UniProtKB - P37197 (YHJA_ECOLI)
Protein
Probable cytochrome c peroxidase
Gene
yhjA
Organism
Escherichia coli (strain K12)
Status
Functioni
Catalytic activityi
- EC:1.11.1.5
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 59 | Heme 1 (covalent)PROSITE-ProRule annotation | 1 | |
Binding sitei | 62 | Heme 1 (covalent)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 63 | Iron (heme 1 axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 195 | Iron (heme 1 axial ligand)PROSITE-ProRule annotation | 1 | |
Binding sitei | 207 | Heme 2 (covalent)PROSITE-ProRule annotation | 1 | |
Binding sitei | 210 | Heme 2 (covalent)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 211 | Iron (heme 2 axial ligand)PROSITE-ProRule annotation | 1 | |
Binding sitei | 351 | Heme 3 (covalent)PROSITE-ProRule annotation | 1 | |
Binding sitei | 354 | Heme 3 (covalent)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 355 | Iron (heme 3 axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 415 | Iron (heme 2 axial ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 429 | Iron (heme 3 axial ligand)PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cytochrome-c peroxidase activity Source: EcoCyc
- electron transfer activity Source: InterPro
- heme binding Source: EcoCyc
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- anaerobic electron transport chain Source: EcoCyc
- hydrogen peroxide metabolic process Source: EcoCyc
- response to hydrogen peroxide Source: EcoCyc
Keywordsi
Molecular function | Oxidoreductase, Peroxidase |
Biological process | Electron transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12244-MONOMER MetaCyc:EG12244-MONOMER |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:yhjA Ordered Locus Names:b3518, JW3486 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000108444 | 1 – 465 | Probable cytochrome c peroxidaseAdd BLAST | 465 |
Post-translational modificationi
Binds 3 heme groups per subunit.Curated
Proteomic databases
jPOSTi | P37197 |
PaxDbi | P37197 |
PRIDEi | P37197 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262525, 14 interactors |
IntActi | P37197, 2 interactors |
STRINGi | 511145.b3518 |
Family & Domainsi
Phylogenomic databases
eggNOGi | COG1858, Bacteria |
HOGENOMi | CLU_034652_2_0_6 |
InParanoidi | P37197 |
PhylomeDBi | P37197 |
Family and domain databases
Gene3Di | 1.10.760.10, 2 hits |
InterProi | View protein in InterPro IPR009056, Cyt_c-like_dom IPR036909, Cyt_c-like_dom_sf IPR004852, Di-haem_cyt_c_peroxidsae IPR025992, Haem-bd |
Pfami | View protein in Pfam PF03150, CCP_MauG, 1 hit PF00034, Cytochrom_C, 1 hit PF14376, Haem_bd, 1 hit |
SMARTi | View protein in SMART SM01235, Haem_bd, 1 hit |
SUPFAMi | SSF46626, SSF46626, 2 hits |
PROSITEi | View protein in PROSITE PS51007, CYTC, 3 hits |
i Sequence
Sequence statusi: Complete.
P37197-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKMVSRITAI GLAGVAICYL GLSGYVWYHD NKRSKQADVQ ASAVSENNKV
60 70 80 90 100
LGFLREKGCD YCHTPSAELP AYYYIPGAKQ LMDYDIKLGY KSFNLEAVRA
110 120 130 140 150
ALLADKPVSQ SDLNKIEWVM QYETMPPTRY TALHWAGKVS DEERAEILAW
160 170 180 190 200
IAKQRAEYYA SNDTAPEHRN EPVQPIPQKL PTDAQKVALG FALYHDPRLS
210 220 230 240 250
ADSTISCAHC HALNAGGVDG RKTSIGVGGA VGPINAPTVF NSVFNVEQFW
260 270 280 290 300
DGRAATLQDQ AGGPPLNPIE MASKSWDEII AKLEKDPQLK TQFLEVYPQG
310 320 330 340 350
FSGENITDAI AEFEKTLITP DSPFDKWLRG DENALTAQQK KGYQLFKDNK
360 370 380 390 400
CATCHGGIIL GGRSFEPLGL KKDFNFGEIT AADIGRMNVT KEERDKLRQK
410 420 430 440 450
VPGLRNVALT APYFHRGDVP TLDGAVKLML RYQVGKELPQ EDVDDIVAFL
460
HSLNGVYTPY MQDKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00039 Genomic DNA Translation: AAB18494.1 U00096 Genomic DNA Translation: AAC76543.1 AP009048 Genomic DNA Translation: BAE77776.1 |
PIRi | S47738 |
RefSeqi | NP_417975.1, NC_000913.3 WP_000784827.1, NZ_SSZK01000039.1 |
Genome annotation databases
EnsemblBacteriai | AAC76543; AAC76543; b3518 BAE77776; BAE77776; BAE77776 |
GeneIDi | 948038 |
KEGGi | ecj:JW3486 eco:b3518 |
PATRICi | fig|1411691.4.peg.3200 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U00039 Genomic DNA Translation: AAB18494.1 U00096 Genomic DNA Translation: AAC76543.1 AP009048 Genomic DNA Translation: BAE77776.1 |
PIRi | S47738 |
RefSeqi | NP_417975.1, NC_000913.3 WP_000784827.1, NZ_SSZK01000039.1 |
3D structure databases
SMRi | P37197 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 4262525, 14 interactors |
IntActi | P37197, 2 interactors |
STRINGi | 511145.b3518 |
Proteomic databases
jPOSTi | P37197 |
PaxDbi | P37197 |
PRIDEi | P37197 |
Genome annotation databases
EnsemblBacteriai | AAC76543; AAC76543; b3518 BAE77776; BAE77776; BAE77776 |
GeneIDi | 948038 |
KEGGi | ecj:JW3486 eco:b3518 |
PATRICi | fig|1411691.4.peg.3200 |
Organism-specific databases
EchoBASEi | EB2155 |
Phylogenomic databases
eggNOGi | COG1858, Bacteria |
HOGENOMi | CLU_034652_2_0_6 |
InParanoidi | P37197 |
PhylomeDBi | P37197 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG12244-MONOMER MetaCyc:EG12244-MONOMER |
Miscellaneous databases
PROi | PR:P37197 |
Family and domain databases
Gene3Di | 1.10.760.10, 2 hits |
InterProi | View protein in InterPro IPR009056, Cyt_c-like_dom IPR036909, Cyt_c-like_dom_sf IPR004852, Di-haem_cyt_c_peroxidsae IPR025992, Haem-bd |
Pfami | View protein in Pfam PF03150, CCP_MauG, 1 hit PF00034, Cytochrom_C, 1 hit PF14376, Haem_bd, 1 hit |
SMARTi | View protein in SMART SM01235, Haem_bd, 1 hit |
SUPFAMi | SSF46626, SSF46626, 2 hits |
PROSITEi | View protein in PROSITE PS51007, CYTC, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | YHJA_ECOLI | |
Accessioni | P37197Primary (citable) accession number: P37197 Secondary accession number(s): Q2M7I0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 1, 1994 | |
Last modified: | December 2, 2020 | |
This is version 154 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |