UniProtKB - P37180 (HYBB_ECOLI)
Protein
Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit
Gene
hybB
Organism
Escherichia coli (strain K12)
Status
Functioni
Probable b-type cytochrome.
GO - Molecular functioni
- formate dehydrogenase (quinone) activity Source: GO_Central
- hydrogenase (acceptor) activity Source: GO_Central
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- anaerobic respiration Source: GO_Central
- formate oxidation Source: GO_Central
Keywordsi
Biological process | Electron transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11800-MONOMER MetaCyc:EG11800-MONOMER |
Names & Taxonomyi
Protein namesi | Recommended name: Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit |
Gene namesi | Name:hybB Ordered Locus Names:b2995, JW5494 |
Organismi | Escherichia coli (strain K12) |
Taxonomic identifieri | 83333 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacterales › Enterobacteriaceae › Escherichia › |
Proteomesi |
|
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: EcoCyc
- plasma membrane Source: EcoCyc
Other locations
- [Ni-Fe] hydrogenase complex Source: GO_Central
- formate dehydrogenase complex Source: GO_Central
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 11 | PeriplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 12 – 32 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 33 – 34 | CytoplasmicSequence analysis | 2 | |
Transmembranei | 35 – 55 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 56 – 58 | PeriplasmicSequence analysis | 3 | |
Transmembranei | 59 – 79 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 80 – 90 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 91 – 111 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 112 – 133 | PeriplasmicSequence analysisAdd BLAST | 22 | |
Transmembranei | 134 – 154 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 155 – 168 | CytoplasmicSequence analysisAdd BLAST | 14 | |
Transmembranei | 169 – 189 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 190 – 207 | PeriplasmicSequence analysisAdd BLAST | 18 | |
Transmembranei | 208 – 228 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 229 – 249 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 250 – 270 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 271 – 281 | PeriplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 282 – 302 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 303 – 333 | CytoplasmicSequence analysisAdd BLAST | 31 | |
Transmembranei | 334 – 354 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 355 | PeriplasmicSequence analysis | 1 | |
Transmembranei | 356 – 376 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 377 – 392 | CytoplasmicSequence analysisAdd BLAST | 16 |
Keywords - Cellular componenti
Cell inner membrane, Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000159326 | 1 – 392 | Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunitAdd BLAST | 392 |
Proteomic databases
PaxDbi | P37180 |
PRIDEi | P37180 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 4262376, 6 interactors |
ComplexPortali | CPX-282, Hydrogenase-2 complex |
STRINGi | 511145.b2995 |
Family & Domainsi
Sequence similaritiesi
Belongs to the NrfD family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | COG5557, Bacteria |
HOGENOMi | CLU_049007_0_0_6 |
InParanoidi | P37180 |
PhylomeDBi | P37180 |
Family and domain databases
InterProi | View protein in InterPro IPR005614, NrfD_fam |
Pfami | View protein in Pfam PF03916, NrfD, 1 hit |
i Sequence
Sequence statusi: Complete.
P37180-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSHDPQPLGG KIISKPVMIF GPLIVICMLL IVKRLVFGLG SVSDLNGGFP
60 70 80 90 100
WGVWIAFDLL IGTGFACGGW ALAWAVYVFN RGQYHPLVRP ALLASLFGYS
110 120 130 140 150
LGGLSITIDV GRYWNLPYFY IPGHFNVNSV LFETAVCMTI YIGVMALEFA
160 170 180 190 200
PALFERLGWK VSLQRLNKVM FFIIALGALL PTMHQSSMGS LMISAGYKVH
210 220 230 240 250
PLWQSYEMLP LFSLLTAFIM GFSIVIFEGS LVQAGLRGNG PDEKSLFVKL
260 270 280 290 300
TNTISVLLAI FIVLRFGELI YRDKLSLAFA GDFYSVMFWI EVLLMLFPLV
310 320 330 340 350
VLRVAKLRND SRMLFLSALS ALLGCATWRL TYSLVAFNPG GGYAYFPTWE
360 370 380 390
ELLISIGFVA IEICAYIVLI RLLPILPPLK QNDHNRHEAS KA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 306 – 307 | KL → NV in AAA21590 (PubMed:8021226).Curated | 2 | |
Sequence conflicti | 306 – 307 | KL → NV in AAA69162 (PubMed:8021226).Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09177 Genomic DNA Translation: AAA21590.1 U28377 Genomic DNA Translation: AAA69162.1 Sequence problems. U00096 Genomic DNA Translation: AAC76031.1 AP009048 Genomic DNA Translation: BAE77056.1 |
PIRi | A65086 |
RefSeqi | NP_417469.1, NC_000913.3 WP_000017703.1, NZ_STEB01000001.1 |
Genome annotation databases
EnsemblBacteriai | AAC76031; AAC76031; b2995 BAE77056; BAE77056; BAE77056 |
GeneIDi | 57729179 948615 |
KEGGi | ecj:JW5494 eco:b2995 |
PATRICi | fig|1411691.4.peg.3734 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09177 Genomic DNA Translation: AAA21590.1 U28377 Genomic DNA Translation: AAA69162.1 Sequence problems. U00096 Genomic DNA Translation: AAC76031.1 AP009048 Genomic DNA Translation: BAE77056.1 |
PIRi | A65086 |
RefSeqi | NP_417469.1, NC_000913.3 WP_000017703.1, NZ_STEB01000001.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 4262376, 6 interactors |
ComplexPortali | CPX-282, Hydrogenase-2 complex |
STRINGi | 511145.b2995 |
Proteomic databases
PaxDbi | P37180 |
PRIDEi | P37180 |
Genome annotation databases
EnsemblBacteriai | AAC76031; AAC76031; b2995 BAE77056; BAE77056; BAE77056 |
GeneIDi | 57729179 948615 |
KEGGi | ecj:JW5494 eco:b2995 |
PATRICi | fig|1411691.4.peg.3734 |
Organism-specific databases
EchoBASEi | EB1748 |
Phylogenomic databases
eggNOGi | COG5557, Bacteria |
HOGENOMi | CLU_049007_0_0_6 |
InParanoidi | P37180 |
PhylomeDBi | P37180 |
Enzyme and pathway databases
BioCyci | EcoCyc:EG11800-MONOMER MetaCyc:EG11800-MONOMER |
Miscellaneous databases
PROi | PR:P37180 |
Family and domain databases
InterProi | View protein in InterPro IPR005614, NrfD_fam |
Pfami | View protein in Pfam PF03916, NrfD, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | HYBB_ECOLI | |
Accessioni | P37180Primary (citable) accession number: P37180 Secondary accession number(s): Q2M9K0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | August 29, 2003 | |
Last modified: | April 7, 2021 | |
This is version 135 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families