UniProtKB - P37058 (DHB3_HUMAN)
17-beta-hydroxysteroid dehydrogenase type 3
HSD17B3
Functioni
Catalyzes the conversion of 17-oxosteroids to 17beta-hydroxysteroids (PubMed:8075637, PubMed:16216911, PubMed:27927697, PubMed:26545797).
Favors the reduction of androstenedione to testosterone (PubMed:16216911, PubMed:27927697, PubMed:26545797).
Testosterone is the key androgen driving male development and function (PubMed:8075637).
Uses NADPH while the two other EDH17B enzymes use NADH (PubMed:26545797, PubMed:8075637, PubMed:16216911).
Androgens such as epiandrosterone, dehydroepiandrosterone, androsterone and androstanedione are accepted as substrates and reduced at C-17 (PubMed:16216911).
Can reduce 11-ketoandrostenedione as well as 11beta-hydroxyandrostenedione at C-17 to the respective testosterone forms (PubMed:16216911, PubMed:27927697).
4 PublicationsCatalytic activityi
- EC:1.1.1.644 Publications
- EC:1.1.1.621 PublicationThis reaction proceeds in the backward1 Publication direction.
- This reaction proceeds in the forward2 Publications direction.
- This reaction proceeds in the backward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- This reaction proceeds in the forward1 Publication direction.
- androst-4-ene-3,11,17-trione + H+ + NADPH = 17β-hydroxyandrost-4-ene-3,11-dione + NADP+2 PublicationsThis reaction proceeds in the forward2 Publications direction.
- 11β-hydroxyandrost-4-ene-3,17-dione + H+ + NADPH = 11β,17β-dihydroxyandrost-4-ene-3-one + NADP+1 PublicationThis reaction proceeds in the forward1 Publication direction.
: testosterone biosynthesis Pathwayi
This protein is involved in the pathway testosterone biosynthesis, which is part of Hormone biosynthesis.2 PublicationsView all proteins of this organism that are known to be involved in the pathway testosterone biosynthesis and in Hormone biosynthesis.
Pathwayi: Steroid metabolism
This protein is involved in Steroid metabolism.CuratedView all proteins of this organism that are known to be involved in Steroid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 185 | SubstrateBy similarity | 1 | |
Active sitei | 198 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 48 – 77 | NADPBy similarityAdd BLAST | 30 |
GO - Molecular functioni
- 17-beta-hydroxysteroid dehydrogenase (NADP+) activity Source: RHEA
- oxidoreductase activity Source: GO_Central
- testosterone 17-beta-dehydrogenase (NADP+) activity Source: UniProtKB
- testosterone dehydrogenase [NAD(P)] activity Source: Reactome
GO - Biological processi
- androgen biosynthetic process Source: Reactome
- male genitalia development Source: ProtInc
- steroid biosynthetic process Source: GO_Central
- testosterone biosynthetic process Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Ligand | NADP |
Enzyme and pathway databases
BRENDAi | 1.1.1.51, 2681 1.1.1.64, 2681 |
PathwayCommonsi | P37058 |
Reactomei | R-HSA-193048, Androgen biosynthesis R-HSA-75876, Synthesis of very long-chain fatty acyl-CoAs |
SignaLinki | P37058 |
UniPathwayi | UPA00367 |
Chemistry databases
SwissLipidsi | SLP:000001270 [P37058-1] |
Names & Taxonomyi
Protein namesi | Recommended name: 17-beta-hydroxysteroid dehydrogenase type 3Short name: 17-beta-HSD 31 Publication Alternative name(s): |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5212, HSD17B3 |
MIMi | 605573, gene |
neXtProti | NX_P37058 |
VEuPathDBi | HostDB:ENSG00000130948 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum 2 Publications
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: Reactome
Other locations
- intracellular membrane-bounded organelle Source: ProtInc
Keywords - Cellular componenti
Endoplasmic reticulumPathology & Biotechi
Involvement in diseasei
Male pseudohermaphrodism with gynecomastia (MPH)6 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_016067 | 56 | A → T in MPH; Cambridge-2; affects NADPH cofactor binding. 1 PublicationCorresponds to variant dbSNP:rs119481078EnsemblClinVar. | 1 | |
Natural variantiVAR_016068 | 65 | S → L in MPH. 1 PublicationCorresponds to variant dbSNP:rs747329682EnsemblClinVar. | 1 | |
Natural variantiVAR_006953 | 80 | R → Q in MPH; Gaza; ; almost complete loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 PublicationCorresponds to variant dbSNP:rs119481075EnsemblClinVar. | 1 | |
Natural variantiVAR_006954 | 80 | R → W in MPH. 1 PublicationCorresponds to variant dbSNP:rs119481077EnsemblClinVar. | 1 | |
Natural variantiVAR_016069 | 130 | N → S in MPH; Cambridge-1; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs119481079EnsemblClinVar. | 1 | |
Natural variantiVAR_075369 | 133 | G → R in MPH; almost complete loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity; no effect on protein abundance; no effect on endoplasmic reticulum location. 1 PublicationCorresponds to variant dbSNP:rs747724352EnsemblClinVar. | 1 | |
Natural variantiVAR_016070 | 176 | Q → P in MPH. 1 PublicationCorresponds to variant dbSNP:rs767259718Ensembl. | 1 | |
Natural variantiVAR_006955 | 203 | A → V in MPH; loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 PublicationCorresponds to variant dbSNP:rs119481076EnsemblClinVar. | 1 | |
Natural variantiVAR_016071 | 205 | V → E in MPH. 1 PublicationCorresponds to variant dbSNP:rs372027264EnsemblClinVar. | 1 | |
Natural variantiVAR_016072 | 208 | F → I in MPH. 1 Publication | 1 | |
Natural variantiVAR_016203 | 215 | E → D in MPH. 1 PublicationCorresponds to variant dbSNP:rs115063639Ensembl. | 1 | |
Natural variantiVAR_006956 | 232 | S → L in MPH; almost complete loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 PublicationCorresponds to variant dbSNP:rs28939085EnsemblClinVar. | 1 | |
Natural variantiVAR_006957 | 235 | M → V in MPH; almost complete loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 PublicationCorresponds to variant dbSNP:rs119481074EnsemblClinVar. | 1 | |
Natural variantiVAR_016073 | 268 | C → Y in MPH; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs119481080EnsemblClinVar. | 1 | |
Natural variantiVAR_016074 | 282 | P → L in MPH. 1 PublicationCorresponds to variant dbSNP:rs144809928EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 133 | G → A: Has 70% of wild-type testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 Publication | 1 | |
Mutagenesisi | 133 | G → F: Almost complete loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 Publication | 1 | |
Mutagenesisi | 133 | G → Q: Almost complete loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 Publication | 1 |
Keywords - Diseasei
Disease variant, PseudohermaphroditismOrganism-specific databases
DisGeNETi | 3293 |
MalaCardsi | HSD17B3 |
MIMi | 264300, phenotype |
OpenTargetsi | ENSG00000130948 |
Orphaneti | 752, 46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency |
PharmGKBi | PA29480 |
Miscellaneous databases
Pharosi | P37058, Tchem |
Chemistry databases
ChEMBLi | CHEMBL4234 |
DrugBanki | DB00157, NADH |
DrugCentrali | P37058 |
Genetic variation databases
BioMutai | HSD17B3 |
DMDMi | 1169300 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054573 | 1 – 310 | 17-beta-hydroxysteroid dehydrogenase type 3Add BLAST | 310 |
Proteomic databases
MassIVEi | P37058 |
PaxDbi | P37058 |
PeptideAtlasi | P37058 |
PRIDEi | P37058 |
ProteomicsDBi | 55255 [P37058-1] 65223 |
PTM databases
iPTMneti | P37058 |
PhosphoSitePlusi | P37058 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000130948, Expressed in right testis and 124 other tissues |
ExpressionAtlasi | P37058, baseline and differential |
Genevisiblei | P37058, HS |
Organism-specific databases
HPAi | ENSG00000130948, Tissue enhanced (liver, testis) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 109526, 28 interactors |
IntActi | P37058, 19 interactors |
MINTi | P37058 |
STRINGi | 9606.ENSP00000364412 |
Chemistry databases
BindingDBi | P37058 |
Miscellaneous databases
RNActi | P37058, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1014, Eukaryota |
GeneTreei | ENSGT00940000160266 |
HOGENOMi | CLU_010194_38_0_1 |
InParanoidi | P37058 |
OMAi | GNMPIPN |
OrthoDBi | 288325at2759 |
PhylomeDBi | P37058 |
TreeFami | TF314591 |
Family and domain databases
InterProi | View protein in InterPro IPR033281, HSD17B3 IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
PANTHERi | PTHR43899:SF7, PTHR43899:SF7, 1 hit |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGDVLEQFFI LTGLLVCLAC LAKCVRFSRC VLLNYWKVLP KSFLRSMGQW
60 70 80 90 100
AVITGAGDGI GKAYSFELAK RGLNVVLISR TLEKLEAIAT EIERTTGRSV
110 120 130 140 150
KIIQADFTKD DIYEHIKEKL AGLEIGILVN NVGMLPNLLP SHFLNAPDEI
160 170 180 190 200
QSLIHCNITS VVKMTQLILK HMESRQKGLI LNISSGIALF PWPLYSMYSA
210 220 230 240 250
SKAFVCAFSK ALQEEYKAKE VIIQVLTPYA VSTAMTKYLN TNVITKTADE
260 270 280 290 300
FVKESLNYVT IGGETCGCLA HEILAGFLSL IPAWAFYSGA FQRLLLTHYV
310
AYLKLNTKVR
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ITT4 | A0A3B3ITT4_HUMAN | Testosterone 17-beta-dehydrogenase ... | HSD17B3 | 245 | Annotation score: | ||
A0A0S2Z3U6 | A0A0S2Z3U6_HUMAN | Hydroxysteroid dehydrogenase 3 isof... | HSD17B3 | 284 | Annotation score: | ||
A0A0S2Z3V7 | A0A0S2Z3V7_HUMAN | Hydroxysteroid dehydrogenase 3 isof... | HSD17B3 | 157 | Annotation score: | ||
A0A3B3ITW2 | A0A3B3ITW2_HUMAN | Testosterone 17-beta-dehydrogenase ... | HSD17B3 | 74 | Annotation score: | ||
A0A0S2Z413 | A0A0S2Z413_HUMAN | Hydroxysteroid dehydrogenase 3 isof... | HSD17B3 | 192 | Annotation score: | ||
A0A0S2Z406 | A0A0S2Z406_HUMAN | Hydroxysteroid dehydrogenase 3 isof... | HSD17B3 | 108 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_014870 | 31 | V → I1 PublicationCorresponds to variant dbSNP:rs2066480EnsemblClinVar. | 1 | |
Natural variantiVAR_016067 | 56 | A → T in MPH; Cambridge-2; affects NADPH cofactor binding. 1 PublicationCorresponds to variant dbSNP:rs119481078EnsemblClinVar. | 1 | |
Natural variantiVAR_016068 | 65 | S → L in MPH. 1 PublicationCorresponds to variant dbSNP:rs747329682EnsemblClinVar. | 1 | |
Natural variantiVAR_006953 | 80 | R → Q in MPH; Gaza; ; almost complete loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 PublicationCorresponds to variant dbSNP:rs119481075EnsemblClinVar. | 1 | |
Natural variantiVAR_006954 | 80 | R → W in MPH. 1 PublicationCorresponds to variant dbSNP:rs119481077EnsemblClinVar. | 1 | |
Natural variantiVAR_016069 | 130 | N → S in MPH; Cambridge-1; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs119481079EnsemblClinVar. | 1 | |
Natural variantiVAR_075369 | 133 | G → R in MPH; almost complete loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity; no effect on protein abundance; no effect on endoplasmic reticulum location. 1 PublicationCorresponds to variant dbSNP:rs747724352EnsemblClinVar. | 1 | |
Natural variantiVAR_016070 | 176 | Q → P in MPH. 1 PublicationCorresponds to variant dbSNP:rs767259718Ensembl. | 1 | |
Natural variantiVAR_006955 | 203 | A → V in MPH; loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 PublicationCorresponds to variant dbSNP:rs119481076EnsemblClinVar. | 1 | |
Natural variantiVAR_016071 | 205 | V → E in MPH. 1 PublicationCorresponds to variant dbSNP:rs372027264EnsemblClinVar. | 1 | |
Natural variantiVAR_016072 | 208 | F → I in MPH. 1 Publication | 1 | |
Natural variantiVAR_016203 | 215 | E → D in MPH. 1 PublicationCorresponds to variant dbSNP:rs115063639Ensembl. | 1 | |
Natural variantiVAR_006956 | 232 | S → L in MPH; almost complete loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 PublicationCorresponds to variant dbSNP:rs28939085EnsemblClinVar. | 1 | |
Natural variantiVAR_006957 | 235 | M → V in MPH; almost complete loss of testosterone 17-beta-dehydrogenase (NADP(+)) activity. 1 PublicationCorresponds to variant dbSNP:rs119481074EnsemblClinVar. | 1 | |
Natural variantiVAR_016073 | 268 | C → Y in MPH; complete loss of activity. 1 PublicationCorresponds to variant dbSNP:rs119481080EnsemblClinVar. | 1 | |
Natural variantiVAR_016074 | 282 | P → L in MPH. 1 PublicationCorresponds to variant dbSNP:rs144809928EnsemblClinVar. | 1 | |
Natural variantiVAR_061844 | 289 | G → C. Corresponds to variant dbSNP:rs2066479EnsemblClinVar. | 1 | |
Natural variantiVAR_061845 | 289 | G → R. Corresponds to variant dbSNP:rs2066479EnsemblClinVar. | 1 | |
Natural variantiVAR_014871 | 289 | G → S2 PublicationsCorresponds to variant dbSNP:rs2066479EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_056640 | 225 – 274 | Missing in isoform 2. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U05659 mRNA Translation: AAC50066.1 AY341031 Genomic DNA Translation: AAP88937.1 BT019371 mRNA Translation: AAV38178.1 AL160269 Genomic DNA No translation available. BC034281 mRNA Translation: AAH34281.1 |
CCDSi | CCDS6716.1 [P37058-1] |
PIRi | S43928 |
RefSeqi | NP_000188.1, NM_000197.1 [P37058-1] XP_011516920.1, XM_011518618.2 [P37058-1] XP_011516921.1, XM_011518619.2 [P37058-1] XP_016870160.1, XM_017014671.1 [P37058-1] XP_016870161.1, XM_017014672.1 [P37058-1] |
Genome annotation databases
Ensembli | ENST00000375262; ENSP00000364411; ENSG00000130948 [P37058-2] ENST00000375263; ENSP00000364412; ENSG00000130948 |
GeneIDi | 3293 |
KEGGi | hsa:3293 |
MANE-Selecti | ENST00000375263.8; ENSP00000364412.3; NM_000197.2; NP_000188.1 |
UCSCi | uc010msc.1, human [P37058-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U05659 mRNA Translation: AAC50066.1 AY341031 Genomic DNA Translation: AAP88937.1 BT019371 mRNA Translation: AAV38178.1 AL160269 Genomic DNA No translation available. BC034281 mRNA Translation: AAH34281.1 |
CCDSi | CCDS6716.1 [P37058-1] |
PIRi | S43928 |
RefSeqi | NP_000188.1, NM_000197.1 [P37058-1] XP_011516920.1, XM_011518618.2 [P37058-1] XP_011516921.1, XM_011518619.2 [P37058-1] XP_016870160.1, XM_017014671.1 [P37058-1] XP_016870161.1, XM_017014672.1 [P37058-1] |
3D structure databases
SMRi | P37058 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109526, 28 interactors |
IntActi | P37058, 19 interactors |
MINTi | P37058 |
STRINGi | 9606.ENSP00000364412 |
Chemistry databases
BindingDBi | P37058 |
ChEMBLi | CHEMBL4234 |
DrugBanki | DB00157, NADH |
DrugCentrali | P37058 |
SwissLipidsi | SLP:000001270 [P37058-1] |
PTM databases
iPTMneti | P37058 |
PhosphoSitePlusi | P37058 |
Genetic variation databases
BioMutai | HSD17B3 |
DMDMi | 1169300 |
Proteomic databases
MassIVEi | P37058 |
PaxDbi | P37058 |
PeptideAtlasi | P37058 |
PRIDEi | P37058 |
ProteomicsDBi | 55255 [P37058-1] 65223 |
Protocols and materials databases
Antibodypediai | 3099, 192 antibodies from 26 providers |
DNASUi | 3293 |
Genome annotation databases
Ensembli | ENST00000375262; ENSP00000364411; ENSG00000130948 [P37058-2] ENST00000375263; ENSP00000364412; ENSG00000130948 |
GeneIDi | 3293 |
KEGGi | hsa:3293 |
MANE-Selecti | ENST00000375263.8; ENSP00000364412.3; NM_000197.2; NP_000188.1 |
UCSCi | uc010msc.1, human [P37058-1] |
Organism-specific databases
CTDi | 3293 |
DisGeNETi | 3293 |
GeneCardsi | HSD17B3 |
HGNCi | HGNC:5212, HSD17B3 |
HPAi | ENSG00000130948, Tissue enhanced (liver, testis) |
MalaCardsi | HSD17B3 |
MIMi | 264300, phenotype 605573, gene |
neXtProti | NX_P37058 |
OpenTargetsi | ENSG00000130948 |
Orphaneti | 752, 46,XY disorder of sex development due to 17-beta-hydroxysteroid dehydrogenase 3 deficiency |
PharmGKBi | PA29480 |
VEuPathDBi | HostDB:ENSG00000130948 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1014, Eukaryota |
GeneTreei | ENSGT00940000160266 |
HOGENOMi | CLU_010194_38_0_1 |
InParanoidi | P37058 |
OMAi | GNMPIPN |
OrthoDBi | 288325at2759 |
PhylomeDBi | P37058 |
TreeFami | TF314591 |
Enzyme and pathway databases
UniPathwayi | UPA00367 |
BRENDAi | 1.1.1.51, 2681 1.1.1.64, 2681 |
PathwayCommonsi | P37058 |
Reactomei | R-HSA-193048, Androgen biosynthesis R-HSA-75876, Synthesis of very long-chain fatty acyl-CoAs |
SignaLinki | P37058 |
Miscellaneous databases
BioGRID-ORCSi | 3293, 2 hits in 1032 CRISPR screens |
ChiTaRSi | HSD17B3, human |
GeneWikii | HSD17B3_(gene) |
GenomeRNAii | 3293 |
Pharosi | P37058, Tchem |
PROi | PR:P37058 |
RNActi | P37058, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130948, Expressed in right testis and 124 other tissues |
ExpressionAtlasi | P37058, baseline and differential |
Genevisiblei | P37058, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033281, HSD17B3 IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
PANTHERi | PTHR43899:SF7, PTHR43899:SF7, 1 hit |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DHB3_HUMAN | |
Accessioni | P37058Primary (citable) accession number: P37058 Secondary accession number(s): Q5U0Q6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | November 1, 1995 | |
Last modified: | February 23, 2022 | |
This is version 200 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families