTAHL
60 70 80 90 100
GPGELAECLT GANVVIIPAG LPRKPGMTRD DLFNTNASIV AELIDSCAKN
110 120 130 140
CPKAMICIIT NPVNSTVPIA AEILKRHNVY DPKRLFGVTT LD
Length:142
Mass (Da):14,956
Last modified:October 1, 1994 - v1
Checksum:iC06BC6726566AE72
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11
Non-terminal residuei1421

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10108 Genomic DNA Translation: AAA29901.1

Genome annotation databases

GeneDBiSmp_047370.1:pep

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L10108 Genomic DNA Translation: AAA29901.1

3D structure databases

ProteinModelPortaliP37227
SMRiP37227
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneDBiSmp_047370.1:pep

Phylogenomic databases

eggNOGiKOG1494 Eukaryota
COG0039 LUCA
OrthoDBiEOG091G0AVO

Enzyme and pathway databases

SABIO-RKiP37227

Family and domain databases

InterProiView protein in InterPro
IPR001236 Lactate/malate_DH_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00056 Ldh_1_N, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMDHM_SCHMA
AccessioniPrimary (citable) accession number: P37227
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: October 25, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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