Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Signal recognition particle 14 kDa protein

Gene

SRP14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.

GO - Molecular functioni

  • 7S RNA binding Source: ProtInc
  • endoplasmic reticulum signal peptide binding Source: InterPro
  • RNA binding Source: UniProtKB

GO - Biological processi

  • cotranslational protein targeting to membrane Source: ProtInc
  • neutrophil degranulation Source: Reactome
  • protein targeting to ER Source: UniProtKB
  • response to drug Source: UniProtKB
  • SRP-dependent cotranslational protein targeting to membrane Source: Reactome

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-6798695 Neutrophil degranulation

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Signal recognition particle 14 kDa protein
Short name:
SRP14
Alternative name(s):
18 kDa Alu RNA-binding protein
Gene namesi
Name:SRP14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000140319.10
HGNCiHGNC:11299 SRP14
MIMi600708 gene
neXtProtiNX_P37108

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Signal recognition particle

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000140319
PharmGKBiPA36123

Polymorphism and mutation databases

BioMutaiSRP14
DMDMi116242801

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources1 Publication
ChainiPRO_00001351892 – 136Signal recognition particle 14 kDa proteinAdd BLAST135

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei27PhosphotyrosineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP37108
MaxQBiP37108
PaxDbiP37108
PeptideAtlasiP37108
PRIDEiP37108
ProteomicsDBi55263
TopDownProteomicsiP37108

2D gel databases

SWISS-2DPAGEiP37108

PTM databases

iPTMnetiP37108
PhosphoSitePlusiP37108
SwissPalmiP37108

Expressioni

Gene expression databases

BgeeiENSG00000140319 Expressed in 238 organ(s), highest expression level in metanephros
CleanExiHS_SRP14
ExpressionAtlasiP37108 baseline and differential
GenevisibleiP37108 HS

Organism-specific databases

HPAiHPA053738
HPA065118

Interactioni

Subunit structurei

Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
SRP9P49458-12EBI-353399,EBI-15490029

Protein-protein interaction databases

BioGridi112605, 80 interactors
CORUMiP37108
DIPiDIP-6152N
IntActiP37108, 25 interactors
MINTiP37108
STRINGi9606.ENSP00000267884

Structurei

Secondary structure

1136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP37108
SMRiP37108
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP37108

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 136Ala/Thr-richAdd BLAST29

Sequence similaritiesi

Belongs to the SRP14 family.Curated

Phylogenomic databases

eggNOGiKOG1761 Eukaryota
ENOG4111PSF LUCA
GeneTreeiENSGT00390000008496
HOGENOMiHOG000184883
HOVERGENiHBG057435
InParanoidiP37108
KOiK03104
OMAiVWLTHKR
OrthoDBiEOG091G1081
PhylomeDBiP37108
TreeFamiTF106247

Family and domain databases

Gene3Di3.30.720.10, 1 hit
InterProiView protein in InterPro
IPR003210 Signal_recog_particle_SRP14
IPR009018 Signal_recog_particle_SRP9/14
PANTHERiPTHR12013 PTHR12013, 1 hit
PfamiView protein in Pfam
PF02290 SRP14, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009170 Signal_recog_particle_SRP14, 1 hit
SUPFAMiSSF54762 SSF54762, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P37108-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLLESEQFL TELTRLFQKC RTSGSVYITL KKYDGRTKPI PKKGTVEGFE
60 70 80 90 100
PADNKCLLRA TDGKKKISTV VSSKEVNKFQ MAYSNLLRAN MDGLKKRDKK
110 120 130
NKTKKTKAAA AAAAAAPAAA ATAPTTAATT AATAAQ
Length:136
Mass (Da):14,570
Last modified:October 17, 2006 - v2
Checksum:i2B5B2D1D62AF5E8E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YLA2H0YLA2_HUMAN
Signal recognition particle 14 kDa ...
SRP14
115Annotation score:
H0YLW0H0YLW0_HUMAN
Signal recognition particle 14 kDa ...
SRP14
56Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti129T → A in BAB69067 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02805751P → S. Corresponds to variant dbSNP:rs1802601Ensembl.1
Natural variantiVAR_02805868S → I. Corresponds to variant dbSNP:rs1802600Ensembl.1
Natural variantiVAR_028059124P → A6 PublicationsCorresponds to variant dbSNP:rs7535Ensembl.1
Natural variantiVAR_028060125T → A. Corresponds to variant dbSNP:rs200831083Ensembl.1
Natural variantiVAR_028061127A → T. Corresponds to variant dbSNP:rs16924521Ensembl.1
Natural variantiVAR_028062130T → A. Corresponds to variant dbSNP:rs4814Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73459 mRNA Translation: CAA51838.1
U07857 mRNA Translation: AAA59066.1
AB061546 mRNA Translation: BAB69067.1
AB451391 mRNA Translation: BAG70205.1
AC025168 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92390.1
BC035495 mRNA Translation: AAH35495.1
BC071716 mRNA Translation: AAH71716.1
BC100031 mRNA Translation: AAI00032.1
CCDSiCCDS42017.1
PIRiA56062
S34196
RefSeqiNP_003125.3, NM_003134.5
UniGeneiHs.533732

Genome annotation databases

EnsembliENST00000267884; ENSP00000267884; ENSG00000140319
GeneIDi6727
KEGGihsa:6727
UCSCiuc001zkq.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Signal recognition particle entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X73459 mRNA Translation: CAA51838.1
U07857 mRNA Translation: AAA59066.1
AB061546 mRNA Translation: BAB69067.1
AB451391 mRNA Translation: BAG70205.1
AC025168 Genomic DNA No translation available.
CH471125 Genomic DNA Translation: EAW92390.1
BC035495 mRNA Translation: AAH35495.1
BC071716 mRNA Translation: AAH71716.1
BC100031 mRNA Translation: AAI00032.1
CCDSiCCDS42017.1
PIRiA56062
S34196
RefSeqiNP_003125.3, NM_003134.5
UniGeneiHs.533732

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1E8OX-ray3.20B/D2-107[»]
1E8SX-ray4.00B2-107[»]
1RY1electron microscopy12.00D2-107[»]
4UYJX-ray3.35B/D1-107[»]
4UYKX-ray3.22B1-107[»]
5AOXX-ray2.04B/E2-95[»]
ProteinModelPortaliP37108
SMRiP37108
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112605, 80 interactors
CORUMiP37108
DIPiDIP-6152N
IntActiP37108, 25 interactors
MINTiP37108
STRINGi9606.ENSP00000267884

Protein family/group databases

TCDBi3.A.5.9.1 the general secretory pathway (sec) family

PTM databases

iPTMnetiP37108
PhosphoSitePlusiP37108
SwissPalmiP37108

Polymorphism and mutation databases

BioMutaiSRP14
DMDMi116242801

2D gel databases

SWISS-2DPAGEiP37108

Proteomic databases

EPDiP37108
MaxQBiP37108
PaxDbiP37108
PeptideAtlasiP37108
PRIDEiP37108
ProteomicsDBi55263
TopDownProteomicsiP37108

Protocols and materials databases

DNASUi6727
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267884; ENSP00000267884; ENSG00000140319
GeneIDi6727
KEGGihsa:6727
UCSCiuc001zkq.3 human

Organism-specific databases

CTDi6727
EuPathDBiHostDB:ENSG00000140319.10
GeneCardsiSRP14
HGNCiHGNC:11299 SRP14
HPAiHPA053738
HPA065118
MIMi600708 gene
neXtProtiNX_P37108
OpenTargetsiENSG00000140319
PharmGKBiPA36123
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1761 Eukaryota
ENOG4111PSF LUCA
GeneTreeiENSGT00390000008496
HOGENOMiHOG000184883
HOVERGENiHBG057435
InParanoidiP37108
KOiK03104
OMAiVWLTHKR
OrthoDBiEOG091G1081
PhylomeDBiP37108
TreeFamiTF106247

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiSRP14 human
EvolutionaryTraceiP37108
GenomeRNAii6727
PROiPR:P37108
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000140319 Expressed in 238 organ(s), highest expression level in metanephros
CleanExiHS_SRP14
ExpressionAtlasiP37108 baseline and differential
GenevisibleiP37108 HS

Family and domain databases

Gene3Di3.30.720.10, 1 hit
InterProiView protein in InterPro
IPR003210 Signal_recog_particle_SRP14
IPR009018 Signal_recog_particle_SRP9/14
PANTHERiPTHR12013 PTHR12013, 1 hit
PfamiView protein in Pfam
PF02290 SRP14, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD009170 Signal_recog_particle_SRP14, 1 hit
SUPFAMiSSF54762 SSF54762, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSRP14_HUMAN
AccessioniPrimary (citable) accession number: P37108
Secondary accession number(s): B5BUF5, Q6B0K5, Q96Q14
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1994
Last sequence update: October 17, 2006
Last modified: October 10, 2018
This is version 182 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again