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UniProtKB - P37032 (ACON_LEGPH)
Protein
Aconitate hydratase A
Gene
acn
Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Functioni
Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. The apo form of AcnA functions as a RNA-binding regulatory protein (PubMed:8366052).
Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate (By similarity).
By similarity1 PublicationCatalytic activityi
Cofactori
[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster per subunit.By similarity
: tricarboxylic acid cycle Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes isocitrate from oxaloacetate.Curated This subpathway is part of the pathway tricarboxylic acid cycle, which is itself part of Carbohydrate metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes isocitrate from oxaloacetate, the pathway tricarboxylic acid cycle and in Carbohydrate metabolism.
Pathwayi: propanoate degradation
This protein is involved in the pathway propanoate degradation, which is part of Organic acid metabolism.CuratedView all proteins of this organism that are known to be involved in the pathway propanoate degradation and in Organic acid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 435 | Iron-sulfur (4Fe-4S)By similarity | 1 | |
Metal bindingi | 501 | Iron-sulfur (4Fe-4S)By similarity | 1 | |
Metal bindingi | 504 | Iron-sulfur (4Fe-4S)By similarity | 1 |
GO - Molecular functioni
- 2-methylisocitrate dehydratase activity Source: UniProtKB
- 4 iron, 4 sulfur cluster binding Source: UniProtKB
- aconitate hydratase activity Source: UniProtKB
- citrate dehydratase activity Source: UniProtKB-EC
- metal ion binding Source: UniProtKB-KW
- mRNA 3'-UTR binding Source: UniProtKB
- mRNA binding Source: UniProtKB
GO - Biological processi
- propionate metabolic process, methylcitrate cycle Source: UniProtKB
- tricarboxylic acid cycle Source: UniProtKB
Keywordsi
Molecular function | Lyase, RNA-binding |
Biological process | Tricarboxylic acid cycle |
Ligand | 4Fe-4S, Iron, Iron-sulfur, Metal-binding |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00718 UPA00946 |
Names & Taxonomyi
Protein namesi | Recommended name: Aconitate hydratase A1 Publication (EC:4.2.1.3By similarity)Short name: ACN1 Publication Short name: Aconitase1 Publication Alternative name(s): (2R,3S)-2-methylisocitrate dehydrataseBy similarity (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate dehydrataseBy similarity IP2101 Publication Iron-responsive protein-like1 Publication Short name: IRP-like1 Publication Major iron-containing protein1 Publication Short name: MICP1 Publication Probable 2-methyl-cis-aconitate hydrataseBy similarity (EC:4.2.1.99By similarity) RNA-binding protein1 Publication |
Gene namesi | Name:acn Ordered Locus Names:lpg1690 |
Organismi | Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513) |
Taxonomic identifieri | 272624 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Legionellales › Legionellaceae › Legionella › |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076662 | 1 – 891 | Aconitate hydratase AAdd BLAST | 891 |
Proteomic databases
PaxDbi | P37032 |
Interactioni
Subunit structurei
Monomer.
1 PublicationProtein-protein interaction databases
STRINGi | 272624.lpg1690 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aconitase/IPM isomerase family.Curated
Phylogenomic databases
eggNOGi | COG1048, Bacteria |
HOGENOMi | CLU_013476_2_1_6 |
OMAi | NGGIMQY |
Family and domain databases
CDDi | cd01580, AcnA_IRP_Swivel, 1 hit |
Gene3Di | 3.20.19.10, 1 hit 3.30.499.10, 2 hits |
InterProi | View protein in InterPro IPR044137, AcnA_IRP_Swivel IPR015931, Acnase/IPM_dHydase_lsu_aba_1/3 IPR001030, Acoase/IPM_deHydtase_lsu_aba IPR015928, Aconitase/3IPM_dehydase_swvl IPR006249, Aconitase/IRP2 IPR018136, Aconitase_4Fe-4S_BS IPR036008, Aconitase_4Fe-4S_dom IPR000573, AconitaseA/IPMdHydase_ssu_swvl |
PANTHERi | PTHR11670, PTHR11670, 1 hit |
Pfami | View protein in Pfam PF00330, Aconitase, 1 hit PF00694, Aconitase_C, 1 hit |
PRINTSi | PR00415, ACONITASE |
SUPFAMi | SSF53732, SSF53732, 1 hit |
TIGRFAMsi | TIGR01341, aconitase_1, 1 hit |
PROSITEi | View protein in PROSITE PS00450, ACONITASE_1, 1 hit PS01244, ACONITASE_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P37032-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVGQDSLST KSQLTVDGKT YNYYSLKEAE NKHFKGINRL PYSLKVLLEN
60 70 80 90 100
LLRFEDGNTV TTKDIKAIAD WLHNKTSQHE IAFRPTRVLM QDFTGVPAVV
110 120 130 140 150
DLAAMRTAIV KMGGNADKIS PLSPVDLVID HSVMVDKFAS ADALEVNTKI
160 170 180 190 200
EIERNKERYE FLRWGQKAFS NFQVVPPGTG ICHQVNLEYL GKTVWNSEND
210 220 230 240 250
GQLYAYPDTL VGTDSHTTMI NGLGVLGWGV GGIEAEAAML GQPVSMLIPE
260 270 280 290 300
VIGFKLSGKL KEGITATDLV LTVTQMLRKK GVVGKFVEFY GPGLNDLPLA
310 320 330 340 350
DRATISNMAP EYGATCGFFP VDKETIKYLE LTGRDKHTIA LVEAYAKAQG
360 370 380 390 400
MWYDKDNEEP VFTDSLHLDL GSVEPSLAGP KRPQDKVNLS SLPVEFNNFL
410 420 430 440 450
IEVGKEKEKE KTFAVKNKDF QMKHGHVVIA AITSCTNTSN PSVLMAAGLV
460 470 480 490 500
AKKAIEKGLQ RKPWVKSSLA PGSKVVTDYL RHAGLQTYLD QLGFNLVGYG
510 520 530 540 550
CTTCIGNSGP LPDDISHCVA EHDLVVSSVL SGNRNFEGRV HPQVRANWLA
560 570 580 590 600
SPPLVVAYAL CGTTCSDLSR EPIGQDKEGN DVYLKDIWPS NEEIAAEVAK
610 620 630 640 650
VSGTMFRKEY AEVFKGDAHW QAIQTSSGQT YEWNPDSTYI QHPPFFENLS
660 670 680 690 700
LKPEPLKPIK QAYVLALFGD SITTDHISPA GSIKASSPAG LYLKSKGVDE
710 720 730 740 750
KDFNSYGSRR GNHEVMMRGT FANIRIRNEM TPGQEGGVTR YVPTGETMSI
760 770 780 790 800
YDAAMRYQEN QQDLVIIAGK EYGTGSSRDW AAKGTNLLGV KAVITESFER
810 820 830 840 850
IHRSNLIGMG ILPLQFKEGT TRKTLKLDGS ERISIEISDK LTPGAMVPVT
860 870 880 890
IERQDGDIEK IETLCRIDTA DELEYYKNGG ILQYVLRKIS S
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22081 Genomic DNA Translation: AAA25295.1 AE017354 Genomic DNA Translation: AAU27770.1 |
PIRi | B48642 |
RefSeqi | WP_010947417.1, NC_002942.5 YP_095717.1, NC_002942.5 |
Genome annotation databases
EnsemblBacteriai | AAU27770; AAU27770; lpg1690 |
GeneIDi | 66490822 |
KEGGi | lpn:lpg1690 |
PATRICi | fig|272624.6.peg.1771 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L22081 Genomic DNA Translation: AAA25295.1 AE017354 Genomic DNA Translation: AAU27770.1 |
PIRi | B48642 |
RefSeqi | WP_010947417.1, NC_002942.5 YP_095717.1, NC_002942.5 |
3D structure databases
SMRi | P37032 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 272624.lpg1690 |
Proteomic databases
PaxDbi | P37032 |
Genome annotation databases
EnsemblBacteriai | AAU27770; AAU27770; lpg1690 |
GeneIDi | 66490822 |
KEGGi | lpn:lpg1690 |
PATRICi | fig|272624.6.peg.1771 |
Phylogenomic databases
eggNOGi | COG1048, Bacteria |
HOGENOMi | CLU_013476_2_1_6 |
OMAi | NGGIMQY |
Enzyme and pathway databases
UniPathwayi | UPA00223;UER00718 UPA00946 |
Family and domain databases
CDDi | cd01580, AcnA_IRP_Swivel, 1 hit |
Gene3Di | 3.20.19.10, 1 hit 3.30.499.10, 2 hits |
InterProi | View protein in InterPro IPR044137, AcnA_IRP_Swivel IPR015931, Acnase/IPM_dHydase_lsu_aba_1/3 IPR001030, Acoase/IPM_deHydtase_lsu_aba IPR015928, Aconitase/3IPM_dehydase_swvl IPR006249, Aconitase/IRP2 IPR018136, Aconitase_4Fe-4S_BS IPR036008, Aconitase_4Fe-4S_dom IPR000573, AconitaseA/IPMdHydase_ssu_swvl |
PANTHERi | PTHR11670, PTHR11670, 1 hit |
Pfami | View protein in Pfam PF00330, Aconitase, 1 hit PF00694, Aconitase_C, 1 hit |
PRINTSi | PR00415, ACONITASE |
SUPFAMi | SSF53732, SSF53732, 1 hit |
TIGRFAMsi | TIGR01341, aconitase_1, 1 hit |
PROSITEi | View protein in PROSITE PS00450, ACONITASE_1, 1 hit PS01244, ACONITASE_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ACON_LEGPH | |
Accessioni | P37032Primary (citable) accession number: P37032 Secondary accession number(s): Q5ZUV2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 1, 1994 |
Last sequence update: | June 1, 1994 | |
Last modified: | February 23, 2022 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families