UniProtKB - P37173 (TGFR2_HUMAN)
TGF-beta receptor type-2
TGFBR2
Functioni
Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways.
1 PublicationCatalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 277 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 379 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 250 – 258 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- activin-activated receptor activity Source: GO_Central
- activin binding Source: GO_Central
- ATP binding Source: UniProtKB-KW
- glycosaminoglycan binding Source: BHF-UCL
- metal ion binding Source: UniProtKB-KW
- mitogen-activated protein kinase kinase kinase binding Source: Ensembl
- protein serine/threonine kinase activity Source: GO_Central
- SMAD binding Source: BHF-UCL
- transforming growth factor beta-activated receptor activity Source: BHF-UCL
- transforming growth factor beta binding Source: BHF-UCL
- transforming growth factor beta receptor activity, type II Source: Ensembl
- transmembrane receptor protein serine/threonine kinase activity Source: BHF-UCL
- type III transforming growth factor beta receptor binding Source: BHF-UCL
- type I transforming growth factor beta receptor binding Source: BHF-UCL
GO - Biological processi
- activation of protein kinase activity Source: BHF-UCL
- aging Source: Ensembl
- animal organ regeneration Source: Ensembl
- apoptotic process Source: UniProtKB
- atrioventricular valve morphogenesis Source: BHF-UCL
- blood vessel development Source: BHF-UCL
- brain development Source: BHF-UCL
- branching involved in blood vessel morphogenesis Source: BHF-UCL
- bronchus morphogenesis Source: Ensembl
- cardiac left ventricle morphogenesis Source: BHF-UCL
- cellular response to growth factor stimulus Source: GO_Central
- common-partner SMAD protein phosphorylation Source: Ensembl
- digestive tract development Source: Ensembl
- embryo implantation Source: Ensembl
- embryonic cranial skeleton morphogenesis Source: BHF-UCL
- embryonic hemopoiesis Source: BHF-UCL
- endocardial cushion fusion Source: BHF-UCL
- gastrulation Source: Ensembl
- growth plate cartilage chondrocyte growth Source: Ensembl
- heart development Source: BHF-UCL
- heart looping Source: BHF-UCL
- inferior endocardial cushion morphogenesis Source: BHF-UCL
- in utero embryonic development Source: Ensembl
- lens development in camera-type eye Source: Ensembl
- lens fiber cell apoptotic process Source: Ensembl
- lung lobe morphogenesis Source: Ensembl
- mammary gland morphogenesis Source: Ensembl
- membranous septum morphogenesis Source: BHF-UCL
- miRNA transport Source: BHF-UCL
- myeloid dendritic cell differentiation Source: BHF-UCL
- negative regulation of cardiac muscle cell proliferation Source: Ensembl
- Notch signaling pathway Source: Ensembl
- outflow tract morphogenesis Source: BHF-UCL
- outflow tract septum morphogenesis Source: BHF-UCL
- pathway-restricted SMAD protein phosphorylation Source: BHF-UCL
- peptidyl-serine phosphorylation Source: BHF-UCL
- peptidyl-threonine phosphorylation Source: BHF-UCL
- positive regulation of angiogenesis Source: Ensembl
- positive regulation of B cell tolerance induction Source: BHF-UCL
- positive regulation of CD4-positive, alpha-beta T cell proliferation Source: BHF-UCL
- positive regulation of cell population proliferation Source: ProtInc
- positive regulation of epithelial cell migration Source: Ensembl
- positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
- positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation Source: BHF-UCL
- positive regulation of mesenchymal cell proliferation Source: BHF-UCL
- positive regulation of NK T cell differentiation Source: BHF-UCL
- positive regulation of pathway-restricted SMAD protein phosphorylation Source: ComplexPortal
- positive regulation of reactive oxygen species metabolic process Source: BHF-UCL
- positive regulation of skeletal muscle tissue regeneration Source: Ensembl
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of T cell tolerance induction Source: BHF-UCL
- positive regulation of tolerance induction to self antigen Source: BHF-UCL
- protein phosphorylation Source: BHF-UCL
- receptor-mediated endocytosis Source: Ensembl
- regulation of cell population proliferation Source: BHF-UCL
- regulation of gene expression Source: Ensembl
- response to cholesterol Source: BHF-UCL
- response to estrogen Source: Ensembl
- response to glucose Source: Ensembl
- response to hypoxia Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to nutrient Source: Ensembl
- response to steroid hormone Source: Ensembl
- response to xenobiotic stimulus Source: BHF-UCL
- secondary palate development Source: BHF-UCL
- smoothened signaling pathway Source: Ensembl
- trachea formation Source: Ensembl
- transforming growth factor beta receptor signaling pathway Source: BHF-UCL
- tricuspid valve morphogenesis Source: BHF-UCL
- vasculogenesis Source: BHF-UCL
- ventricular septum morphogenesis Source: BHF-UCL
- wound healing Source: Ensembl
Keywordsi
Molecular function | Kinase, Receptor, Serine/threonine-protein kinase, Transferase |
Biological process | Apoptosis, Differentiation, Growth regulation |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P37173 |
Reactomei | R-HSA-2173788, Downregulation of TGF-beta receptor signaling R-HSA-2173789, TGF-beta receptor signaling activates SMADs R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-3304356, SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3642279, TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3645790, TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3656532, TGFBR1 KD Mutants in Cancer R-HSA-3656535, TGFBR1 LBD Mutants in Cancer R-HSA-5689603, UCH proteinases |
SignaLinki | P37173 |
SIGNORi | P37173 |
Names & Taxonomyi
Protein namesi | Recommended name: TGF-beta receptor type-2 (EC:2.7.11.30)Short name: TGFR-2 Alternative name(s): TGF-beta type II receptor Transforming growth factor-beta receptor type II Short name: TGF-beta receptor type II Short name: TbetaR-II |
Gene namesi | Name:TGFBR2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11773, TGFBR2 |
MIMi | 190182, gene |
neXtProti | NX_P37173 |
VEuPathDBi | HostDB:ENSG00000163513 |
Subcellular locationi
Plasma membrane
- Cell membrane 2 Publications; Single-pass type I membrane protein 1 Publication
Other locations
- Membrane raft 1 Publication
Cytosol
- cytosol Source: Reactome
Plasma Membrane
- caveola Source: BHF-UCL
- external side of plasma membrane Source: BHF-UCL
- integral component of plasma membrane Source: Ensembl
- plasma membrane Source: UniProtKB
- transforming growth factor beta ligand-receptor complex Source: ComplexPortal
Other locations
- integral component of membrane Source: BHF-UCL
- membrane raft Source: UniProtKB
- receptor complex Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 23 – 166 | ExtracellularSequence analysisAdd BLAST | 144 | |
Transmembranei | 167 – 187 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 188 – 567 | CytoplasmicSequence analysisAdd BLAST | 380 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Involvement in diseasei
Hereditary non-polyposis colorectal cancer 6 (HNPCC6)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_008156 | 315 | T → M in HNPCC6. 2 PublicationsCorresponds to variant dbSNP:rs34833812EnsemblClinVar. | 1 |
Esophageal cancer (ESCR)1 Publication
Loeys-Dietz syndrome 2 (LDS2)10 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_076167 | 190 | R → H in LDS2. 1 PublicationCorresponds to variant dbSNP:rs780542125EnsemblClinVar. | 1 | |
Natural variantiVAR_076168 | 247 | D → V in LDS2. 1 PublicationCorresponds to variant dbSNP:rs761231369EnsemblClinVar. | 1 | |
Natural variantiVAR_066723 | 306 | Q → HE in LDS2. 1 Publication | 1 | |
Natural variantiVAR_022351 | 308 | L → P in LDS2; has a negative effect on TGF-beta signaling. 2 PublicationsCorresponds to variant dbSNP:rs28934568EnsemblClinVar. | 1 | |
Natural variantiVAR_076169 | 325 | T → P in LDS2. 1 Publication | 1 | |
Natural variantiVAR_022352 | 336 | Y → N in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893812EnsemblClinVar. | 1 | |
Natural variantiVAR_022353 | 355 | A → P in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893813EnsemblClinVar. | 1 | |
Natural variantiVAR_076170 | 357 | G → R in LDS2. 1 Publication | 1 | |
Natural variantiVAR_022354 | 357 | G → W in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893814EnsemblClinVar. | 1 | |
Natural variantiVAR_066724 | 377 | H → R in LDS2. 1 PublicationCorresponds to variant dbSNP:rs1553630274EnsemblClinVar. | 1 | |
Natural variantiVAR_066725 | 446 | D → N in LDS2. 1 PublicationCorresponds to variant dbSNP:rs886039551EnsemblClinVar. | 1 | |
Natural variantiVAR_022358 | 449 | S → F in LDS2; has a negative effect on TGF-beta signaling. 2 PublicationsCorresponds to variant dbSNP:rs104893807EnsemblClinVar. | 1 | |
Natural variantiVAR_066726 | 457 | M → K in LDS2. 1 Publication | 1 | |
Natural variantiVAR_029760 | 460 | R → C in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893811EnsemblClinVar. | 1 | |
Natural variantiVAR_029761 | 460 | R → H in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893816EnsemblClinVar. | 1 | |
Natural variantiVAR_066727 | 509 | G → V in LDS2. 1 PublicationCorresponds to variant dbSNP:rs863223853EnsemblClinVar. | 1 | |
Natural variantiVAR_066728 | 510 | I → F in LDS2. 1 Publication | 1 | |
Natural variantiVAR_066729 | 510 | I → S in LDS2. 1 Publication | 1 | |
Natural variantiVAR_066730 | 514 | C → R in LDS2. 1 PublicationCorresponds to variant dbSNP:rs193922664EnsemblClinVar. | 1 | |
Natural variantiVAR_066731 | 521 | W → R in LDS2. 1 PublicationCorresponds to variant dbSNP:rs1575166666EnsemblClinVar. | 1 | |
Natural variantiVAR_022360 | 528 | R → C in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893810EnsemblClinVar. | 1 | |
Natural variantiVAR_022361 | 528 | R → H in LDS2. 2 PublicationsCorresponds to variant dbSNP:rs104893815EnsemblClinVar. | 1 | |
Natural variantiVAR_076171 | 530 | T → I in LDS2. 1 Publication | 1 | |
Natural variantiVAR_022362 | 537 | R → C in LDS2; has a negative effect on TGF-beta signaling. 1 PublicationCorresponds to variant dbSNP:rs104893809EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 277 | K → R: Abolishes kinase activity, TGF-beta signaling and interaction with DAXX. 1 Publication | 1 |
Keywords - Diseasei
Aortic aneurysm, Craniosynostosis, Disease variant, Hereditary nonpolyposis colorectal cancerOrganism-specific databases
DisGeNETi | 7048 |
GeneReviewsi | TGFBR2 |
MalaCardsi | TGFBR2 |
MIMi | 133239, phenotype 610168, phenotype 614331, phenotype |
OpenTargetsi | ENSG00000163513 |
Orphaneti | 91387, Familial thoracic aortic aneurysm and aortic dissection 60030, Loeys-Dietz syndrome 144, Lynch syndrome 284973, Marfan syndrome type 2 99977, Squamous cell carcinoma of the esophagus |
PharmGKBi | PA36486 |
Miscellaneous databases
Pharosi | P37173, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4267 |
DrugBanki | DB10770, Foreskin fibroblast (neonatal) DB10772, Foreskin keratinocyte (neonatal) DB12010, Fostamatinib |
DrugCentrali | P37173 |
GuidetoPHARMACOLOGYi | 1795 |
Genetic variation databases
BioMutai | TGFBR2 |
DMDMi | 116242818 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 22 | 1 PublicationAdd BLAST | 22 | |
ChainiPRO_0000024426 | 23 – 567 | TGF-beta receptor type-2Add BLAST | 545 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 51 ↔ 84 | 5 Publications | ||
Disulfide bondi | 54 ↔ 71 | 5 Publications | ||
Disulfide bondi | 61 ↔ 67 | 5 Publications | ||
Glycosylationi | 70 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 77 ↔ 101 | 5 Publications | ||
Glycosylationi | 94 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 121 ↔ 136 | 5 Publications | ||
Disulfide bondi | 138 ↔ 143 | 5 Publications | ||
Glycosylationi | 154 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Modified residuei | 409 | PhosphoserineBy similarity | 1 | |
Modified residuei | 548 | PhosphoserineCombined sources | 1 | |
Modified residuei | 553 | PhosphoserineBy similarity | 1 |
Post-translational modificationi
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
EPDi | P37173 |
jPOSTi | P37173 |
MassIVEi | P37173 |
MaxQBi | P37173 |
PaxDbi | P37173 |
PeptideAtlasi | P37173 |
PRIDEi | P37173 |
ProteomicsDBi | 55264 [P37173-1] 55265 [P37173-2] |
PTM databases
GlyConnecti | 1979, 9 N-Linked glycans (3 sites) |
GlyGeni | P37173, 5 sites, 9 N-linked glycans (3 sites) |
iPTMneti | P37173 |
PhosphoSitePlusi | P37173 |
Expressioni
Gene expression databases
Bgeei | ENSG00000163513, Expressed in metanephric glomerulus and 244 other tissues |
ExpressionAtlasi | P37173, baseline and differential |
Genevisiblei | P37173, HS |
Organism-specific databases
HPAi | ENSG00000163513, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer. Heterohexamer; TGFB1, TGFB2 and TGFB3 homodimeric ligands assemble a functional receptor composed of two TGFBR1 and TGFBR2 heterodimers to form a ligand-receptor heterohexamer. The respective affinity of TGFRB1 and TGFRB2 for the ligands may modulate the kinetics of assembly of the receptor and may explain the different biological activities of TGFB1, TGFB2 and TGFB3.
Interacts with DAXX.
Interacts with DYNLT4.
Interacts with ZFYVE9; ZFYVE9 recruits SMAD2 and SMAD3 to the TGF-beta receptor.
Interacts with and is activated by SCUBE3; this interaction does not affect TGFB1-binding to TGFBR2.
Interacts with VPS39; this interaction is independent of the receptor kinase activity and of the presence of TGF-beta.
Interacts with CLU (PubMed:8555189).
9 PublicationsBinary interactionsi
P37173
Isoform 2 [P37173-2]
With | #Exp. | IntAct |
---|---|---|
LRG1 [P02750] | 3 | EBI-16065370,EBI-9083443 |
GO - Molecular functioni
- mitogen-activated protein kinase kinase kinase binding Source: Ensembl
- SMAD binding Source: BHF-UCL
- transforming growth factor beta binding Source: BHF-UCL
- type III transforming growth factor beta receptor binding Source: BHF-UCL
- type I transforming growth factor beta receptor binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112906, 181 interactors |
ComplexPortali | CPX-2544, TGF-beta-3-TGFR complex CPX-529, TGF-beta-1-TGFR complex CPX-834, TGF-beta-2-TGFR complex |
CORUMi | P37173 |
DIPi | DIP-5939N |
IntActi | P37173, 123 interactors |
MINTi | P37173 |
STRINGi | 9606.ENSP00000351905 |
Chemistry databases
BindingDBi | P37173 |
Miscellaneous databases
RNActi | P37173, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P37173 |
SMRi | P37173 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P37173 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 244 – 544 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 301 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 439 – 567 | Sufficient for interaction with CLU1 PublicationAdd BLAST | 129 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3653, Eukaryota |
GeneTreei | ENSGT00940000157527 |
HOGENOMi | CLU_000288_8_3_1 |
InParanoidi | P37173 |
OMAi | MCSCSAE |
PhylomeDBi | P37173 |
TreeFami | TF314724 |
Family and domain databases
DisProti | DP01760 |
Gene3Di | 2.10.60.10, 1 hit |
IDEALi | IID00414 |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR045860, Snake_toxin-like_sf IPR000333, TGFB_receptor IPR017194, Transform_growth_fac-b_typ-2 IPR015013, Transforming_GF_b_rcpt_2_ecto |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF08917, ecTbetaR2, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF037393, TGFRII, 1 hit |
PRINTSi | PR00653, ACTIVIN2R |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57302, SSF57302, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGRGLLRGLW PLHIVLWTRI ASTIPPHVQK SVNNDMIVTD NNGAVKFPQL
60 70 80 90 100
CKFCDVRFST CDNQKSCMSN CSITSICEKP QEVCVAVWRK NDENITLETV
110 120 130 140 150
CHDPKLPYHD FILEDAASPK CIMKEKKKPG ETFFMCSCSS DECNDNIIFS
160 170 180 190 200
EEYNTSNPDL LLVIFQVTGI SLLPPLGVAI SVIIIFYCYR VNRQQKLSST
210 220 230 240 250
WETGKTRKLM EFSEHCAIIL EDDRSDISST CANNINHNTE LLPIELDTLV
260 270 280 290 300
GKGRFAEVYK AKLKQNTSEQ FETVAVKIFP YEEYASWKTE KDIFSDINLK
310 320 330 340 350
HENILQFLTA EERKTELGKQ YWLITAFHAK GNLQEYLTRH VISWEDLRKL
360 370 380 390 400
GSSLARGIAH LHSDHTPCGR PKMPIVHRDL KSSNILVKND LTCCLCDFGL
410 420 430 440 450
SLRLDPTLSV DDLANSGQVG TARYMAPEVL ESRMNLENVE SFKQTDVYSM
460 470 480 490 500
ALVLWEMTSR CNAVGEVKDY EPPFGSKVRE HPCVESMKDN VLRDRGRPEI
510 520 530 540 550
PSFWLNHQGI QMVCETLTEC WDHDPEARLT AQCVAERFSE LEHLDRLSGR
560
SCSEEKIPED GSLNTTK
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 381 | K → N in BAA09332 (PubMed:8973329).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_020510 | 36 | M → V1 PublicationCorresponds to variant dbSNP:rs17025864EnsemblClinVar. | 1 | |
Natural variantiVAR_041414 | 61 | C → R in a gastric adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_036070 | 73 | I → V in a colorectal cancer sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_076167 | 190 | R → H in LDS2. 1 PublicationCorresponds to variant dbSNP:rs780542125EnsemblClinVar. | 1 | |
Natural variantiVAR_017606 | 191 | V → I2 PublicationsCorresponds to variant dbSNP:rs56105708EnsemblClinVar. | 1 | |
Natural variantiVAR_076168 | 247 | D → V in LDS2. 1 PublicationCorresponds to variant dbSNP:rs761231369EnsemblClinVar. | 1 | |
Natural variantiVAR_066723 | 306 | Q → HE in LDS2. 1 Publication | 1 | |
Natural variantiVAR_022351 | 308 | L → P in LDS2; has a negative effect on TGF-beta signaling. 2 PublicationsCorresponds to variant dbSNP:rs28934568EnsemblClinVar. | 1 | |
Natural variantiVAR_008156 | 315 | T → M in HNPCC6. 2 PublicationsCorresponds to variant dbSNP:rs34833812EnsemblClinVar. | 1 | |
Natural variantiVAR_076169 | 325 | T → P in LDS2. 1 Publication | 1 | |
Natural variantiVAR_041415 | 328 | H → Y in a lung neuroendocrine carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_022352 | 336 | Y → N in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893812EnsemblClinVar. | 1 | |
Natural variantiVAR_022353 | 355 | A → P in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893813EnsemblClinVar. | 1 | |
Natural variantiVAR_076170 | 357 | G → R in LDS2. 1 Publication | 1 | |
Natural variantiVAR_022354 | 357 | G → W in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893814EnsemblClinVar. | 1 | |
Natural variantiVAR_041416 | 373 | M → I1 PublicationCorresponds to variant dbSNP:rs35719192EnsemblClinVar. | 1 | |
Natural variantiVAR_066724 | 377 | H → R in LDS2. 1 PublicationCorresponds to variant dbSNP:rs1553630274EnsemblClinVar. | 1 | |
Natural variantiVAR_022355 | 387 | V → M in a breast tumor. 2 PublicationsCorresponds to variant dbSNP:rs35766612EnsemblClinVar. | 1 | |
Natural variantiVAR_022356 | 435 | N → S in a breast tumor; signaling of TGF-beta significantly inhibited. 1 Publication | 1 | |
Natural variantiVAR_028063 | 439 | V → A4 PublicationsCorresponds to variant dbSNP:rs1050833EnsemblClinVar. | 1 | |
Natural variantiVAR_066725 | 446 | D → N in LDS2. 1 PublicationCorresponds to variant dbSNP:rs886039551EnsemblClinVar. | 1 | |
Natural variantiVAR_022357 | 447 | V → A in a breast tumor; signaling of TGF-beta significantly inhibited. 1 Publication | 1 | |
Natural variantiVAR_022358 | 449 | S → F in LDS2; has a negative effect on TGF-beta signaling. 2 PublicationsCorresponds to variant dbSNP:rs104893807EnsemblClinVar. | 1 | |
Natural variantiVAR_022359 | 452 | L → M in a breast tumor; signaling of TGF-beta significantly inhibited. 1 Publication | 1 | |
Natural variantiVAR_066726 | 457 | M → K in LDS2. 1 Publication | 1 | |
Natural variantiVAR_029760 | 460 | R → C in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893811EnsemblClinVar. | 1 | |
Natural variantiVAR_029761 | 460 | R → H in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893816EnsemblClinVar. | 1 | |
Natural variantiVAR_041417 | 490 | N → S in a gastric adenocarcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_066727 | 509 | G → V in LDS2. 1 PublicationCorresponds to variant dbSNP:rs863223853EnsemblClinVar. | 1 | |
Natural variantiVAR_066728 | 510 | I → F in LDS2. 1 Publication | 1 | |
Natural variantiVAR_066729 | 510 | I → S in LDS2. 1 Publication | 1 | |
Natural variantiVAR_066730 | 514 | C → R in LDS2. 1 PublicationCorresponds to variant dbSNP:rs193922664EnsemblClinVar. | 1 | |
Natural variantiVAR_066731 | 521 | W → R in LDS2. 1 PublicationCorresponds to variant dbSNP:rs1575166666EnsemblClinVar. | 1 | |
Natural variantiVAR_015816 | 526 | E → Q in esophageal cancer. 1 PublicationCorresponds to variant dbSNP:rs121918714EnsemblClinVar. | 1 | |
Natural variantiVAR_022360 | 528 | R → C in LDS2. 1 PublicationCorresponds to variant dbSNP:rs104893810EnsemblClinVar. | 1 | |
Natural variantiVAR_022361 | 528 | R → H in LDS2. 2 PublicationsCorresponds to variant dbSNP:rs104893815EnsemblClinVar. | 1 | |
Natural variantiVAR_076171 | 530 | T → I in LDS2. 1 Publication | 1 | |
Natural variantiVAR_022362 | 537 | R → C in LDS2; has a negative effect on TGF-beta signaling. 1 PublicationCorresponds to variant dbSNP:rs104893809EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_012157 | 31 – 32 | SV → SDVEMEAQKDEIICPSCNRT AHPLRHI in isoform 2. 2 Publications | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85079 mRNA Translation: AAA61164.1 D28131 mRNA Translation: BAA05673.1 U52246 , U52240, U52241, U52242, U52244, U52245 Genomic DNA Translation: AAB17553.1 U69152 , U69146, U69147, U69148, U69149, U69150, U69151 Genomic DNA Translation: AAB40916.1 D50683 mRNA Translation: BAA09332.1 AY675319 Genomic DNA Translation: AAT70724.1 AK300383 mRNA Translation: BAG62117.1 CH471055 Genomic DNA Translation: EAW64412.1 |
CCDSi | CCDS2648.1 [P37173-1] CCDS33727.1 [P37173-2] |
PIRi | A42100 |
RefSeqi | NP_001020018.1, NM_001024847.2 [P37173-2] NP_003233.4, NM_003242.5 [P37173-1] |
Genome annotation databases
Ensembli | ENST00000295754; ENSP00000295754; ENSG00000163513 ENST00000359013; ENSP00000351905; ENSG00000163513 [P37173-2] |
GeneIDi | 7048 |
KEGGi | hsa:7048 |
MANE-Selecti | ENST00000295754.10; ENSP00000295754.5; NM_003242.6; NP_003233.4 |
UCSCi | uc003cen.4, human [P37173-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | M85079 mRNA Translation: AAA61164.1 D28131 mRNA Translation: BAA05673.1 U52246 , U52240, U52241, U52242, U52244, U52245 Genomic DNA Translation: AAB17553.1 U69152 , U69146, U69147, U69148, U69149, U69150, U69151 Genomic DNA Translation: AAB40916.1 D50683 mRNA Translation: BAA09332.1 AY675319 Genomic DNA Translation: AAT70724.1 AK300383 mRNA Translation: BAG62117.1 CH471055 Genomic DNA Translation: EAW64412.1 |
CCDSi | CCDS2648.1 [P37173-1] CCDS33727.1 [P37173-2] |
PIRi | A42100 |
RefSeqi | NP_001020018.1, NM_001024847.2 [P37173-2] NP_003233.4, NM_003242.5 [P37173-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1KTZ | X-ray | 2.15 | B | 38-159 | [»] | |
1M9Z | X-ray | 1.05 | A | 49-159 | [»] | |
1PLO | NMR | - | A | 38-159 | [»] | |
2PJY | X-ray | 3.00 | B | 42-149 | [»] | |
3KFD | X-ray | 3.00 | E/F/G/H | 38-153 | [»] | |
4P7U | X-ray | 1.50 | A | 49-159 | [»] | |
4XJJ | X-ray | 1.40 | A | 50-159 | [»] | |
5E8V | X-ray | 1.69 | A | 237-549 | [»] | |
5E8Y | X-ray | 2.05 | A | 237-549 | [»] | |
5E91 | X-ray | 2.42 | A | 237-549 | [»] | |
5E92 | X-ray | 2.08 | A | 237-549 | [»] | |
5QIN | X-ray | 1.57 | A | 237-549 | [»] | |
5TX4 | X-ray | 1.88 | A | 38-153 | [»] | |
5TY4 | electron microscopy | 2.90 | A | 47-149 | [»] | |
7DV6 | X-ray | 2.39 | A | 237-549 | [»] | |
BMRBi | P37173 | |||||
SMRi | P37173 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112906, 181 interactors |
ComplexPortali | CPX-2544, TGF-beta-3-TGFR complex CPX-529, TGF-beta-1-TGFR complex CPX-834, TGF-beta-2-TGFR complex |
CORUMi | P37173 |
DIPi | DIP-5939N |
IntActi | P37173, 123 interactors |
MINTi | P37173 |
STRINGi | 9606.ENSP00000351905 |
Chemistry databases
BindingDBi | P37173 |
ChEMBLi | CHEMBL4267 |
DrugBanki | DB10770, Foreskin fibroblast (neonatal) DB10772, Foreskin keratinocyte (neonatal) DB12010, Fostamatinib |
DrugCentrali | P37173 |
GuidetoPHARMACOLOGYi | 1795 |
PTM databases
GlyConnecti | 1979, 9 N-Linked glycans (3 sites) |
GlyGeni | P37173, 5 sites, 9 N-linked glycans (3 sites) |
iPTMneti | P37173 |
PhosphoSitePlusi | P37173 |
Genetic variation databases
BioMutai | TGFBR2 |
DMDMi | 116242818 |
Proteomic databases
EPDi | P37173 |
jPOSTi | P37173 |
MassIVEi | P37173 |
MaxQBi | P37173 |
PaxDbi | P37173 |
PeptideAtlasi | P37173 |
PRIDEi | P37173 |
ProteomicsDBi | 55264 [P37173-1] 55265 [P37173-2] |
Protocols and materials databases
Antibodypediai | 11570, 840 antibodies from 39 providers |
DNASUi | 7048 |
Genome annotation databases
Ensembli | ENST00000295754; ENSP00000295754; ENSG00000163513 ENST00000359013; ENSP00000351905; ENSG00000163513 [P37173-2] |
GeneIDi | 7048 |
KEGGi | hsa:7048 |
MANE-Selecti | ENST00000295754.10; ENSP00000295754.5; NM_003242.6; NP_003233.4 |
UCSCi | uc003cen.4, human [P37173-1] |
Organism-specific databases
CTDi | 7048 |
DisGeNETi | 7048 |
GeneCardsi | TGFBR2 |
GeneReviewsi | TGFBR2 |
HGNCi | HGNC:11773, TGFBR2 |
HPAi | ENSG00000163513, Low tissue specificity |
MalaCardsi | TGFBR2 |
MIMi | 133239, phenotype 190182, gene 610168, phenotype 614331, phenotype |
neXtProti | NX_P37173 |
OpenTargetsi | ENSG00000163513 |
Orphaneti | 91387, Familial thoracic aortic aneurysm and aortic dissection 60030, Loeys-Dietz syndrome 144, Lynch syndrome 284973, Marfan syndrome type 2 99977, Squamous cell carcinoma of the esophagus |
PharmGKBi | PA36486 |
VEuPathDBi | HostDB:ENSG00000163513 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3653, Eukaryota |
GeneTreei | ENSGT00940000157527 |
HOGENOMi | CLU_000288_8_3_1 |
InParanoidi | P37173 |
OMAi | MCSCSAE |
PhylomeDBi | P37173 |
TreeFami | TF314724 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P37173 |
Reactomei | R-HSA-2173788, Downregulation of TGF-beta receptor signaling R-HSA-2173789, TGF-beta receptor signaling activates SMADs R-HSA-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) R-HSA-3304356, SMAD2/3 Phosphorylation Motif Mutants in Cancer R-HSA-3642279, TGFBR2 MSI Frameshift Mutants in Cancer R-HSA-3645790, TGFBR2 Kinase Domain Mutants in Cancer R-HSA-3656532, TGFBR1 KD Mutants in Cancer R-HSA-3656535, TGFBR1 LBD Mutants in Cancer R-HSA-5689603, UCH proteinases |
SignaLinki | P37173 |
SIGNORi | P37173 |
Miscellaneous databases
BioGRID-ORCSi | 7048, 34 hits in 1087 CRISPR screens |
ChiTaRSi | TGFBR2, human |
EvolutionaryTracei | P37173 |
GeneWikii | TGF_beta_receptor_2 |
GenomeRNAii | 7048 |
Pharosi | P37173, Tchem |
PROi | PR:P37173 |
RNActi | P37173, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000163513, Expressed in metanephric glomerulus and 244 other tissues |
ExpressionAtlasi | P37173, baseline and differential |
Genevisiblei | P37173, HS |
Family and domain databases
DisProti | DP01760 |
Gene3Di | 2.10.60.10, 1 hit |
IDEALi | IID00414 |
InterProi | View protein in InterPro IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR001245, Ser-Thr/Tyr_kinase_cat_dom IPR008271, Ser/Thr_kinase_AS IPR045860, Snake_toxin-like_sf IPR000333, TGFB_receptor IPR017194, Transform_growth_fac-b_typ-2 IPR015013, Transforming_GF_b_rcpt_2_ecto |
PANTHERi | PTHR23255, PTHR23255, 1 hit |
Pfami | View protein in Pfam PF08917, ecTbetaR2, 1 hit PF07714, PK_Tyr_Ser-Thr, 1 hit |
PIRSFi | PIRSF037393, TGFRII, 1 hit |
PRINTSi | PR00653, ACTIVIN2R |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit SSF57302, SSF57302, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TGFR2_HUMAN | |
Accessioni | P37173Primary (citable) accession number: P37173 Secondary accession number(s): B4DTV5 Q99474 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1994 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 23, 2022 | |
This is version 240 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families