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Entry version 111 (10 Apr 2019)
Sequence version 1 (01 Oct 1994)
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Protein

Probable lipid II flippase MurJ

Gene

murJ

Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.UniRule annotation

Caution

Was originally (PubMed:2680969) thought to be involved in mouse virulence. It was later shown that the mutation responsible for the virulence phenotype maps to nearby genes (PubMed:8288531).2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis, Transport

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
SENT99287:STM1170-MONOMER

UniPathway: a resource for the exploration and annotation of metabolic pathways

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UniPathwayi
UPA00219

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.66.4.1 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable lipid II flippase MurJUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:murJUniRule annotation
Synonyms:mviB, mviN, mviS
Ordered Locus Names:STM1170
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSalmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri99287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeSalmonella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001014 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei44 – 64HelicalUniRule annotationAdd BLAST21
Transmembranei103 – 123HelicalUniRule annotationAdd BLAST21
Transmembranei146 – 166HelicalUniRule annotationAdd BLAST21
Transmembranei172 – 192HelicalUniRule annotationAdd BLAST21
Transmembranei195 – 215HelicalUniRule annotationAdd BLAST21
Transmembranei250 – 270HelicalUniRule annotationAdd BLAST21
Transmembranei284 – 304HelicalUniRule annotationAdd BLAST21
Transmembranei322 – 342HelicalUniRule annotationAdd BLAST21
Transmembranei367 – 387HelicalUniRule annotationAdd BLAST21
Transmembranei396 – 416HelicalUniRule annotationAdd BLAST21
Transmembranei420 – 440HelicalUniRule annotationAdd BLAST21
Transmembranei456 – 476HelicalUniRule annotationAdd BLAST21
Transmembranei494 – 514HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001820141 – 524Probable lipid II flippase MurJAdd BLAST524

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P37169

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MurJ/MviN family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CJR Bacteria
COG0728 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000263812

KEGG Orthology (KO)

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KOi
K03980

Identification of Orthologs from Complete Genome Data

More...
OMAi
IFFVAFK

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P37169

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13123 MATE_MurJ_like, 1 hit

HAMAP database of protein families

More...
HAMAPi
MF_02078 MurJ_MviN, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR004268 MurJ

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03023 MurJ, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002869 MviN, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01806 VIRFACTRMVIN

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01695 murJ_mviN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P37169-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQEFYARVWN TKEMNLLKSL AAVSSMTMFS RVLGFARDAI VARIFGAGMA
60 70 80 90 100
TDAFFVAFKL PNLLRRIFAE GAFSQAFVPI LAEYKSKQGE EATRIFVAYV
110 120 130 140 150
SGLLTLALAV VTVAGMLAAP WVIMVTAPGF ADTADKFALT TQLLRITFPY
160 170 180 190 200
ILLISLASLV GAILNTWNRF SIPAFAPTFL NISMIGFALF AAPYFNPPVL
210 220 230 240 250
ALAWAVTVGG VLQLVYQLPY LKKIGMLVLP RINFRDTGAM RVVKQMGPAI
260 270 280 290 300
LGVSVSQISL IINTIFASFL ASGSVSWMYY ADRLMEFPSG VLGVALGTIL
310 320 330 340 350
LPSLSKSFAS GNHDEYCRLM DWGLRLCFLL ALPSAVALGI LAKPLTVSLF
360 370 380 390 400
QYGKFTAFDA AMTQRALIAY SVGLIGLIVV KVLAPGFYSR QDIKTPVKIA
410 420 430 440 450
IVTLIMTQLM NLAFIGPLKH AGLSLSIGLA ACLNASLLYW QLRKQNIFTP
460 470 480 490 500
QPGWMWFLMR LIISVLVMAA VLFGVLHIMP EWSQGSMLWR LLRLMAVVIA
510 520
GIAAYFAALA VLGFKVKEFV RRTA
Length:524
Mass (Da):57,315
Last modified:October 1, 1994 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i105BB31AF805E048
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z26133 Genomic DNA Translation: CAA81134.1
D25292 Genomic DNA Translation: BAA04980.1
AE006468 Genomic DNA Translation: AAL20100.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S40271

NCBI Reference Sequences

More...
RefSeqi
NP_460141.1, NC_003197.2
WP_001155214.1, NC_003197.2

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL20100; AAL20100; STM1170

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1252688

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
stm:STM1170

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|99287.12.peg.1238

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z26133 Genomic DNA Translation: CAA81134.1
D25292 Genomic DNA Translation: BAA04980.1
AE006468 Genomic DNA Translation: AAL20100.1
PIRiS40271
RefSeqiNP_460141.1, NC_003197.2
WP_001155214.1, NC_003197.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

TCDBi2.A.66.4.1 the multidrug/oligosaccharidyl-lipid/polysaccharide (mop) flippase superfamily

Proteomic databases

PaxDbiP37169

Genome annotation databases

EnsemblBacteriaiAAL20100; AAL20100; STM1170
GeneIDi1252688
KEGGistm:STM1170
PATRICifig|99287.12.peg.1238

Phylogenomic databases

eggNOGiENOG4105CJR Bacteria
COG0728 LUCA
HOGENOMiHOG000263812
KOiK03980
OMAiIFFVAFK
PhylomeDBiP37169

Enzyme and pathway databases

UniPathwayiUPA00219
BioCyciSENT99287:STM1170-MONOMER

Family and domain databases

CDDicd13123 MATE_MurJ_like, 1 hit
HAMAPiMF_02078 MurJ_MviN, 1 hit
InterProiView protein in InterPro
IPR004268 MurJ
PfamiView protein in Pfam
PF03023 MurJ, 1 hit
PIRSFiPIRSF002869 MviN, 1 hit
PRINTSiPR01806 VIRFACTRMVIN
TIGRFAMsiTIGR01695 murJ_mviN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMURJ_SALTY
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P37169
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 1, 1994
Last modified: April 10, 2019
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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