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UniProtKB - P37197 (YHJA_ECOLI)

Entry version 149 (11 Dec 2019)
Sequence version 1 (01 Oct 1994)
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Protein

Probable cytochrome c peroxidase

Gene

yhjA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei59Heme 1 (covalent)PROSITE-ProRule annotation1
Binding sitei62Heme 1 (covalent)PROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi63Iron (heme 1 axial ligand)PROSITE-ProRule annotation1
Metal bindingi195Iron (heme 1 axial ligand)PROSITE-ProRule annotation1
Binding sitei207Heme 2 (covalent)PROSITE-ProRule annotation1
Binding sitei210Heme 2 (covalent)PROSITE-ProRule annotation1
Metal bindingi211Iron (heme 2 axial ligand)PROSITE-ProRule annotation1
Binding sitei351Heme 3 (covalent)PROSITE-ProRule annotation1
Binding sitei354Heme 3 (covalent)PROSITE-ProRule annotation1
Metal bindingi355Iron (heme 3 axial ligand)PROSITE-ProRule annotation1
Metal bindingi415Iron (heme 2 axial ligand)PROSITE-ProRule annotation1
Metal bindingi429Iron (heme 3 axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		EcoCyc:EG12244-MONOMER
ECOL316407:JW3486-MONOMER
MetaCyc:EG12244-MONOMER

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable cytochrome c peroxidase (EC:1.11.1.5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:yhjA
Ordered Locus Names:b3518, JW3486
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiEscherichia coli (strain K12)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri83333 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000318 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001084441 – 465Probable cytochrome c peroxidaseAdd BLAST465

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Binds 3 heme groups per subunit.Curated

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P37197

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P37197

PRoteomics IDEntifications database

More...PRIDEi		P37197

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		4262525, 14 interactors

Protein interaction database and analysis system

More...IntActi		P37197, 2 interactors

STRING: functional protein association networks

More...STRINGi		511145.b3518

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P37197

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG4105CA0 Bacteria
COG1858 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000173943

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P37197

KEGG Orthology (KO)

More...KOi		K00428

Database for complete collections of gene phylogenies

More...PhylomeDBi		P37197

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.760.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR004852 Di-haem_cyt_c_peroxidsae
IPR025992 Haem-bd

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03150 CCP_MauG, 1 hit
PF00034 Cytochrom_C, 1 hit
PF14376 Haem_bd, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM01235 Haem_bd, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46626 SSF46626, 2 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51007 CYTC, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P37197-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKMVSRITAI GLAGVAICYL GLSGYVWYHD NKRSKQADVQ ASAVSENNKV 
        60         70         80         90        100
LGFLREKGCD YCHTPSAELP AYYYIPGAKQ LMDYDIKLGY KSFNLEAVRA 
       110        120        130        140        150
ALLADKPVSQ SDLNKIEWVM QYETMPPTRY TALHWAGKVS DEERAEILAW 
       160        170        180        190        200
IAKQRAEYYA SNDTAPEHRN EPVQPIPQKL PTDAQKVALG FALYHDPRLS 
       210        220        230        240        250
ADSTISCAHC HALNAGGVDG RKTSIGVGGA VGPINAPTVF NSVFNVEQFW 
       260        270        280        290        300
DGRAATLQDQ AGGPPLNPIE MASKSWDEII AKLEKDPQLK TQFLEVYPQG 
       310        320        330        340        350
FSGENITDAI AEFEKTLITP DSPFDKWLRG DENALTAQQK KGYQLFKDNK 
       360        370        380        390        400
CATCHGGIIL GGRSFEPLGL KKDFNFGEIT AADIGRMNVT KEERDKLRQK 
       410        420        430        440        450
VPGLRNVALT APYFHRGDVP TLDGAVKLML RYQVGKELPQ EDVDDIVAFL 
       460 
HSLNGVYTPY MQDKQ
Length:465
Mass (Da):51,571
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9F494A698949E6DA
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18494.1
U00096 Genomic DNA Translation: AAC76543.1
AP009048 Genomic DNA Translation: BAE77776.1

Protein sequence database of the Protein Information Resource

More...PIRi		S47738

NCBI Reference Sequences

More...RefSeqi		NP_417975.1, NC_000913.3
WP_000784827.1, NZ_SSZK01000039.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...EnsemblBacteriai		AAC76543; AAC76543; b3518
BAE77776; BAE77776; BAE77776

Database of genes from NCBI RefSeq genomes

More...GeneIDi		948038

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		ecj:JW3486
eco:b3518

Pathosystems Resource Integration Center (PATRIC)

More...PATRICi		fig|1411691.4.peg.3200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U00039 Genomic DNA Translation: AAB18494.1
U00096 Genomic DNA Translation: AAC76543.1
AP009048 Genomic DNA Translation: BAE77776.1
PIRiS47738
RefSeqiNP_417975.1, NC_000913.3
WP_000784827.1, NZ_SSZK01000039.1

3D structure databases

SMRiP37197
ModBaseiSearch...

Protein-protein interaction databases

BioGridi4262525, 14 interactors
IntActiP37197, 2 interactors
STRINGi511145.b3518

Proteomic databases

jPOSTiP37197
PaxDbiP37197
PRIDEiP37197

Genome annotation databases

EnsemblBacteriaiAAC76543; AAC76543; b3518
BAE77776; BAE77776; BAE77776
GeneIDi948038
KEGGiecj:JW3486
eco:b3518
PATRICifig|1411691.4.peg.3200

Organism-specific databases

EchoBASE - an integrated post-genomic database for E. coli

More...EchoBASEi		EB2155

Phylogenomic databases

eggNOGiENOG4105CA0 Bacteria
COG1858 LUCA
HOGENOMiHOG000173943
InParanoidiP37197
KOiK00428
PhylomeDBiP37197

Enzyme and pathway databases

BioCyciEcoCyc:EG12244-MONOMER
ECOL316407:JW3486-MONOMER
MetaCyc:EG12244-MONOMER

Miscellaneous databases

Protein Ontology

More...PROi		PR:P37197

Family and domain databases

Gene3Di1.10.760.10, 2 hits
InterProiView protein in InterPro
IPR009056 Cyt_c-like_dom
IPR036909 Cyt_c-like_dom_sf
IPR004852 Di-haem_cyt_c_peroxidsae
IPR025992 Haem-bd
PfamiView protein in Pfam
PF03150 CCP_MauG, 1 hit
PF00034 Cytochrom_C, 1 hit
PF14376 Haem_bd, 1 hit
SMARTiView protein in SMART
SM01235 Haem_bd, 1 hit
SUPFAMiSSF46626 SSF46626, 2 hits
PROSITEiView protein in PROSITE
PS51007 CYTC, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiYHJA_ECOLI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37197
Secondary accession number(s): Q2M7I0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: December 11, 2019
This is version 149 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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